Enduring vulnerability to transient reinstatement of hemiplegia by prazosin after traumatic brain injury.

abstract：:Persistent pain is experienced by more than 50% of persons who sustain a traumatic brain injury (TBI), and more than 30% experience significant pain as early as 6 weeks after injury. Although neuropathic pain is a common consequence after CNS injuries, little attention has been given to neuropathic pain symptoms after...

journal_title：Journal of neurotrauma

authors： Widerström-Noga E,Govind V,Adcock JP,Levin BE,Maudsley AA

更新日期：2016-07-15 00:00:00

abstract：:The Balance Error Scoring System (BESS) is a commonly used concussion assessment tool. Recent studies have questioned the stability and reliability of baseline BESS scores. The purpose of this longitudinal prospective cohort study is to examine differences in yearly baseline BESS scores in athletes participating on an...

journal_title：Journal of neurotrauma

authors： Mathiasen R,Hogrefe C,Harland K,Peterson A,Smoot MK

更新日期：2018-02-15 00:00:00

abstract：:Athletes who sustain a concussion demonstrate a variety of symptoms and neuropsychological alterations that could be brought on by neurometabolic abnormalities. However, no study has yet investigated these aspects in female athletes using magnetic resonance spectroscopy. The present study investigated the neurometabol...

journal_title：Journal of neurotrauma

authors： Chamard E,Henry L,Boulanger Y,Lassonde M,Théoret H

更新日期：2014-02-15 00:00:00

abstract：:Severe traumatic brain injury (TBI) results in significant functional disturbances in the hippocampus. Studies support that sodium cromoglycate (CG) induces neuroprotective effects. This study focused on investigating the effects of post-TBI subchronic administration of CG on hippocampal hyperexcitability and damage a...

journal_title：Journal of neurotrauma

authors： Segovia-Oropeza M,Santiago-Castañeda C,Orozco-Suárez SA,Concha L,Rocha L

更新日期：2020-12-01 00:00:00

abstract：:Patients with spinal cord injury (SCI) typically experience body weight loss, motor function deficits, and a general decline of physical fitness. Animal models with these characteristics can serve to study the detailed adaptive changes following SCI. In the present study, we report the use of an adult paraplegic mouse...

journal_title：Journal of neurotrauma

authors： Landry E,Frenette J,Guertin PA

更新日期：2004-08-01 00:00:00

abstract：:4-Aminopyridine (4AP), a potassium channel antagonist, can improve hindlimb motor function in dogs with chronic thoracolumbar spinal cord injury (SCI); however, individual response is variable. We hypothesized that injury characteristics would differ between dogs that do and do not respond to 4AP. Our objective was to...

journal_title：Journal of neurotrauma

authors： Lewis MJ,Laber E,Olby NJ

更新日期：2019-05-01 00:00:00

abstract：:Return to living at home is an important patient-reported outcome following traumatic spinal cord injury (tSCI). Specialized inpatient rehabilitation assists such patients in maximizing function and independence. Our project aim was to describe those patients receiving specialized rehabilitation after tSCI in Canada, ...

journal_title：Journal of neurotrauma

authors： Cheng CL,Plashkes T,Shen T,Fallah N,Humphreys S,O'Connell C,Linassi AG,Ho C,Short C,Ethans K,Charbonneau R,Paquet J,Noonan VK

更新日期：2017-10-15 00:00:00

abstract：:Posttraumatic ischemia appears to be largely responsible for the extension of lesions in acute injury of the spinal cord. In the present study, we have evaluated the putative improvement of axonal function by the calcium channel blocker nimodipine after acute trauma of the spinal cord. Three techniques were used: (1) ...

journal_title：Journal of neurotrauma

authors： Pointillart V,Gense D,Gross C,Bidabé AM,Gin AM,Rivel J,Caillé JM,Sénégas J

更新日期：1993-07-01 00:00:00

abstract：:Closed head injury often has a devastating outcome, partly because the insult, like other injuries to the central nervous system (CNS), triggers self-destructive processes. During studies of the response to other CNS insults, it was unexpectedly discovered that the immune system, if well controlled, provides protectio...

journal_title：Journal of neurotrauma

authors： Kipnis J,Nevo U,Panikashvili D,Alexandrovich A,Yoles E,Akselrod S,Shohami E,Schwartz M

更新日期：2003-06-01 00:00:00

abstract：:Inflammatory cellular responses to brain injury are promoted by proinflammatory messengers. Cyclooxygenases (prostaglandin endoperoxide H synthases [PGH]) are key enzymes in the conversion of arachidonic acid into prostanoids, which mediate immunomodulation, mitogenesis, apoptosis, blood flow, secondary injury (lipid ...

journal_title：Journal of neurotrauma

authors： Schwab JM,Seid K,Schluesener HJ

更新日期：2001-09-01 00:00:00

abstract：:Spinal cord injury caused by stab wounds (SCISW) results from a partial or complete transection of the cord, and presents opportunities for interventional research. It is recognized that there is low incidence, but little is known about the natural history or the patient's suitability for long-term clinical outcome st...

journal_title：Journal of neurotrauma

authors： McCaughey EJ,Purcell M,Barnett SC,Allan DB

更新日期：2016-08-01 00:00:00

abstract：:Recent calls have been made for the inclusion of health-related quality of life (HRQoL) in traumatic brain injury studies. This study reports the impact of TBI on traditional measures (general health, depression, social isolation, labor force participation), self-assessed health function status using the SF-36 version...

journal_title：Journal of neurotrauma

authors： Hawthorne G,Gruen RL,Kaye AH

更新日期：2009-10-01 00:00:00

abstract：:Increasing evidence indicates that post-traumatic stress disorder (PTSD) may develop following traumatic brain injury (TBI), despite most patients having no conscious memory of their accident. This prospective study examined the frequency, timing of onset, symptom profile, and trajectory of PTSD and its psychiatric co...

journal_title：Journal of neurotrauma

authors： Alway Y,Gould KR,McKay A,Johnston L,Ponsford J

更新日期：2016-05-01 00:00:00

abstract：:Abstract Although several functional magnetic resonance imaging (fMRI) studies have been conducted in human models of mild traumatic brain injury (mTBI), to date no studies have explicitly examined how injury may differentially affect both the positive phase of the hemodynamic response function (HRF) as well as the po...

journal_title：Journal of neurotrauma

authors： Mayer AR,Toulouse T,Klimaj S,Ling JM,Pena A,Bellgowan PS

更新日期：2014-01-15 00:00:00

abstract：:Traumatic brain injury (TBI) is associated with loss of autoregulation due to impaired responsiveness to cerebrovascular dilator stimuli, which leads to cerebral hypoperfusion and neuronal impairment or death. Upregulation of tissue plasminogen activator (tPA) post-TBI exacerbates loss of cerebral autoregulation and N...

journal_title：Journal of neurotrauma

authors： Armstead WM,Riley J,Yarovoi S,Cines DB,Smith DH,Higazi AA

更新日期：2012-06-10 00:00:00

abstract：:Using diffusion tensor imaging (DTI), we assessed the relationship of white matter integrity and performance on the Boston Naming Test (BNT) in a group of retired professional football players and a control group. We examined correlations between fractional anisotropy (FA) and mean diffusivity (MD) with BNT T-scores i...

journal_title：Journal of neurotrauma

authors： Strain JF,Didehbani N,Spence J,Conover H,Bartz EK,Mansinghani S,Jeroudi MK,Rao NK,Fields LM,Kraut MA,Cullum CM,Hart J Jr,Womack KB

更新日期：2017-01-15 00:00:00

abstract：:Spinal cord injury (SCI) launches a complex cascade of events that leads to progressive damage and loss of function. Compromise of plasma membrane integrity due to the mechanical impact is an acute event that may contribute to cellular dysfunction. Therefore, the objective of this study was to better understand the ex...

journal_title：Journal of neurotrauma

authors： Simon CM,Sharif S,Tan RP,LaPlaca MC

更新日期：2009-04-01 00:00:00

abstract：:We have previously shown that early treatment with fresh frozen plasma (FFP) is neuroprotective in a swine model of hemorrhagic shock (HS) and traumatic brain injury (TBI). However, it remains unknown whether this strategy would be beneficial in a more clinical polytrauma model. Yorkshire swine (42-50 kg) were instrum...

journal_title：Journal of neurotrauma

authors： Imam A,Jin G,Sillesen M,Dekker SE,Bambakidis T,Hwabejire JO,Jepsen CH,Halaweish I,Alam HB

更新日期：2015-03-01 00:00:00

abstract：:The lack of effective therapies for moderate-to-severe traumatic brain injuries (TBIs) leaves patients with lifelong disabilities. Neural stem cells (NSCs) have demonstrated great promise for neural repair and regeneration. However, direct evidence to support their use as a cell replacement therapy for neural injuries...

journal_title：Journal of neurotrauma

authors： Sun MK,Passaro AP,Latchoumane CF,Spellicy SE,Bowler M,Goeden M,Martin WJ,Holmes PV,Stice SL,Karumbaiah L

更新日期：2020-06-01 00:00:00

abstract：:Spinal cord injury (SCI) frequently results in chronic neuropathic pain (CNP). However, the understanding of brain neural circuits in CNP modulation is unclear. The present study examined the changes of ventral tegmental area (VTA) putative GABAergic and dopaminergic neuronal activity with CNP attenuation in rats. SCI...

journal_title：Journal of neurotrauma

authors： Ko MY,Jang EY,Lee JY,Kim SP,Whang SH,Lee BH,Kim HY,Yang CH,Cho HJ,Gwak YS

更新日期：2018-08-01 00:00:00

abstract：:Spinal cord injury (SCI) is a devastating condition that affects patients on both a personal and societal level. The objective of the study is to improve the prediction of long-term functional outcome following SCI based on the acute clinical findings. A total of 76 patients with acute traumatic SCI were prospectively...

journal_title：Journal of neurotrauma

authors： Kaminski L,Cordemans V,Cernat E,M'Bra KI,Mac-Thiong JM

更新日期：2017-06-15 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) is commonly observed in military service members with mild traumatic brain injury (mTBI); however, the relationship between mTBI and PTSD is complex and not well understood. The present study aims to elucidate a link between the degree of alteration in limbic system-related white ...

journal_title：Journal of neurotrauma

authors： Santhanam P,Teslovich T,Wilson SH,Yeh PH,Oakes TR,Weaver LK

更新日期：2019-04-01 00:00:00

abstract：:Levetiracetam (LEV) is an antiepileptic agent targeting novel pathways. Coupled with a favorable safety profile and increasing empirical clinical use, it was the fifth drug tested by Operation Brain Trauma Therapy (OBTT). We assessed the efficacy of a single 15 min post-injury intravenous (IV) dose (54 or 170 mg/kg) o...

journal_title：Journal of neurotrauma

authors： Browning M,Shear DA,Bramlett HM,Dixon CE,Mondello S,Schmid KE,Poloyac SM,Dietrich WD,Hayes RL,Wang KK,Povlishock JT,Tortella FC,Kochanek PM

更新日期：2016-03-15 00:00:00

abstract：:Human head trauma is frequently associated with respiratory problems resulting in secondary hypoxic insult. To document the behavioral consequences of secondary hypoxia in an established model of traumatic brain injury (TBI), intubated anesthetized animals were subjected to fluid percussion (FP) injury (1.87-2.17 atm)...

journal_title：Journal of neurotrauma

authors： Bramlett HM,Dietrich WD,Green EJ

更新日期：1999-11-01 00:00:00

abstract：:Growing evidence suggests that temporally proximal acute concussions and repetitive subconcussive head injuries may lead to long-term neurological deficits. However, the underlying mechanisms of injury and their relative time-scales are not well documented in human injury models. The current study therefore investigat...

journal_title：Journal of neurotrauma

authors： Mayer AR,Ling JM,Dodd AB,Gasparovic C,Klimaj SD,Meier TB

更新日期：2015-11-15 00:00:00

abstract：:The rate of paroxysmal sympathetic hyperactivity (PSH) was retrospectively assessed using the Paroxysmal Sympathetic Hyperactivity-Assessment Measure (PSH-AM) scale in patients with disorders of consciousness attributed to traumatic and non-traumatic acquired brain injury during the rehabilitation phase. These results...

journal_title：Journal of neurotrauma

authors： Lucca LF,Pignolo L,Leto E,Ursino M,Rogano S,Cerasa A

更新日期：2019-08-15 00:00:00

abstract：:Urokinase (uPA) and tissue plasminogen activator (tPA) are serine proteases implicated in fibrinolysis, but their role in the regulation of the cerebrovascular response to brain trauma has not been investigated. This study was designed to (1) characterize the cerebrovascular activity of uPA and tPA, (2) investigate th...

journal_title：Journal of neurotrauma

authors： Armstead WM,Cines DB,Al-Roof Higazi A

更新日期：2004-09-01 00:00:00

abstract：:Behavioral assessment after spinal cord contusion has long focused on open field locomotion using modifications of a rating scale developed by Tarlov and Klinger (1954). However, on-going modifications by several groups have made interlaboratory comparison of locomotor outcome measures difficult. The purpose of the pr...

journal_title：Journal of neurotrauma

authors： Basso DM,Beattie MS,Bresnahan JC

更新日期：1995-02-01 00:00:00

abstract：:Oxidative energy metabolism is depressed after mild/moderate traumatic brain injury (TBI) during early development, accompanied by behavioral debilitation and secondary neuronal death. A TBI metabolome analysis revealed broad effects with a striking impact on energy metabolism. Our studies on mitochondrial modulators ...

journal_title：Journal of neurotrauma

authors： Chitturi J,Santhakumar V,Kannurpatti SS

更新日期：2019-04-15 00:00:00

abstract：:The mass media have recently pointed out the likelihood of diagnostic errors in post-coma patients. Late recoveries of consciousness, even after 20 years, might indicate hidden misdiagnoses that are not corrected over a long period of time. The rate of misdiagnoses of patients in a vegetative state is very high when b...

journal_title：Journal of neurotrauma

authors： Pistoia F,Sarà M

更新日期：2012-09-01 00:00:00