Variation in PPP3CC Genotype Is Associated with Long-Term Recovery after Severe Brain Injury.

abstract：:Restraint stress (RS) protects auditory function against acoustic trauma by activating glucocorticoid receptors (GR) in the cochlea. In a search for the signaling pathways downstream to GR that may be involved in RS-induced protection we report here (1) a downregulation of phosphorylated extracellular signal-regulated...

journal_title：Journal of neurotrauma

authors： Meltser I,Tahera Y,Canlon B

更新日期：2009-10-01 00:00:00

abstract：:Using diffusion-weighted imaging (DWI), research has demonstrated changes suggestive of damage to white matter tracts (WMT) following mild traumatic brain injury (mTBI). Yet due to the predominant use of the diffusion tensor imaging (DTI) model, which has numerous well-established limitations, it has not yet been poss...

journal_title：Journal of neurotrauma

authors： Oehr LE,Yang JY,Chen J,Maller J,Seal M,Anderson J

更新日期：2020-12-14 00:00:00

abstract：:We sought to determine sensitivity of the cortical impact injury model of traumatic brain injury (TBI) to severity of injury and to treatment. We examined the pattern of motor and cognitive deficits and recovery following TBI over a range of injury severities, and examined the efficacy of surface-induced moderate hypo...

journal_title：Journal of neurotrauma

authors： Markgraf CG,Clifton GL,Aguirre M,Chaney SF,Knox-Du Bois C,Kennon K,Verma N

更新日期：2001-02-01 00:00:00

abstract：:Cytokine measurement directly from the brain parenchyma by means of microdialysis has documented the activation of certain procedures in vivo, after brain trauma in humans. However, the intercalation of the micro-catheter insertion with the phenomena triggered by the head trauma renders the assessment of the findings ...

journal_title：Journal of neurotrauma

authors： Bouras TI,Gatzonis SS,Georgakoulias N,Karatza M,Sianouni A,Stranjalis G,Boviatsis E,Vasileiou S,Sakas DE

更新日期：2011-11-18 00:00:00

abstract：:Efforts to understand spinal cord injury (SCI) and other complex neurotrauma disorders at the pre-clinical level have shown progress in recent years. However, successful translation of basic research into clinical practice has been slow, partly because of the large, heterogeneous data sets involved. In this sense, tra...

journal_title：Journal of neurotrauma

authors： Nielson JL,Guandique CF,Liu AW,Burke DA,Lash AT,Moseanko R,Hawbecker S,Strand SC,Zdunowski S,Irvine KA,Brock JH,Nout-Lomas YS,Gensel JC,Anderson KD,Segal MR,Rosenzweig ES,Magnuson DS,Whittemore SR,McTigue DM,Popovic

更新日期：2014-11-01 00:00:00

abstract：:Collaboration among investigators, centers, countries, and disciplines is essential to advancing the care for traumatic brain injury (TBI). It is thus important that we "speak the same language." Great variability, however, exists in data collection and coding of variables in TBI studies, confounding comparisons betwe...

journal_title：Journal of neurotrauma

authors： Maas AI,Harrison-Felix CL,Menon D,Adelson PD,Balkin T,Bullock R,Engel DC,Gordon W,Langlois-Orman J,Lew HL,Robertson C,Temkin N,Valadka A,Verfaellie M,Wainwright M,Wright DW,Schwab K

更新日期：2011-02-01 00:00:00

abstract：:Fatalities or injuries following motorized and non-motorized vehicle accidents (MNMVA) are reported by police or health care systems. However, limited data exist for spinal injuries. Using an epidemiological database of road accidents occurring in a defined geographic area, we measured the incidence of major spinal tr...

journal_title：Journal of neurotrauma

authors： Lieutaud T,Ndiaye A,Frost F,Chiron M,Registry Group.

更新日期：2010-06-01 00:00:00

abstract：:The efficacy of end-to-side repair as a method of nerve reconstruction has been questioned, and most studies that characterize the mode of re-innervation are marred by inappropriate experimental design and lack quantitative analysis. This makes characterization of re-innervating neurons confusing and consequently cont...

journal_title：Journal of neurotrauma

authors： Sananpanich K,Galea MP,Morrison WA,Messina A

更新日期：2007-05-01 00:00:00

abstract：:A critical component for accelerating the clinical uptake of research data in the area of pediatric concussion or mild traumatic brain injury (MTBI) pertains to the establishment and utilization of common databases. The objective of the first phase of our CanPedCDE initiative was to agree upon pediatric common data el...

journal_title：Journal of neurotrauma

authors： Gagnon I,Friedman D,Beauchamp MH,Christie B,DeMatteo C,Macartney G,McFadyen BJ,Sirois K,Taneja C,Zabjek K,Zemek R,Mrazik M

更新日期：2018-08-15 00:00:00

abstract：:Autonomic dysreflexia (AD) is a potentially life-threatening syndrome in individuals with spinal cord injury (SCI) above the T6 spinal level that is characterized by episodic hypertension in response to noxious stimuli below the lesion. Maladaptive intraspinal plasticity is thought to contribute to the temporal develo...

journal_title：Journal of neurotrauma

authors： Eldahan KC,Cox DH,Gollihue JL,Patel SP,Rabchevsky AG

更新日期：2018-03-15 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading cause of death and functional disability in western countries, affecting mostly young patients. Despite intense and sustained efforts deployed for the development of new therapeutic strategies, no clinical benefit has been shown by any of the investigated compounds. Increasing...

journal_title：Journal of neurotrauma

authors： Soustiel JF,Palzur E,Nevo O,Thaler I,Vlodavsky E

更新日期：2005-03-01 00:00:00

abstract：:Early decompression may improve neurological outcome after spinal cord injury (SCI), but is often difficult to achieve because of logistical issues. The aims of this study were to 1) determine the time to decompression in cases of isolated cervical SCI in Australia and New Zealand and 2) determine where substantial de...

journal_title：Journal of neurotrauma

authors： Battistuzzo CR,Armstrong A,Clark J,Worley L,Sharwood L,Lin P,Rooke G,Skeers P,Nolan S,Geraghty T,Nunn A,Brown DJ,Hill S,Alexander J,Millard M,Cox SF,Rao S,Watts A,Goods L,Allison GT,Agostinello J,Cameron PA,Mo

更新日期：2016-06-15 00:00:00

abstract：:Studies measuring the volume of infarcted tissue and survival after pharmacologic intervention in stroke are complicated by the potential effect of survival time on infarct volume. In this study, the volume of infarcted tissue as defined by 2,3,5-triphenyltetrazolium chloride staining was determined in rabbits at 28 h...

journal_title：Journal of neurotrauma

authors： Browning JL,Widmayer MA,Hoffmann KK,Dudley AW Jr,Baskin DS

更新日期：1996-10-01 00:00:00

abstract：:Urokinase (uPA) and tissue plasminogen activator (tPA) are serine proteases implicated in fibrinolysis, but their role in the regulation of the cerebrovascular response to brain trauma has not been investigated. This study was designed to (1) characterize the cerebrovascular activity of uPA and tPA, (2) investigate th...

journal_title：Journal of neurotrauma

authors： Armstead WM,Cines DB,Al-Roof Higazi A

更新日期：2004-09-01 00:00:00

abstract：:ABSTRACT Preliminary evidence has shown that intracerebral hemorrhages, either spontaneous (sICH) or traumatic (tICH) often expand over time. An association between hemorrhage expansion and clinical outcomes has been described for sICH. The intent of this prospective, observational study was to characterize the tempor...

journal_title：Journal of neurotrauma

authors： Narayan RK,Maas AI,Servadei F,Skolnick BE,Tillinger MN,Marshall LF,Traumatic Intracerebral Hemorrhage Study Group.

更新日期：2008-06-01 00:00:00

abstract：:There is a need for better tools to objectively, reliably, and precisely assess neurological function after sport-related concussion (SRC). The aim of this study was to use a robotic device (Kinesiological Instrument for Normal and Altered Reaching Movements; KINARM) to quantify neurological impairments in athletes ac...

journal_title：Journal of neurotrauma

authors： Mang CS,Whitten TA,Cosh MS,Scott SH,Wiley JP,Debert CT,Dukelow SP,Benson BW

更新日期：2019-01-15 00:00:00

abstract：:Mild traumatic brain injury (mTBI) accounts for the majority of head trauma cases. Despite some lasting cognitive, emotional, and behavioral deficits, there are frequently no overt morphological defects, suggesting that changes may result from alterations in the physiology of individual neurons. We investigated hippoc...

journal_title：Journal of neurotrauma

authors： Eakin K,Miller JP

更新日期：2012-04-10 00:00:00

abstract：:We conducted a study to evaluate the degree of corticospinal tract (CST) dysfunction associated with diffuse axonal injury (DAI) through analyses of both diffusion-tensor magnetic resonance imaging (DTMRI) and motor-evoked potential (MEP). Using DTMRI and MEP with transcranial magnetic stimulation, we evaluated 138 in...

journal_title：Journal of neurotrauma

authors： Yasokawa YT,Shinoda J,Okumura A,Nakayama N,Miwa K,Iwama T

更新日期：2007-01-01 00:00:00

abstract：:Mild traumatic brain injury (mTBI) patients frequently experience emotion dysregulation symptoms, including post-traumatic stress. Although mTBI likely affects cortical activation and structure, resulting in cognitive symptoms after mTBI, early effects of mTBI on cortical emotion processing circuits have rarely been e...

journal_title：Journal of neurotrauma

authors： Wang X,Xie H,Cotton AS,Brickman KR,Lewis TJ,Wall JT,Tamburrino MB,Bauer WR,Law K,McLean SA,Liberzon I

更新日期：2017-01-15 00:00:00

abstract：:Despite clinical symptoms, a large majority of people with mild traumatic brain injury (TBI) have normal computed tomography (CT) and magnetic resonance imaging (MRI) scans. Therefore, present-day neuroimaging tools are insufficient to diagnose or classify low grades of TBI. Advanced neuroimaging techniques, such as d...

journal_title：Journal of neurotrauma

authors： Sinke MRT,Otte WM,Meerwaldt AE,Franx BAA,Ali MHM,Rakib F,van der Toorn A,van Heijningen CL,Smeele C,Ahmed T,Blezer ELA,Dijkhuizen RM

更新日期：2021-01-11 00:00:00

abstract：:Traumatic brain injury (TBI) is known to be accompanied by an increase in intracranial pressure (ICP) and in some cases, by spontaneous generation of cortical spreading depression (CSD) cycles. However, the role of CSD in the pathophysiology of cerebral contusion is still unknown. A multiparametric monitoring assembly...

journal_title：Journal of neurotrauma

authors： Rogatsky GG,Sonn J,Kamenir Y,Zarchin N,Mayevsky A

更新日期：2003-12-01 00:00:00

abstract：:With a rising number of cranioplasty (CP) procedures and an increasing percentage of patients with a good clinical outcome and prolonged survival after CP, looking at the functional and aesthetic outcome of these patients becomes more and more important. The aim of our study was to evaluate a novel score, combining fu...

journal_title：Journal of neurotrauma

authors： Henker C,Hoppmann MC,Sherman MUS,Glass A,Piek J

更新日期：2018-04-15 00:00:00

abstract：:This study characterized the Infinite Horizon (IH) Impactor for use in mouse models of contusion spinal cord injury (SCI), and investigated the feasibility and reliability of using magnetic resonance imaging (MRI) as a method to accurately measure lesion volume after mouse contusion SCI. Eight-week-old female C57Bl/6 ...

journal_title：Journal of neurotrauma

authors： Nishi RA,Liu H,Chu Y,Hamamura M,Su MY,Nalcioglu O,Anderson AJ

更新日期：2007-04-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a silent epidemic affecting approximately 1.4 million Americans annually, at an estimated annual cost of $60 billion in the United States alone. Despite an increased understanding of the pathophysiology of closed head injury, there remains no pharmacological intervention proven to impro...

journal_title：Journal of neurotrauma

authors： Laskowitz DT,McKenna SE,Song P,Wang H,Durham L,Yeung N,Christensen D,Vitek MP

更新日期：2007-07-01 00:00:00

abstract：:Risk factors for head injury are also risk factors for becoming homeless but there is little research on this vulnerable group, who can be neglected by health services that specialize in acquired brain injury. This study investigates the prevalence of admissions to hospital with a head injury in the homeless and assoc...

journal_title：Journal of neurotrauma

authors： McMillan TM,Laurie M,Oddy M,Menzies M,Stewart E,Wainman-Lefley J

更新日期：2015-01-15 00:00:00

abstract：:Progesterone is an anti-inflammatory and promyelinating agent after spinal cord injury, but its effectiveness on functional recovery is still controversial. In the current study, we tested the effects of chronic progesterone administration on tissue preservation and functional recovery in a clinically relevant model o...

journal_title：Journal of neurotrauma

authors： Garcia-Ovejero D,González S,Paniagua-Torija B,Lima A,Molina-Holgado E,De Nicola AF,Labombarda F

更新日期：2014-05-01 00:00:00

abstract：:This paper encompasses the prediction of early and late recovery from traumatic brain injury (TBI). Predictors of the duration of coma and the utilization of posttraumatic amnesia duration to predict residual memory function are discussed. The issues surrounding prediction of long-term neurobehavioral recovery from TB...

journal_title：Journal of neurotrauma

authors： Levin HS

更新日期：1995-10-01 00:00:00

abstract：:Traumatic brain damage may cause acute emotional symptoms such as uncontrolled crying, apathy, and sleep problems. Rehabilitation may be less effective in patients afflicted by these symptoms. Citalopram, a selective serotonin reuptake inhibitor (SSRI), has a documented immediate and dramatic effect on pathological cr...

journal_title：Journal of neurotrauma

authors： Andersen G,Stylsvig M,Sunde N

更新日期：1999-04-01 00:00:00

abstract：:Accumulating evidence suggests that the extent of brain injury and the clinical outcome after traumatic brain injury (TBI) are modulated, to some degree, by genetic variants. Aquaporin-4 (AQP4) is the predominant water channel in the central nervous system and plays a critical role in controlling the water content of ...

journal_title：Journal of neurotrauma

authors： Dardiotis E,Paterakis K,Tsivgoulis G,Tsintou M,Hadjigeorgiou GF,Dardioti M,Grigoriadis S,Simeonidou C,Komnos A,Kapsalaki E,Fountas K,Hadjigeorgiou GM

更新日期：2014-12-01 00:00:00

abstract：:Depression is associated with poorer recovery after traumatic brain injury (TBI), yet awareness of depression risk post-TBI among providers and patients is low. The aim of this study was to estimate risk of depression post-TBI among adults 18 years of age and older and to identify risk factors associated with developi...

journal_title：Journal of neurotrauma

authors： Albrecht JS,Barbour L,Abariga SA,Rao V,Perfetto EM

更新日期：2019-01-15 00:00:00