Metabolic and cognitive response to human traumatic brain injury: a quantitative proton magnetic resonance study.

abstract：:Worldwide, different strategies are being applied for symptomatic chronic subdural hematoma (CSDH). The aim of this study was to evaluate the efficacy of two treatment strategies for symptomatic CSDH: initial dexamethasone (DXM) therapy versus primary surgery by burr hole craniostomy (BHC). We retrospectively collecte...

journal_title：Journal of neurotrauma

authors： Miah IP,Herklots M,Roks G,Peul WC,Walchenbach R,Dammers R,Lingsma HF,den Hertog HM,Jellema K,Van der Gaag NA

更新日期：2020-01-15 00:00:00

abstract：:Neuroendocrine disturbances are common after traumatic brain injury (TBI) and aneurysmal subarachnoid hemorrhage (SAH), but only a few data exist on long-term anterior pituitary deficiencies after brain injury. We present data from the Structured Data Assessment of Hypopituitarism after TBI and SAH, a multi-center stu...

journal_title：Journal of neurotrauma

authors： Krewer C,Schneider M,Schneider HJ,Kreitschmann-Andermahr I,Buchfelder M,Faust M,Berg C,Wallaschofski H,Renner C,Uhl E,Koenig E,Jordan M,Stalla GK,Kopczak A

更新日期：2016-08-15 00:00:00

abstract：:The exact mechanism of hypothermic cerebroprotection after traumatic brain injury (TBI) is not fully understood. The present study was conducted to investigate the effects of mild hypothermia on trauma-induced synthesis of nitric oxide (NO), which has been implicated in the pathogenesis of ischemic brain damage associ...

journal_title：Journal of neurotrauma

authors： Sakamoto KI,Fujisawa H,Koizumi H,Tsuchida E,Ito H,Sadamitsu D,Maekawa T

更新日期：1997-05-01 00:00:00

abstract：:The relative safety and efficacy of direct versus indirect methods of spinal cord stimulation for the production of descending motor-evoked responses was studied in pentobarbital-anesthetized rats (n = 39). Electrical stimuli were delivered for 1 h, either directly to the cord dorsum using silver ball electrodes or in...

journal_title：Journal of neurotrauma

authors： Sabato S,Agresta CA,Freeman GM,Salzman SK

更新日期：1991-04-01 00:00:00

abstract：:Task-specific rehabilitation has been shown to promote functional recovery after acute spinal cord injury (SCI). Recently, the omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA), has been shown to promote neuroplasticity after SCI. Here, we investigated whether the combination of a single bolus of DHA with...

journal_title：Journal of neurotrauma

authors： Liu ZH,Yip PK,Priestley JV,Michael-Titus AT

更新日期：2017-05-01 00:00:00

abstract：:This paper encompasses the prediction of early and late recovery from traumatic brain injury (TBI). Predictors of the duration of coma and the utilization of posttraumatic amnesia duration to predict residual memory function are discussed. The issues surrounding prediction of long-term neurobehavioral recovery from TB...

journal_title：Journal of neurotrauma

authors： Levin HS

更新日期：1995-10-01 00:00:00

abstract：:Traumatic brain injury (TBI) evokes diffuse (traumatic) axonal injury (TAI), which contributes to morbidity and mortality. Damaged axons display progressive alterations gradually evolving to axonal disconnection. In severe TAI, the tensile forces of injury lead to a focal influx of Ca2+, initiating a series of proteol...

journal_title：Journal of neurotrauma

authors： Buki A,Farkas O,Doczi T,Povlishock JT

更新日期：2003-03-01 00:00:00

abstract：:Dementia pugilistica (DP) is associated with chronic traumatic brain injury (CTBI), and leads to a "punch drunk" syndrome characterized by impairments in memory and executive function, behavioral changes, and motor signs. Microscopic features include the accumulation of neurofibrillary tangles (NFTs), beta-amyloid (Aβ...

journal_title：Journal of neurotrauma

authors： Saing T,Dick M,Nelson PT,Kim RC,Cribbs DH,Head E

更新日期：2012-04-10 00:00:00

abstract：:The Glasgow Coma Scale (GCS) score is used in clinical practice for patient assessment and communication among clinicians and also in outcome prediction models such as the Trauma and Injury Severity Score (TRIS). The objective of this study is to determine which GCS subscore is best associated with outcome, taking tim...

journal_title：Journal of neurotrauma

authors： Lesko MM,Jenks T,O'Brien SJ,Childs C,Bouamra O,Woodford M,Lecky F

更新日期：2013-01-01 00:00:00

abstract：:Phosphorus 31 magnetic resonance spectroscopy (31P MRS) was used to study noninvasively the intracellular free Mg2+ concentration and cellular bioenergetic state of rat brain in vivo before and after fluid percussion-induced traumatic brain injury of graded severity. Brain injury was induced at four levels: low (1.0 +...

journal_title：Journal of neurotrauma

authors： Vink R,Faden AI,McIntosh TK

更新日期：1988-01-01 00:00:00

abstract：:To compare the effect of levodopa-carbidopa on the visual outcome of patients with indirect traumatic optic neuropathy (ITON), this randomized, double-blind, placebo-controlled study was conducted on 32 patients with ITON within 6 days after trauma. Patients underwent a complete ocular examination, pattern visual evok...

journal_title：Journal of neurotrauma

authors： Razeghinejad MR,Rahat F,Bagheri M

更新日期：2010-10-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a major health problem causing disability and death worldwide. There is no effective treatment, due in part to the complexity of the injury pathology and factors affecting its outcome. The extent of brain injury depends on the type of insult, age, sex, lifestyle, genetic risk factors, s...

journal_title：Journal of neurotrauma

authors： Inampudi C,Ciccotosto GD,Cappai R,Crack PJ

更新日期：2020-03-01 00:00:00

abstract：:Mild traumatic brain injury (mTBI) accounts for the majority of head trauma cases. Despite some lasting cognitive, emotional, and behavioral deficits, there are frequently no overt morphological defects, suggesting that changes may result from alterations in the physiology of individual neurons. We investigated hippoc...

journal_title：Journal of neurotrauma

authors： Eakin K,Miller JP

更新日期：2012-04-10 00:00:00

abstract：:Functional recovery is markedly restricted following traumatic brain injury (TBI), partly due to myelin-associated inhibitors including Nogo-A, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMgp), that all bind to the Nogo-66 receptor-1 (NgR1). In previous studies, pharmacological neutr...

journal_title：Journal of neurotrauma

authors： Hånell A,Clausen F,Björk M,Jansson K,Philipson O,Nilsson LN,Hillered L,Weinreb PH,Lee D,McIntosh TK,Gimbel DA,Strittmatter SM,Marklund N

更新日期：2010-07-01 00:00:00

abstract：:Autonomic dysreflexia (AD) is a potentially life-threatening syndrome in individuals with spinal cord injury (SCI) above the T6 spinal level that is characterized by episodic hypertension in response to noxious stimuli below the lesion. Maladaptive intraspinal plasticity is thought to contribute to the temporal develo...

journal_title：Journal of neurotrauma

authors： Eldahan KC,Cox DH,Gollihue JL,Patel SP,Rabchevsky AG

更新日期：2018-03-15 00:00:00

abstract：:Sports-related concussion is a major public health problem in the United States and yet its biomechanical mechanisms remain unclear. In vitro studies demonstrate axonal elongation as a potential injury mechanism; however, current response-based injury predictors (e.g., maximum principal strain, ε(ep)) typically do not...

journal_title：Journal of neurotrauma

authors： Ji S,Zhao W,Ford JC,Beckwith JG,Bolander RP,Greenwald RM,Flashman LA,Paulsen KD,McAllister TW

更新日期：2015-04-01 00:00:00

abstract：:The increase in the volume of a traumatic intracerebral hemorrhage (TICH) is a widely studied phenomenon that has a direct impact on the prognosis of patients. The objective of this study was to identify the risk factors associated with the progression of TICH. We retrospectively analyzed the records of 1970 adult pat...

journal_title：Journal of neurotrauma

authors： Cepeda S,Gómez PA,Castaño-Leon AM,Martínez-Pérez R,Munarriz PM,Lagares A

更新日期：2015-08-15 00:00:00

abstract：:The neuroprotective effects of 17 beta -estradiol have been shown in models of central nervous system injury, including ischemia, brain injury, and more recently, spinal cord injury (SCI). Recent epidemiological trends suggest that SCIs in elderly women are increasing; however, the effects of menopause on estrogen-med...

journal_title：Journal of neurotrauma

authors： Chaovipoch P,Jelks KA,Gerhold LM,West EJ,Chongthammakun S,Floyd CL

更新日期：2006-06-01 00:00:00

abstract：:We measured quantitative cortical mantle cerebral blood flow (CBF) by stable xenon computed tomography (CT) within the first 12 h after severe traumatic brain injury (TBI) to determine whether neurologic outcome can be predicted by CBF stratification early after injury. Stable xenon CT was used for quantitative measur...

journal_title：Journal of neurotrauma

authors： Kaloostian P,Robertson C,Gopinath SP,Stippler M,King CC,Qualls C,Yonas H,Nemoto EM

更新日期：2012-03-20 00:00:00

abstract：:Acute subdural hemorrhage (ASDH) is common and associated with severe morbidity and mortality. To date, the role of spontaneous cortical spreading depression (sCSD) in exaggerating secondary injury after ASDH, is poorly understood. The present study contains two experimental groups: First, we investigated and characte...

journal_title：Journal of neurotrauma

authors： Krenzlin H,Jussen D,Plath M,Tretzel SJ,Krämer T,Kempski O,Alessandri B

更新日期：2019-01-15 00:00:00

abstract：:Although sleep-wake disturbances are prevalent and well described after traumatic brain injury, their pathophysiology remains unclear, most likely because human traumatic brain injury is a highly heterogeneous entity that makes the systematic study of sleep-wake disturbances in relation to trauma-induced histological ...

journal_title：Journal of neurotrauma

authors： Noain D,Büchele F,Schreglmann SR,Valko PO,Gavrilov YV,Morawska MM,Imbach LL,Baumann CR

更新日期：2018-01-01 00:00:00

abstract：:Outcome of traumatic brain injury (TBI) is impaired by hyperglycemia, hypotension, and glutamate, and improved by insulin. Insulin reduces glutamate concentration, making it uncertain whether its beneficial effect accrues from euglycemia. Glucagon decreases CNS glutamate, lessens neuronal cell injury, and improves neu...

journal_title：Journal of neurotrauma

authors： Armstead WM,Kiessling JW,Cines DB,Higazi AA

更新日期：2011-03-01 00:00:00

abstract：:Several recent global traumatic brain injury (TBI) initiatives rely on practice variation in diagnostic and treatment methods to answer effectiveness questions. One of these scientific dilemmas, the surgical management of the traumatic acute subdural hematoma (ASDH) might be variable among countries, among centers wit...

journal_title：Journal of neurotrauma

authors： van Essen TA,de Ruiter GC,Kho KH,Peul WC

更新日期：2017-02-15 00:00:00

abstract：:Penetrating traumatic brain injury (PTBI) is one of the major cause of death and disability worldwide. Previous studies with penetrating ballistic-like brain injury (PBBI), a PTBI rat model revealed widespread perilesional neurodegeneration, similar to that seen in humans following gunshot wound to the head, which is ...

journal_title：Journal of neurotrauma

authors： Spurlock MS,Ahmed AI,Rivera KN,Yokobori S,Lee SW,Sam PN,Shear DA,Hefferan MP,Hazel TG,Johe KK,Gajavelli S,Tortella FC,Bullock RM

更新日期：2017-06-01 00:00:00

abstract：:Depression is associated with poorer recovery after traumatic brain injury (TBI), yet awareness of depression risk post-TBI among providers and patients is low. The aim of this study was to estimate risk of depression post-TBI among adults 18 years of age and older and to identify risk factors associated with developi...

journal_title：Journal of neurotrauma

authors： Albrecht JS,Barbour L,Abariga SA,Rao V,Perfetto EM

更新日期：2019-01-15 00:00:00

abstract：:We have investigated time course and characteristics of retinal ganglion cell (RGC) death after partial optic nerve injury. In situ end labeling of DNA fragments with the terminal deoxynucleotidyl transferase (TdT)-mediated deoxyuridine (dUTP)-biotin nick end labeling (TUNEL) method revealed the presence of apoptotic ...

journal_title：Journal of neurotrauma

authors： Bien A,Seidenbecher CI,Böckers TM,Sabel BA,Kreutz MR

更新日期：1999-02-01 00:00:00

abstract：:Injury to the meninges is not uncommon after traumatic brain injury (TBI), yet minimal research has been directed toward understanding the relevant biology. After a concussive event, the meninges are observed to abnormally enhance on post-contrast magnetic resonance imaging (MRI) in some patients, but not all. The aim...

journal_title：Journal of neurotrauma

authors： Livingston WS,Gill JM,Cota MR,Olivera A,O'Keefe JL,Martin C,Latour LL

更新日期：2017-02-15 00:00:00

abstract：:Severe traumatic brain injury (TBI) is one of the major causes of death in younger age groups. In Umeå, Sweden, an intracranial pressure (ICP) targeted therapy protocol, the Lund concept, has been used in treatment of severe TBI since 1994. Decompressive craniectomy is used as a protocol-guided treatment step. The pri...

journal_title：Journal of neurotrauma

authors： Olivecrona M,Rodling-Wahlström M,Naredi S,Koskinen LO

更新日期：2007-06-01 00:00:00

abstract：:Although the citation index of an article is not a direct measure of its quality or importance, it is a measure of recognition that may suggest its impact on the scientific community. This study was undertaken to examine the characteristics of the top 100 most frequently cited articles (so-called "citation classics") ...

journal_title：Journal of neurotrauma

authors： Furlan JC,Fehlings MG

更新日期：2006-02-01 00:00:00

abstract：:Ischemic insults to the brain in stroke or traumatic brain injury produce excessive release of glutamate from depolarized nerve terminals. This excessive glutamate release in turn stimulates massive calcium entry into nerve cells, activating a biochemical cascade that results in cell death. A major pathway of calcium ...

journal_title：Journal of neurotrauma

authors： McBurney RN,Daly D,Fischer JB,Hu LY,Subbarao K,Knapp AG,Kobayashi K,Margolin L,Reddy NL,Goldin SM

更新日期：1992-05-01 00:00:00