当前位置： SCI文献检索 > JOURNAL OF NEUROTRAUMA期刊下所有文献 > Comparing model performance for survival prediction using total Glasgow Coma Scale and its components in traumatic brain injury.

Comparing model performance for survival prediction using total Glasgow Coma Scale and its components in traumatic brain injury.

Abstract：

:The Glasgow Coma Scale (GCS) score is used in clinical practice for patient assessment and communication among clinicians and also in outcome prediction models such as the Trauma and Injury Severity Score (TRIS). The objective of this study is to determine which GCS subscore is best associated with outcome, taking time of assessment into account. Records of patients with brain injury who presented after 1989 were extracted from the Trauma Audit and Research Network (TARN) database. Using logistic regression, a baseline model was derived with age, Injury Severity Score (ISS), and year of injury as covariates and survival at discharge as the dependent variable. Total GCS, its subscores, and their combinations at various time points were separately added to the baseline model to compare their effect on model performance. The dataset contained 21,657 cases. The total GCS score at scene and its subscores had significantly lower predictive power compared with those recorded on arrival at the Emergency Department (ED) (scene total GCS: Area Under the Curve-AUC: 0.89; 95% confidence interval [CI]: 0.89-0.90) and Nagelkerke R(2) of 0.55, admission total GCS: AUC of 0.91; 95% CI: 0.91-0.91, and Nagelkerke R(2) of 0.59). Eye and verbal subscores had significantly lower performances compared with total GCS, motor subscore, and various combinations of subscores. Motor subscore and total GCS appeared to have similar predictive performance (admission total and motor GCS both had AUC of 0.91 (95% CI: 0.91-0.92) and Nagelkerke R(2) of 0.59 and 0.58, respectively). Motor subscore contains most of the predictive power of the total score. GCS on arrival is a significantly better predictor of outcome than that recorded at scene.

journal_name

J Neurotrauma

journal_title

Journal of neurotrauma

authors

Lesko MM,Jenks T,O'Brien SJ,Childs C,Bouamra O,Woodford M,Lecky F

doi

10.1089/neu.2012.2438

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

17-22

issue

1

eissn

0897-7151

issn

1557-9042

journal_volume

30

pub_type

杂志文章

相关文献

JOURNAL OF NEUROTRAUMA文献大全
  • Effects of dorsal column demyelination on evoked potentials in nucleus gracilis.

    abstract：:Intraspinal injections of lysolecithin were used to produce unilateral demyelination in the dorsal columns of the rat spinal cord. The purpose of this study was to evaluate the effects of demyelination on the conductive properties of axons belonging to a spinal pathway of known origin and site of termination. At 5 and...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章

    doi：10.1089/neu.1992.9.231

    authors： Yezierski RP,Devon RM,Vicedomini JP,Broton JG

    更新日期：1992-10-01 00:00:00

  • The effect of hypothermia on the expression of TIMP-3 after traumatic brain injury in rats.

    abstract：:Here we investigate the effect of hypothermia on the expression of apoptosis-regulating protein TIMP-3 after fluid percussion traumatic brain injury (TBI) in rats. We began with 210 adult male Sprague-Dawley rats and randomly assigned them to three groups: TBI with hypothermia treatment (32°C), TBI with normothermia (...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章

    doi：10.1089/neu.2008.0814

    authors： Jia F,Mao Q,Liang YM,Jiang JY

    更新日期：2014-02-15 00:00:00

  • Abnormal corticospinal excitability in traumatic diffuse axonal brain injury.

    abstract：:This study aimed to investigate the cortical motor excitability characteristics in diffuse axonal injury (DAI) due to severe traumatic brain injury (TBI). A variety of excitatory and inhibitory transcranial magnetic stimulation (TMS) paradigms were applied to primary motor cortices of 17 patients and 11 healthy contro...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章

    doi：10.1089/neu.2008.0859

    authors： Bernabeu M,Demirtas-Tatlidede A,Opisso E,Lopez R,Tormos JM,Pascual-Leone A

    更新日期：2009-12-01 00:00:00

  • Age, outcome, and rehabilitation costs after paraplegia caused by traumatic injury of the thoracic spinal cord, conus medullaris, and cauda equina.

    abstract：:The object of this study was to investigate the relationships of age on neurologic and functional outcome, hospitalization length of stay (LOS), and hospital charges after spinal cord injury (SCI). At 20 medical centers, 2,169 consecutive adult patients with paraplegia SCI were assessed in acute care and inpatient reh...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章,多中心研究

    doi：10.1089/neu.1999.16.805

    authors： Cifu DX,Huang ME,Kolakowsky-Hayner SA,Seel RT

    更新日期：1999-09-01 00:00:00

  • Recommendations for the use of common outcome measures in pediatric traumatic brain injury research.

    abstract：:This article addresses the need for age-relevant outcome measures for traumatic brain injury (TBI) research and summarizes the recommendations by the inter-agency Pediatric TBI Outcomes Workgroup. The Pediatric Workgroup's recommendations address primary clinical research objectives including characterizing course of ...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章,实务指引

    doi：10.1089/neu.2011.1838

    authors： McCauley SR,Wilde EA,Anderson VA,Bedell G,Beers SR,Campbell TF,Chapman SB,Ewing-Cobbs L,Gerring JP,Gioia GA,Levin HS,Michaud LJ,Prasad MR,Swaine BR,Turkstra LS,Wade SL,Yeates KO,Pediatric TBI Outcomes Workgroup.

    更新日期：2012-03-01 00:00:00

  • Monosialogangliosides, neuroprotection, and neuronal repair processes.

    abstract：:Gangliosides play important roles in the physiologic operations of the nervous system, in particular that of the brain. Changes in ganglioside composition occur in the mammalian brain not only during development, but also in aging and in several neuropathologic situations. Gangliosides may modulate the ability of the ...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章,评审

    doi：

    authors： Skaper SD,Leon A

    更新日期：1992-05-01 00:00:00

  • Non-neurological outcomes after complete traumatic spinal cord injury: the impact of surgical timing.

    abstract：:It remains unclear whether the benefits of early surgical timing are significant in neurologically complete spinal cord injury (SCI). We wanted to compare the effects of early and late surgical timing on non-neurological outcomes in persons with traumatic complete SCI. All cases of traumatic complete SCI referred to a...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章

    doi：10.1089/neu.2013.2957

    authors： Bourassa-Moreau E,Mac-Thiong JM,Feldman DE,Thompson C,Parent S

    更新日期：2013-09-15 00:00:00

  • Management of cardiovascular disease risk factors in individuals with chronic spinal cord injury: an evidence-based review.

    abstract：:Clinical scenario: A 37-year-old man suffered a complete spinal cord injury (C8, American Spinal Injury Association Impairment Scale [ASIA] score A) 10 years ago in a car accident. Should primary prevention of cardiovascular disease be a priority in this patient? In order to answer this question, we performed a system...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章,评审

    doi：10.1089/neu.2012.2313

    authors： Cragg JJ,Stone JA,Krassioukov AV

    更新日期：2012-07-20 00:00:00

  • Efficacy of progesterone following a moderate unilateral cortical contusion injury.

    abstract：:Traumatic brain injury (TBI) results in an accumulation of edema and loss of brain tissue. Progesterone (PROG) has been reported to reduce edema and cortical tissue loss in a bilateral prefrontal cortex injury. This study tests the hypothesis that PROG is neuroprotective following a unilateral parietal cortical contus...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章

    doi：10.1089/neu.2007.0477

    authors： Gilmer LK,Roberts KN,Scheff SW

    更新日期：2008-06-01 00:00:00

  • Acute Downregulation of Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 after Experimental Traumatic Brain Injury.

    abstract：:Traumatic brain injury (TBI) causes damage to the hypothalamo-hypophyseal axis, leading to endocrine dysregulation in up to 40% of TBI patients. Hence, there is an urgent need to identify non-invasive biomarkers for TBI-associated hypothalamo-hypophyseal pathology. Sushi repeat-containing protein X-linked 2 (SRPX2) is...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章

    doi：10.1089/neu.2019.6739

    authors： Anwer M,Lara-Valderrabano L,Karttunen J,Ndode-Ekane XE,Puhakka N,Pitkänen A

    更新日期：2020-04-01 00:00:00

  • Voluntary muscle weakness and co-activation after chronic cervical spinal cord injury.

    abstract：:Muscle strength was assessed from the maximum force that could be exerted voluntarily by triceps brachii muscles of 72 people with chronic cervical spinal cord injury (SCI) at or above C7, and 18 able-bodied (A-B) subjects. The magnitude of co-activation was estimated from the ratio of biceps brachii surface EMG to tr...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章

    doi：10.1089/neu.1998.15.149

    authors： Thomas CK,Tucker ME,Bigland-Ritchie B

    更新日期：1998-02-01 00:00:00

  • A Method of Managing Severe Traumatic Brain Injury in the Absence of Intracranial Pressure Monitoring: The Imaging and Clinical Examination Protocol.

    abstract：:The imaging and clinical examination (ICE) algorithm used in the Benchmark Evidence from South American Trials: Treatment of Intracranial Pressure (BEST TRIP) randomized controlled trial is the only prospectively investigated clinical protocol for traumatic brain injury management without intracranial pressure (ICP) m...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1089/neu.2016.4472

    authors： Chesnut RM,Temkin N,Dikmen S,Rondina C,Videtta W,Petroni G,Lujan S,Alanis V,Falcao A,de la Fuenta G,Gonzalez L,Jibaja M,Lavarden A,Sandi F,Mérida R,Romero R,Pridgeon J,Barber J,Machamer J,Chaddock K

    更新日期：2018-01-01 00:00:00

  • Talampanel, a novel noncompetitive AMPA antagonist, is neuroprotective after traumatic brain injury in rats.

    abstract：:Talampanel [(R)-7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3] benzodiazepine] is an orally active noncompetitive antagonist of the AMPA subtype of glutamate excitatory amino acid receptors. The purpose of this study was to determine whether treatment with talampanel would protect in a rat ...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章

    doi：10.1089/08977150152693728

    authors： Belayev L,Alonso OF,Liu Y,Chappell AS,Zhao W,Ginsberg MD,Busto R

    更新日期：2001-10-01 00:00:00

  • Continuous Monitoring and Visualization of Optimum Spinal Cord Perfusion Pressure in Patients with Acute Cord Injury.

    abstract：:The optimum spinal cord perfusion pressure (SCPP) after traumatic spinal cord injury (TSCI) is unknown. Here, we describe techniques to compute and display the optimum SCPP in real time. We recruited adults within 72 h of severe TSCI (American Spinal Injuries Association [ASIA] grades A-C). A pressure probe and a micr...

    journal_title：Journal of neurotrauma

    pub_type： 临床试验,杂志文章

    doi：10.1089/neu.2017.4982

    authors： Chen S,Smielewski P,Czosnyka M,Papadopoulos MC,Saadoun S

    更新日期：2017-11-01 00:00:00

  • Loureirin B Promotes Axon Regeneration by Inhibiting Endoplasmic Reticulum Stress: Induced Mitochondrial Dysfunction and Regulating the Akt/GSK-3β Pathway after Spinal Cord Injury.

    abstract：:Axon retraction greatly limits functional recovery after spinal cord injury (SCI) and neuron polarization, which affects processes including axon formation and development, is a promising target for promoting axon regeneration. Increasing microtubule stability has been demonstrated to improve intrinsic axon regenerati...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章

    doi：10.1089/neu.2018.5966

    authors： Wang Q,Cai H,Hu Z,Wu Y,Guo X,Li J,Wang H,Liu Y,Liu Y,Xie L,Xu K,Xu H,He H,Zhang H,Xiao J

    更新日期：2019-06-15 00:00:00

  • White matter tract-oriented deformation is dependent on real-time axonal fiber orientation.

    abstract：:Traumatic axonal injury (TAI) is a critical public health issue with its pathogenesis remaining largely elusive. Finite element (FE) head models are promising tools to bridge the gap between mechanical insult, localized brain response, and resultant injury. In particular, the FE-derived deformation along the direction...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章

    doi：10.1089/neu.2020.7412

    authors： Zhou Z,Domel AG,Li X,Grant G,Kleiven S,Camarillo DB,Zeineh M

    更新日期：2021-01-15 00:00:00

  • Mechanical stretch to neurons results in a strain rate and magnitude-dependent increase in plasma membrane permeability.

    abstract：:The mechanism by which mechanical impact to brain tissue is transduced to neuronal impairment remains poorly understood. Using an in vitro model of neuronal stretch, we found that mechanical stretch of neurons resulted in a transient plasma membrane permeability increase. Primary cortical neurons, seeded on silicone s...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章

    doi：10.1089/089771503770195885

    authors： Geddes DM,Cargill RS 2nd,LaPlaca MC

    更新日期：2003-10-01 00:00:00

  • L-arginine and free radical scavengers increase cerebral blood flow and brain tissue nitric oxide concentrations after controlled cortical impact injury in rats.

    abstract：:To examine the mechanism of the increase in cerebral blood flow induced by L-arginine administration after traumatic brain injury, the cerebral hemodynamic effects of L-arginine, D-arginine, and the free radical scavengers superoxide dismutase (SOD) and catalase were compared in the controlled cortical impact injury m...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章

    doi：10.1089/08977150360517209

    authors： Cherian L,Robertson CS

    更新日期：2003-01-01 00:00:00

  • Repeated mild traumatic brain injury: mechanisms of cerebral vulnerability.

    abstract：:Among the 3.5 million annual new head injury cases is a subpopulation of children and young adults who experience repeated traumatic brain injury (TBI). The duration of vulnerability after a single TBI remains unknown, and biomarkers have yet to be determined. Decreases in glucose metabolism (cerebral metabolic rate o...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章

    doi：10.1089/neu.2012.2399

    authors： Prins ML,Alexander D,Giza CC,Hovda DA

    更新日期：2013-01-01 00:00:00

  • Relative Deficiency of Plasma A Disintegrin and Metalloprotease with Thrombospondin Type 1 Repeats 13 Activity and Elevation of Human Neutrophil Peptides in Patients with Traumatic Brain Injury.

    abstract：:Traumatic microvascular injury (tMVI) is a universal endophenotype of traumatic brain injury (TBI) that is responsible for significant neurological morbidity and mortality. The mechanism underlying tMVI is not fully understood. The present study aims to determine plasma levels of von Willebrand factor (VWF), a disinte...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章

    doi：10.1089/neu.2018.5696

    authors： Kumar MA,Cao W,Pham HP,Raju D,Nawalinski K,Maloney-Wilensky E,Schuster J,Zheng XL

    更新日期：2019-01-15 00:00:00

  • Neuron-specific enolase serum levels after controlled cortical impact injury in the rat.

    abstract：:The aim of this study was to investigate the time course and the correlation of neuron-specific enolase (NSE) serum levels to the severity of traumatic brain injury in rats. Sixty-five male Wistar rats were subjected to severe cortical impact injury (100 PSI, 2 mm deformation). Blood samples were drawn directly after ...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章

    doi：10.1089/089771501300227378

    authors： Woertgen C,Rothoerl RD,Brawanski A

    更新日期：2001-05-01 00:00:00

  • Increased Levels of Circulating Glial Fibrillary Acidic Protein and Collapsin Response Mediator Protein-2 Autoantibodies in the Acute Stage of Spinal Cord Injury Predict the Subsequent Development of Neuropathic Pain.

    abstract：:Neuropathic pain develops in 40-70% of spinal cord injury (SCI) patients and markedly compromises quality of life. We examined plasma from SCI patients for autoantibodies to glial fibrillary acidic protein (GFAP) and collapsin response mediator protein-2 (CRMP2) and evaluated their relationship to the development of n...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章

    doi：10.1089/neu.2018.5675

    authors： Hergenroeder GW,Redell JB,Choi HA,Schmitt L,Donovan W,Francisco GE,Schmitt K,Moore AN,Dash PK

    更新日期：2018-11-01 00:00:00

  • Mechanical Design and Analysis of a Unilateral Cervical Spinal Cord Contusion Injury Model in Non-Human Primates.

    abstract：:Non-human primate (NHP) models of spinal cord injury better reflect human injury and provide a better foundation to evaluate potential treatments and functional outcomes. We combined finite element (FE) and surrogate models with impact data derived from in vivo experiments to define the impact mechanics needed to gene...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章

    doi：10.1089/neu.2015.3974

    authors： Sparrey CJ,Salegio EA,Camisa W,Tam H,Beattie MS,Bresnahan JC

    更新日期：2016-06-15 00:00:00

  • The Second National Acute Spinal Cord Injury Study.

    abstract：:In 1990, the Second National Acute Spinal Cord Injury Study reported that high-dosage methylprednisolone improves neurologic recovery in spinal-injured humans. The study showed that patients who received the drug within 8 hr after injury improved, whereas those who received the drug later did not. The drug significant...

    journal_title：Journal of neurotrauma

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Young W,Bracken MB

    更新日期：1992-03-01 00:00:00

  • Quantitative analysis of microvascular alterations in traumatic brain injury by endothelial barrier antigen immunohistochemistry.

    abstract：:Endothelial barrier antigen (EBA) is a protein triplet located in the plasma membrane of microvascular endothelium and selectively expressed in the normal nervous system. In this study, microvascular alterations following traumatic brain injury were studied using EBA immunohistochemistry. Anesthetized, physiologically...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章

    doi：10.1089/089771501750170958

    authors： Lin B,Ginsberg MD,Zhao W,Alonso OF,Belayev L,Busto R

    更新日期：2001-04-01 00:00:00

  • Resting-State Magnetoencephalography Source Imaging Pilot Study in Children with Mild Traumatic Brain Injury.

    abstract：:Mild traumatic brain injury (mTBI) accounts for the vast majority of all pediatric TBI. An important minority of children who have suffered an mTBI have enduring cognitive and emotional symptoms. However, the mechanisms of chronic symptoms in children with pediatric mTBI are not fully understood. This is in part due t...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章

    doi：10.1089/neu.2019.6417

    authors： Huang MX,Robb Swan A,Angeles Quinto A,Huang JW,De-la-Garza BG,Huang CW,Hesselink JR,Bigler ED,Wilde EA,Max JE

    更新日期：2020-04-01 00:00:00

  • Unique Sensory and Motor Behavior in Thy1-GFP-M Mice before and after Spinal Cord Injury.

    abstract：:Sensorimotor recovery after spinal cord injury (SCI) is of utmost importance to injured individuals and will rely on improved understanding of SCI pathology and recovery. Novel transgenic mouse lines facilitate discovery, but must be understood to be effective. The purpose of this study was to characterize the sensory...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章

    doi：10.1089/neu.2017.5395

    authors： Faw TD,Lerch JK,Thaxton TT,Deibert RJ,Fisher LC,Basso DM

    更新日期：2018-09-15 00:00:00

  • Decreases in White Matter Integrity of Ventro-Limbic Pathway Linked to Post-Traumatic Stress Disorder in Mild Traumatic Brain Injury.

    abstract：:Post-traumatic stress disorder (PTSD) is commonly observed in military service members with mild traumatic brain injury (mTBI); however, the relationship between mTBI and PTSD is complex and not well understood. The present study aims to elucidate a link between the degree of alteration in limbic system-related white ...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章

    doi：10.1089/neu.2017.5541

    authors： Santhanam P,Teslovich T,Wilson SH,Yeh PH,Oakes TR,Weaver LK

    更新日期：2019-04-01 00:00:00

  • Coagulopathy as a Surrogate of Severity of Injury in Penetrating Brain Injury.

    abstract：:Penetrating brain injury (PBI) is the most devastating type of traumatic brain injury. Development of coagulopathy in the acute setting of PBI, though common, remains of unclear significance as does its reversal. The aim of this study is to investigate the relationship between coagulopathy and clinical presentation, r...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章

    doi：10.1089/neu.2020.7422

    authors： Mansour A,Loggini A,Goldenberg FD,Kramer C,Naidech AM,Ammar FE,Vasenina V,Castro B,Das P,Horowitz PM,Karrison T,Zakrison T,Hampton D,Rogers SO,Lazaridis C

    更新日期：2021-01-20 00:00:00

  • Noninvasive brain stimulation for persistent postconcussion symptoms in mild traumatic brain injury.

    abstract：:Mild traumatic brain injury (mTBI) is typically followed by various postconcussive symptoms (PCS), including headache, depression, and cognitive deficits. In 15-25% of cases, PCS persists beyond the usual 3-month recovery period, interfering with activities of daily living and responding poorly to pharmacotherapy. We ...

    journal_title：Journal of neurotrauma

    pub_type： 杂志文章

    doi：10.1089/neu.2014.3449

    authors： Koski L,Kolivakis T,Yu C,Chen JK,Delaney S,Ptito A

    更新日期：2015-01-01 00:00:00