Quantitative characterization of regenerating axons after end-to-side and end-to-end coaptation in a rat brachial plexus model: a retrograde tracer study.

abstract：:Chronic verbal retrieval deficits have been noted in traumatic brain injury (TBI), but no U.S. Food and Drug Administration-approved interventions are available. The present study investigated whether 10 sessions of 20 min of 1 mA anodal high-definition transcranial direct current stimulation (HD-tDCS) targeting pre-s...

journal_title：Journal of neurotrauma

authors： Motes MA,Spence JS,Yeatman K,Jones PM,Lutrell M,O'Hair R,Shakal S,DeLaRosa BL,To W,Vanneste S,Kraut MA,Hart J , Jr

更新日期：2020-01-01 00:00:00

abstract：:Physician prescribed rest after traumatic brain injury (TBI) is both commonplace and an increasingly scrutinized approach to TBI treatment. Although this practice remains a standard of patient care for TBI, research of patient outcomes reveals little to no benefit of prescribed rest after TBI, and in some cases prolon...

journal_title：Journal of neurotrauma

authors： Karelina K,Schneiderman K,Shah S,Fitzgerald J,Velazquez Cruz R,Oliverio R,Whitehead B,Yang J,Weil Z

更新日期：2021-01-20 00:00:00

abstract：:Proton magnetic resonance spectroscopy (1H-MRS) offers a unique insight into brain cellular metabolism following traumatic brain injury (TBI). The aim of the present study was to assess change in neurometabolite markers of brain injury during the recovery period following TBI. We studied 19 TBI patients at 1.5, 3, and...

journal_title：Journal of neurotrauma

authors： Brooks WM,Stidley CA,Petropoulos H,Jung RE,Weers DC,Friedman SD,Barlow MA,Sibbitt WL Jr,Yeo RA

更新日期：2000-08-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) has been shown to protect cranial and spinal motoneurons, which suggests potential uses of GDNF in the treatment of spinal cord injury (SCI) and motor neuron disease. We examined neuroprotective effect of cationic liposome-mediated GDNF gene transfer in vivo on axonal...

journal_title：Journal of neurotrauma

authors： Lu KW,Chen ZY,Jin DD,Hou TS,Cao L,Fu Q

更新日期：2002-09-01 00:00:00

abstract：:Controlled cortical impact (CCI) produces blood-brain barrier (BBB) permeability and an acute inflammatory response in injured brain, associated with upregulation of cell adhesion molecules and accumulation of neutrophils. Nevertheless, the role of acute inflammation in the pathogenesis of BBB permeability after traum...

journal_title：Journal of neurotrauma

authors： Whalen MJ,Carlos TM,Kochanek PM,Clark RS,Heineman S,Schiding JK,Franicola D,Memarzadeh F,Lo W,Marion DW,Dekosky ST

更新日期：1999-07-01 00:00:00

abstract：:We sought to determine sensitivity of the cortical impact injury model of traumatic brain injury (TBI) to severity of injury and to treatment. We examined the pattern of motor and cognitive deficits and recovery following TBI over a range of injury severities, and examined the efficacy of surface-induced moderate hypo...

journal_title：Journal of neurotrauma

authors： Markgraf CG,Clifton GL,Aguirre M,Chaney SF,Knox-Du Bois C,Kennon K,Verma N

更新日期：2001-02-01 00:00:00

abstract：:We investigated associations between blood glucose levels and clinical outcomes in participants of the multi-center randomized controlled Brain-Hypothermia (B-HYPO) study. Patients with severe traumatic brain injury (TBI, Glasgow Coma Scale 4-8) were assigned to therapeutic hypothermia (TH, 32-34°C, n = 98) or fever c...

journal_title：Journal of neurotrauma

authors： Kobata H,Sugie A,Suehiro E,Dohi K,Kaneko T,Fujita M,Oda Y,Kuroda Y,Yamashita S,Maekawa T

更新日期：2017-03-01 00:00:00

abstract：:Despite the shift in demographics of spinal cord injury (SCI) due to an aging population, relatively little has been reported regarding the effect of age on outcomes after SCI. This study examines the potential confounding effect of co-morbidities on the age-related differences in the hospital mortality following acut...

journal_title：Journal of neurotrauma

authors： Furlan JC,Kattail D,Fehlings MG

更新日期：2009-08-01 00:00:00

abstract：:Traumatic brain injury (TBI) evokes diffuse (traumatic) axonal injury (TAI), which contributes to morbidity and mortality. Damaged axons display progressive alterations gradually evolving to axonal disconnection. In severe TAI, the tensile forces of injury lead to a focal influx of Ca2+, initiating a series of proteol...

journal_title：Journal of neurotrauma

authors： Buki A,Farkas O,Doczi T,Povlishock JT

更新日期：2003-03-01 00:00:00

abstract：:Heterogeneity within brain injury presents a challenge to the development of informative molecular diagnostics. Recent studies show progress, particularly in cerebrospinal fluid, with biomarker assays targeting one or a few structural proteins. Protein-based assays in peripheral fluids, however, have been more challen...

journal_title：Journal of neurotrauma

authors： Ottens AK,Stafflinger JE,Griffin HE,Kunz RD,Cifu DX,Niemeier JP

更新日期：2014-04-15 00:00:00

abstract：:Diffusion tensor imaging (DTI) has demonstrated success as a biomarker of spinal cord injury (SCI) severity as shown from numerous pre-clinical studies. However, artifacts from stabilization hardware at the lesion have precluded its use for longitudinal assessments. Previous research has documented ex vivo diffusion c...

journal_title：Journal of neurotrauma

authors： Motovylyak A,Skinner NP,Schmit BD,Wilkins N,Kurpad SN,Budde MD

更新日期：2019-05-01 00:00:00

abstract：:Participation in contact sports places athletes at elevated risk for repeated head injuries and is associated with negative mental health outcomes later in life. The current study identified changes observable on neuroimaging that persisted beyond the apparent resolution of acute symptoms of concussion. Sixteen young ...

journal_title：Journal of neurotrauma

authors： Orr CA,Albaugh MD,Watts R,Garavan H,Andrews T,Nickerson JP,Gonyea J,Hipko S,Zweber C,Logan K,Hudziak JJ

更新日期：2016-05-01 00:00:00

abstract：:The current lack of diagnostic and prognostic biomarkers for traumatic brain injury (TBI) confounds treatment and management of patients and is of increasing concern as the TBI population grows. We have generated plasma proteomic profiles from mice receiving TBI by controlled cortical impact at either 1.3 mm or 1.8 mm...

journal_title：Journal of neurotrauma

authors： Crawford F,Crynen G,Reed J,Mouzon B,Bishop A,Katz B,Ferguson S,Phillips J,Ganapathi V,Mathura V,Roses A,Mullan M

更新日期：2012-01-20 00:00:00

abstract：:Predicting outcome after pediatric traumatic brain injury (TBI) is important for providing information to families and prescribing rehabilitation services. The study objective was to assess whether biomarkers concentrations obtained at the time of injury are associated with outcome. Serial serum concentrations of neur...

journal_title：Journal of neurotrauma

authors： Berger RP,Beers SR,Richichi R,Wiesman D,Adelson PD

更新日期：2007-12-01 00:00:00

abstract：:Human head trauma is frequently associated with respiratory problems resulting in secondary hypoxic insult. To document the behavioral consequences of secondary hypoxia in an established model of traumatic brain injury (TBI), intubated anesthetized animals were subjected to fluid percussion (FP) injury (1.87-2.17 atm)...

journal_title：Journal of neurotrauma

authors： Bramlett HM,Dietrich WD,Green EJ

更新日期：1999-11-01 00:00:00

abstract：:Growing evidence suggests that temporally proximal acute concussions and repetitive subconcussive head injuries may lead to long-term neurological deficits. However, the underlying mechanisms of injury and their relative time-scales are not well documented in human injury models. The current study therefore investigat...

journal_title：Journal of neurotrauma

authors： Mayer AR,Ling JM,Dodd AB,Gasparovic C,Klimaj SD,Meier TB

更新日期：2015-11-15 00:00:00

abstract：:The fluid-percussion technique produces experimental brain injury by rapid injection of a fluid volume into the closed cranial cavity. The experiments reported here characterize a new, more controlled technique for fluid-percussion brain injury in the rat and systematically examine systemic physiologic, histopathologi...

journal_title：Journal of neurotrauma

authors： Dixon CE,Lighthall JW,Anderson TE

更新日期：1988-01-01 00:00:00

abstract：:Traumatic axonal injury (TAI) is a critical public health issue with its pathogenesis remaining largely elusive. Finite element (FE) head models are promising tools to bridge the gap between mechanical insult, localized brain response, and resultant injury. In particular, the FE-derived deformation along the direction...

journal_title：Journal of neurotrauma

authors： Zhou Z,Domel AG,Li X,Grant G,Kleiven S,Camarillo DB,Zeineh M

更新日期：2021-01-15 00:00:00

abstract：:Transient receptor potential vanilloid 1 (TRPV1) is expressed widely in the central nervous system and is activated by various stimuli. Inhibiting TRPV1 has neuroprotective effects in cerebral ischemia. The role of inhibiting TRPV1 to maintain blood-brain barrier (BBB) integrity after traumatic brain injury (TBI) rema...

journal_title：Journal of neurotrauma

authors： Yang DX,Jing Y,Liu YL,Xu ZM,Yuan F,Wang ML,Geng Z,Tian HL

更新日期：2019-04-15 00:00:00

abstract：:Multipotent neural progenitors and stem cells may integrate appropriately into the developing and degenerating central nervous system. They may also be effective in the replacement of genes, cells, and nondiffusible factors in either a widespread or a more circumscribed manner, depending on the therapeutic demands of ...

journal_title：Journal of neurotrauma

authors： Park KI,Liu S,Flax JD,Nissim S,Stieg PE,Snyder EY

更新日期：1999-08-01 00:00:00

abstract：:In human diffuse axonal injury (DAI), axons are exposed to transient tensile strain. Over the ensuing several hours, injured axons enter a "pathological cascade" of events that lead to secondary axotomy. Use of animal models of traumatic axonal injury (TAI) has allowed description of a number of pathological changes b...

journal_title：Journal of neurotrauma

authors： Maxwell WL,Donnelly S,Sun X,Fenton T,Puri N,Graham DI

更新日期：1999-12-01 00:00:00

abstract：:Traumatic brain injury (TBI) affects millions of individuals each year and is a leading cause of death and disability worldwide. TBI is heterogeneous and outcome is influenced by a combination of factors that include injury location, severity, genetics, and environmental factors. More recently, sex as a biological var...

journal_title：Journal of neurotrauma

authors： Giordano KR,Rojas-Valencia LM,Bhargava V,Lifshitz J

更新日期：2020-12-01 00:00:00

abstract：:It is now generally accepted that excitotoxic cell death involves bioenergetic failure resulting from the cycling of Ca2+ and the generation of reactive oxygen species (ROS) by mitochondria. Both Ca2+ cycling and ROS formation by mitochondria are dependent on the mitochondrial membrane potential (Deltapsi(m)) that res...

journal_title：Journal of neurotrauma

authors： Korde AS,Sullivan PG,Maragos WF

更新日期：2005-10-01 00:00:00

abstract：:Clinical scenario: A 37-year-old man suffered a complete spinal cord injury (C8, American Spinal Injury Association Impairment Scale [ASIA] score A) 10 years ago in a car accident. Should primary prevention of cardiovascular disease be a priority in this patient? In order to answer this question, we performed a system...

journal_title：Journal of neurotrauma

authors： Cragg JJ,Stone JA,Krassioukov AV

更新日期：2012-07-20 00:00:00

abstract：:The role of endothelin (ET) in the pathophysiology of secondary neural damage after experimental spinal cord injury (SCI) was examined in a rat model of weight-drop contusion injury. Initial studies demonstrated a significant increase in spinal ET concentrations in a 7.5-mm segment of tissue (centered at the impact si...

journal_title：Journal of neurotrauma

authors： Salzman SK,Acosta R,Beck G,Madden J,Boxer B,Ohlstein EH

更新日期：1996-02-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading cause of death and functional disability in western countries, affecting mostly young patients. Despite intense and sustained efforts deployed for the development of new therapeutic strategies, no clinical benefit has been shown by any of the investigated compounds. Increasing...

journal_title：Journal of neurotrauma

authors： Soustiel JF,Palzur E,Nevo O,Thaler I,Vlodavsky E

更新日期：2005-03-01 00:00:00

abstract：:A therapeutic strategy for acute spinal cord injury would be to reduce the progressive degeneration and disconnection of axons from their targets. Here, we describe a model to evaluate degeneration of the ascending sensory projections to the nuclei in the medulla following graded spinal cord contusions in adult female...

journal_title：Journal of neurotrauma

authors： Baker KA,Hagg T

更新日期：2005-04-01 00:00:00

abstract：:The potential pathophysiological role of circulating microparticles (MPs) has been recognized in various conditions, such as cardiovascular and thrombotic diseases. Traumatic brain injury (TBI) has a complex pathophysiology that involves coagulopathy and inflammation. We investigated endothelial-, platelet-, and leuko...

journal_title：Journal of neurotrauma

authors： Nekludov M,Mobarrez F,Gryth D,Bellander BM,Wallen H

更新日期：2014-12-01 00:00:00

abstract：:Chronic pain and dysesthesias are debilitating conditions that can arise following spinal cord injury (SCI). Research studies frequently employ rodent models of SCI to better understand the underlying mechanisms and develop better treatments for these phenomena. While evoked withdrawal tests can assess hypersensitivit...

journal_title：Journal of neurotrauma

authors： Hoschouer EL,Finseth T,Flinn S,Basso DM,Jakeman LB

更新日期：2010-05-01 00:00:00

abstract：:The lack of effective therapies for moderate-to-severe traumatic brain injuries (TBIs) leaves patients with lifelong disabilities. Neural stem cells (NSCs) have demonstrated great promise for neural repair and regeneration. However, direct evidence to support their use as a cell replacement therapy for neural injuries...

journal_title：Journal of neurotrauma

authors： Sun MK,Passaro AP,Latchoumane CF,Spellicy SE,Bowler M,Goeden M,Martin WJ,Holmes PV,Stice SL,Karumbaiah L

更新日期：2020-06-01 00:00:00