Electrophysiology and functional MRI in post-acute mild traumatic brain injury.

abstract：:Spinal cord injury damaging the rubrospinal tract (RST) interferes with skilled forelimb movement, but identification of the precise role of the RST in this behavior is impeded by the difficulty of surgically isolating the RST from other pathways running within the lateral funiculus (LF). The present study used a skil...

journal_title：Journal of neurotrauma

authors： Morris R,Tosolini AP,Goldstein JD,Whishaw IQ

更新日期：2011-12-01 00:00:00

abstract：:In this review we consider recovery of function after spinal cord injury, and, in particular, recovery improved following intraspinal cellular transplants. Some recovery occurs spontaneously and this can be especially dramatic in neonates, supporting the notion that developing and adult spinal cord respond differently...

journal_title：Journal of neurotrauma

authors： Murray M,Fischer I,Smeraski C,Tessler A,Giszter S

更新日期：2004-04-01 00:00:00

abstract：:Experimental compression injury of the spinal cord in guinea pigs results in delayed neurologic deficits that continue to increase in severity for several days following trauma, coincident with inflammatory responses, including invasion of the lesion by mononuclear phagocytes and increased levels of the neurotoxin qui...

journal_title：Journal of neurotrauma

authors： Blight AR,Leroy EC Jr,Heyes MP

更新日期：1997-02-01 00:00:00

abstract：:Early decompression may improve neurological outcome after spinal cord injury (SCI), but is often difficult to achieve because of logistical issues. The aims of this study were to 1) determine the time to decompression in cases of isolated cervical SCI in Australia and New Zealand and 2) determine where substantial de...

journal_title：Journal of neurotrauma

authors： Battistuzzo CR,Armstrong A,Clark J,Worley L,Sharwood L,Lin P,Rooke G,Skeers P,Nolan S,Geraghty T,Nunn A,Brown DJ,Hill S,Alexander J,Millard M,Cox SF,Rao S,Watts A,Goods L,Allison GT,Agostinello J,Cameron PA,Mo

更新日期：2016-06-15 00:00:00

abstract：:Although mechanisms involved in progression of cell death in spinal cord injury (SCI) have been studied extensively, few are clear targets for translation to clinical application. One of the best-understood mechanisms of cell survival in SCI is phosphatidylinositol-3-kinase (PI3K)/Akt and associated downstream signali...

journal_title：Journal of neurotrauma

authors： Walker CL,Wu X,Liu NK,Xu XM

更新日期：2019-09-15 00:00:00

abstract：:Transient receptor potential vanilloid 1 (TRPV1) is expressed widely in the central nervous system and is activated by various stimuli. Inhibiting TRPV1 has neuroprotective effects in cerebral ischemia. The role of inhibiting TRPV1 to maintain blood-brain barrier (BBB) integrity after traumatic brain injury (TBI) rema...

journal_title：Journal of neurotrauma

authors： Yang DX,Jing Y,Liu YL,Xu ZM,Yuan F,Wang ML,Geng Z,Tian HL

更新日期：2019-04-15 00:00:00

abstract：:Spinal cord injury (SCI) launches a complex cascade of events that leads to progressive damage and loss of function. Compromise of plasma membrane integrity due to the mechanical impact is an acute event that may contribute to cellular dysfunction. Therefore, the objective of this study was to better understand the ex...

journal_title：Journal of neurotrauma

authors： Simon CM,Sharif S,Tan RP,LaPlaca MC

更新日期：2009-04-01 00:00:00

abstract：:Blast injury to the brain is one of the major causes of death and can also significantly affect cognition and physical and psychological skills in survivors of blast. The complex mechanisms via which blast injury causes impairment of cognition and other symptoms are poorly understood. In this study, we investigated th...

journal_title：Journal of neurotrauma

authors： Lu J,Ng KC,Ling G,Wu J,Poon DJ,Kan EM,Tan MH,Wu YJ,Li P,Moochhala S,Yap E,Lee LK,Teo M,Yeh IB,Sergio DM,Chua F,Kumar SD,Ling EA

更新日期：2012-05-01 00:00:00

abstract：:Diffuse axonal injury is recognized as a progressive and long-term consequence of traumatic brain injury. Axonal injury can have sustained negative consequences on neuronal functions such as anterograde and retrograde transport and cellular processes such as autophagy that depend on cytoarchitecture and axon integrity...

journal_title：Journal of neurotrauma

authors： Hensley K,Poteshkina A,Johnson MF,Eslami P,Gabbita SP,Hristov AM,Venkova-Hristova KM,Harris-White ME

更新日期：2016-08-15 00:00:00

abstract：:The aims of this study were to assess the trajectories of community integration in individuals with traumatic brain injury (TBI) through one, two, and five years post-injury and to examine whether those trajectories could be predicted by demographic and injury characteristics. A longitudinal cohort study was conducted...

journal_title：Journal of neurotrauma

authors： Andelic N,Arango-Lasprilla JC,Perrin PB,Sigurdardottir S,Lu J,Landa LO,Forslund MV,Roe C

更新日期：2016-01-01 00:00:00

abstract：:Cardiometabolic risk factors are sorely underreported after spinal cord injury (SCI), despite the high prevalence of metabolic disorders and cardiovascular mortality in this population. Body-composition analysis and serum-lipid profiling are two assessments that are beginning to be more widely used to document metabol...

journal_title：Journal of neurotrauma

authors： Inskip J,Plunet W,Ramer L,Ramsey JB,Yung A,Kozlowski P,Ramer M,Krassioukov A

更新日期：2010-01-01 00:00:00

abstract：:We have used an in vitro trauma model to examine the effects of modulation of group III metabotropic glutamate receptors (mGluR) on post-traumatic neuronal cell death. Rat cortical neuronal/glial cultures were subjected to standardized mechanical injury using a punch that delivers 28 parallel cuts to 96-well culture p...

journal_title：Journal of neurotrauma

authors： Faden AI,Ivanova SA,Yakovlev AG,Mukhin AG

更新日期：1997-12-01 00:00:00

abstract：:Diffusion tensor imaging (DTI) has demonstrated success as a biomarker of spinal cord injury (SCI) severity as shown from numerous pre-clinical studies. However, artifacts from stabilization hardware at the lesion have precluded its use for longitudinal assessments. Previous research has documented ex vivo diffusion c...

journal_title：Journal of neurotrauma

authors： Motovylyak A,Skinner NP,Schmit BD,Wilkins N,Kurpad SN,Budde MD

更新日期：2019-05-01 00:00:00

abstract：:Gap junctions are conductive channels formed by membrane proteins termed connexins (Cx), which permit the intercellular exchange of metabolites, ions, and small molecules. Junctional permeability is regulated by pH, membrane potential, and intracellular secondary messengers. The purpose of this study was to elucidate ...

journal_title：Journal of neurotrauma

authors： Ohsumi A,Nawashiro H,Otani N,Ooigawa H,Toyooka T,Shima K

更新日期：2010-07-01 00:00:00

abstract：:Previous studies convincingly suggest that the biopsychosocial fear-avoidance model (FAM) may be of added value in understanding chronic disability after traumatic brain injury (TBI). In this model, persistent symptoms occur as a result of catastrophizing and fear-avoidance regarding initial symptoms, leading to depre...

journal_title：Journal of neurotrauma

authors： Wijenberg MLM,Hicks AJ,Downing MG,van Heugten CM,Stapert SZ,Ponsford JL

更新日期：2020-12-15 00:00:00

abstract：:The detection of neuron-specific proteins in blood might allow quantification of the degree of neuropathology in experimental and clinical contexts. We have been studying a novel blood biomarker of axonal injury, the heavily phosphorylated axonal form of the high molecular weight neurofilament subunit NF-H (pNF-H). We...

journal_title：Journal of neurotrauma

authors： Anderson KJ,Scheff SW,Miller KM,Roberts KN,Gilmer LK,Yang C,Shaw G

更新日期：2008-09-01 00:00:00

abstract：:The aim of this study is to assess the utility and effectiveness of diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) of the entire pediatric cervical and thoracic spinal cord toward discrimination of typically developing (TD) controls and subjects with spinal cord injury (SCI). A total of 43 pedi...

journal_title：Journal of neurotrauma

authors： Alizadeh M,Fisher J,Saksena S,Sultan Y,Conklin CJ,Middleton DM,Finsterbusch J,Krisa L,Flanders AE,Faro SH,Mulcahey MJ,Mohamed FB

更新日期：2018-02-01 00:00:00

abstract：:We have investigated time course and characteristics of retinal ganglion cell (RGC) death after partial optic nerve injury. In situ end labeling of DNA fragments with the terminal deoxynucleotidyl transferase (TdT)-mediated deoxyuridine (dUTP)-biotin nick end labeling (TUNEL) method revealed the presence of apoptotic ...

journal_title：Journal of neurotrauma

authors： Bien A,Seidenbecher CI,Böckers TM,Sabel BA,Kreutz MR

更新日期：1999-02-01 00:00:00

abstract：:This prospective multicenter study investigated the association of the course of coagulation abnormalities with initial computed tomography (CT) characteristics and outcome in patients with isolated traumatic brain injury (TBI). Patient demographics, coagulation parameters, CT characteristics, and outcome data of mode...

journal_title：Journal of neurotrauma

authors： Franschman G,Boer C,Andriessen TM,van der Naalt J,Horn J,Haitsma I,Jacobs B,Vos PE

更新日期：2012-01-01 00:00:00

abstract：:Acute subdural hematoma (ASDH) is associated with high morbidity and mortality. Whether the volume effect of the hematoma and increase of intracranial pressure (ICP) or the local effect of blood are responsible for this severe pathophysiology is unclear. Therefore, we compared subdural infusion of autologous blood and...

journal_title：Journal of neurotrauma

authors： Jussen D,Krenzlin H,Papaioannou C,Ens S,Kempski O,Alessandri B

更新日期：2017-02-15 00:00:00

abstract：:Previous work in this laboratory has demonstrated that rats show substantial deficits on the cued and hidden versions of the Morris water maze, as well as an apparent time-dependent recovery over a period of months, following moderate parasagittal fluid-percussion (FP) injury. However, the longitudinal nature of those...

journal_title：Journal of neurotrauma

authors： Sanders MJ,Dietrich WD,Green EJ

更新日期：1999-10-01 00:00:00

abstract：:Although sleep-wake disturbances are prevalent and well described after traumatic brain injury, their pathophysiology remains unclear, most likely because human traumatic brain injury is a highly heterogeneous entity that makes the systematic study of sleep-wake disturbances in relation to trauma-induced histological ...

journal_title：Journal of neurotrauma

authors： Noain D,Büchele F,Schreglmann SR,Valko PO,Gavrilov YV,Morawska MM,Imbach LL,Baumann CR

更新日期：2018-01-01 00:00:00

abstract：:Previous studies in our laboratory have shown that polyethylene glycol-conjugated superoxide dismutase (PEG-SOD) or lidocaine treatment before experimental fluid-percussion brain injury in rats reduces the cortical hypoperfusion normally found in the early posttraumatic period. The purpose of the current study was to ...

journal_title：Journal of neurotrauma

authors： Hamm RJ,Temple MD,Pike BR,Ellis EF

更新日期：1996-06-01 00:00:00

abstract：:This study evaluated the utility of the Balance Error Scoring System (BESS) and the Sensory Organization Test (SOT) as tools for the screening and monitoring of Service members (SMs) with mild traumatic brain injury (mTBI) in a deployed setting during the acute and subacute phases of recovery. Patient records (N = 699...

journal_title：Journal of neurotrauma

authors： Haran FJ,Slaboda JC,King LA,Wright WG,Houlihan D,Norris JN

更新日期：2016-04-01 00:00:00

abstract：:A new experimental model was developed to induce diffuse brain injury (DBI) in rats through pure coronal plane angular acceleration. An impactor was propelled down a guide tube toward the lateral extension of the helmet fixture. Upon impactor-helmet contact, helmet and head were constrained to rotate in the coronal pl...

journal_title：Journal of neurotrauma

authors： Fijalkowski RJ,Stemper BD,Pintar FA,Yoganandan N,Crowe MJ,Gennarelli TA

更新日期：2007-08-01 00:00:00

abstract：:Chronic pain and dysesthesias are debilitating conditions that can arise following spinal cord injury (SCI). Research studies frequently employ rodent models of SCI to better understand the underlying mechanisms and develop better treatments for these phenomena. While evoked withdrawal tests can assess hypersensitivit...

journal_title：Journal of neurotrauma

authors： Hoschouer EL,Finseth T,Flinn S,Basso DM,Jakeman LB

更新日期：2010-05-01 00:00:00

abstract：:This article addresses the need for age-relevant outcome measures for traumatic brain injury (TBI) research and summarizes the recommendations by the inter-agency Pediatric TBI Outcomes Workgroup. The Pediatric Workgroup's recommendations address primary clinical research objectives including characterizing course of ...

journal_title：Journal of neurotrauma

authors： McCauley SR,Wilde EA,Anderson VA,Bedell G,Beers SR,Campbell TF,Chapman SB,Ewing-Cobbs L,Gerring JP,Gioia GA,Levin HS,Michaud LJ,Prasad MR,Swaine BR,Turkstra LS,Wade SL,Yeates KO,Pediatric TBI Outcomes Workgroup.

更新日期：2012-03-01 00:00:00

abstract：:Muscle strength was assessed from the maximum force that could be exerted voluntarily by triceps brachii muscles of 72 people with chronic cervical spinal cord injury (SCI) at or above C7, and 18 able-bodied (A-B) subjects. The magnitude of co-activation was estimated from the ratio of biceps brachii surface EMG to tr...

journal_title：Journal of neurotrauma

authors： Thomas CK,Tucker ME,Bigland-Ritchie B

更新日期：1998-02-01 00:00:00

abstract：:Fluid percussion (FP) brain injury causes spatial memory dysfunction in rats regardless of injury location (midline vs. lateral). Standard histological analysis of the injured brains shows hippocampal neuronal loss after lateral, but not midline FP injury. We have used the optical volume fractionator (OVF) stereologic...

journal_title：Journal of neurotrauma

authors： Grady MS,Charleston JS,Maris D,Witgen BM,Lifshitz J

更新日期：2003-10-01 00:00:00

abstract：:How effectively the survivor of CNS trauma can function in society is the ultimate clinical outcome. Many victims of spinal cord injury (SCI) and traumatic brain injury (TBI) are frequently left with permanent impairment. Measurements of impairment, and the direct relationship to the functional loss and resultant disa...

journal_title：Journal of neurotrauma

authors： Ditunno JF Jr

更新日期：1992-03-01 00:00:00