Abstract:
:Dementia pugilistica (DP) is associated with chronic traumatic brain injury (CTBI), and leads to a "punch drunk" syndrome characterized by impairments in memory and executive function, behavioral changes, and motor signs. Microscopic features include the accumulation of neurofibrillary tangles (NFTs), beta-amyloid (Aβ), and TAR DNA binding protein 43 (TDP-43) pathology. Here we describe detailed clinical and neuropathological data about a 55-year-old retired boxer (ApoE3/4), who presented with executive dysfunction and behavioral impairments. At autopsy, significant Aβ pathology was seen, primarily in the form of diffuse plaques. Tau pathology was extensive and was determined to be of Braak and Braak stage VI. Frontal white matter showed evidence of glial tau inclusions (astrocytes and oligodendroglia). Cerebrovascular pathology was minimal with patchy amyloid angiopathy. Inflammation was another key feature, including microglial activation and significant C1q labeling of neurons, along with NFTs. TDP-43-positive pathology was also observed. Inflammation may be a key inciting as well as propagating feature of DP neuropathology.
journal_name
J Neurotraumajournal_title
Journal of neurotraumaauthors
Saing T,Dick M,Nelson PT,Kim RC,Cribbs DH,Head Edoi
10.1089/neu.2011.1957subject
Has Abstractpub_date
2012-04-10 00:00:00pages
1054-70issue
6eissn
0897-7151issn
1557-9042journal_volume
29pub_type
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pub_type: 杂志文章,评审
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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journal_title:Journal of neurotrauma
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pub_type: 杂志文章,随机对照试验
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更新日期:2015-04-01 00:00:00
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doi:10.1089/neu.2010.1374
更新日期:2010-10-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2016.4602
更新日期:2017-06-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2012.2376
更新日期:2012-11-20 00:00:00
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doi:10.1089/neu.2019.6796
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of neurotrauma
pub_type: 杂志文章,多中心研究
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更新日期:2012-01-01 00:00:00
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journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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