AQP4 tag single nucleotide polymorphisms in patients with traumatic brain injury.

abstract：:This study characterized the effects of fluid percussion brain injury (FPI) on angiotensin II (AII)-induced cerebral vasodilation, determined the role of prostaglandins in such changes and evaluated the contribution of two subtypes of AII receptors (AT(1) and AT(2)) to the effects of AII on cerebrovascular regulation....

journal_title：Journal of neurotrauma

authors： Baranov D,Armstead WM

更新日期：2002-11-01 00:00:00

abstract：:For patients surviving serious traumatic brain injury (TBI), families and other stakeholders often desire information on long-term functional prognosis, but accurate and easy-to-use clinical tools are lacking. We aimed to build utilitarian decision trees from commonly collected clinical variables to predict Glasgow Ou...

journal_title：Journal of neurotrauma

authors： Walker WC,Stromberg KA,Marwitz JH,Sima AP,Agyemang AA,Graham KM,Harrison-Felix C,Hoffman JM,Brown AW,Kreutzer JS,Merchant R

更新日期：2018-07-15 00:00:00

abstract：:Chronic pain and dysesthesias are debilitating conditions that can arise following spinal cord injury (SCI). Research studies frequently employ rodent models of SCI to better understand the underlying mechanisms and develop better treatments for these phenomena. While evoked withdrawal tests can assess hypersensitivit...

journal_title：Journal of neurotrauma

authors： Hoschouer EL,Finseth T,Flinn S,Basso DM,Jakeman LB

更新日期：2010-05-01 00:00:00

abstract：:We have previously shown that early treatment with fresh frozen plasma (FFP) is neuroprotective in a swine model of hemorrhagic shock (HS) and traumatic brain injury (TBI). However, it remains unknown whether this strategy would be beneficial in a more clinical polytrauma model. Yorkshire swine (42-50 kg) were instrum...

journal_title：Journal of neurotrauma

authors： Imam A,Jin G,Sillesen M,Dekker SE,Bambakidis T,Hwabejire JO,Jepsen CH,Halaweish I,Alam HB

更新日期：2015-03-01 00:00:00

abstract：:In human diffuse axonal injury (DAI), axons are exposed to transient tensile strain. Over the ensuing several hours, injured axons enter a "pathological cascade" of events that lead to secondary axotomy. Use of animal models of traumatic axonal injury (TAI) has allowed description of a number of pathological changes b...

journal_title：Journal of neurotrauma

authors： Maxwell WL,Donnelly S,Sun X,Fenton T,Puri N,Graham DI

更新日期：1999-12-01 00:00:00

abstract：:Although mechanisms involved in progression of cell death in spinal cord injury (SCI) have been studied extensively, few are clear targets for translation to clinical application. One of the best-understood mechanisms of cell survival in SCI is phosphatidylinositol-3-kinase (PI3K)/Akt and associated downstream signali...

journal_title：Journal of neurotrauma

authors： Walker CL,Wu X,Liu NK,Xu XM

更新日期：2019-09-15 00:00:00

abstract：:Traumatic brain injuries (TBI) impose a significant burden on the health care system. The aim of the current study was to explore variation in costs in a group of rehabilitation patients in Victoria, Australia, following complicated mild-to-severe TBI treated under the accident compensation system administered by the ...

journal_title：Journal of neurotrauma

authors： Ponsford JL,Spitz G,Cromarty F,Gifford D,Attwood D

更新日期：2013-09-01 00:00:00

abstract：:Prevention of the immediate excitotoxic phase occurring in response to spinal cord injury (SCI) is a major issue to reduce the neuronal damage responsible for any ensuing motor deficits. The present study evaluated the neuroprotective efficacy of three noncompetitive NMDA receptor antagonists: Gacyclidine (GK-11), a n...

journal_title：Journal of neurotrauma

authors： Feldblum S,Arnaud S,Simon M,Rabin O,D'Arbigny P

更新日期：2000-11-01 00:00:00

abstract：:Behavioral assessment after spinal cord contusion has long focused on open field locomotion using modifications of a rating scale developed by Tarlov and Klinger (1954). However, on-going modifications by several groups have made interlaboratory comparison of locomotor outcome measures difficult. The purpose of the pr...

journal_title：Journal of neurotrauma

authors： Basso DM,Beattie MS,Bresnahan JC

更新日期：1995-02-01 00:00:00

abstract：:Mild traumatic brain injury (mTBI) accounts for the majority of head trauma cases. Despite some lasting cognitive, emotional, and behavioral deficits, there are frequently no overt morphological defects, suggesting that changes may result from alterations in the physiology of individual neurons. We investigated hippoc...

journal_title：Journal of neurotrauma

authors： Eakin K,Miller JP

更新日期：2012-04-10 00:00:00

abstract：:Large-scale network analysis characterizes the brain as a complex network of nodes and edges to evaluate functional connectivity patterns. The utility of graph-based techniques has been demonstrated in an increasing number of resting-state functional MRI (rs-fMRI) studies in the normal and diseased brain. However, to ...

journal_title：Journal of neurotrauma

authors： Kaushal M,Oni-Orisan A,Chen G,Li W,Leschke J,Ward BD,Kalinosky B,Budde MD,Schmit BD,Li SJ,Muqeet V,Kurpad SN

更新日期：2017-03-15 00:00:00

abstract：:Glycosylation is a fundamental cellular process that has a dramatic impact on the functionality of glycoconjugates such as proteins or lipids and mediates many different biological interactions including cell migration, cellular signaling, and synaptic interactions in the nervous system. In spinal cord injury (SCI), a...

journal_title：Journal of neurotrauma

authors： Osimanjiang W,Roballo KCS,Houck BD,Ito M,Antonopoulos A,Dell A,Haslam SM,Bushman JS

更新日期：2020-09-15 00:00:00

abstract：:We investigated the role of the axon guidance molecule EphA4 following traumatic brain injury (TBI) in mice. Neutralization of EphA4 improved motor function and axonal regeneration following experimental spinal cord injury (SCI). We hypothesized that genetic absence of EphA4 could improve functional and histological o...

journal_title：Journal of neurotrauma

authors： Hånell A,Clausen F,Djupsjö A,Vallstedt A,Patra K,Israelsson C,Larhammar M,Björk M,Paixão S,Kullander K,Marklund N

更新日期：2012-11-20 00:00:00

abstract：:Cultured astrocytes, exposed to glutamate at a dose that is generally neurotoxic in vitro (1 mM), exhibit transient swelling in the absence of cell death. In the present study, we further characterize this response by examining the distribution of intermediate filaments and evaluating cellular ultrastructure in primar...

journal_title：Journal of neurotrauma

authors： Noble LJ,Hall JJ,Chen S,Chan PH

更新日期：1992-10-01 00:00:00

abstract：:Spinal cord injury (SCI) frequently results in chronic neuropathic pain (CNP). However, the understanding of brain neural circuits in CNP modulation is unclear. The present study examined the changes of ventral tegmental area (VTA) putative GABAergic and dopaminergic neuronal activity with CNP attenuation in rats. SCI...

journal_title：Journal of neurotrauma

authors： Ko MY,Jang EY,Lee JY,Kim SP,Whang SH,Lee BH,Kim HY,Yang CH,Cho HJ,Gwak YS

更新日期：2018-08-01 00:00:00

abstract：:Spinal cord injury damaging the rubrospinal tract (RST) interferes with skilled forelimb movement, but identification of the precise role of the RST in this behavior is impeded by the difficulty of surgically isolating the RST from other pathways running within the lateral funiculus (LF). The present study used a skil...

journal_title：Journal of neurotrauma

authors： Morris R,Tosolini AP,Goldstein JD,Whishaw IQ

更新日期：2011-12-01 00:00:00

abstract：:The rate of paroxysmal sympathetic hyperactivity (PSH) was retrospectively assessed using the Paroxysmal Sympathetic Hyperactivity-Assessment Measure (PSH-AM) scale in patients with disorders of consciousness attributed to traumatic and non-traumatic acquired brain injury during the rehabilitation phase. These results...

journal_title：Journal of neurotrauma

authors： Lucca LF,Pignolo L,Leto E,Ursino M,Rogano S,Cerasa A

更新日期：2019-08-15 00:00:00

abstract：:Previous studies have shown that oxygen radical scavengers prevent the reduced cerebral blood flow that occurs following experimental traumatic brain injury. The exact chemical species responsible for the posttraumatic reduction in flow is unknown. We tested whether isoprostanes, which are formed by non-cyclooxygenase...

journal_title：Journal of neurotrauma

authors： Hoffman SW,Rzigalinski BA,Willoughby KA,Ellis EF

更新日期：2000-05-01 00:00:00

abstract：:Sixty-eight patients were entered into a randomized, prospective, double-blinded controlled trial of supplemental zinc versus standard zinc therapy to study the effects of zinc supplementation on neurologic recovery and nutritional/metabolic status after severe closed head injury. One month after injury, the mortality...

journal_title：Journal of neurotrauma

authors： Young B,Ott L,Kasarskis E,Rapp R,Moles K,Dempsey RJ,Tibbs PA,Kryscio R,McClain C

更新日期：1996-01-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) is commonly observed in military service members with mild traumatic brain injury (mTBI); however, the relationship between mTBI and PTSD is complex and not well understood. The present study aims to elucidate a link between the degree of alteration in limbic system-related white ...

journal_title：Journal of neurotrauma

authors： Santhanam P,Teslovich T,Wilson SH,Yeh PH,Oakes TR,Weaver LK

更新日期：2019-04-01 00:00:00

abstract：:Behavioral and morphological changes were examined for up to 9 days after moderate cerebral ischemia caused by slow compression of a specific brain area in the sensorimotor cortex of Sprague-Dawley rats. Functional deficits after the cerebral ischemia were assessed by daily beam-walking tests, whereas morphological ch...

journal_title：Journal of neurotrauma

authors： Kundrotiené J,Wägner A,Liljequist S

更新日期：2002-01-01 00:00:00

abstract：:Talampanel [(R)-7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3] benzodiazepine] is an orally active noncompetitive antagonist of the AMPA subtype of glutamate excitatory amino acid receptors. The purpose of this study was to determine whether treatment with talampanel would protect in a rat ...

journal_title：Journal of neurotrauma

authors： Belayev L,Alonso OF,Liu Y,Chappell AS,Zhao W,Ginsberg MD,Busto R

更新日期：2001-10-01 00:00:00

abstract：:Post-traumatic amnesia (PTA) is an acute characteristic of traumatic brain injury (TBI) and the duration of PTA is commonly used to estimate the severity of brain injury. In the context of mild traumatic brain injury (MTBI), PTA is an essential part of the routine clinical assessment. Macroscopic lesions in temporal l...

journal_title：Journal of neurotrauma

authors： Holli-Helenius K,Luoto TM,Brander A,Wäljas M,Iverson GL,Ohman J

更新日期：2014-07-01 00:00:00

abstract：:To examine the mechanism of the increase in cerebral blood flow induced by L-arginine administration after traumatic brain injury, the cerebral hemodynamic effects of L-arginine, D-arginine, and the free radical scavengers superoxide dismutase (SOD) and catalase were compared in the controlled cortical impact injury m...

journal_title：Journal of neurotrauma

authors： Cherian L,Robertson CS

更新日期：2003-01-01 00:00:00

abstract：:Central nervous system (CNS) destruction in spinal cord injury (SCI) is caused by a complex series of cellular and molecular events. Recent studies have concentrated on signaling by receptors in the tumor necrosis factor receptor (TNFR) superfamily that mediate diverse biological outcomes ranging from inflammation to ...

journal_title：Journal of neurotrauma

authors： Keane RW,Davis AR,Dietrich WD

更新日期：2006-03-01 00:00:00

abstract：:The etiology of multiple sclerosis (MS) is still not well known. Previous data show conflicting results regarding the association between MS and prior brain trauma. This study aims to investigate the risk for MS following a traumatic brain injury (TBI) using a large-scale cohort study design. This study used data from...

journal_title：Journal of neurotrauma

authors： Kang JH,Lin HC

更新日期：2012-01-01 00:00:00

abstract：:There is a need for better tools to objectively, reliably, and precisely assess neurological function after sport-related concussion (SRC). The aim of this study was to use a robotic device (Kinesiological Instrument for Normal and Altered Reaching Movements; KINARM) to quantify neurological impairments in athletes ac...

journal_title：Journal of neurotrauma

authors： Mang CS,Whitten TA,Cosh MS,Scott SH,Wiley JP,Debert CT,Dukelow SP,Benson BW

更新日期：2019-01-15 00:00:00

abstract：:Traumatic spinal cord injury (SCI) can cause permanent disabilities that seriously reduce quality of life. We evaluated the effects of chronic hyperglycemia before SCI on inflammatory markers and functional recovery after SCI in human patients and a rat model. In the human study, multivariate logistical regression ana...

journal_title：Journal of neurotrauma

authors： Park KS,Kim JB,Keung M,Seo YJ,Seo SY,Mun SA,Lee YS,Cho DC,Hwang JH,Han I,Kim CH,Kim KT

更新日期：2020-05-01 00:00:00

abstract：:Recently, locomotor training has been shown to improve overground locomotion in patients with spinal cord injury (SCI). This has triggered renewed interest in the role of exercise in rehabilitation after SCI. However, there are no mouse models for voluntary exercise and recovery of function following SCI. Here, we rep...

journal_title：Journal of neurotrauma

authors： Engesser-Cesar C,Anderson AJ,Basso DM,Edgerton VR,Cotman CW

更新日期：2005-01-01 00:00:00

abstract：:Delirium is a commonly reported acute care adverse event in patients with traumatic spinal cord injury (TSCI), but studies specifically investigating it in this population are lacking. The purpose of this study was to characterize the onset, risk factors, and impact of delirium in patients with TSCI. Patients discharg...

journal_title：Journal of neurotrauma

authors： Cheung A,Thorogood NP,Noonan VK,Zhong Y,Fisher CG,Dvorak MF,Street J

更新日期：2013-11-01 00:00:00