Structural integrity of medial temporal lobes of patients with acute mild traumatic brain injury.

abstract：:Prognostic models that were developed by the International Mission on Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) study group and the Corticosteroid Randomization After Signification Head injury (CRASH) collaborators are the most commonly used prognostic models for outcome after trauma...

journal_title：Journal of neurotrauma

authors： Castaño-Leon AM,Lora D,Munarriz PM,Cepeda S,Paredes I,de la Cruz J,Gómez Lopez PA,Lagares A

更新日期：2016-09-01 00:00:00

abstract：:Remarkable advances have been made in pharmacologic treatments of acute and chronic spinal cord injury. The recent National Acute Spinal Cord Injury Study (NASCIS) showed that very high dose methylprednisolone given within 8 hr after injury improves neurologic recovery. The mechanism is believed to be inhibition of li...

journal_title：Journal of neurotrauma

authors： Nockels R,Young W

更新日期：1992-03-01 00:00:00

abstract：:Neuropathic pain and motor deficits are detrimental consequences of injury to the spinal cord. In experimental settings, numerous neuroprotective agents are being explored for their therapeutic benefits. Vascular endothelial growth factor (VEGF) is an interesting candidate molecule in this respect since it is not only...

journal_title：Journal of neurotrauma

authors： van Neerven S,Joosten EA,Brook GA,Lambert CA,Mey J,Weis J,Marcus MA,Steinbusch HW,van Kleef M,Patijn J,Deumens R

更新日期：2010-10-01 00:00:00

abstract：:Diffuse axonal injury is recognized as a progressive and long-term consequence of traumatic brain injury. Axonal injury can have sustained negative consequences on neuronal functions such as anterograde and retrograde transport and cellular processes such as autophagy that depend on cytoarchitecture and axon integrity...

journal_title：Journal of neurotrauma

authors： Hensley K,Poteshkina A,Johnson MF,Eslami P,Gabbita SP,Hristov AM,Venkova-Hristova KM,Harris-White ME

更新日期：2016-08-15 00:00:00

abstract：:Glycosylation is a fundamental cellular process that has a dramatic impact on the functionality of glycoconjugates such as proteins or lipids and mediates many different biological interactions including cell migration, cellular signaling, and synaptic interactions in the nervous system. In spinal cord injury (SCI), a...

journal_title：Journal of neurotrauma

authors： Osimanjiang W,Roballo KCS,Houck BD,Ito M,Antonopoulos A,Dell A,Haslam SM,Bushman JS

更新日期：2020-09-15 00:00:00

abstract：:Inducible nitric oxide synthase (iNOS) has been suggested to play a complex role in the response to central nervous system insults such as traumatic brain injury (TBI) and cerebral ischemia. In the current study, we quantified maps of regional cerebral blood flow (CBF) using an arterial spin-labeling magnetic resonanc...

journal_title：Journal of neurotrauma

authors： Foley LM,Hitchens TK,Melick JA,Bayir H,Ho C,Kochanek PM

更新日期：2008-04-01 00:00:00

abstract：:Cultured astrocytes, exposed to glutamate at a dose that is generally neurotoxic in vitro (1 mM), exhibit transient swelling in the absence of cell death. In the present study, we further characterize this response by examining the distribution of intermediate filaments and evaluating cellular ultrastructure in primar...

journal_title：Journal of neurotrauma

authors： Noble LJ,Hall JJ,Chen S,Chan PH

更新日期：1992-10-01 00:00:00

abstract：:The majority of clinical spinal cord injuries (SCIs) are contusive and occur at the cervical level of the spinal cord. Most scientists and clinicians agree that the preclinical evaluation of novel candidate treatments should include testing in a cervical SCI contusion model. Because mice are increasingly used because ...

journal_title：Journal of neurotrauma

authors： Streijger F,Beernink TM,Lee JH,Bhatnagar T,Park S,Kwon BK,Tetzlaff W

更新日期：2013-05-15 00:00:00

abstract：:The presence of pelvic visceral inputs to neurons in the rostral medulla that are responsive to electrical stimulation of the abdominal branches of the vagus nerve (VAG-abd) was investigated in a complete chronic T8 spinal transection rat model. Using extracellular electrophysiological recordings from single medullary...

journal_title：Journal of neurotrauma

authors： Kaddumi EG,Hubscher CH

更新日期：2007-07-01 00:00:00

abstract：:Traumatic brain injury (TBI) is associated with enhanced osteogenesis. The aim of this study was to investigate the effect of serum from TBI rats on fracture healing. Results from this study showed that the serum from TBI rats enhanced the expression of bone gamma carboxyglutamate protein (BGLAP), and promoted in vitr...

journal_title：Journal of neurotrauma

authors： Yang S,Ma Y,Liu Y,Que H,Zhu C,Liu S

更新日期：2012-11-20 00:00:00

abstract：:Stretching of cultured neurons has been used to model diffuse axonal injury associated with brain trauma. N-Methyl-D-aspartate receptor (NMDAR) activation and group I metabotropic glutamate receptors (mGluRs) are implicated in the pathophysiology of such injury. Here we detail the effects of culture condition and mGlu...

journal_title：Journal of neurotrauma

authors： Lea PM 4th,Custer SJ,Stoica BA,Faden AI

更新日期：2003-11-01 00:00:00

abstract：:Minimal traumatic brain injury (mTBI) is partially defined by the existence of retrograde amnesia and is associated with microscopic bleeds containing activated coagulation factors. In a previous study, we have found that mTBI immediately releases thrombin-like activity in the brain, which induces amnesia by activatin...

journal_title：Journal of neurotrauma

authors： Itsekson-Hayosh Z,Shavit-Stein E,Katzav A,Rubovitch V,Maggio N,Chapman J,Harnof S,Pick CG

更新日期：2016-10-15 00:00:00

abstract：:Although sleep-wake disturbances are prevalent and well described after traumatic brain injury, their pathophysiology remains unclear, most likely because human traumatic brain injury is a highly heterogeneous entity that makes the systematic study of sleep-wake disturbances in relation to trauma-induced histological ...

journal_title：Journal of neurotrauma

authors： Noain D,Büchele F,Schreglmann SR,Valko PO,Gavrilov YV,Morawska MM,Imbach LL,Baumann CR

更新日期：2018-01-01 00:00:00

abstract：:Since free radicals play a role in the mechanisms of brain injury after hemorrhagic stroke, the effect of melatonin (a potent antioxidant and free-radical scavenger) on outcomes was investigated after intracerebral hemorrhage (ICH) in rats. ICH was induced by clostridial collagenase infusion into the right caudate put...

journal_title：Journal of neurotrauma

authors： Lekic T,Hartman R,Rojas H,Manaenko A,Chen W,Ayer R,Tang J,Zhang JH

更新日期：2010-03-01 00:00:00

abstract：:The purpose of this study was to define the relationships among clinical characteristics of chronic pain, injury characteristics, affective factors and autonomic dysreflexia (AD) in people with chronic cervical spinal cord injury (SCI). A survey containing questions concerning the presence of AD, demographic factors, ...

journal_title：Journal of neurotrauma

authors： Widerström-Noga E,Cruz-Almeida Y,Krassioukov A

更新日期：2004-02-01 00:00:00

abstract：:Multipotent neural progenitors and stem cells may integrate appropriately into the developing and degenerating central nervous system. They may also be effective in the replacement of genes, cells, and nondiffusible factors in either a widespread or a more circumscribed manner, depending on the therapeutic demands of ...

journal_title：Journal of neurotrauma

authors： Park KI,Liu S,Flax JD,Nissim S,Stieg PE,Snyder EY

更新日期：1999-08-01 00:00:00

abstract：:Traumatic injury to the central nervous system (CNS) is accompanied by the spreading damage of secondary degeneration, resulting in further loss of neurons and function. Partial transection of the optic nerve (ON) has been used as a model of secondary degeneration, in which axons of retinal ganglion cells in the ventr...

journal_title：Journal of neurotrauma

authors： Fitzgerald M,Bartlett CA,Payne SC,Hart NS,Rodger J,Harvey AR,Dunlop SA

更新日期：2010-11-01 00:00:00

abstract：:Although experience suggests a shift in the epidemiology of spinal cord injury (SCI) toward an older demographic, population studies are lacking. We aimed to evaluate (1) how the epidemiology and age profile of SCI have changed over time, and (2) how increased age impacts health outcomes up to 15 years post-injury. A ...

journal_title：Journal of neurotrauma

authors： Wilson JR,Cronin S,Fehlings MG,Kwon BK,Badhiwala JH,Ginsberg HJ,Witiw C,Jaglal S

更新日期：2020-08-01 00:00:00

abstract：:This study aimed to investigate the cortical motor excitability characteristics in diffuse axonal injury (DAI) due to severe traumatic brain injury (TBI). A variety of excitatory and inhibitory transcranial magnetic stimulation (TMS) paradigms were applied to primary motor cortices of 17 patients and 11 healthy contro...

journal_title：Journal of neurotrauma

authors： Bernabeu M,Demirtas-Tatlidede A,Opisso E,Lopez R,Tormos JM,Pascual-Leone A

更新日期：2009-12-01 00:00:00

abstract：:Traumatic brain injury (TBI) is an established risk factor for neurodegenerative disorders and dementias. Epigenetic modifications, such as DNA methylation, may alter the expression of genes without altering the DNA sequence in response to environmental factors. We hypothesized that DNA methylation changes may occur i...

journal_title：Journal of neurotrauma

authors： Abu Hamdeh S,Ciuculete DM,Sarkisyan D,Bakalkin G,Ingelsson M,Schiöth HB,Marklund N

更新日期：2021-01-08 00:00:00

abstract：:Traumatic Brain Injury (TBI) can be associated with partial or total smell loss. Recent studies have suggested that olfactory outcome can be positively modulated after olfactory training (OT). This study's aim was to investigate OT's potential role in smell recovery after TBI-induced olfactory loss. A prospective, ran...

journal_title：Journal of neurotrauma

authors： Langdon C,Lehrer E,Berenguer J,Laxe S,Alobid I,Quintó L,Mariño-Sánchez F,Bernabeu M,Marin C,Mullol J

更新日期：2018-11-15 00:00:00

abstract：:Neuropathic pain develops in 40-70% of spinal cord injury (SCI) patients and markedly compromises quality of life. We examined plasma from SCI patients for autoantibodies to glial fibrillary acidic protein (GFAP) and collapsin response mediator protein-2 (CRMP2) and evaluated their relationship to the development of n...

journal_title：Journal of neurotrauma

authors： Hergenroeder GW,Redell JB,Choi HA,Schmitt L,Donovan W,Francisco GE,Schmitt K,Moore AN,Dash PK

更新日期：2018-11-01 00:00:00

abstract：:Fluid percussion brain injury is associated with an immediate rise in mean arterial pressure (MAP). However, the cerebral morphologic basis for this response is still not clear. Thirty-four anesthetized rats were injured using a lateral craniotomy preparation. In 19 rats, impact level was set at 1.73 +/- 0.04 atm, and...

journal_title：Journal of neurotrauma

authors： Yuan XQ,Wade CE,Clifford CB

更新日期：1991-10-01 00:00:00

abstract：:Endothelial barrier antigen (EBA) is a protein triplet located in the plasma membrane of microvascular endothelium and selectively expressed in the normal nervous system. In this study, microvascular alterations following traumatic brain injury were studied using EBA immunohistochemistry. Anesthetized, physiologically...

journal_title：Journal of neurotrauma

authors： Lin B,Ginsberg MD,Zhao W,Alonso OF,Belayev L,Busto R

更新日期：2001-04-01 00:00:00

abstract：:Traumatic brain injury (TBI) is associated with loss of autoregulation due to impaired responsiveness to cerebrovascular dilator stimuli, which leads to cerebral hypoperfusion and neuronal impairment or death. Upregulation of tissue plasminogen activator (tPA) post-TBI exacerbates loss of cerebral autoregulation and N...

journal_title：Journal of neurotrauma

authors： Armstead WM,Riley J,Yarovoi S,Cines DB,Smith DH,Higazi AA

更新日期：2012-06-10 00:00:00

abstract：:Caspases are a family of mammalian proteases related to the ced-3 gene of Caenorhabditis elegans. They mediate many of the morphological and biochemical features of apoptosis, including structural dismantling of cell bodies and nuclei, fragmentation of genomic DNA, destruction of regulatory proteins, and propagation o...

journal_title：Journal of neurotrauma

authors： Eldadah BA,Faden AI

更新日期：2000-10-01 00:00:00

abstract：:The fluid-percussion technique produces experimental brain injury by rapid injection of a fluid volume into the closed cranial cavity. The experiments reported here characterize a new, more controlled technique for fluid-percussion brain injury in the rat and systematically examine systemic physiologic, histopathologi...

journal_title：Journal of neurotrauma

authors： Dixon CE,Lighthall JW,Anderson TE

更新日期：1988-01-01 00:00:00

abstract：:Our aim for this study was to quantitatively develop an early epidural hematoma (EDH) natural evolutionary curve and assess association of the most common radiological signs of initially nonsurgical supratentorial EDHs on early computed tomography (CT), in addition to their CT time for EDH enlargement. We retrospectiv...

journal_title：Journal of neurotrauma

authors： Xiao B,Ma MY,Duan ZX,Liu JG,Chen RP,Mao Q

更新日期：2015-04-01 00:00:00

abstract：:Traumatic brain injury (TBI) often occurs in conjunction with additional trauma, resulting in secondary complications, such as hypotension as a result of blood loss. This study investigated the combined effects of penetrating ballistic-like brain injury (PBBI) and hemorrhagic shock (HS) on physiological parameters, in...

journal_title：Journal of neurotrauma

authors： Leung LY,Wei G,Shear DA,Tortella FC

更新日期：2013-07-15 00:00:00

abstract：:Hippocampal-dependent deficits in learning and memory formation are a prominent feature of traumatic brain injury (TBI); however, the role of the hippocampus in cognitive dysfunction after concussion (mild TBI) is unknown. We therefore investigated functional and structural changes in the swine hippocampus following T...

journal_title：Journal of neurotrauma

authors： Wolf JA,Johnson BN,Johnson VE,Putt ME,Browne KD,Mietus CJ,Brown DP,Wofford KL,Smith DH,Grady MS,Cohen AS,Cullen DK

更新日期：2017-07-15 00:00:00