Occurrence of Spontaneous Cortical Spreading Depression Is Increased by Blood Constituents and Impairs Neurological Recovery after Subdural Hematoma in Rats.

abstract：:High-mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that is passively released from damaged and necrotic cells, and actively released from immune cells. In contrast, cytochrome c is released from mitochondria in apoptotic cells, and is considered a reliable biomarker of apoptosis. Thus, HMGB1 and cytochr...

journal_title：Journal of neurotrauma

authors： Au AK,Aneja RK,Bell MJ,Bayir H,Feldman K,Adelson PD,Fink EL,Kochanek PM,Clark RS

更新日期：2012-07-20 00:00:00

abstract：:The lack of effective therapies for moderate-to-severe traumatic brain injuries (TBIs) leaves patients with lifelong disabilities. Neural stem cells (NSCs) have demonstrated great promise for neural repair and regeneration. However, direct evidence to support their use as a cell replacement therapy for neural injuries...

journal_title：Journal of neurotrauma

authors： Sun MK,Passaro AP,Latchoumane CF,Spellicy SE,Bowler M,Goeden M,Martin WJ,Holmes PV,Stice SL,Karumbaiah L

更新日期：2020-06-01 00:00:00

abstract：:Restraint stress (RS) protects auditory function against acoustic trauma by activating glucocorticoid receptors (GR) in the cochlea. In a search for the signaling pathways downstream to GR that may be involved in RS-induced protection we report here (1) a downregulation of phosphorylated extracellular signal-regulated...

journal_title：Journal of neurotrauma

authors： Meltser I,Tahera Y,Canlon B

更新日期：2009-10-01 00:00:00

abstract：:The present study evaluated the survival and integration of human postmitotic neurons (hNT) following transplantation into the traumatically injured rodent brain. Anesthetized male Sprague-Dawley rats (n = 47) were subjected to lateral fluid percussion brain injury of moderate severity (2.4-2.6 atm). Sham animals (n =...

journal_title：Journal of neurotrauma

authors： Muir JK,Raghupathi R,Saatman KE,Wilson CA,Lee VM,Trojanowski JQ,Philips MF,McIntosh TK

更新日期：1999-05-01 00:00:00

abstract：:Laser Doppler flowmetry (LDF) was used to study acute ipsilateral and contralateral disturbances of regional cerebral blood flow (rCBF) in a rat model of cerebral cortical contusion trauma. Twelve rats were intubated and artificially ventilated during and after trauma. Injury was produced with a weight drop technique ...

journal_title：Journal of neurotrauma

authors： Nilsson P,Gazelius B,Carlson H,Hillered L

更新日期：1996-04-01 00:00:00

abstract：:We sought to determine sensitivity of the cortical impact injury model of traumatic brain injury (TBI) to severity of injury and to treatment. We examined the pattern of motor and cognitive deficits and recovery following TBI over a range of injury severities, and examined the efficacy of surface-induced moderate hypo...

journal_title：Journal of neurotrauma

authors： Markgraf CG,Clifton GL,Aguirre M,Chaney SF,Knox-Du Bois C,Kennon K,Verma N

更新日期：2001-02-01 00:00:00

abstract：:Sensorimotor recovery after spinal cord injury (SCI) is of utmost importance to injured individuals and will rely on improved understanding of SCI pathology and recovery. Novel transgenic mouse lines facilitate discovery, but must be understood to be effective. The purpose of this study was to characterize the sensory...

journal_title：Journal of neurotrauma

authors： Faw TD,Lerch JK,Thaxton TT,Deibert RJ,Fisher LC,Basso DM

更新日期：2018-09-15 00:00:00

abstract：:Multipotent neural progenitors and stem cells may integrate appropriately into the developing and degenerating central nervous system. They may also be effective in the replacement of genes, cells, and nondiffusible factors in either a widespread or a more circumscribed manner, depending on the therapeutic demands of ...

journal_title：Journal of neurotrauma

authors： Park KI,Liu S,Flax JD,Nissim S,Stieg PE,Snyder EY

更新日期：1999-08-01 00:00:00

abstract：:Increasing evidence indicates that post-traumatic stress disorder (PTSD) may develop following traumatic brain injury (TBI), despite most patients having no conscious memory of their accident. This prospective study examined the frequency, timing of onset, symptom profile, and trajectory of PTSD and its psychiatric co...

journal_title：Journal of neurotrauma

authors： Alway Y,Gould KR,McKay A,Johnston L,Ponsford J

更新日期：2016-05-01 00:00:00

abstract：:Subconcussive hits to the head and physical fitness both have been associated with alterations in white matter (WM) microstructure in partly overlapping areas of the brain. The aim of the present study was to determine whether WM damage associated with repeated exposure to subconcussive hits to the head in university ...

journal_title：Journal of neurotrauma

authors： Lefebvre G,Guay S,Chamard E,Theaud G,de Guise E,Bacon BA,Descoteaux M,De Beaumont L,Théoret H

更新日期：2020-08-10 00:00:00

abstract：:Delirium is a commonly reported acute care adverse event in patients with traumatic spinal cord injury (TSCI), but studies specifically investigating it in this population are lacking. The purpose of this study was to characterize the onset, risk factors, and impact of delirium in patients with TSCI. Patients discharg...

journal_title：Journal of neurotrauma

authors： Cheung A,Thorogood NP,Noonan VK,Zhong Y,Fisher CG,Dvorak MF,Street J

更新日期：2013-11-01 00:00:00

abstract：:Secondary insults, such as hemorrhagic shock (HS), worsen outcome from traumatic brain injury (TBI). Both TBI and HS modulate levels of inflammatory mediators. We evaluated the addition of HS on the inflammatory response to TBI. Adult male C57BL6J mice were randomized into five groups (n=4 [naïve] or 8/group): naïve; ...

journal_title：Journal of neurotrauma

authors： Shein SL,Shellington DK,Exo JL,Jackson TC,Wisniewski SR,Jackson EK,Vagni VA,Bayır H,Clark RS,Dixon CE,Janesko-Feldman KL,Kochanek PM

更新日期：2014-08-15 00:00:00

abstract：:The lectin pathway of the complement system has been implicated in secondary ischemic/inflammatory injury after traumatic brain injury (TBI). However, previous experimental studies have yielded conflicting results, and human studies are scarce. In this exploratory study, we investigated associations of several lectin ...

journal_title：Journal of neurotrauma

authors： Osthoff M,Walder B,Delhumeau C,Trendelenburg M,Turck N

更新日期：2017-09-01 00:00:00

abstract：:Traumatic brain injury (TBI) results in an accumulation of edema and loss of brain tissue. Progesterone (PROG) has been reported to reduce edema and cortical tissue loss in a bilateral prefrontal cortex injury. This study tests the hypothesis that PROG is neuroprotective following a unilateral parietal cortical contus...

journal_title：Journal of neurotrauma

authors： Gilmer LK,Roberts KN,Scheff SW

更新日期：2008-06-01 00:00:00

abstract：:Severe traumatic brain injury (TBI) results in significant functional disturbances in the hippocampus. Studies support that sodium cromoglycate (CG) induces neuroprotective effects. This study focused on investigating the effects of post-TBI subchronic administration of CG on hippocampal hyperexcitability and damage a...

journal_title：Journal of neurotrauma

authors： Segovia-Oropeza M,Santiago-Castañeda C,Orozco-Suárez SA,Concha L,Rocha L

更新日期：2020-12-01 00:00:00

abstract：:Spinal cord injury (SCI) is associated with immune deficiencies and life-threatening infections. However, the specific mechanisms underlying this pathological condition remain unclear. In recent years, increasing evidence has suggested that anabolic hormones may be involved in immunological complications. Here, we mon...

journal_title：Journal of neurotrauma

authors： Rouleau P,Ung RV,Lapointe NP,Guertin PA

更新日期：2007-02-01 00:00:00

abstract：:Spinal cord injury (SCI) causes neurodegeneration, impairs locomotor function, and impacts the quality of life particularly in those individuals in whom neuropathic pain develops. Whether the time course of neurodegeneration, locomotor impairment, or neuropathic pain varies with sex, however, remains understudied. The...

journal_title：Journal of neurotrauma

authors： McFarlane K,Otto TE,Bailey WM,Veldhorst AK,Donahue RR,Taylor BK,Gensel JC

更新日期：2020-09-15 00:00:00

abstract：:Diffusion tensor imaging (DTI) has demonstrated success as a biomarker of spinal cord injury (SCI) severity as shown from numerous pre-clinical studies. However, artifacts from stabilization hardware at the lesion have precluded its use for longitudinal assessments. Previous research has documented ex vivo diffusion c...

journal_title：Journal of neurotrauma

authors： Motovylyak A,Skinner NP,Schmit BD,Wilkins N,Kurpad SN,Budde MD

更新日期：2019-05-01 00:00:00

abstract：:Symptoms persisting beyond the acute phase (>2 months) after a mild traumatic brain injury (MTBI) are often reported, but their origin remains controversial. Some investigators evoke dysfunctional cerebral mechanisms, while others ascribe them to the psychological consequences of the injury. We address this controvers...

journal_title：Journal of neurotrauma

authors： Gosselin N,Bottari C,Chen JK,Petrides M,Tinawi S,de Guise E,Ptito A

更新日期：2011-03-01 00:00:00

abstract：:Mild traumatic brain injury (mTBI) disrupts hippocampal function and can lead to long-lasting episodic memory impairments. The encoding of episodic memories relies on spatial information processing within the hippocampus. As the primary entry point for spatial information into the hippocampus, the dentate gyrus is tho...

journal_title：Journal of neurotrauma

authors： Folweiler KA,Samuel S,Metheny HE,Cohen AS

更新日期：2018-06-01 00:00:00

abstract：:The mass media have recently pointed out the likelihood of diagnostic errors in post-coma patients. Late recoveries of consciousness, even after 20 years, might indicate hidden misdiagnoses that are not corrected over a long period of time. The rate of misdiagnoses of patients in a vegetative state is very high when b...

journal_title：Journal of neurotrauma

authors： Pistoia F,Sarà M

更新日期：2012-09-01 00:00:00

abstract：:Peptides related to melanotropin (alphaMSH) and corticotropin (ACTH), collectively termed melanocortins, are known to improve the postlesion repair of injured peripheral nerves. In addition, melanocortins exert trophic effects on the outgrowth of neurites from central nervous system neurons in vitro. Here we report, f...

journal_title：Journal of neurotrauma

authors： Joosten EA,Majewska B,Houweling DA,Bär PR,Gispen WH

更新日期：1999-06-01 00:00:00

abstract：:Traumatic brain injury (TBI) in humans and in animals leads to an acute and sustained increase in tissue glutamate concentrations within the brain, triggering glutamate-mediated excitotoxicity. Excitatory amino acid transporters (EAATs) are responsible for maintaining extracellular central nervous system glutamate con...

journal_title：Journal of neurotrauma

authors： Fontana AC,Fox DP,Zoubroulis A,Mortensen OV,Raghupathi R

更新日期：2016-06-01 00:00:00

abstract：:The majority of patients with traumatic brain injury (TBI) sustain a mild injury (mTBI). One out of 4 patients experiences persistent complaints, despite their often normal neuropsychological test results and the absence of structural brain damage on conventional neuroimaging. Susceptibility to develop persistent comp...

journal_title：Journal of neurotrauma

authors： van der Horn HJ,Liemburg EJ,Aleman A,Spikman JM,van der Naalt J

更新日期：2016-01-01 00:00:00

abstract：:Perceived injustice is a belief that one has been treated unfairly and disrespectfully, and is suffering unnecessarily as a result of another person's actions. Perceived injustice predicts chronic disability after musculoskeletal injury but to our knowledge has not been empirically studied in people with mild traumati...

journal_title：Journal of neurotrauma

authors： Iverson GL,Terry DP,Karr JE,Panenka WJ,Silverberg ND

更新日期：2018-05-15 00:00:00

abstract：:Diagnosis and early prognosis of the vegetative state/unresponsive wakefulness syndrome (VS/UWS) and its differentiation from the minimally-conscious state still rest on the clinical observation of responsiveness. The incidence of established clinical indicators of responsiveness also has proven variable in the single...

journal_title：Journal of neurotrauma

authors： Riganello F,Cortese MD,Dolce G,Lucca LF,Sannita WG

更新日期：2015-07-15 00:00:00

abstract：:Pediatric traumatic brain injury (TBI) research depends on comparisons of profiles and outcomes between brain-injured individuals and groups consisting either of injured controls (e.g., orthopedic injuries, OI) or uninjured, typically developing children recruited from the community (community controls, CC). Children ...

journal_title：Journal of neurotrauma

authors： Beauchamp MH,Landry-Roy C,Gravel J,Beaudoin C,Bernier A

更新日期：2017-09-01 00:00:00

abstract：:The protective effect of chlorpromazine on rat spinal cord injury was investigated using a dynamic impact model. A 10 g weight was dropped 5 cm on an impounder placed on the exposed spinal cord at the T-11 level. Changes in potassium concentration on the epidural surface of the injured spinal cord were measured using ...

journal_title：Journal of neurotrauma

authors： Sadanaga KK,Ohnishi ST

更新日期：1989-10-01 00:00:00

abstract：:4-Aminopyridine (4AP), a potassium channel antagonist, can improve hindlimb motor function in dogs with chronic thoracolumbar spinal cord injury (SCI); however, individual response is variable. We hypothesized that injury characteristics would differ between dogs that do and do not respond to 4AP. Our objective was to...

journal_title：Journal of neurotrauma

authors： Lewis MJ,Laber E,Olby NJ

更新日期：2019-05-01 00:00:00

abstract：:This study evaluated the utility of the Balance Error Scoring System (BESS) and the Sensory Organization Test (SOT) as tools for the screening and monitoring of Service members (SMs) with mild traumatic brain injury (mTBI) in a deployed setting during the acute and subacute phases of recovery. Patient records (N = 699...

journal_title：Journal of neurotrauma

authors： Haran FJ,Slaboda JC,King LA,Wright WG,Houlihan D,Norris JN

更新日期：2016-04-01 00:00:00