Characterization of a novel rat model of penetrating traumatic brain injury.

abstract：:To evaluate new pharmacologic agents with potentially beneficial effects on posttraumatic spinal cord function, we used a modified weight drop (WD) technique to induce spinal cord injuries. These contusive spinal cord injuries in the rat closely mimic the human clinicopathologic situation. Especially for drug screenin...

journal_title：Journal of neurotrauma

authors： van de Meent H,Hamers FP,Lankhorst AJ,Buise MP,Joosten EA,Gispen WH

更新日期：1996-12-01 00:00:00

abstract：:Traumatic brain damage may cause acute emotional symptoms such as uncontrolled crying, apathy, and sleep problems. Rehabilitation may be less effective in patients afflicted by these symptoms. Citalopram, a selective serotonin reuptake inhibitor (SSRI), has a documented immediate and dramatic effect on pathological cr...

journal_title：Journal of neurotrauma

authors： Andersen G,Stylsvig M,Sunde N

更新日期：1999-04-01 00:00:00

abstract：:Repair of the spinal cord and improvement of mobility after injury has been a matter of basic and clinical research for several decades. A number of repair approaches were performed in animals, mainly rodent models of spinal cord injury (SCI). Some of these experimental therapies resulted in significant regeneration o...

journal_title：Journal of neurotrauma

authors： Dietz V,Schwab ME

更新日期：2017-05-01 00:00:00

abstract：:Contusion-type cervical spinal cord injury (SCI) is one of the most common forms of SCI observed in patients. In particular, injuries targeting the C3-C5 region affect the pool of phrenic motor neurons (PhMNs) that innervates the diaphragm, resulting in significant and often chronic respiratory dysfunction. Using a pr...

journal_title：Journal of neurotrauma

authors： Nicaise C,Frank DM,Hala TJ,Authelet M,Pochet R,Adriaens D,Brion JP,Wright MC,Lepore AC

更新日期：2013-06-15 00:00:00

abstract：:Despite the shift in demographics of spinal cord injury (SCI) due to an aging population, relatively little has been reported regarding the effect of age on outcomes after SCI. This study examines the potential confounding effect of co-morbidities on the age-related differences in the hospital mortality following acut...

journal_title：Journal of neurotrauma

authors： Furlan JC,Kattail D,Fehlings MG

更新日期：2009-08-01 00:00:00

abstract：:Progesterone is an anti-inflammatory and promyelinating agent after spinal cord injury, but its effectiveness on functional recovery is still controversial. In the current study, we tested the effects of chronic progesterone administration on tissue preservation and functional recovery in a clinically relevant model o...

journal_title：Journal of neurotrauma

authors： Garcia-Ovejero D,González S,Paniagua-Torija B,Lima A,Molina-Holgado E,De Nicola AF,Labombarda F

更新日期：2014-05-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a silent epidemic affecting approximately 1.4 million Americans annually, at an estimated annual cost of $60 billion in the United States alone. Despite an increased understanding of the pathophysiology of closed head injury, there remains no pharmacological intervention proven to impro...

journal_title：Journal of neurotrauma

authors： Laskowitz DT,McKenna SE,Song P,Wang H,Durham L,Yeung N,Christensen D,Vitek MP

更新日期：2007-07-01 00:00:00

abstract：:Spinal cord injury (SCI) leading to neurological deficits produces long-term effects that persist over a lifetime. Survival analysis of patients with SCI, at individual and population level, is important for public health management and the assessment of treatment achievements. The current study evaluated survival fol...

journal_title：Journal of neurotrauma

authors： van den Berg ME,Castellote JM,de Pedro-Cuesta J,Mahillo-Fernandez I

更新日期：2010-08-01 00:00:00

abstract：:The present study examined the effect of severe traumatic brain injury (TBI) on the myogenic response in the rat middle cerebral artery (MCA). Rats were subjected to severe controlled cortical impact (CCI; 5 m/sec, 130-msec duration, 3-mm deformation) injury over the right parietal cortex. At 2, 24, and 120 h postinju...

journal_title：Journal of neurotrauma

authors： Golding EM,Contant CF Jr,Robertson CS,Bryan RM Jr

更新日期：1998-11-01 00:00:00

abstract：:Autonomic dysreflexia (AD) is a potentially life-threatening syndrome in individuals with spinal cord injury (SCI) above the T6 spinal level that is characterized by episodic hypertension in response to noxious stimuli below the lesion. Maladaptive intraspinal plasticity is thought to contribute to the temporal develo...

journal_title：Journal of neurotrauma

authors： Eldahan KC,Cox DH,Gollihue JL,Patel SP,Rabchevsky AG

更新日期：2018-03-15 00:00:00

abstract：:Ischemic insults to the brain in stroke or traumatic brain injury produce excessive release of glutamate from depolarized nerve terminals. This excessive glutamate release in turn stimulates massive calcium entry into nerve cells, activating a biochemical cascade that results in cell death. A major pathway of calcium ...

journal_title：Journal of neurotrauma

authors： McBurney RN,Daly D,Fischer JB,Hu LY,Subbarao K,Knapp AG,Kobayashi K,Margolin L,Reddy NL,Goldin SM

更新日期：1992-05-01 00:00:00

abstract：:Functional recovery is markedly restricted following traumatic brain injury (TBI), partly due to myelin-associated inhibitors including Nogo-A, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMgp), that all bind to the Nogo-66 receptor-1 (NgR1). In previous studies, pharmacological neutr...

journal_title：Journal of neurotrauma

authors： Hånell A,Clausen F,Björk M,Jansson K,Philipson O,Nilsson LN,Hillered L,Weinreb PH,Lee D,McIntosh TK,Gimbel DA,Strittmatter SM,Marklund N

更新日期：2010-07-01 00:00:00

abstract：:In terms of human suffering, medical expenses, and lost productivity, head injury is one of the major health care problems in the United States, and inadequate cerebral blood flow is an important contributor to mortality and morbidity after traumatic brain injury. Despite the importance of cerebral vascular dysfunctio...

journal_title：Journal of neurotrauma

authors： DeWitt DS,Prough DS

更新日期：2003-09-01 00:00:00

abstract：:Minimal traumatic brain injury (mTBI) is partially defined by the existence of retrograde amnesia and is associated with microscopic bleeds containing activated coagulation factors. In a previous study, we have found that mTBI immediately releases thrombin-like activity in the brain, which induces amnesia by activatin...

journal_title：Journal of neurotrauma

authors： Itsekson-Hayosh Z,Shavit-Stein E,Katzav A,Rubovitch V,Maggio N,Chapman J,Harnof S,Pick CG

更新日期：2016-10-15 00:00:00

abstract：:Post-traumatic epilepsy (PTE) is a consequence of traumatic brain injury (TBI), occurring in 10-25% of patients with moderate to severe injuries. The development of animal models for testing antiepileptogenic therapies and validation of biomarkers to follow epileptogenesis in humans necessitates sophisticated understa...

journal_title：Journal of neurotrauma

authors： Gupta PK,Sayed N,Ding K,Agostini MA,Van Ness PC,Yablon S,Madden C,Mickey B,D'Ambrosio R,Diaz-Arrastia R

更新日期：2014-08-15 00:00:00

abstract：:Traumatic brain injury (TBI) is an established risk factor for neurodegenerative disorders and dementias. Epigenetic modifications, such as DNA methylation, may alter the expression of genes without altering the DNA sequence in response to environmental factors. We hypothesized that DNA methylation changes may occur i...

journal_title：Journal of neurotrauma

authors： Abu Hamdeh S,Ciuculete DM,Sarkisyan D,Bakalkin G,Ingelsson M,Schiöth HB,Marklund N

更新日期：2021-01-08 00:00:00

abstract：:Using diffusion-weighted imaging (DWI), research has demonstrated changes suggestive of damage to white matter tracts (WMT) following mild traumatic brain injury (mTBI). Yet due to the predominant use of the diffusion tensor imaging (DTI) model, which has numerous well-established limitations, it has not yet been poss...

journal_title：Journal of neurotrauma

authors： Oehr LE,Yang JY,Chen J,Maller J,Seal M,Anderson J

更新日期：2020-12-14 00:00:00

abstract：:Protection against the progression of secondary injury appears to be an effective therapeutic strategy in spinal cord injury (SCI). Evidence indicates that nicotine can induce potent neuroprotective effects against injury to spinal cord neurons. Therefore, the present study was focused on the effects of nicotine on th...

journal_title：Journal of neurotrauma

authors： Ravikumar R,Fugaccia I,Scheff SW,Geddes JW,Srinivasan C,Toborek M

更新日期：2005-02-01 00:00:00

abstract：:In human diffuse axonal injury (DAI), axons are exposed to transient tensile strain. Over the ensuing several hours, injured axons enter a "pathological cascade" of events that lead to secondary axotomy. Use of animal models of traumatic axonal injury (TAI) has allowed description of a number of pathological changes b...

journal_title：Journal of neurotrauma

authors： Maxwell WL,Donnelly S,Sun X,Fenton T,Puri N,Graham DI

更新日期：1999-12-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading cause of death and disability in the United States, with children who sustain a TBI having a greater risk of developing long-lasting cognitive, behavioral, and motor function deficits. This has led to increased interest in utilizing large animal models to study pathophysiologi...

journal_title：Journal of neurotrauma

authors： Kinder HA,Baker EW,Howerth EW,Duberstein KJ,West FD

更新日期：2019-10-01 00:00:00

abstract：:Gap junctions are conductive channels formed by membrane proteins termed connexins (Cx), which permit the intercellular exchange of metabolites, ions, and small molecules. Junctional permeability is regulated by pH, membrane potential, and intracellular secondary messengers. The purpose of this study was to elucidate ...

journal_title：Journal of neurotrauma

authors： Ohsumi A,Nawashiro H,Otani N,Ooigawa H,Toyooka T,Shima K

更新日期：2010-07-01 00:00:00

abstract：:Athletes who sustain a concussion demonstrate a variety of symptoms and neuropsychological alterations that could be brought on by neurometabolic abnormalities. However, no study has yet investigated these aspects in female athletes using magnetic resonance spectroscopy. The present study investigated the neurometabol...

journal_title：Journal of neurotrauma

authors： Chamard E,Henry L,Boulanger Y,Lassonde M,Théoret H

更新日期：2014-02-15 00:00:00

abstract：:The Balance Error Scoring System (BESS) is a commonly used concussion assessment tool. Recent studies have questioned the stability and reliability of baseline BESS scores. The purpose of this longitudinal prospective cohort study is to examine differences in yearly baseline BESS scores in athletes participating on an...

journal_title：Journal of neurotrauma

authors： Mathiasen R,Hogrefe C,Harland K,Peterson A,Smoot MK

更新日期：2018-02-15 00:00:00

abstract：:Clinical scenario: A 37-year-old man suffered a complete spinal cord injury (C8, American Spinal Injury Association Impairment Scale [ASIA] score A) 10 years ago in a car accident. Should primary prevention of cardiovascular disease be a priority in this patient? In order to answer this question, we performed a system...

journal_title：Journal of neurotrauma

authors： Cragg JJ,Stone JA,Krassioukov AV

更新日期：2012-07-20 00:00:00

abstract：:Blast injury to the brain is one of the major causes of death and can also significantly affect cognition and physical and psychological skills in survivors of blast. The complex mechanisms via which blast injury causes impairment of cognition and other symptoms are poorly understood. In this study, we investigated th...

journal_title：Journal of neurotrauma

authors： Lu J,Ng KC,Ling G,Wu J,Poon DJ,Kan EM,Tan MH,Wu YJ,Li P,Moochhala S,Yap E,Lee LK,Teo M,Yeh IB,Sergio DM,Chua F,Kumar SD,Ling EA

更新日期：2012-05-01 00:00:00

abstract：:Stretching of cultured neurons has been used to model diffuse axonal injury associated with brain trauma. N-Methyl-D-aspartate receptor (NMDAR) activation and group I metabotropic glutamate receptors (mGluRs) are implicated in the pathophysiology of such injury. Here we detail the effects of culture condition and mGlu...

journal_title：Journal of neurotrauma

authors： Lea PM 4th,Custer SJ,Stoica BA,Faden AI

更新日期：2003-11-01 00:00:00

abstract：:Mild traumatic brain injury (mTBI) contributes to development of affective disorders, including post-traumatic stress disorder (PTSD). Psychiatric symptoms typically emerge in a tardive fashion post-TBI, with negative effects on recovery. Patients with PTSD, as well as rodent models of PTSD, demonstrate structural and...

journal_title：Journal of neurotrauma

authors： Schneider BL,Ghoddoussi F,Charlton JL,Kohler RJ,Galloway MP,Perrine SA,Conti AC

更新日期：2016-09-01 00:00:00

abstract：:Studies measuring the volume of infarcted tissue and survival after pharmacologic intervention in stroke are complicated by the potential effect of survival time on infarct volume. In this study, the volume of infarcted tissue as defined by 2,3,5-triphenyltetrazolium chloride staining was determined in rabbits at 28 h...

journal_title：Journal of neurotrauma

authors： Browning JL,Widmayer MA,Hoffmann KK,Dudley AW Jr,Baskin DS

更新日期：1996-10-01 00:00:00

abstract：:Penetrating brain injury (PBI) is the most devastating type of traumatic brain injury. Development of coagulopathy in the acute setting of PBI, though common, remains of unclear significance as does its reversal. The aim of this study is to investigate the relationship between coagulopathy and clinical presentation, r...

journal_title：Journal of neurotrauma

authors： Mansour A,Loggini A,Goldenberg FD,Kramer C,Naidech AM,Ammar FE,Vasenina V,Castro B,Das P,Horowitz PM,Karrison T,Zakrison T,Hampton D,Rogers SO,Lazaridis C

更新日期：2021-01-20 00:00:00

abstract：:Traumatic brain injury (TBI) is associated with the development of numerous psychiatric diseases. Of particular concern for TBI patients is the impact of chronic impulsivity on daily functioning. Despite the scope of the human problem, little has been done to address impulsivity in animal models of brain injury. In th...

journal_title：Journal of neurotrauma

authors： Vonder Haar C,Martens KM,Riparip LK,Rosi S,Wellington CL,Winstanley CA

更新日期：2017-10-01 00:00:00