Altered expression of amyloid precursors proteins after traumatic brain injury in rats: in situ hybridization and immunohistochemical study.

abstract：:A retrospective case-control study was undertaken to determine the best technique to measure neural canal encroachment at each lumbar level following burst fracture and its relationship to the presence of neurologic deficit. Only patients with postinjury CT scans demonstrating a disrupted posterior body with a retropu...

journal_title：Journal of neurotrauma

authors： Rasmussen PA,Rabin MH,Mann DC,Perl JR 2nd,Lorenz MA,Vrbos LA

更新日期：1994-12-01 00:00:00

abstract：:Proton magnetic resonance spectroscopy (1H-MRS) offers a unique insight into brain cellular metabolism following traumatic brain injury (TBI). The aim of the present study was to assess change in neurometabolite markers of brain injury during the recovery period following TBI. We studied 19 TBI patients at 1.5, 3, and...

journal_title：Journal of neurotrauma

authors： Brooks WM,Stidley CA,Petropoulos H,Jung RE,Weers DC,Friedman SD,Barlow MA,Sibbitt WL Jr,Yeo RA

更新日期：2000-08-01 00:00:00

abstract：:This prospective multicenter study investigated the association of the course of coagulation abnormalities with initial computed tomography (CT) characteristics and outcome in patients with isolated traumatic brain injury (TBI). Patient demographics, coagulation parameters, CT characteristics, and outcome data of mode...

journal_title：Journal of neurotrauma

authors： Franschman G,Boer C,Andriessen TM,van der Naalt J,Horn J,Haitsma I,Jacobs B,Vos PE

更新日期：2012-01-01 00:00:00

abstract：:Microdialysis sampling was used to characterize the release of norepinephrine and serotonin upon impact injury to the rat spinal cord. Increases in extracellular norepinephrine concentrations in response to injury were small and of short duration. In contrast, serotonin concentrations quickly rose 35-90 times followin...

journal_title：Journal of neurotrauma

authors： Liu DX,Valadez V,Sorkin LS,McAdoo DJ

更新日期：1990-01-01 00:00:00

abstract：:Closed-head concussive injury is one of the most common causes of traumatic brain injury (TBI). Isolated concussions frequently produce acute neurological impairments, and individuals typically recover spontaneously within a short time frame. In contrast, brain injuries resulting from multiple concussions can result i...

journal_title：Journal of neurotrauma

authors： Mountney A,Boutté AM,Cartagena CM,Flerlage WF,Johnson WD,Rho C,Lu XC,Yarnell A,Marcsisin S,Sousa J,Vuong C,Zottig V,Leung LY,Deng-Bryant Y,Gilsdorf J,Tortella FC,Shear DA

更新日期：2017-10-01 00:00:00

abstract：:Clinical studies have documented the importance of secondary brain insults in determining neurologic outcome after head injury. Delayed intracranial hematomas are one of the most easily remediable causes of secondary injury if identified early, but can cause significant disability or death if not promptly recognized a...

journal_title：Journal of neurotrauma

authors： Robertson CS,Gopinath SP,Chance B

更新日期：1995-08-01 00:00:00

abstract：:Muscle strength was assessed from the maximum force that could be exerted voluntarily by triceps brachii muscles of 72 people with chronic cervical spinal cord injury (SCI) at or above C7, and 18 able-bodied (A-B) subjects. The magnitude of co-activation was estimated from the ratio of biceps brachii surface EMG to tr...

journal_title：Journal of neurotrauma

authors： Thomas CK,Tucker ME,Bigland-Ritchie B

更新日期：1998-02-01 00:00:00

abstract：:Following a controlled, severe contusion lesion to the lower thoracic spinal cord in adult rats, we found that apoptosis occurred in cells located in both gray and white matter. This suggested that both nonneuronal cells, including astrocytes, oligodendroglia and microglia, as well as neurons, might participate in pro...

journal_title：Journal of neurotrauma

authors： Yong C,Arnold PM,Zoubine MN,Citron BA,Watanabe I,Berman NE,Festoff BW

更新日期：1998-07-01 00:00:00

abstract：:Rotational acceleration of the head, as occurs in falls, car crashes, and sport injuries, may result in diffuse brain damage, with acute and chronic neurological and psychiatric symptoms. The present study addresses the effects of rotational trauma on the neuronal cytoskeleton, which stabilizes perikaryal, dendritic a...

journal_title：Journal of neurotrauma

authors： Hamberger A,Huang YL,Zhu H,Bao F,Ding M,Blennow K,Olsson A,Hansson HA,Viano D,Haglid KG

更新日期：2003-02-01 00:00:00

abstract：:Diffusion tensor imaging (DTI) has demonstrated success as a biomarker of spinal cord injury (SCI) severity as shown from numerous pre-clinical studies. However, artifacts from stabilization hardware at the lesion have precluded its use for longitudinal assessments. Previous research has documented ex vivo diffusion c...

journal_title：Journal of neurotrauma

authors： Motovylyak A,Skinner NP,Schmit BD,Wilkins N,Kurpad SN,Budde MD

更新日期：2019-05-01 00:00:00

abstract：:Oxidative energy metabolism is depressed after mild/moderate traumatic brain injury (TBI) during early development, accompanied by behavioral debilitation and secondary neuronal death. A TBI metabolome analysis revealed broad effects with a striking impact on energy metabolism. Our studies on mitochondrial modulators ...

journal_title：Journal of neurotrauma

authors： Chitturi J,Santhakumar V,Kannurpatti SS

更新日期：2019-04-15 00:00:00

abstract：:Traumatic brain injury (TBI) has been identified as a risk factor for Alzheimer's disease (AD). However, how such neural damage contributes to AD pathology remains unclear; specifically, the relationship between the timing of a TBI relative to aging and the onset of AD pathology is not known. In this study, we have ex...

journal_title：Journal of neurotrauma

authors： Collins JM,King AE,Woodhouse A,Kirkcaldie MTK,Vickers JC

更新日期：2019-06-01 00:00:00

abstract：:Central nervous system injuries such as focal brain ischemia and trauma are known to initiate inflammatory reactions. To demonstrate the involvement of adhesion molecules in these inflammatory responses, we have observed significant increases of ICAM-1 and ELAM-1 mRNA expression in the ischemic cortex of rats by means...

journal_title：Journal of neurotrauma

authors： Wang X,Feuerstein GZ

更新日期：1995-10-01 00:00:00

abstract：:Behavioral assessment after spinal cord contusion has long focused on open field locomotion using modifications of a rating scale developed by Tarlov and Klinger (1954). However, on-going modifications by several groups have made interlaboratory comparison of locomotor outcome measures difficult. The purpose of the pr...

journal_title：Journal of neurotrauma

authors： Basso DM,Beattie MS,Bresnahan JC

更新日期：1995-02-01 00:00:00

abstract：:The endoplasmic reticulum stress response (ERSR) is activated in a variety of neurodegenerative diseases and/or traumatic injuries. Subsequent restoration of ER homeostasis may contribute to improvement in the functional outcome of these diseases. We recently demonstrated improvements in hindlimb locomotion after thor...

journal_title：Journal of neurotrauma

authors： Saraswat Ohri S,Mullins A,Hetman M,Whittemore SR

更新日期：2018-02-01 00:00:00

abstract：:Spinal cord injury (SCI) is a devastating condition that affects patients on both a personal and societal level. The objective of the study is to improve the prediction of long-term functional outcome following SCI based on the acute clinical findings. A total of 76 patients with acute traumatic SCI were prospectively...

journal_title：Journal of neurotrauma

authors： Kaminski L,Cordemans V,Cernat E,M'Bra KI,Mac-Thiong JM

更新日期：2017-06-15 00:00:00

abstract：:The mass media have recently pointed out the likelihood of diagnostic errors in post-coma patients. Late recoveries of consciousness, even after 20 years, might indicate hidden misdiagnoses that are not corrected over a long period of time. The rate of misdiagnoses of patients in a vegetative state is very high when b...

journal_title：Journal of neurotrauma

authors： Pistoia F,Sarà M

更新日期：2012-09-01 00:00:00

abstract：:Acute subdural hemorrhage (ASDH) is common and associated with severe morbidity and mortality. To date, the role of spontaneous cortical spreading depression (sCSD) in exaggerating secondary injury after ASDH, is poorly understood. The present study contains two experimental groups: First, we investigated and characte...

journal_title：Journal of neurotrauma

authors： Krenzlin H,Jussen D,Plath M,Tretzel SJ,Krämer T,Kempski O,Alessandri B

更新日期：2019-01-15 00:00:00

abstract：:To assess the safety and accuracy of the Camino intraparenchymal sensor, we prospectively evaluated hemorrhagic complications, zero-drift, infection, and system malfunction in 163 patients monitored after a severe head injury. Mean duration of intracranial pressure (ICP) monitoring was 5 +/- 2.2 days (range: 12 h to 1...

journal_title：Journal of neurotrauma

authors： Poca MA,Sahuquillo J,Arribas M,Báguena M,Amorós S,Rubio E

更新日期：2002-04-01 00:00:00

abstract：:Experimental compression injury of the spinal cord in guinea pigs results in delayed neurologic deficits that continue to increase in severity for several days following trauma, coincident with inflammatory responses, including invasion of the lesion by mononuclear phagocytes and increased levels of the neurotoxin qui...

journal_title：Journal of neurotrauma

authors： Blight AR,Leroy EC Jr,Heyes MP

更新日期：1997-02-01 00:00:00

abstract：:There is an urgent need for both the scientific development and clinical validation of novel therapies for acute spinal cord injury (SCI). The scientific development of novel therapies would be facilitated by a better understanding of the acute pathophysiology of human SCI. Clinical validation of such therapies would ...

journal_title：Journal of neurotrauma

authors： Kwon BK,Stammers AM,Belanger LM,Bernardo A,Chan D,Bishop CM,Slobogean GP,Zhang H,Umedaly H,Giffin M,Street J,Boyd MC,Paquette SJ,Fisher CG,Dvorak MF

更新日期：2010-04-01 00:00:00

abstract：:Phosphorus 31 magnetic resonance spectroscopy (31P MRS) was used to study noninvasively the intracellular free Mg2+ concentration and cellular bioenergetic state of rat brain in vivo before and after fluid percussion-induced traumatic brain injury of graded severity. Brain injury was induced at four levels: low (1.0 +...

journal_title：Journal of neurotrauma

authors： Vink R,Faden AI,McIntosh TK

更新日期：1988-01-01 00:00:00

abstract：:We have used an in vitro trauma model to examine the effects of modulation of group III metabotropic glutamate receptors (mGluR) on post-traumatic neuronal cell death. Rat cortical neuronal/glial cultures were subjected to standardized mechanical injury using a punch that delivers 28 parallel cuts to 96-well culture p...

journal_title：Journal of neurotrauma

authors： Faden AI,Ivanova SA,Yakovlev AG,Mukhin AG

更新日期：1997-12-01 00:00:00

abstract：:Anatomical studies of spinal cord injury (SCI) using magnetic resonance imaging (MRI) report diverging observations, from "no changes" to "tissue atrophy in motor and non-motor regions." These discrepancies among studies can be attributed to heterogeneity in extent, level, and post-injury duration observed within the ...

journal_title：Journal of neurotrauma

authors： Karunakaran KD,He J,Zhao J,Cui JL,Zang YF,Zhang Z,Biswal BB

更新日期：2019-06-15 00:00:00

abstract：:The International Mission on Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) and Corticoid Randomisation After Significant Head injury (CRASH) prognostic models predict functional outcome after moderate and severe traumatic brain injury (TBI). We aimed to assess their performance in a cont...

journal_title：Journal of neurotrauma

authors： Dijkland SA,Helmrich IRAR,Nieboer D,van der Jagt M,Dippel DWJ,Menon DK,Stocchetti N,Maas AIR,Lingsma HF,Steyerberg EW,CENTER-TBI Participants and Investigators.

更新日期：2020-12-14 00:00:00

abstract：:Talampanel [(R)-7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3] benzodiazepine] is an orally active noncompetitive antagonist of the AMPA subtype of glutamate excitatory amino acid receptors. The purpose of this study was to determine whether treatment with talampanel would protect in a rat ...

journal_title：Journal of neurotrauma

authors： Belayev L,Alonso OF,Liu Y,Chappell AS,Zhao W,Ginsberg MD,Busto R

更新日期：2001-10-01 00:00:00

abstract：:High-mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that is passively released from damaged and necrotic cells, and actively released from immune cells. In contrast, cytochrome c is released from mitochondria in apoptotic cells, and is considered a reliable biomarker of apoptosis. Thus, HMGB1 and cytochr...

journal_title：Journal of neurotrauma

authors： Au AK,Aneja RK,Bell MJ,Bayir H,Feldman K,Adelson PD,Fink EL,Kochanek PM,Clark RS

更新日期：2012-07-20 00:00:00

abstract：:Neuroimaging demonstrates that athletes of collision sports can suffer significant changes to their brain in the absence of concussion, due to head acceleration event (HAE) exposure. In a sample of 24 male Division I collegiate football players, we examine the relationships between TPH2, a gene involved in neurovascul...

journal_title：Journal of neurotrauma

authors： Chen Y,Herrold A,Walter A,Reilly J,Seidenberg P,Nauman E,Talavage TM,Vandenbergh D,Slobounov S,Breiter H

更新日期：2021-01-07 00:00:00

abstract：:In a new, reproducible model of rodent focal cortical injury, we have shown that in the absence of early traumatic disruption of the microvasculature and subsequent hemorrhage, delayed perivascular protein leakage and polymorphonuclear leukocyte infiltration of the injured cortex occur. In this study we employed a sen...

journal_title：Journal of neurotrauma

authors： Mathew P,Bullock R,Teasdale G,McCulloch J

更新日期：1996-08-01 00:00:00

abstract：:Athletes in contact sports sustain repetitive subconcussive head impacts in a brief window, yet neurophysiological sequelae from repetitive subconcussion remain unclear. This prospective longitudinal study examined a relationship between changes in plasma Tau protein levels and subconcussive impact kinematic data in 2...

journal_title：Journal of neurotrauma

authors： Kawata K,Rubin LH,Wesley L,Lee JH,Sim T,Takahagi M,Bellamy A,Tierney R,Langford D

更新日期：2018-01-15 00:00:00