Frontal Traumatic Brain Injury Increases Impulsive Decision Making in Rats: A Potential Role for the Inflammatory Cytokine Interleukin-12.

abstract：:Penetrating brain injury (PBI) is the most devastating type of traumatic brain injury. Development of coagulopathy in the acute setting of PBI, though common, remains of unclear significance as does its reversal. The aim of this study is to investigate the relationship between coagulopathy and clinical presentation, r...

journal_title：Journal of neurotrauma

authors： Mansour A,Loggini A,Goldenberg FD,Kramer C,Naidech AM,Ammar FE,Vasenina V,Castro B,Das P,Horowitz PM,Karrison T,Zakrison T,Hampton D,Rogers SO,Lazaridis C

更新日期：2021-01-20 00:00:00

abstract：:In human diffuse axonal injury (DAI), axons are exposed to transient tensile strain. Over the ensuing several hours, injured axons enter a "pathological cascade" of events that lead to secondary axotomy. Use of animal models of traumatic axonal injury (TAI) has allowed description of a number of pathological changes b...

journal_title：Journal of neurotrauma

authors： Maxwell WL,Donnelly S,Sun X,Fenton T,Puri N,Graham DI

更新日期：1999-12-01 00:00:00

abstract：:Traumatic brain injury (TBI) evokes diffuse (traumatic) axonal injury (TAI), which contributes to morbidity and mortality. Damaged axons display progressive alterations gradually evolving to axonal disconnection. In severe TAI, the tensile forces of injury lead to a focal influx of Ca2+, initiating a series of proteol...

journal_title：Journal of neurotrauma

authors： Buki A,Farkas O,Doczi T,Povlishock JT

更新日期：2003-03-01 00:00:00

abstract：:Experimental traumatic brain injury (TBI) initiates massive disturbances in Ca2+ concentrations in the brain that may contribute to neuronal damage. Intracellular Ca2+ may be elevated via influx through voltage-operated cation channels, ligand-gated ionotropic channels, and store-operated cation channels (SOCs). In th...

journal_title：Journal of neurotrauma

authors： Cheney JA,Brown AL,Bareyre FM,Russ AB,Weisser JD,Ensinger HA,Leusch A,Raghupathi R,Saatman KE

更新日期：2000-01-01 00:00:00

abstract：:Spinal cord injury damaging the rubrospinal tract (RST) interferes with skilled forelimb movement, but identification of the precise role of the RST in this behavior is impeded by the difficulty of surgically isolating the RST from other pathways running within the lateral funiculus (LF). The present study used a skil...

journal_title：Journal of neurotrauma

authors： Morris R,Tosolini AP,Goldstein JD,Whishaw IQ

更新日期：2011-12-01 00:00:00

abstract：:The imaging and clinical examination (ICE) algorithm used in the Benchmark Evidence from South American Trials: Treatment of Intracranial Pressure (BEST TRIP) randomized controlled trial is the only prospectively investigated clinical protocol for traumatic brain injury management without intracranial pressure (ICP) m...

journal_title：Journal of neurotrauma

authors： Chesnut RM,Temkin N,Dikmen S,Rondina C,Videtta W,Petroni G,Lujan S,Alanis V,Falcao A,de la Fuenta G,Gonzalez L,Jibaja M,Lavarden A,Sandi F,Mérida R,Romero R,Pridgeon J,Barber J,Machamer J,Chaddock K

更新日期：2018-01-01 00:00:00

abstract：:Following crush injury to the facial nerve in Syrian hamsters, treatment with androgens enhances axonal regeneration rates and decreases time to recovery. It has been demonstrated in vitro that the ability of androgen to enhance neurite outgrowth in motoneurons is dependent on neuritin-a protein that is involved in th...

journal_title：Journal of neurotrauma

authors： Fargo KN,Alexander TD,Tanzer L,Poletti A,Jones KJ

更新日期：2008-05-01 00:00:00

abstract：:Carbon dioxide is perhaps the most potent available modulator of cerebrovascular tone and thus cerebral blood flow (CBF). These experiments evaluate the impact of induced hypercarbia on the matching of blood flow and metabolism in the injured brain. We explore the hypothesis that hypercarbia will restore the relations...

journal_title：Journal of neurotrauma

authors： Glass TF,Fabian MJ,Schweitzer JB,Weinberg JA,Proctor KG

更新日期：2001-01-01 00:00:00

abstract：:Progesterone is an anti-inflammatory and promyelinating agent after spinal cord injury, but its effectiveness on functional recovery is still controversial. In the current study, we tested the effects of chronic progesterone administration on tissue preservation and functional recovery in a clinically relevant model o...

journal_title：Journal of neurotrauma

authors： Garcia-Ovejero D,González S,Paniagua-Torija B,Lima A,Molina-Holgado E,De Nicola AF,Labombarda F

更新日期：2014-05-01 00:00:00

abstract：:The excessive generation of free radicals is thought to be one of the major mechanisms leading to tissue injury in various pathological conditions, including ischemia, inflammation, and trauma. Conversion of xanthine dehydrogenase (XDH) to xanthine oxidase (XO) contributes to the formation of superoxide, an oxygen rad...

journal_title：Journal of neurotrauma

authors： Xu J,Beckman JS,Hogan EL,Hsu CY

更新日期：1991-04-01 00:00:00

abstract：:Delirium is a commonly reported acute care adverse event in patients with traumatic spinal cord injury (TSCI), but studies specifically investigating it in this population are lacking. The purpose of this study was to characterize the onset, risk factors, and impact of delirium in patients with TSCI. Patients discharg...

journal_title：Journal of neurotrauma

authors： Cheung A,Thorogood NP,Noonan VK,Zhong Y,Fisher CG,Dvorak MF,Street J

更新日期：2013-11-01 00:00:00

abstract：:To assess the safety and accuracy of the Camino intraparenchymal sensor, we prospectively evaluated hemorrhagic complications, zero-drift, infection, and system malfunction in 163 patients monitored after a severe head injury. Mean duration of intracranial pressure (ICP) monitoring was 5 +/- 2.2 days (range: 12 h to 1...

journal_title：Journal of neurotrauma

authors： Poca MA,Sahuquillo J,Arribas M,Báguena M,Amorós S,Rubio E

更新日期：2002-04-01 00:00:00

abstract：:To test if observed vs. expected mortality differs by age among traumatic brain injury (TBI) cases, a population-based, historical cohort study was conducted in Olmsted County, Minnesota. From all residents with any diagnosis suggestive of TBI 1985-1999, we randomly sampled 7,800 and reviewed their medical records to ...

journal_title：Journal of neurotrauma

authors： Flaada JT,Leibson CL,Mandrekar JN,Diehl N,Perkins PK,Brown AW,Malec JF

更新日期：2007-03-01 00:00:00

abstract：:Mild traumatic brain injury (mTBI) accounts for the vast majority of all pediatric TBI. An important minority of children who have suffered an mTBI have enduring cognitive and emotional symptoms. However, the mechanisms of chronic symptoms in children with pediatric mTBI are not fully understood. This is in part due t...

journal_title：Journal of neurotrauma

authors： Huang MX,Robb Swan A,Angeles Quinto A,Huang JW,De-la-Garza BG,Huang CW,Hesselink JR,Bigler ED,Wilde EA,Max JE

更新日期：2020-04-01 00:00:00

abstract：:The expression of alternatively spliced mRNAs for amyloid precursor protein (APP) isoforms and their translation products were examined in the rat cerebral cortex 1, 3, 6, and 12 h and 1, 3, and 7 days (n = 4-5 in each group) after fluid-percussion brain injury. In situ hybridization studies demonstrated that the expr...

journal_title：Journal of neurotrauma

authors： Masumura M,Hata R,Uramoto H,Murayama N,Ohno T,Sawada T

更新日期：2000-02-01 00:00:00

abstract：:Pairing vagus nerve stimulation (VNS) with rehabilitation has emerged as a potential strategy to enhance plasticity and improve recovery in a range of neurological disorders. A recent study highlights the therapeutic promise of VNS in promoting motor recovery after spinal cord injury (SCI). We investigated the safety ...

journal_title：Journal of neurotrauma

authors： Sachdeva R,Krassioukov AV,Bucksot JE,Hays SA

更新日期：2020-05-01 00:00:00

abstract：:Persistent pain is experienced by more than 50% of persons who sustain a traumatic brain injury (TBI), and more than 30% experience significant pain as early as 6 weeks after injury. Although neuropathic pain is a common consequence after CNS injuries, little attention has been given to neuropathic pain symptoms after...

journal_title：Journal of neurotrauma

authors： Widerström-Noga E,Govind V,Adcock JP,Levin BE,Maudsley AA

更新日期：2016-07-15 00:00:00

abstract：:It has been demonstrated that ethanol exerts dose-dependent effects, both beneficial and detrimental, on the outcome of traumatic brain injury (TBI). Recently, it has been reported that co-administration of caffeine (10 mg/kg) and a low amount of alcohol (0.65 g/kg; caffeinol) reduces cortical infarct volume up to 80%...

journal_title：Journal of neurotrauma

authors： Dash PK,Moore AN,Moody MR,Treadwell R,Felix JL,Clifton GL

更新日期：2004-11-01 00:00:00

abstract：:This study was designed to investigate the additional benefits of a multimodal early onset stimulation (MEOS) paradigm when combined with enriched environment (EE) versus EE only and standard housing (SH) on the recovery after experimental traumatic brain injury (TBI). Male Sprague- Dawley rats were subjected to moder...

journal_title：Journal of neurotrauma

authors： Maegele M,Lippert-Gruener M,Ester-Bode T,Sauerland S,Schäfer U,Molcanyi M,Lefering R,Bouillon B,Neiss WF,Angelov DN,Klug N,McIntosh TK,Neugebauer EA

更新日期：2005-07-01 00:00:00

abstract：:Prognostic models that were developed by the International Mission on Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) study group and the Corticosteroid Randomization After Signification Head injury (CRASH) collaborators are the most commonly used prognostic models for outcome after trauma...

journal_title：Journal of neurotrauma

authors： Castaño-Leon AM,Lora D,Munarriz PM,Cepeda S,Paredes I,de la Cruz J,Gómez Lopez PA,Lagares A

更新日期：2016-09-01 00:00:00

abstract：:The horizontal ladder task is an established method to assess skilled locomotor recovery after neurological dysfunction. Walking speed is often used as a standardized measure in locomotor assessment of overground walking in human and pre-clinical studies, but the assessment of walking speed is typically ignored during...

journal_title：Journal of neurotrauma

authors： Richards TM,Sharma P,Kuang A,Whitty D,Ahmed Z,Shah PK

更新日期：2019-09-15 00:00:00

abstract：:A retrospective case-control study was undertaken to determine the best technique to measure neural canal encroachment at each lumbar level following burst fracture and its relationship to the presence of neurologic deficit. Only patients with postinjury CT scans demonstrating a disrupted posterior body with a retropu...

journal_title：Journal of neurotrauma

authors： Rasmussen PA,Rabin MH,Mann DC,Perl JR 2nd,Lorenz MA,Vrbos LA

更新日期：1994-12-01 00:00:00

abstract：:The detection of reactive oxygen species (ROS) after traumatic brain injury (TBI) is based on indirect methods due to the high reactivity and short half-life of ROS in biological tissue. The commonly used salicylate trapping method has several disadvantages making it unsuitable for human use. We have evaluated 4-hydro...

journal_title：Journal of neurotrauma

authors： Marklund N,Clausen F,Lewander T,Hillered L

更新日期：2001-11-01 00:00:00

abstract：:Outcomes can be challenging to predict in children with mild traumatic brain injury (TBI). Transcranial Doppler (TCD) ultrasound has become an increasingly useful modality in adult and pediatric TBI by measuring blood flow velocities within the circle of Willis. In children with moderate-to-severe TBI, multiple studie...

journal_title：Journal of neurotrauma

authors： Deines JJ,Chang J,Reuter-Rice K

更新日期：2018-09-06 00:00:00

abstract：:Noise exposure is known to induce cell death signaling in the cochlea. Since c-Jun N-terminal kinase (JNK) signaling is known to induce both cell survival and apoptosis, the present study focused on early changes (within 24 h) after impulse noise exposure, inquiring whether cell death is always related to phosphorylat...

journal_title：Journal of neurotrauma

authors： Murai N,Kirkegaard M,Järlebark L,Risling M,Suneson A,Ulfendahl M

更新日期：2008-01-01 00:00:00

abstract：:Sensorimotor recovery after spinal cord injury (SCI) is of utmost importance to injured individuals and will rely on improved understanding of SCI pathology and recovery. Novel transgenic mouse lines facilitate discovery, but must be understood to be effective. The purpose of this study was to characterize the sensory...

journal_title：Journal of neurotrauma

authors： Faw TD,Lerch JK,Thaxton TT,Deibert RJ,Fisher LC,Basso DM

更新日期：2018-09-15 00:00:00

abstract：:The potential pathophysiological role of circulating microparticles (MPs) has been recognized in various conditions, such as cardiovascular and thrombotic diseases. Traumatic brain injury (TBI) has a complex pathophysiology that involves coagulopathy and inflammation. We investigated endothelial-, platelet-, and leuko...

journal_title：Journal of neurotrauma

authors： Nekludov M,Mobarrez F,Gryth D,Bellander BM,Wallen H

更新日期：2014-12-01 00:00:00

abstract：:Spinal cord injury caused by stab wounds (SCISW) results from a partial or complete transection of the cord, and presents opportunities for interventional research. It is recognized that there is low incidence, but little is known about the natural history or the patient's suitability for long-term clinical outcome st...

journal_title：Journal of neurotrauma

authors： McCaughey EJ,Purcell M,Barnett SC,Allan DB

更新日期：2016-08-01 00:00:00

abstract：:The Glasgow Coma Scale (GCS) score is used in clinical practice for patient assessment and communication among clinicians and also in outcome prediction models such as the Trauma and Injury Severity Score (TRIS). The objective of this study is to determine which GCS subscore is best associated with outcome, taking tim...

journal_title：Journal of neurotrauma

authors： Lesko MM,Jenks T,O'Brien SJ,Childs C,Bouamra O,Woodford M,Lecky F

更新日期：2013-01-01 00:00:00

abstract：:Despite the shift in demographics of spinal cord injury (SCI) due to an aging population, relatively little has been reported regarding the effect of age on outcomes after SCI. This study examines the potential confounding effect of co-morbidities on the age-related differences in the hospital mortality following acut...

journal_title：Journal of neurotrauma

authors： Furlan JC,Kattail D,Fehlings MG

更新日期：2009-08-01 00:00:00