White matter tract-oriented deformation is dependent on real-time axonal fiber orientation.

abstract：:This study characterized the effects of fluid percussion brain injury (FPI) on angiotensin II (AII)-induced cerebral vasodilation, determined the role of prostaglandins in such changes and evaluated the contribution of two subtypes of AII receptors (AT(1) and AT(2)) to the effects of AII on cerebrovascular regulation....

journal_title：Journal of neurotrauma

authors： Baranov D,Armstead WM

更新日期：2002-11-01 00:00:00

abstract：:The role of endothelin (ET) in the pathophysiology of secondary neural damage after experimental spinal cord injury (SCI) was examined in a rat model of weight-drop contusion injury. Initial studies demonstrated a significant increase in spinal ET concentrations in a 7.5-mm segment of tissue (centered at the impact si...

journal_title：Journal of neurotrauma

authors： Salzman SK,Acosta R,Beck G,Madden J,Boxer B,Ohlstein EH

更新日期：1996-02-01 00:00:00

abstract：:Traumatic brain injury (TBI) can trigger disturbances of cerebral pressure autoregulation that can translate into the generation of secondary insults and increased morbidity/mortality. Few therapies have been developed to attenuate the damaging consequences of disturbed autoregulatory control, although some suggest th...

journal_title：Journal of neurotrauma

authors： Fujita M,Wei EP,Povlishock JT

更新日期：2012-05-01 00:00:00

abstract：:The purpose of this paper is to present results from methodologies used in our laboratory that are targeted toward identifying specific brain injury thresholds. Results from studying one form of brain injury, diffuse axonal injury, are presented in this report. Physical models, or surrogates, of the skull-brain comple...

journal_title：Journal of neurotrauma

authors： Meaney DF,Smith DH,Shreiber DI,Bain AC,Miller RT,Ross DT,Gennarelli TA

更新日期：1995-08-01 00:00:00

abstract：:Formation of a glial scar is one of the major obstacles to axonal growth after injury to the adult CNS. In this study, we have addressed this issue by focusing on reactive astrocytes in a mouse model of spinal cord injury (SCI). First, we attempted to identify profile changes in the expression of astrocytic gliosis 10...

journal_title：Journal of neurotrauma

authors： Ito M,Natsume A,Takeuchi H,Shimato S,Ohno M,Wakabayashi T,Yoshida J

更新日期：2009-01-01 00:00:00

abstract：:For patients surviving serious traumatic brain injury (TBI), families and other stakeholders often desire information on long-term functional prognosis, but accurate and easy-to-use clinical tools are lacking. We aimed to build utilitarian decision trees from commonly collected clinical variables to predict Glasgow Ou...

journal_title：Journal of neurotrauma

authors： Walker WC,Stromberg KA,Marwitz JH,Sima AP,Agyemang AA,Graham KM,Harrison-Felix C,Hoffman JM,Brown AW,Kreutzer JS,Merchant R

更新日期：2018-07-15 00:00:00

abstract：:The presence of pelvic visceral inputs to neurons in the rostral medulla that are responsive to electrical stimulation of the abdominal branches of the vagus nerve (VAG-abd) was investigated in a complete chronic T8 spinal transection rat model. Using extracellular electrophysiological recordings from single medullary...

journal_title：Journal of neurotrauma

authors： Kaddumi EG,Hubscher CH

更新日期：2007-07-01 00:00:00

abstract：:This paper encompasses the prediction of early and late recovery from traumatic brain injury (TBI). Predictors of the duration of coma and the utilization of posttraumatic amnesia duration to predict residual memory function are discussed. The issues surrounding prediction of long-term neurobehavioral recovery from TB...

journal_title：Journal of neurotrauma

authors： Levin HS

更新日期：1995-10-01 00:00:00

abstract：:Anesthetics can either promote or inhibit the development of neurogenic pulmonary edema (NPE) after central nervous system (CNS) injury. The influence of isoflurane was examined in male Wistar rats using 1.5%, 2%, 2.5%, 3%, 4%, or 5% isoflurane in air. Epidural balloon compression of the thoracic spinal cord was perfo...

journal_title：Journal of neurotrauma

authors： Sedý J,Urdzíková L,Likavcanová K,Hejcl A,Burian M,Jendelová P,Zicha J,Kunes J,Syková E

更新日期：2007-09-01 00:00:00

abstract：:Prognostic models that were developed by the International Mission on Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) study group and the Corticosteroid Randomization After Signification Head injury (CRASH) collaborators are the most commonly used prognostic models for outcome after trauma...

journal_title：Journal of neurotrauma

authors： Castaño-Leon AM,Lora D,Munarriz PM,Cepeda S,Paredes I,de la Cruz J,Gómez Lopez PA,Lagares A

更新日期：2016-09-01 00:00:00

abstract：:Experimental compression injury of the spinal cord in guinea pigs results in delayed neurologic deficits that continue to increase in severity for several days following trauma, coincident with inflammatory responses, including invasion of the lesion by mononuclear phagocytes and increased levels of the neurotoxin qui...

journal_title：Journal of neurotrauma

authors： Blight AR,Leroy EC Jr,Heyes MP

更新日期：1997-02-01 00:00:00

abstract：:Delirium is a commonly reported acute care adverse event in patients with traumatic spinal cord injury (TSCI), but studies specifically investigating it in this population are lacking. The purpose of this study was to characterize the onset, risk factors, and impact of delirium in patients with TSCI. Patients discharg...

journal_title：Journal of neurotrauma

authors： Cheung A,Thorogood NP,Noonan VK,Zhong Y,Fisher CG,Dvorak MF,Street J

更新日期：2013-11-01 00:00:00

abstract：:Fatalities or injuries following motorized and non-motorized vehicle accidents (MNMVA) are reported by police or health care systems. However, limited data exist for spinal injuries. Using an epidemiological database of road accidents occurring in a defined geographic area, we measured the incidence of major spinal tr...

journal_title：Journal of neurotrauma

authors： Lieutaud T,Ndiaye A,Frost F,Chiron M,Registry Group.

更新日期：2010-06-01 00:00:00

abstract：:The purpose of this study was to evaluate the effects of posttraumatic hyperglycemia on contusion volume and neutrophil accumulation following moderate traumatic brain injury (TBI) in rats. A parasagittal fluid-percussion (F-P) brain injury (1.8-2.1 atm) was induced in male Sprague-Dawley rats. Rats were then randomiz...

journal_title：Journal of neurotrauma

authors： Kinoshita K,Kraydieh S,Alonso O,Hayashi N,Dietrich WD

更新日期：2002-06-01 00:00:00

abstract：:Closed-head concussive injury is one of the most common causes of traumatic brain injury (TBI). While single concussions result in short-term neurologic dysfunction, multiple concussions can result in cumulative damage and increased risk for neurodegenerative disease. Despite the prevalence of concussion, knowledge ab...

journal_title：Journal of neurotrauma

authors： Chen Z,Leung LY,Mountney A,Liao Z,Yang W,Lu XC,Dave J,Deng-Bryant Y,Wei G,Schmid K,Shear DA,Tortella FC

更新日期：2012-01-20 00:00:00

abstract：:The effectiveness of cerebrospinal fluid (CSF) drainage in lowering high intracranial pressure (ICP) is well established in severe traumatic brain injury (TBI). Recently, however, the use of external ventricular drains (EVDs) and ICP monitors in TBI has come under question. The aim of this retrospective study was to i...

journal_title：Journal of neurotrauma

authors： Akbik OS,Krasberg M,Nemoto EM,Yonas H

更新日期：2017-11-15 00:00:00

abstract：:Posttraumatic ischemia appears to be largely responsible for the extension of lesions in acute injury of the spinal cord. In the present study, we have evaluated the putative improvement of axonal function by the calcium channel blocker nimodipine after acute trauma of the spinal cord. Three techniques were used: (1) ...

journal_title：Journal of neurotrauma

authors： Pointillart V,Gense D,Gross C,Bidabé AM,Gin AM,Rivel J,Caillé JM,Sénégas J

更新日期：1993-07-01 00:00:00

abstract：:Traumatic brain injury (TBI) alters function and behavior, which can be characterized by changes in electrophysiological function in vitro. A common cognitive deficit after mild-to-moderate TBI is disruption of persistent working memory, of which the in vitro correlate is long-lasting, neuronal network synchronization...

journal_title：Journal of neurotrauma

authors： Kang WH,Cao W,Graudejus O,Patel TP,Wagner S,Meaney DF,Morrison B 3rd

更新日期：2015-07-01 00:00:00

abstract：:Our aim for this study was to quantitatively develop an early epidural hematoma (EDH) natural evolutionary curve and assess association of the most common radiological signs of initially nonsurgical supratentorial EDHs on early computed tomography (CT), in addition to their CT time for EDH enlargement. We retrospectiv...

journal_title：Journal of neurotrauma

authors： Xiao B,Ma MY,Duan ZX,Liu JG,Chen RP,Mao Q

更新日期：2015-04-01 00:00:00

abstract：:The translation of therapeutic interventions to humans with spinal cord injury with the goal of promoting growth and repair in the central nervous system could, inadvertently, drive mechanisms associated with the development of neuropathic pain. A framework is needed to evaluate the probability that a therapeutic inte...

journal_title：Journal of neurotrauma

authors： Warner FM,Cragg JJ,Jutzeler CR,Finnerup NB,Werhagen L,Weidner N,Maier D,Kalke YB,Curt A,Kramer JLK

更新日期：2019-05-01 00:00:00

abstract：:Task-specific rehabilitation has been shown to promote functional recovery after acute spinal cord injury (SCI). Recently, the omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA), has been shown to promote neuroplasticity after SCI. Here, we investigated whether the combination of a single bolus of DHA with...

journal_title：Journal of neurotrauma

authors： Liu ZH,Yip PK,Priestley JV,Michael-Titus AT

更新日期：2017-05-01 00:00:00

abstract：:Cultured astrocytes, exposed to glutamate at a dose that is generally neurotoxic in vitro (1 mM), exhibit transient swelling in the absence of cell death. In the present study, we further characterize this response by examining the distribution of intermediate filaments and evaluating cellular ultrastructure in primar...

journal_title：Journal of neurotrauma

authors： Noble LJ,Hall JJ,Chen S,Chan PH

更新日期：1992-10-01 00:00:00

abstract：:Diffuse axonal injury is recognized as a progressive and long-term consequence of traumatic brain injury. Axonal injury can have sustained negative consequences on neuronal functions such as anterograde and retrograde transport and cellular processes such as autophagy that depend on cytoarchitecture and axon integrity...

journal_title：Journal of neurotrauma

authors： Hensley K,Poteshkina A,Johnson MF,Eslami P,Gabbita SP,Hristov AM,Venkova-Hristova KM,Harris-White ME

更新日期：2016-08-15 00:00:00

abstract：:Traumatic injury is a common cause of coagulopathy, primarily due to blood loss and hemodilution secondary to fluid resuscitation. Traumatic injury-associated coagulopathy often follows a course of transition from hyper- to hypocoagulable state exemplified in disseminated intravascular coagulation. The incidence of co...

journal_title：Journal of neurotrauma

authors： Zhang J,Jiang R,Liu L,Watkins T,Zhang F,Dong JF

更新日期：2012-11-20 00:00:00

abstract：:Athletes in contact sports sustain repetitive subconcussive head impacts in a brief window, yet neurophysiological sequelae from repetitive subconcussion remain unclear. This prospective longitudinal study examined a relationship between changes in plasma Tau protein levels and subconcussive impact kinematic data in 2...

journal_title：Journal of neurotrauma

authors： Kawata K,Rubin LH,Wesley L,Lee JH,Sim T,Takahagi M,Bellamy A,Tierney R,Langford D

更新日期：2018-01-15 00:00:00

abstract：:Spinal cord injury caused by stab wounds (SCISW) results from a partial or complete transection of the cord, and presents opportunities for interventional research. It is recognized that there is low incidence, but little is known about the natural history or the patient's suitability for long-term clinical outcome st...

journal_title：Journal of neurotrauma

authors： McCaughey EJ,Purcell M,Barnett SC,Allan DB

更新日期：2016-08-01 00:00:00

abstract：:Traumatic injury to the central nervous system (CNS) is accompanied by the spreading damage of secondary degeneration, resulting in further loss of neurons and function. Partial transection of the optic nerve (ON) has been used as a model of secondary degeneration, in which axons of retinal ganglion cells in the ventr...

journal_title：Journal of neurotrauma

authors： Fitzgerald M,Bartlett CA,Payne SC,Hart NS,Rodger J,Harvey AR,Dunlop SA

更新日期：2010-11-01 00:00:00

abstract：:Muscle strength was assessed from the maximum force that could be exerted voluntarily by triceps brachii muscles of 72 people with chronic cervical spinal cord injury (SCI) at or above C7, and 18 able-bodied (A-B) subjects. The magnitude of co-activation was estimated from the ratio of biceps brachii surface EMG to tr...

journal_title：Journal of neurotrauma

authors： Thomas CK,Tucker ME,Bigland-Ritchie B

更新日期：1998-02-01 00:00:00

abstract：:Traumatic brain injury (TBI) causes damage to the hypothalamo-hypophyseal axis, leading to endocrine dysregulation in up to 40% of TBI patients. Hence, there is an urgent need to identify non-invasive biomarkers for TBI-associated hypothalamo-hypophyseal pathology. Sushi repeat-containing protein X-linked 2 (SRPX2) is...

journal_title：Journal of neurotrauma

authors： Anwer M,Lara-Valderrabano L,Karttunen J,Ndode-Ekane XE,Puhakka N,Pitkänen A

更新日期：2020-04-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading cause of death and functional disability in western countries, affecting mostly young patients. Despite intense and sustained efforts deployed for the development of new therapeutic strategies, no clinical benefit has been shown by any of the investigated compounds. Increasing...

journal_title：Journal of neurotrauma

authors： Soustiel JF,Palzur E,Nevo O,Thaler I,Vlodavsky E

更新日期：2005-03-01 00:00:00