Longitudinal In Vivo Diffusion Magnetic Resonance Imaging Remote from the Lesion Site in Rat Spinal Cord Injury.

abstract：:The aim of this study was to evaluate the neuroprotective efficacy of the inert gas xenon as a treatment for patients with blast-induced traumatic brain injury in an in vitro laboratory model. We developed a novel blast traumatic brain injury model using C57BL/6N mouse organotypic hippocampal brain-slice cultures expo...

journal_title：Journal of neurotrauma

authors： Campos-Pires R,Koziakova M,Yonis A,Pau A,Macdonald W,Harris K,Edge CJ,Franks NP,Mahoney PF,Dickinson R

更新日期：2018-04-15 00:00:00

abstract：:Multipotent neural progenitors and stem cells may integrate appropriately into the developing and degenerating central nervous system. They may also be effective in the replacement of genes, cells, and nondiffusible factors in either a widespread or a more circumscribed manner, depending on the therapeutic demands of ...

journal_title：Journal of neurotrauma

authors： Park KI,Liu S,Flax JD,Nissim S,Stieg PE,Snyder EY

更新日期：1999-08-01 00:00:00

abstract：:An increasing number of therapies for spinal cord injury (SCI) are emerging from the laboratory and seeking translation into human clinical trials. Many of these are administered as soon as possible after injury with the hope of attenuating secondary damage and maximizing the extent of spared neurologic tissue. In thi...

journal_title：Journal of neurotrauma

authors： Kwon BK,Okon EB,Plunet W,Baptiste D,Fouad K,Hillyer J,Weaver LC,Fehlings MG,Tetzlaff W

更新日期：2011-08-01 00:00:00

abstract：:Repair of the spinal cord and improvement of mobility after injury has been a matter of basic and clinical research for several decades. A number of repair approaches were performed in animals, mainly rodent models of spinal cord injury (SCI). Some of these experimental therapies resulted in significant regeneration o...

journal_title：Journal of neurotrauma

authors： Dietz V,Schwab ME

更新日期：2017-05-01 00:00:00

abstract：:Neuropathic pain and motor deficits are detrimental consequences of injury to the spinal cord. In experimental settings, numerous neuroprotective agents are being explored for their therapeutic benefits. Vascular endothelial growth factor (VEGF) is an interesting candidate molecule in this respect since it is not only...

journal_title：Journal of neurotrauma

authors： van Neerven S,Joosten EA,Brook GA,Lambert CA,Mey J,Weis J,Marcus MA,Steinbusch HW,van Kleef M,Patijn J,Deumens R

更新日期：2010-10-01 00:00:00

abstract：:Traumatic brain injury (TBI) is frequently complicated by acute lung injury, which is predictive for poor outcome. However, it is unclear whether lung injury develops independently or as a result of mechanical ventilation after TBI. Further, TBI is strongly associated with the development of pneumonia, suggesting a sp...

journal_title：Journal of neurotrauma

authors： Vermeij JD,Aslami H,Fluiter K,Roelofs JJ,van den Bergh WM,Juffermans NP,Schultz MJ,Van der Sluijs K,van de Beek D,van Westerloo DJ

更新日期：2013-12-15 00:00:00

abstract：:Depression is associated with poorer recovery after traumatic brain injury (TBI), yet awareness of depression risk post-TBI among providers and patients is low. The aim of this study was to estimate risk of depression post-TBI among adults 18 years of age and older and to identify risk factors associated with developi...

journal_title：Journal of neurotrauma

authors： Albrecht JS,Barbour L,Abariga SA,Rao V,Perfetto EM

更新日期：2019-01-15 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading cause of death and functional disability in western countries, affecting mostly young patients. Despite intense and sustained efforts deployed for the development of new therapeutic strategies, no clinical benefit has been shown by any of the investigated compounds. Increasing...

journal_title：Journal of neurotrauma

authors： Soustiel JF,Palzur E,Nevo O,Thaler I,Vlodavsky E

更新日期：2005-03-01 00:00:00

abstract：:Fluid percussion brain injury is associated with an immediate rise in mean arterial pressure (MAP). However, the cerebral morphologic basis for this response is still not clear. Thirty-four anesthetized rats were injured using a lateral craniotomy preparation. In 19 rats, impact level was set at 1.73 +/- 0.04 atm, and...

journal_title：Journal of neurotrauma

authors： Yuan XQ,Wade CE,Clifford CB

更新日期：1991-10-01 00:00:00

abstract：:Controlled cortical impact (CCI) is a contemporary model of experimental cerebral contusion. We examined the cerebrovascular and neuropathologic effects of a severe CCI in rats. The utility of magnetic resonance imaging (MRI) for the assessment of contusion volume after severe CCI was also established. Severe CCI (3.0...

journal_title：Journal of neurotrauma

authors： Kochanek PM,Marion DW,Zhang W,Schiding JK,White M,Palmer AM,Clark RS,O'Malley ME,Styren SD,Ho C

更新日期：1995-12-01 00:00:00

abstract：:Spinal cord injury damaging the rubrospinal tract (RST) interferes with skilled forelimb movement, but identification of the precise role of the RST in this behavior is impeded by the difficulty of surgically isolating the RST from other pathways running within the lateral funiculus (LF). The present study used a skil...

journal_title：Journal of neurotrauma

authors： Morris R,Tosolini AP,Goldstein JD,Whishaw IQ

更新日期：2011-12-01 00:00:00

abstract：:A penetrating traumatic brain injury (pTBI) occurs when an object impacts the head with sufficient force to penetrate the skin, skull, and meninges, and inflict injury directly to the brain parenchyma. This type of injury has been notoriously difficult to model in small laboratory animals such as rats or mice. To this...

journal_title：Journal of neurotrauma

authors： Plantman S,Ng KC,Lu J,Davidsson J,Risling M

更新日期：2012-04-10 00:00:00

abstract：:We conducted a study to evaluate the degree of corticospinal tract (CST) dysfunction associated with diffuse axonal injury (DAI) through analyses of both diffusion-tensor magnetic resonance imaging (DTMRI) and motor-evoked potential (MEP). Using DTMRI and MEP with transcranial magnetic stimulation, we evaluated 138 in...

journal_title：Journal of neurotrauma

authors： Yasokawa YT,Shinoda J,Okumura A,Nakayama N,Miwa K,Iwama T

更新日期：2007-01-01 00:00:00

abstract：:Injured neurons in the mammalian central nervous system (CNS) do not normally regenerate their axons after injury. Neurotrauma to the CNS usually results in axonal damage and subsequent loss of communication between neuronal networks, causing long-term functional deficits. For CNS regeneration, repair strategies need ...

journal_title：Journal of neurotrauma

authors： Ruitenberg MJ,Vukovic J,Sarich J,Busfield SJ,Plant GW

更新日期：2006-03-01 00:00:00

abstract：:There has been a recent call for longitudinal cohort studies to track the physiological recovery of sport-related concussion (SRC) and its relationship with clinical recovery. Resting-state functional magnetic resonance imaging (rs-fMRI) has shown potential for detecting subtle changes in brain function after SRC. We ...

journal_title：Journal of neurotrauma

authors： Meier TB,Giraldo-Chica M,España LY,Mayer AR,Harezlak J,Nencka AS,Wang Y,Koch KM,Wu YC,Saykin AJ,Giza CC,Goldman J,DiFiori JP,Guskiewicz KM,Mihalik JP,Brooks A,Broglio SP,McAllister T,McCrea MA

更新日期：2020-01-01 00:00:00

abstract：:Adequate nutritional support is a major challenge in brain injury patients, because malnutrition cannot be reversed by standard enteral nutrition. We hypothesized that an oligomeric formula could improve nutritional status by restoring intestinal trophicity. Eighteen male Sprague-Dawley rats (300-330 g) underwent gast...

journal_title：Journal of neurotrauma

authors： Moinard C,Delpierre E,Loï C,Neveux N,Butel MJ,Cynober L,Charrueau C

更新日期：2013-06-01 00:00:00

abstract：:Traumatic injury is a common cause of coagulopathy, primarily due to blood loss and hemodilution secondary to fluid resuscitation. Traumatic injury-associated coagulopathy often follows a course of transition from hyper- to hypocoagulable state exemplified in disseminated intravascular coagulation. The incidence of co...

journal_title：Journal of neurotrauma

authors： Zhang J,Jiang R,Liu L,Watkins T,Zhang F,Dong JF

更新日期：2012-11-20 00:00:00

abstract：:Gangliosides play important roles in the physiologic operations of the nervous system, in particular that of the brain. Changes in ganglioside composition occur in the mammalian brain not only during development, but also in aging and in several neuropathologic situations. Gangliosides may modulate the ability of the ...

journal_title：Journal of neurotrauma

authors： Skaper SD,Leon A

更新日期：1992-05-01 00:00:00

abstract：:Persistent pain is experienced by more than 50% of persons who sustain a traumatic brain injury (TBI), and more than 30% experience significant pain as early as 6 weeks after injury. Although neuropathic pain is a common consequence after CNS injuries, little attention has been given to neuropathic pain symptoms after...

journal_title：Journal of neurotrauma

authors： Widerström-Noga E,Govind V,Adcock JP,Levin BE,Maudsley AA

更新日期：2016-07-15 00:00:00

abstract：:The inflammatory response to moderate-severe controlled cortical impact (CCI) in adult male mice has been shown to exhibit greater glial activation compared with age-matched female mice. However, the relative contributions of resident microglia and infiltrating peripheral myeloid cells to this sexually dimorphic neuro...

journal_title：Journal of neurotrauma

authors： Doran SJ,Ritzel RM,Glaser EP,Henry RJ,Faden AI,Loane DJ

更新日期：2019-04-01 00:00:00

abstract：:Prognostic models that were developed by the International Mission on Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) study group and the Corticosteroid Randomization After Signification Head injury (CRASH) collaborators are the most commonly used prognostic models for outcome after trauma...

journal_title：Journal of neurotrauma

authors： Castaño-Leon AM,Lora D,Munarriz PM,Cepeda S,Paredes I,de la Cruz J,Gómez Lopez PA,Lagares A

更新日期：2016-09-01 00:00:00

abstract：:Spinal cord injury (SCI) can cause physical disability and psychological distress; however, whether SCI is a risk factor for dementia is unclear. This study evaluated the incidence of dementia in patients with SCI. Study participants were recruited from a nationwide cohort during 2004-2007 and categorized into SCI (pa...

journal_title：Journal of neurotrauma

authors： Huang SW,Wang WT,Chou LC,Liou TH,Lin HW

更新日期：2017-02-01 00:00:00

abstract：:Stretching of cultured neurons has been used to model diffuse axonal injury associated with brain trauma. N-Methyl-D-aspartate receptor (NMDAR) activation and group I metabotropic glutamate receptors (mGluRs) are implicated in the pathophysiology of such injury. Here we detail the effects of culture condition and mGlu...

journal_title：Journal of neurotrauma

authors： Lea PM 4th,Custer SJ,Stoica BA,Faden AI

更新日期：2003-11-01 00:00:00

abstract：:The serum phosphorylated neurofilament heavy subunit (pNF-H) is a nervous system-specific protein that is released from damaged neural tissue after traumatic brain injury (TBI). The aim of this study was to elucidate the usefulness of serum pNF-H as a predictive marker for the outcome of patients after TBI. Patients w...

journal_title：Journal of neurotrauma

authors： Shibahashi K,Doi T,Tanaka S,Hoda H,Chikuda H,Sawada Y,Takasu Y,Chiba K,Nozaki T,Hamabe Y,Ogata T

更新日期：2016-10-15 00:00:00

abstract：:The majority of patients with traumatic brain injury (TBI) sustain a mild injury (mTBI). One out of 4 patients experiences persistent complaints, despite their often normal neuropsychological test results and the absence of structural brain damage on conventional neuroimaging. Susceptibility to develop persistent comp...

journal_title：Journal of neurotrauma

authors： van der Horn HJ,Liemburg EJ,Aleman A,Spikman JM,van der Naalt J

更新日期：2016-01-01 00:00:00

abstract：:Following crush injury to the facial nerve in Syrian hamsters, treatment with androgens enhances axonal regeneration rates and decreases time to recovery. It has been demonstrated in vitro that the ability of androgen to enhance neurite outgrowth in motoneurons is dependent on neuritin-a protein that is involved in th...

journal_title：Journal of neurotrauma

authors： Fargo KN,Alexander TD,Tanzer L,Poletti A,Jones KJ

更新日期：2008-05-01 00:00:00

abstract：:Mild traumatic brain injury (mTBI) accounts for the majority of head trauma cases. Despite some lasting cognitive, emotional, and behavioral deficits, there are frequently no overt morphological defects, suggesting that changes may result from alterations in the physiology of individual neurons. We investigated hippoc...

journal_title：Journal of neurotrauma

authors： Eakin K,Miller JP

更新日期：2012-04-10 00:00:00

abstract：:Efforts to understand spinal cord injury (SCI) and other complex neurotrauma disorders at the pre-clinical level have shown progress in recent years. However, successful translation of basic research into clinical practice has been slow, partly because of the large, heterogeneous data sets involved. In this sense, tra...

journal_title：Journal of neurotrauma

authors： Nielson JL,Guandique CF,Liu AW,Burke DA,Lash AT,Moseanko R,Hawbecker S,Strand SC,Zdunowski S,Irvine KA,Brock JH,Nout-Lomas YS,Gensel JC,Anderson KD,Segal MR,Rosenzweig ES,Magnuson DS,Whittemore SR,McTigue DM,Popovic

更新日期：2014-11-01 00:00:00

abstract：:After experimental traumatic brain injury (TBI), calcineurin is upregulated; blocking calcineurin is associated with improved outcomes. In humans, variation in the calcineurin A-gamma gene (PPP3CC) has been associated with neuropsychiatric disorders, though any role in TBI recovery remains unknown. This study examines...

journal_title：Journal of neurotrauma

authors： Osier ND,Bales JW,Pugh B,Shin S,Wyrobek J,Puccio AM,Okonkwo DO,Ren D,Alexander S,Conley YP,Dixon CE

更新日期：2017-01-01 00:00:00

abstract：:Phosphorus 31 magnetic resonance spectroscopy (31P MRS) was used to study noninvasively the intracellular free Mg2+ concentration and cellular bioenergetic state of rat brain in vivo before and after fluid percussion-induced traumatic brain injury of graded severity. Brain injury was induced at four levels: low (1.0 +...

journal_title：Journal of neurotrauma

authors： Vink R,Faden AI,McIntosh TK

更新日期：1988-01-01 00:00:00