Brain perfusion bridges virtual-reality spatial behavior to TPH2 genotype for head acceleration events.

abstract：:Abnormal sympathetic tone after spinal cord injury (SCI) initially results in hypotension and is subsequently associated with autonomic dysreflexia characterized by paroxysmal hypertension and bradycardia in response to noxious or visceral stimuli. To evaluate the effect of a clinically relevant compression model of S...

journal_title：Journal of neurotrauma

authors： Maiorov DN,Fehlings MG,Krassioukov AV

更新日期：1998-05-01 00:00:00

abstract：:Traumatic brain injury (TBI) results in an accumulation of edema and loss of brain tissue. Progesterone (PROG) has been reported to reduce edema and cortical tissue loss in a bilateral prefrontal cortex injury. This study tests the hypothesis that PROG is neuroprotective following a unilateral parietal cortical contus...

journal_title：Journal of neurotrauma

authors： Gilmer LK,Roberts KN,Scheff SW

更新日期：2008-06-01 00:00:00

abstract：:A new experimental model was developed to induce diffuse brain injury (DBI) in rats through pure coronal plane angular acceleration. An impactor was propelled down a guide tube toward the lateral extension of the helmet fixture. Upon impactor-helmet contact, helmet and head were constrained to rotate in the coronal pl...

journal_title：Journal of neurotrauma

authors： Fijalkowski RJ,Stemper BD,Pintar FA,Yoganandan N,Crowe MJ,Gennarelli TA

更新日期：2007-08-01 00:00:00

abstract：:Improving survival and brain function after initial resuscitation from cardiac arrest remains a critical challenge with few therapeutic options. The publication of several randomized controlled trials supporting the use of therapeutic hypothermia in cardiac arrest survivors has provided a remarkable opportunity to red...

journal_title：Journal of neurotrauma

authors： Sugerman NT,Abella BS

更新日期：2009-03-01 00:00:00

abstract：:The majority of clinical spinal cord injuries (SCIs) are contusive and occur at the cervical level of the spinal cord. Most scientists and clinicians agree that the preclinical evaluation of novel candidate treatments should include testing in a cervical SCI contusion model. Because mice are increasingly used because ...

journal_title：Journal of neurotrauma

authors： Streijger F,Beernink TM,Lee JH,Bhatnagar T,Park S,Kwon BK,Tetzlaff W

更新日期：2013-05-15 00:00:00

abstract：:The goal of this investigation was to develop a method to study the neurophysiological integrity of the central motor tract using motor evoked potentials in the awake rat and assess the effects of different anesthetics in this model. Rats were implanted with six subcutaneous electrodes (pediatric myocardial pacing lea...

journal_title：Journal of neurotrauma

authors： Oria M,Chatauret N,Raguer N,Córdoba J

更新日期：2008-03-01 00:00:00

abstract：:Traumatic brain injury (TBI) is associated with enhanced osteogenesis. The aim of this study was to investigate the effect of serum from TBI rats on fracture healing. Results from this study showed that the serum from TBI rats enhanced the expression of bone gamma carboxyglutamate protein (BGLAP), and promoted in vitr...

journal_title：Journal of neurotrauma

authors： Yang S,Ma Y,Liu Y,Que H,Zhu C,Liu S

更新日期：2012-11-20 00:00:00

abstract：:Guidelines for patients with severe traumatic brain injury (sTBI) published in 2007 recommend providing early nutrition after trauma. Early enteral nutrition (EN) started within 48 h post-injury reduces clinical malnutrition, prevents bacterial translocation from the gastrointestinal tract, and improves outcome in sTB...

journal_title：Journal of neurotrauma

authors： Chiang YH,Chao DP,Chu SF,Lin HW,Huang SY,Yeh YS,Lui TN,Binns CW,Chiu WT

更新日期：2012-01-01 00:00:00

abstract：:Multipotent neural progenitors and stem cells may integrate appropriately into the developing and degenerating central nervous system. They may also be effective in the replacement of genes, cells, and nondiffusible factors in either a widespread or a more circumscribed manner, depending on the therapeutic demands of ...

journal_title：Journal of neurotrauma

authors： Park KI,Liu S,Flax JD,Nissim S,Stieg PE,Snyder EY

更新日期：1999-08-01 00:00:00

abstract：:Injured neurons in the mammalian central nervous system (CNS) do not normally regenerate their axons after injury. Neurotrauma to the CNS usually results in axonal damage and subsequent loss of communication between neuronal networks, causing long-term functional deficits. For CNS regeneration, repair strategies need ...

journal_title：Journal of neurotrauma

authors： Ruitenberg MJ,Vukovic J,Sarich J,Busfield SJ,Plant GW

更新日期：2006-03-01 00:00:00

abstract：:Traumatic axonal injury (TAI) is a critical public health issue with its pathogenesis remaining largely elusive. Finite element (FE) head models are promising tools to bridge the gap between mechanical insult, localized brain response, and resultant injury. In particular, the FE-derived deformation along the direction...

journal_title：Journal of neurotrauma

authors： Zhou Z,Domel AG,Li X,Grant G,Kleiven S,Camarillo DB,Zeineh M

更新日期：2021-01-15 00:00:00

abstract：:Traumatic brain injury (TBI) causes damage to the hypothalamo-hypophyseal axis, leading to endocrine dysregulation in up to 40% of TBI patients. Hence, there is an urgent need to identify non-invasive biomarkers for TBI-associated hypothalamo-hypophyseal pathology. Sushi repeat-containing protein X-linked 2 (SRPX2) is...

journal_title：Journal of neurotrauma

authors： Anwer M,Lara-Valderrabano L,Karttunen J,Ndode-Ekane XE,Puhakka N,Pitkänen A

更新日期：2020-04-01 00:00:00

abstract：:After experimental traumatic brain injury (TBI), calcineurin is upregulated; blocking calcineurin is associated with improved outcomes. In humans, variation in the calcineurin A-gamma gene (PPP3CC) has been associated with neuropsychiatric disorders, though any role in TBI recovery remains unknown. This study examines...

journal_title：Journal of neurotrauma

authors： Osier ND,Bales JW,Pugh B,Shin S,Wyrobek J,Puccio AM,Okonkwo DO,Ren D,Alexander S,Conley YP,Dixon CE

更新日期：2017-01-01 00:00:00

abstract：:To assess the safety and accuracy of the Camino intraparenchymal sensor, we prospectively evaluated hemorrhagic complications, zero-drift, infection, and system malfunction in 163 patients monitored after a severe head injury. Mean duration of intracranial pressure (ICP) monitoring was 5 +/- 2.2 days (range: 12 h to 1...

journal_title：Journal of neurotrauma

authors： Poca MA,Sahuquillo J,Arribas M,Báguena M,Amorós S,Rubio E

更新日期：2002-04-01 00:00:00

abstract：:The expression of the heat shock proteins hsp27 and hsp70 was examined in the spinal cord and sciatic nerves of developing rats. Using immunohistochemistry, we found that hsp27 is present in many motoneurones at birth. With development, the intensity of staining increases, reaching adult levels by 21 days, when all sc...

journal_title：Journal of neurotrauma

authors： Kalmár B,Burnstock G,Vrbová G,Greensmith L

更新日期：2002-05-01 00:00:00

abstract：:Cardiometabolic risk factors are sorely underreported after spinal cord injury (SCI), despite the high prevalence of metabolic disorders and cardiovascular mortality in this population. Body-composition analysis and serum-lipid profiling are two assessments that are beginning to be more widely used to document metabol...

journal_title：Journal of neurotrauma

authors： Inskip J,Plunet W,Ramer L,Ramsey JB,Yung A,Kozlowski P,Ramer M,Krassioukov A

更新日期：2010-01-01 00:00:00

abstract：:While autonomic dysreflexia (AD) is well recognized in the chronic stage of spinal cord injury (SCI) this potentially life-threatening complication has been only rarely documented in the acute phase (1 month) after SCI. Based on our clinical experience we hypothesized that AD is under-recognized in the acute phase of ...

journal_title：Journal of neurotrauma

authors： Krassioukov AV,Furlan JC,Fehlings MG

更新日期：2003-08-01 00:00:00

abstract：:Traumatic brain injury (TBI) induces vascular changes that may influence neurological outcome by causing the brain to be more susceptible to secondary ischemic insults. In rat models of TBI, L-arginine administration has been shown to restore cerebral blood flow and improve neurological outcome. The purpose of this st...

journal_title：Journal of neurotrauma

authors： Liu H,Goodman JC,Robertson CS

更新日期：2002-03-01 00:00:00

abstract：:Inflammatory cellular responses to brain injury are promoted by proinflammatory messengers. Cyclooxygenases (prostaglandin endoperoxide H synthases [PGH]) are key enzymes in the conversion of arachidonic acid into prostanoids, which mediate immunomodulation, mitogenesis, apoptosis, blood flow, secondary injury (lipid ...

journal_title：Journal of neurotrauma

authors： Schwab JM,Seid K,Schluesener HJ

更新日期：2001-09-01 00:00:00

abstract：:Clinical scenario: A 37-year-old man suffered a complete spinal cord injury (C8, American Spinal Injury Association Impairment Scale [ASIA] score A) 10 years ago in a car accident. Should primary prevention of cardiovascular disease be a priority in this patient? In order to answer this question, we performed a system...

journal_title：Journal of neurotrauma

authors： Cragg JJ,Stone JA,Krassioukov AV

更新日期：2012-07-20 00:00:00

abstract：:Mild traumatic brain injury (mTBI) disrupts hippocampal function and can lead to long-lasting episodic memory impairments. The encoding of episodic memories relies on spatial information processing within the hippocampus. As the primary entry point for spatial information into the hippocampus, the dentate gyrus is tho...

journal_title：Journal of neurotrauma

authors： Folweiler KA,Samuel S,Metheny HE,Cohen AS

更新日期：2018-06-01 00:00:00

abstract：:There is a need for better tools to objectively, reliably, and precisely assess neurological function after sport-related concussion (SRC). The aim of this study was to use a robotic device (Kinesiological Instrument for Normal and Altered Reaching Movements; KINARM) to quantify neurological impairments in athletes ac...

journal_title：Journal of neurotrauma

authors： Mang CS,Whitten TA,Cosh MS,Scott SH,Wiley JP,Debert CT,Dukelow SP,Benson BW

更新日期：2019-01-15 00:00:00

abstract：:Urokinase (uPA) and tissue plasminogen activator (tPA) are serine proteases implicated in fibrinolysis, but their role in the regulation of the cerebrovascular response to brain trauma has not been investigated. This study was designed to (1) characterize the cerebrovascular activity of uPA and tPA, (2) investigate th...

journal_title：Journal of neurotrauma

authors： Armstead WM,Cines DB,Al-Roof Higazi A

更新日期：2004-09-01 00:00:00

abstract：:Spinal cord injury (SCI) launches a complex cascade of events that leads to progressive damage and loss of function. Compromise of plasma membrane integrity due to the mechanical impact is an acute event that may contribute to cellular dysfunction. Therefore, the objective of this study was to better understand the ex...

journal_title：Journal of neurotrauma

authors： Simon CM,Sharif S,Tan RP,LaPlaca MC

更新日期：2009-04-01 00:00:00

abstract：:Prognostic biomarkers for post-injury outcome are necessary for the development of neuroprotective and antiepileptogenic treatments for traumatic brain injury (TBI). We hypothesized that T2 relaxation magnetic resonance imaging (MRI) predicts the progression of perilesional cortical pathology and epileptogenesis. The ...

journal_title：Journal of neurotrauma

authors： Manninen E,Chary K,Lapinlampi N,Andrade P,Paananen T,Sierra A,Tohka J,Gröhn O,Pitkänen A

更新日期：2020-12-01 00:00:00

abstract：:Behavioral and morphological changes were examined for up to 9 days after moderate cerebral ischemia caused by slow compression of a specific brain area in the sensorimotor cortex of Sprague-Dawley rats. Functional deficits after the cerebral ischemia were assessed by daily beam-walking tests, whereas morphological ch...

journal_title：Journal of neurotrauma

authors： Kundrotiené J,Wägner A,Liljequist S

更新日期：2002-01-01 00:00:00

abstract：:The aim of this study was to investigate the time course and the correlation of neuron-specific enolase (NSE) serum levels to the severity of traumatic brain injury in rats. Sixty-five male Wistar rats were subjected to severe cortical impact injury (100 PSI, 2 mm deformation). Blood samples were drawn directly after ...

journal_title：Journal of neurotrauma

authors： Woertgen C,Rothoerl RD,Brawanski A

更新日期：2001-05-01 00:00:00

abstract：:This study characterizes the histological and immunohistochemical changes in the adult rat spinal cord following photochemically induced spinal cord lesions. The spinal cord was exposed by laminectomy (T12-L1 vertebrae) and bathed with 1.5% rose bengal solution for 10 min. The excess dye was removed by saline rinse an...

journal_title：Journal of neurotrauma

authors： Verdú E,García-Alías G,Forés J,Vela JM,Cuadras J,López-Vales R,Navarro X

更新日期：2003-05-01 00:00:00

abstract：:The development of anxiety disorders after a traumatic brain injury (TBI) is a strong predictor of social, personal, and work dysfunction; nevertheless, the emergence of anxiety has been largely unexplored and poorly understood in the context of TBI. This article provides an overview of the limited published research ...

journal_title：Journal of neurotrauma

authors： Mallya S,Sutherland J,Pongracic S,Mainland B,Ornstein TJ

更新日期：2015-04-01 00:00:00

abstract：:The relative safety and efficacy of direct versus indirect methods of spinal cord stimulation for the production of descending motor-evoked responses was studied in pentobarbital-anesthetized rats (n = 39). Electrical stimuli were delivered for 1 h, either directly to the cord dorsum using silver ball electrodes or in...

journal_title：Journal of neurotrauma

authors： Sabato S,Agresta CA,Freeman GM,Salzman SK

更新日期：1991-04-01 00:00:00