Concussion Induces Hippocampal Circuitry Disruption in Swine.

abstract：:Adequate nutritional support is a major challenge in brain injury patients, because malnutrition cannot be reversed by standard enteral nutrition. We hypothesized that an oligomeric formula could improve nutritional status by restoring intestinal trophicity. Eighteen male Sprague-Dawley rats (300-330 g) underwent gast...

journal_title：Journal of neurotrauma

authors： Moinard C,Delpierre E,Loï C,Neveux N,Butel MJ,Cynober L,Charrueau C

更新日期：2013-06-01 00:00:00

abstract：:Injured neurons in the mammalian central nervous system (CNS) do not normally regenerate their axons after injury. Neurotrauma to the CNS usually results in axonal damage and subsequent loss of communication between neuronal networks, causing long-term functional deficits. For CNS regeneration, repair strategies need ...

journal_title：Journal of neurotrauma

authors： Ruitenberg MJ,Vukovic J,Sarich J,Busfield SJ,Plant GW

更新日期：2006-03-01 00:00:00

abstract：:Oxidative energy metabolism is depressed after mild/moderate traumatic brain injury (TBI) during early development, accompanied by behavioral debilitation and secondary neuronal death. A TBI metabolome analysis revealed broad effects with a striking impact on energy metabolism. Our studies on mitochondrial modulators ...

journal_title：Journal of neurotrauma

authors： Chitturi J,Santhakumar V,Kannurpatti SS

更新日期：2019-04-15 00:00:00

abstract：:Studies measuring the volume of infarcted tissue and survival after pharmacologic intervention in stroke are complicated by the potential effect of survival time on infarct volume. In this study, the volume of infarcted tissue as defined by 2,3,5-triphenyltetrazolium chloride staining was determined in rabbits at 28 h...

journal_title：Journal of neurotrauma

authors： Browning JL,Widmayer MA,Hoffmann KK,Dudley AW Jr,Baskin DS

更新日期：1996-10-01 00:00:00

abstract：:The effects of ethanol intoxication on brain injury and cerebral blood flow (CBF) were investigated in a porcine fluid-percussion model of traumatic brain injury (TBI). Immature swine, under halothane anesthesia (1%), had a TBI delivered with a fluid-percussion device. The experimental group (n = 10) received ethanol ...

journal_title：Journal of neurotrauma

authors： Zink BJ,Walsh RF,Feustel PJ

更新日期：1993-10-01 00:00:00

abstract：:With a rising number of cranioplasty (CP) procedures and an increasing percentage of patients with a good clinical outcome and prolonged survival after CP, looking at the functional and aesthetic outcome of these patients becomes more and more important. The aim of our study was to evaluate a novel score, combining fu...

journal_title：Journal of neurotrauma

authors： Henker C,Hoppmann MC,Sherman MUS,Glass A,Piek J

更新日期：2018-04-15 00:00:00

abstract：:Traumatic brain injury (TBI) is known to be accompanied by an increase in intracranial pressure (ICP) and in some cases, by spontaneous generation of cortical spreading depression (CSD) cycles. However, the role of CSD in the pathophysiology of cerebral contusion is still unknown. A multiparametric monitoring assembly...

journal_title：Journal of neurotrauma

authors： Rogatsky GG,Sonn J,Kamenir Y,Zarchin N,Mayevsky A

更新日期：2003-12-01 00:00:00

abstract：:Outcome following traumatic brain injury (TBI) is not only dependent on the nature and severity of injury and subsequent treatment, but also on constituent characteristics of injured individuals. We aimed to describe and quantify the relationship between demographic characteristics and six month outcome assessed by th...

journal_title：Journal of neurotrauma

authors： Mushkudiani NA,Engel DC,Steyerberg EW,Butcher I,Lu J,Marmarou A,Slieker F,McHugh GS,Murray GD,Maas AI

更新日期：2007-02-01 00:00:00

abstract：:Proton magnetic resonance spectroscopy (1H-MRS) offers a unique insight into brain cellular metabolism following traumatic brain injury (TBI). The aim of the present study was to assess change in neurometabolite markers of brain injury during the recovery period following TBI. We studied 19 TBI patients at 1.5, 3, and...

journal_title：Journal of neurotrauma

authors： Brooks WM,Stidley CA,Petropoulos H,Jung RE,Weers DC,Friedman SD,Barlow MA,Sibbitt WL Jr,Yeo RA

更新日期：2000-08-01 00:00:00

abstract：:This study characterized the effects of fluid percussion brain injury (FPI) on angiotensin II (AII)-induced cerebral vasodilation, determined the role of prostaglandins in such changes and evaluated the contribution of two subtypes of AII receptors (AT(1) and AT(2)) to the effects of AII on cerebrovascular regulation....

journal_title：Journal of neurotrauma

authors： Baranov D,Armstead WM

更新日期：2002-11-01 00:00:00

abstract：:Spinal cord injury (SCI) frequently results in chronic neuropathic pain (CNP). However, the understanding of brain neural circuits in CNP modulation is unclear. The present study examined the changes of ventral tegmental area (VTA) putative GABAergic and dopaminergic neuronal activity with CNP attenuation in rats. SCI...

journal_title：Journal of neurotrauma

authors： Ko MY,Jang EY,Lee JY,Kim SP,Whang SH,Lee BH,Kim HY,Yang CH,Cho HJ,Gwak YS

更新日期：2018-08-01 00:00:00

abstract：:Although atrophic changes have been well described following traumatic brain injury (TBI) in humans, little is known concerning the mechanisms or progression of brain tissue loss. In the present study, we evaluated the temporal profile of histopathological changes following parasagittal fluid-percussion (FP) brain inj...

journal_title：Journal of neurotrauma

authors： Smith DH,Chen XH,Pierce JE,Wolf JA,Trojanowski JQ,Graham DI,McIntosh TK

更新日期：1997-10-01 00:00:00

abstract：:Traumatic brain injury (TBI) is associated with enhanced osteogenesis. The aim of this study was to investigate the effect of serum from TBI rats on fracture healing. Results from this study showed that the serum from TBI rats enhanced the expression of bone gamma carboxyglutamate protein (BGLAP), and promoted in vitr...

journal_title：Journal of neurotrauma

authors： Yang S,Ma Y,Liu Y,Que H,Zhu C,Liu S

更新日期：2012-11-20 00:00:00

abstract：:Death of Central Nervous System (CNS) neurons following traumatic brain injury (TBI) is a complex process arising from a combination of factors, many of which are still unknown. It has been found that inhibition of transient receptor potential (TRP) channels constitutes an effective strategy for preventing death of CN...

journal_title：Journal of neurotrauma

authors： Peters M,Trembovler V,Alexandrovich A,Parnas M,Birnbaumer L,Minke B,Shohami E

更新日期：2012-12-10 00:00:00

abstract：:Traumatic brain injury (TBI) is a silent epidemic affecting approximately 1.4 million Americans annually, at an estimated annual cost of $60 billion in the United States alone. Despite an increased understanding of the pathophysiology of closed head injury, there remains no pharmacological intervention proven to impro...

journal_title：Journal of neurotrauma

authors： Laskowitz DT,McKenna SE,Song P,Wang H,Durham L,Yeung N,Christensen D,Vitek MP

更新日期：2007-07-01 00:00:00

abstract：:The generation of oxygen radicals and the process of lipid peroxidation have become a focus of attention for investigators in the fields of central nervous system (CNS) injury and stroke (e.g., ischemia). While absolute proof for their involvement in the pathophysiology of traumatic and ischemic damage to the CNS rema...

journal_title：Journal of neurotrauma

authors： Braughler JM,Hall ED

更新日期：1992-03-01 00:00:00

abstract：:We investigated the effect of sports activity on physically-disabled individuals using behavioral and electrophysiological techniques. Visual go/no-go discriminative and simple response tasks were used. Participants included 17 disabled athletes, 9 from open-skill (wheelchair basketball) and eight from closed-skill (s...

journal_title：Journal of neurotrauma

authors： Di Russo F,Bultrini A,Brunelli S,Delussu AS,Polidori L,Taddei F,Traballesi M,Spinelli D

更新日期：2010-12-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) play a key role in tissue repair and regeneration. Previous studies have shown a positive correlation between the number of circulating EPCs and clinical outcomes of patients with traumatic brain injury (TBI). A recent study has further shown that intravenous infusion of human umbil...

journal_title：Journal of neurotrauma

authors： Huang XT,Zhang YQ,Li SJ,Li SH,Tang Q,Wang ZT,Dong JF,Zhang JN

更新日期：2013-12-15 00:00:00

abstract：:Gap junctions are conductive channels formed by membrane proteins termed connexins (Cx), which permit the intercellular exchange of metabolites, ions, and small molecules. Junctional permeability is regulated by pH, membrane potential, and intracellular secondary messengers. The purpose of this study was to elucidate ...

journal_title：Journal of neurotrauma

authors： Ohsumi A,Nawashiro H,Otani N,Ooigawa H,Toyooka T,Shima K

更新日期：2010-07-01 00:00:00

abstract：:While autonomic dysreflexia (AD) is well recognized in the chronic stage of spinal cord injury (SCI) this potentially life-threatening complication has been only rarely documented in the acute phase (1 month) after SCI. Based on our clinical experience we hypothesized that AD is under-recognized in the acute phase of ...

journal_title：Journal of neurotrauma

authors： Krassioukov AV,Furlan JC,Fehlings MG

更新日期：2003-08-01 00:00:00

abstract：:. ...

journal_title：Journal of neurotrauma

authors： Maas A

更新日期：2018-08-04 00:00:00

abstract：:It remains unclear whether the benefits of early surgical timing are significant in neurologically complete spinal cord injury (SCI). We wanted to compare the effects of early and late surgical timing on non-neurological outcomes in persons with traumatic complete SCI. All cases of traumatic complete SCI referred to a...

journal_title：Journal of neurotrauma

authors： Bourassa-Moreau E,Mac-Thiong JM,Feldman DE,Thompson C,Parent S

更新日期：2013-09-15 00:00:00

abstract：:Accumulating evidence suggests that the extent of brain injury and the clinical outcome after traumatic brain injury (TBI) are modulated, to some degree, by genetic variants. Aquaporin-4 (AQP4) is the predominant water channel in the central nervous system and plays a critical role in controlling the water content of ...

journal_title：Journal of neurotrauma

authors： Dardiotis E,Paterakis K,Tsivgoulis G,Tsintou M,Hadjigeorgiou GF,Dardioti M,Grigoriadis S,Simeonidou C,Komnos A,Kapsalaki E,Fountas K,Hadjigeorgiou GM

更新日期：2014-12-01 00:00:00

abstract：:Ocular blast injury is a major medical concern for soldiers and explosion victims due to poor visual outcomes. To define the changes in gene expression following a blast injury to the eye, we examined retinal ribonucleic acid (RNA) expression in 54 mouse strains 5 days after a single 50-psi overpressure air wave blast...

journal_title：Journal of neurotrauma

authors： Struebing FL,King R,Li Y,Chrenek MA,Lyuboslavsky PN,Sidhu CS,Iuvone PM,Geisert EE

更新日期：2018-01-01 00:00:00

abstract：:The purpose of this study was to determine the relationship between endothelin-1 (ET-1), a prominent vasoactive agent, and the breakdown of the blood-spinal cord barrier along the axis of the cord after a moderate spinal cord injury. In the first study rats (n = 10) were euthanized 24 h after spinal cord injury and co...

journal_title：Journal of neurotrauma

authors： McKenzie AL,Hall JJ,Aihara N,Fukuda K,Noble LJ

更新日期：1995-06-01 00:00:00

abstract：:Studies have shown reduced life expectancy following moderate-severe traumatic brain injury (TBI) with death from unintentional poisoning (UP) being 11 times higher following TBI than in the general population. The characteristics of those who die of unintentional poisoning are compared with the characteristics of tho...

journal_title：Journal of neurotrauma

authors： Hammond FM,Ketchum J,Dams-O'Connor K,Corrigan JD,Miller C,Haarbauer-Krupa J,Faul M,Trexler LE,Harrison-Felix C

更新日期：2020-12-01 00:00:00

abstract：:Acute subdural hemorrhage (ASDH) is common and associated with severe morbidity and mortality. To date, the role of spontaneous cortical spreading depression (sCSD) in exaggerating secondary injury after ASDH, is poorly understood. The present study contains two experimental groups: First, we investigated and characte...

journal_title：Journal of neurotrauma

authors： Krenzlin H,Jussen D,Plath M,Tretzel SJ,Krämer T,Kempski O,Alessandri B

更新日期：2019-01-15 00:00:00

abstract：:The purpose of this study was to evaluate the effects of posttraumatic hyperglycemia on contusion volume and neutrophil accumulation following moderate traumatic brain injury (TBI) in rats. A parasagittal fluid-percussion (F-P) brain injury (1.8-2.1 atm) was induced in male Sprague-Dawley rats. Rats were then randomiz...

journal_title：Journal of neurotrauma

authors： Kinoshita K,Kraydieh S,Alonso O,Hayashi N,Dietrich WD

更新日期：2002-06-01 00:00:00

abstract：:This study was designed to investigate the additional benefits of a multimodal early onset stimulation (MEOS) paradigm when combined with enriched environment (EE) versus EE only and standard housing (SH) on the recovery after experimental traumatic brain injury (TBI). Male Sprague- Dawley rats were subjected to moder...

journal_title：Journal of neurotrauma

authors： Maegele M,Lippert-Gruener M,Ester-Bode T,Sauerland S,Schäfer U,Molcanyi M,Lefering R,Bouillon B,Neiss WF,Angelov DN,Klug N,McIntosh TK,Neugebauer EA

更新日期：2005-07-01 00:00:00

abstract：:The family of the collapsin response mediator proteins (CRMPs) plays a significant physiological role in neuronal cell bodies and axons within the integrated mammalian central nervous system (CNS). Trauma-induced damage to the CNS results in variable degrees of axonal degeneration, and this may lead to neuronal cell d...

journal_title：Journal of neurotrauma

authors： Taghian K,Lee JY,Petratos S

更新日期：2012-06-10 00:00:00