Behavioral, histological, and ex vivo magnetic resonance imaging assessment of graded contusion spinal cord injury in mice.

abstract：:Worldwide, different strategies are being applied for symptomatic chronic subdural hematoma (CSDH). The aim of this study was to evaluate the efficacy of two treatment strategies for symptomatic CSDH: initial dexamethasone (DXM) therapy versus primary surgery by burr hole craniostomy (BHC). We retrospectively collecte...

journal_title：Journal of neurotrauma

authors： Miah IP,Herklots M,Roks G,Peul WC,Walchenbach R,Dammers R,Lingsma HF,den Hertog HM,Jellema K,Van der Gaag NA

更新日期：2020-01-15 00:00:00

abstract：:The relationship between psychotropic medication use and traumatic brain injury (TBI) is not well understood. The objective of this study was to describe patterns of psychotropic medication use during the months before and after TBI and compare with a non-TBI cohort. We conducted a retrospective cohort study using adm...

journal_title：Journal of neurotrauma

authors： Albrecht JS,Wickwire EM,Mullins CD,Rao V

更新日期：2020-04-15 00:00:00

abstract：:Although mild therapeutic hypothermia is an effective neuroprotective strategy for cardiac arrest/resuscitated patients, and asphyxic newborns, recent randomized controlled trials (RCTs) have equally shown good neurological outcome between targeted temperature management at 33 °C versus 36 °C, and have not shown consi...

journal_title：Journal of neurotrauma

authors： Maekawa T,Yamashita S,Nagao S,Hayashi N,Ohashi Y,Brain-Hypothermia Study Group.

更新日期：2015-04-01 00:00:00

abstract：:Mild traumatic brain injury (mTBI) contributes to development of affective disorders, including post-traumatic stress disorder (PTSD). Psychiatric symptoms typically emerge in a tardive fashion post-TBI, with negative effects on recovery. Patients with PTSD, as well as rodent models of PTSD, demonstrate structural and...

journal_title：Journal of neurotrauma

authors： Schneider BL,Ghoddoussi F,Charlton JL,Kohler RJ,Galloway MP,Perrine SA,Conti AC

更新日期：2016-09-01 00:00:00

abstract：:Magnetic resonance imaging data were acquired at ∼24 h and ∼3 months post-injury on mild traumatic brain injury (mTBI; n = 75) and orthopedic injury (n = 60) cohorts. The mTBI subjects were randomly assigned to a treatment group with atorvastatin or a non-treatment mTBI group. The treatment group was further divided i...

journal_title：Journal of neurotrauma

authors： Govindarajan KA,Narayana PA,Hasan KM,Wilde EA,Levin HS,Hunter JV,Miller ER,Patel VK,Robertson CS,McCarthy JJ

更新日期：2016-10-15 00:00:00

abstract：:Diffusion tensor imaging (DTI) has demonstrated success as a biomarker of spinal cord injury (SCI) severity as shown from numerous pre-clinical studies. However, artifacts from stabilization hardware at the lesion have precluded its use for longitudinal assessments. Previous research has documented ex vivo diffusion c...

journal_title：Journal of neurotrauma

authors： Motovylyak A,Skinner NP,Schmit BD,Wilkins N,Kurpad SN,Budde MD

更新日期：2019-05-01 00:00:00

abstract：:Magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) studies have demonstrated that measures of altered metabolism and axonal injury can be detected following traumatic brain injury. The aim of this study was to characterize and compare the distributions of altered image parameters obtained by thes...

journal_title：Journal of neurotrauma

authors： Maudsley AA,Govind V,Levin B,Saigal G,Harris L,Sheriff S

更新日期：2015-07-15 00:00:00

abstract：:Information on the nature of deficits and adaptive mechanisms occurring after spinal cord injury is essential to the design of strategies for promoting functional recovery. Motor impairments and compensations were quantified by three-dimensional kinematic analysis in freely walking rats, 6 months after mild cervical (...

journal_title：Journal of neurotrauma

authors： Collazos-Castro JE,Soto VM,Gutiérrez-Dávila M,Nieto-Sampedro M

更新日期：2005-05-01 00:00:00

abstract：:Neuroendocrine disturbances are common after traumatic brain injury (TBI) and aneurysmal subarachnoid hemorrhage (SAH), but only a few data exist on long-term anterior pituitary deficiencies after brain injury. We present data from the Structured Data Assessment of Hypopituitarism after TBI and SAH, a multi-center stu...

journal_title：Journal of neurotrauma

authors： Krewer C,Schneider M,Schneider HJ,Kreitschmann-Andermahr I,Buchfelder M,Faust M,Berg C,Wallaschofski H,Renner C,Uhl E,Koenig E,Jordan M,Stalla GK,Kopczak A

更新日期：2016-08-15 00:00:00

abstract：:Transient receptor potential vanilloid 1 (TRPV1) is expressed widely in the central nervous system and is activated by various stimuli. Inhibiting TRPV1 has neuroprotective effects in cerebral ischemia. The role of inhibiting TRPV1 to maintain blood-brain barrier (BBB) integrity after traumatic brain injury (TBI) rema...

journal_title：Journal of neurotrauma

authors： Yang DX,Jing Y,Liu YL,Xu ZM,Yuan F,Wang ML,Geng Z,Tian HL

更新日期：2019-04-15 00:00:00

abstract：:Ocular blast injury is a major medical concern for soldiers and explosion victims due to poor visual outcomes. To define the changes in gene expression following a blast injury to the eye, we examined retinal ribonucleic acid (RNA) expression in 54 mouse strains 5 days after a single 50-psi overpressure air wave blast...

journal_title：Journal of neurotrauma

authors： Struebing FL,King R,Li Y,Chrenek MA,Lyuboslavsky PN,Sidhu CS,Iuvone PM,Geisert EE

更新日期：2018-01-01 00:00:00

abstract：:The canine double hemorrhage model is an established model to study cerebral vasospasm, the late sequelae of subarachnoid hemorrhage (SAH). The present study uses magnetic resonance imaging (MRI) to examine the recently reported early brain injury after SAH. Double hemorrhage SAH modeling was obtained by injecting 0.5...

journal_title：Journal of neurotrauma

authors： Jadhav V,Sugawara T,Zhang J,Jacobson P,Obenaus A

更新日期：2008-09-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) is commonly observed in military service members with mild traumatic brain injury (mTBI); however, the relationship between mTBI and PTSD is complex and not well understood. The present study aims to elucidate a link between the degree of alteration in limbic system-related white ...

journal_title：Journal of neurotrauma

authors： Santhanam P,Teslovich T,Wilson SH,Yeh PH,Oakes TR,Weaver LK

更新日期：2019-04-01 00:00:00

abstract：:Oxidative energy metabolism is depressed after mild/moderate traumatic brain injury (TBI) during early development, accompanied by behavioral debilitation and secondary neuronal death. A TBI metabolome analysis revealed broad effects with a striking impact on energy metabolism. Our studies on mitochondrial modulators ...

journal_title：Journal of neurotrauma

authors： Chitturi J,Santhakumar V,Kannurpatti SS

更新日期：2019-04-15 00:00:00

abstract：:Acute administration of a monoclonal antibody (mAb) raised against the CD11d subunit of the leukocyte CD11d/CD18 integrin after spinal cord injury (SCI) in the rat greatly improves neurological outcomes. This has been chiefly attributed to the reduced infiltration of neutrophils into the injured spinal cord in treated...

journal_title：Journal of neurotrauma

authors： Geremia NM,Bao F,Rosenzweig TE,Hryciw T,Weaver L,Dekaban GA,Brown A

更新日期：2012-02-10 00:00:00

abstract：:ABSTRACT Preliminary evidence has shown that intracerebral hemorrhages, either spontaneous (sICH) or traumatic (tICH) often expand over time. An association between hemorrhage expansion and clinical outcomes has been described for sICH. The intent of this prospective, observational study was to characterize the tempor...

journal_title：Journal of neurotrauma

authors： Narayan RK,Maas AI,Servadei F,Skolnick BE,Tillinger MN,Marshall LF,Traumatic Intracerebral Hemorrhage Study Group.

更新日期：2008-06-01 00:00:00

abstract：:The family of the collapsin response mediator proteins (CRMPs) plays a significant physiological role in neuronal cell bodies and axons within the integrated mammalian central nervous system (CNS). Trauma-induced damage to the CNS results in variable degrees of axonal degeneration, and this may lead to neuronal cell d...

journal_title：Journal of neurotrauma

authors： Taghian K,Lee JY,Petratos S

更新日期：2012-06-10 00:00:00

abstract：:Striking gender differences have been reported in the pathophysiology and outcome of acute neurological injury. Greater neuroprotection in females versus males may be due, in part, to direct and indirect sex hormone-mediated antioxidant mechanisms. Progesterone administration decreases brain levels of F(2)-isoprostane...

journal_title：Journal of neurotrauma

authors： Bayir H,Marion DW,Puccio AM,Wisniewski SR,Janesko KL,Clark RS,Kochanek PM

更新日期：2004-01-01 00:00:00

abstract：:Previous studies have resulted in conflicting results regarding the predictive effect of various clinical symptoms, signs, and plain imaging for intracranial pathology in adults with minor head injury. We sought to perform a meta-analysis of the literature to assess the significance of these factors for the prediction...

journal_title：Journal of neurotrauma

authors： Dunning J,Stratford-Smith P,Lecky F,Batchelor J,Hogg K,Browne J,Sharpin C,Mackway-Jones K,Emergency Medicine Research Group.

更新日期：2004-07-01 00:00:00

abstract：:The majority of studies do not support the use of the prophylactic anticonvulsants studied thus far for the prevention of late PTS. Routine seizure prophylaxis later than 1 week following head injury is, therefore, not recommended. If late PTS occur, patients should be managed in accordance with standard approaches to...

journal_title：Journal of neurotrauma

authors：

更新日期：2000-06-01 00:00:00

abstract：:Growing evidence suggests that temporally proximal acute concussions and repetitive subconcussive head injuries may lead to long-term neurological deficits. However, the underlying mechanisms of injury and their relative time-scales are not well documented in human injury models. The current study therefore investigat...

journal_title：Journal of neurotrauma

authors： Mayer AR,Ling JM,Dodd AB,Gasparovic C,Klimaj SD,Meier TB

更新日期：2015-11-15 00:00:00

abstract：:The effectiveness of cerebrospinal fluid (CSF) drainage in lowering high intracranial pressure (ICP) is well established in severe traumatic brain injury (TBI). Recently, however, the use of external ventricular drains (EVDs) and ICP monitors in TBI has come under question. The aim of this retrospective study was to i...

journal_title：Journal of neurotrauma

authors： Akbik OS,Krasberg M,Nemoto EM,Yonas H

更新日期：2017-11-15 00:00:00

abstract：:Controlled cortical impact (CCI) is a contemporary model of experimental cerebral contusion. We examined the cerebrovascular and neuropathologic effects of a severe CCI in rats. The utility of magnetic resonance imaging (MRI) for the assessment of contusion volume after severe CCI was also established. Severe CCI (3.0...

journal_title：Journal of neurotrauma

authors： Kochanek PM,Marion DW,Zhang W,Schiding JK,White M,Palmer AM,Clark RS,O'Malley ME,Styren SD,Ho C

更新日期：1995-12-01 00:00:00

abstract：:Intraspinal injections of lysolecithin were used to produce unilateral demyelination in the dorsal columns of the rat spinal cord. The purpose of this study was to evaluate the effects of demyelination on the conductive properties of axons belonging to a spinal pathway of known origin and site of termination. At 5 and...

journal_title：Journal of neurotrauma

authors： Yezierski RP,Devon RM,Vicedomini JP,Broton JG

更新日期：1992-10-01 00:00:00

abstract：:To assess the safety and accuracy of the Camino intraparenchymal sensor, we prospectively evaluated hemorrhagic complications, zero-drift, infection, and system malfunction in 163 patients monitored after a severe head injury. Mean duration of intracranial pressure (ICP) monitoring was 5 +/- 2.2 days (range: 12 h to 1...

journal_title：Journal of neurotrauma

authors： Poca MA,Sahuquillo J,Arribas M,Báguena M,Amorós S,Rubio E

更新日期：2002-04-01 00:00:00

abstract：:Efforts to understand spinal cord injury (SCI) and other complex neurotrauma disorders at the pre-clinical level have shown progress in recent years. However, successful translation of basic research into clinical practice has been slow, partly because of the large, heterogeneous data sets involved. In this sense, tra...

journal_title：Journal of neurotrauma

authors： Nielson JL,Guandique CF,Liu AW,Burke DA,Lash AT,Moseanko R,Hawbecker S,Strand SC,Zdunowski S,Irvine KA,Brock JH,Nout-Lomas YS,Gensel JC,Anderson KD,Segal MR,Rosenzweig ES,Magnuson DS,Whittemore SR,McTigue DM,Popovic

更新日期：2014-11-01 00:00:00

abstract：:Controlled cortical impact (CCI) produces blood-brain barrier (BBB) permeability and an acute inflammatory response in injured brain, associated with upregulation of cell adhesion molecules and accumulation of neutrophils. Nevertheless, the role of acute inflammation in the pathogenesis of BBB permeability after traum...

journal_title：Journal of neurotrauma

authors： Whalen MJ,Carlos TM,Kochanek PM,Clark RS,Heineman S,Schiding JK,Franicola D,Memarzadeh F,Lo W,Marion DW,Dekosky ST

更新日期：1999-07-01 00:00:00

abstract：:Non-human primate (NHP) models of spinal cord injury better reflect human injury and provide a better foundation to evaluate potential treatments and functional outcomes. We combined finite element (FE) and surrogate models with impact data derived from in vivo experiments to define the impact mechanics needed to gene...

journal_title：Journal of neurotrauma

authors： Sparrey CJ,Salegio EA,Camisa W,Tam H,Beattie MS,Bresnahan JC

更新日期：2016-06-15 00:00:00

abstract：:The activation of oxidative damage, neuroinflammation, and mitochondrial dysfunction has been implicated in secondary pathomechanisms following spinal cord injury (SCI). These pathophysiological processes lead to cell death and are tightly regulated by nuclear factor E2-related factor 2/antioxidant response element (N...

journal_title：Journal of neurotrauma

authors： Wang X,de Rivero Vaccari JP,Wang H,Diaz P,German R,Marcillo AE,Keane RW

更新日期：2012-03-20 00:00:00

abstract：:Acute pain is a common symptom experienced after spinal cord injury (SCI). The presence of this pain calls for treatment with analgesics, such as buprenorphine. However, there are concerns that the drug may exert other effects besides alleviation of pain. Among those reported are in vitro changes in gene expression, a...

journal_title：Journal of neurotrauma

authors： Santiago JM,Rosas O,Torrado AI,González MM,Kalyan-Masih PO,Miranda JD

更新日期：2009-10-01 00:00:00