Astrocytes generate isoprostanes in response to trauma or oxygen radicals.

abstract：:Endothelial barrier antigen (EBA) is a protein triplet located in the plasma membrane of microvascular endothelium and selectively expressed in the normal nervous system. In this study, microvascular alterations following traumatic brain injury were studied using EBA immunohistochemistry. Anesthetized, physiologically...

journal_title：Journal of neurotrauma

authors： Lin B,Ginsberg MD,Zhao W,Alonso OF,Belayev L,Busto R

更新日期：2001-04-01 00:00:00

abstract：:Anatomical studies of spinal cord injury (SCI) using magnetic resonance imaging (MRI) report diverging observations, from "no changes" to "tissue atrophy in motor and non-motor regions." These discrepancies among studies can be attributed to heterogeneity in extent, level, and post-injury duration observed within the ...

journal_title：Journal of neurotrauma

authors： Karunakaran KD,He J,Zhao J,Cui JL,Zang YF,Zhang Z,Biswal BB

更新日期：2019-06-15 00:00:00

abstract：:An increasing number of therapies for spinal cord injury (SCI) are emerging from the laboratory and seeking translation into human clinical trials. Many of these are administered as soon as possible after injury with the hope of attenuating secondary damage and maximizing the extent of spared neurologic tissue. In thi...

journal_title：Journal of neurotrauma

authors： Kwon BK,Okon EB,Plunet W,Baptiste D,Fouad K,Hillyer J,Weaver LC,Fehlings MG,Tetzlaff W

更新日期：2011-08-01 00:00:00

abstract：:Accumulating evidence suggests that the extent of brain injury and the clinical outcome after traumatic brain injury (TBI) are modulated, to some degree, by genetic variants. Aquaporin-4 (AQP4) is the predominant water channel in the central nervous system and plays a critical role in controlling the water content of ...

journal_title：Journal of neurotrauma

authors： Dardiotis E,Paterakis K,Tsivgoulis G,Tsintou M,Hadjigeorgiou GF,Dardioti M,Grigoriadis S,Simeonidou C,Komnos A,Kapsalaki E,Fountas K,Hadjigeorgiou GM

更新日期：2014-12-01 00:00:00

abstract：:Statins constitute a class of medications commonly used in the treatment of elevated cholesterol. However, in experimental studies, statins also have other non-cholesterol-mediated mechanisms of action, which may have neuroprotective effects. The aim of this study was to determine whether administration of atorvastati...

journal_title：Journal of neurotrauma

authors： Robertson CS,McCarthy JJ,Miller ER,Levin H,McCauley SR,Swank PR

更新日期：2017-02-27 00:00:00

abstract：:Traumatic brain injury (TBI) is known to be accompanied by an increase in intracranial pressure (ICP) and in some cases, by spontaneous generation of cortical spreading depression (CSD) cycles. However, the role of CSD in the pathophysiology of cerebral contusion is still unknown. A multiparametric monitoring assembly...

journal_title：Journal of neurotrauma

authors： Rogatsky GG,Sonn J,Kamenir Y,Zarchin N,Mayevsky A

更新日期：2003-12-01 00:00:00

abstract：:Gangliosides play important roles in the physiologic operations of the nervous system, in particular that of the brain. Changes in ganglioside composition occur in the mammalian brain not only during development, but also in aging and in several neuropathologic situations. Gangliosides may modulate the ability of the ...

journal_title：Journal of neurotrauma

authors： Skaper SD,Leon A

更新日期：1992-05-01 00:00:00

abstract：:This study aimed to investigate the cortical motor excitability characteristics in diffuse axonal injury (DAI) due to severe traumatic brain injury (TBI). A variety of excitatory and inhibitory transcranial magnetic stimulation (TMS) paradigms were applied to primary motor cortices of 17 patients and 11 healthy contro...

journal_title：Journal of neurotrauma

authors： Bernabeu M,Demirtas-Tatlidede A,Opisso E,Lopez R,Tormos JM,Pascual-Leone A

更新日期：2009-12-01 00:00:00

abstract：:Few studies have assessed the long-term functional outcomes of patients with a disorder of consciousness due to traumatic brain injury (TBI). This study examined functional status during the first 10 years after TBI among a cohort with disorders of consciousness (i.e., coma, vegetative state, minimally conscious state...

journal_title：Journal of neurotrauma

authors： Hammond FM,Giacino JT,Nakase Richardson R,Sherer M,Zafonte RD,Whyte J,Arciniegas DB,Tang X

更新日期：2019-04-01 00:00:00

abstract：:The Balance Error Scoring System (BESS) is a commonly used concussion assessment tool. Recent studies have questioned the stability and reliability of baseline BESS scores. The purpose of this longitudinal prospective cohort study is to examine differences in yearly baseline BESS scores in athletes participating on an...

journal_title：Journal of neurotrauma

authors： Mathiasen R,Hogrefe C,Harland K,Peterson A,Smoot MK

更新日期：2018-02-15 00:00:00

abstract：:Current thinking views mild head impact (i.e., subconcussion) as an underrecognized phenomenon that has the ability to cause significant current and future detrimental neurological effects. Repeated mild impacts to the head, however, often display no observable behavioral deficits based on standard clinical tests, whi...

journal_title：Journal of neurotrauma

authors： Hwang S,Ma L,Kawata K,Tierney R,Jeka JJ

更新日期：2017-01-01 00:00:00

abstract：:To assess the safety and accuracy of the Camino intraparenchymal sensor, we prospectively evaluated hemorrhagic complications, zero-drift, infection, and system malfunction in 163 patients monitored after a severe head injury. Mean duration of intracranial pressure (ICP) monitoring was 5 +/- 2.2 days (range: 12 h to 1...

journal_title：Journal of neurotrauma

authors： Poca MA,Sahuquillo J,Arribas M,Báguena M,Amorós S,Rubio E

更新日期：2002-04-01 00:00:00

abstract：:The fluid-percussion technique produces experimental brain injury by rapid injection of a fluid volume into the closed cranial cavity. The experiments reported here characterize a new, more controlled technique for fluid-percussion brain injury in the rat and systematically examine systemic physiologic, histopathologi...

journal_title：Journal of neurotrauma

authors： Dixon CE,Lighthall JW,Anderson TE

更新日期：1988-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a principal cause of long-term physical, cognitive, behavioral, and social deficits in young adults, which frequently coexist with a high incidence of substance abuse disorders. However, few studies have examined the long-term effects of TBI on the neuroendocrine-immune system. TBI was ...

journal_title：Journal of neurotrauma

authors： Taylor AN,Rahman SU,Tio DL,Sanders MJ,Bando JK,Truong AH,Prolo P

更新日期：2006-12-01 00:00:00

abstract：:In the present study, long-term and short-term rat preparations were used to develop a model for investigating external anal sphincter (EAS) reflexes in intact and spinal cord-injured (SCI) rats. In this model, EAS distension with an external probe elicits reflex contractions of the EAS in intact, unanesthetized anima...

journal_title：Journal of neurotrauma

authors： Holmes GM,Rogers RC,Bresnahan JC,Beattie MS

更新日期：1998-06-01 00:00:00

abstract：:Pituitary adenylate cyclase activating polypeptide (PACAP) has several different actions in the nervous system. Numerous studies have shown its neuroprotective effects both in vitro and in vivo. Previously, it has been demonstrated that PACAP reduces brain damage in rat models of global and focal cerebral ischemia. Ba...

journal_title：Journal of neurotrauma

authors： Tamás A,Zsombok A,Farkas O,Reglödi D,Pál J,Büki A,Lengvári I,Povlishock JT,Dóczi T

更新日期：2006-05-01 00:00:00

abstract：:The past 10 years have seen a rapid increase in the use of diffusion tensor imaging to identify biomarkers of traumatic brain injury (TBI). Although the literature generally indicates decreased anisotropic diffusion at more chronic injury periods and in more severe injuries, considerable debate remains regarding the d...

journal_title：Journal of neurotrauma

authors： Dodd AB,Epstein K,Ling JM,Mayer AR

更新日期：2014-07-15 00:00:00

abstract：:Quantitative gait measurements can identify persistent postconcussion impairments. However, their prognostic utility after injury to identify the likelihood of prolonged concussion symptoms remains unknown. Our objective was to examine if dual-task gait performance measures are independently associated with persistent...

journal_title：Journal of neurotrauma

authors： Howell DR,Brilliant A,Berkstresser B,Wang F,Fraser J,Meehan WP 3rd

更新日期：2017-12-01 00:00:00

abstract：:Traumatic brain injury (TBI) has been identified as a risk factor for Alzheimer's disease (AD). However, how such neural damage contributes to AD pathology remains unclear; specifically, the relationship between the timing of a TBI relative to aging and the onset of AD pathology is not known. In this study, we have ex...

journal_title：Journal of neurotrauma

authors： Collins JM,King AE,Woodhouse A,Kirkcaldie MTK,Vickers JC

更新日期：2019-06-01 00:00:00

abstract：:Closed-head concussive injury is one of the most common causes of traumatic brain injury (TBI). While single concussions result in short-term neurologic dysfunction, multiple concussions can result in cumulative damage and increased risk for neurodegenerative disease. Despite the prevalence of concussion, knowledge ab...

journal_title：Journal of neurotrauma

authors： Chen Z,Leung LY,Mountney A,Liao Z,Yang W,Lu XC,Dave J,Deng-Bryant Y,Wei G,Schmid K,Shear DA,Tortella FC

更新日期：2012-01-20 00:00:00

abstract：:Proton magnetic resonance spectroscopy (1H-MRS) and neuropsychological assessment were utilized in a longitudinal investigation of traumatic brain injury (TBI) in children. A spectroscopic imaging protocol was implemented, and neurometabolite ratios of NAA/Cre and Cho/Cre were calculated for anterior and posterior hal...

journal_title：Journal of neurotrauma

authors： Yeo RA,Phillips JP,Jung RE,Brown AJ,Campbell RC,Brooks WM

更新日期：2006-10-01 00:00:00

abstract：:Although chronic sleepiness is common after head trauma, the cause remains unclear. Transcranial magnetic stimulation (TMS) represents a useful complementary approach in the study of sleep pathophysiology. We aimed to determine in this study whether post-traumatic sleep-wake disturbances (SWD) are associated with chan...

journal_title：Journal of neurotrauma

authors： Nardone R,Bergmann J,Kunz A,Caleri F,Seidl M,Tezzon F,Gerstenbrand F,Trinka E,Golaszewski S

更新日期：2011-07-01 00:00:00

abstract：:Previous studies from our laboratory have shown the neuroprotective potential of ketones after TBI in the juvenile brain. It is our premise that acutely after TBI, glucose may not be the optimum fuel and decreasing metabolism of glucose in the presence of an alternative substrate will improve cellular metabolism and r...

journal_title：Journal of neurotrauma

authors： Prins ML,Hovda DA

更新日期：2009-07-01 00:00:00

abstract：:Contusion-type cervical spinal cord injury (SCI) is one of the most common forms of SCI observed in patients. In particular, injuries targeting the C3-C5 region affect the pool of phrenic motor neurons (PhMNs) that innervates the diaphragm, resulting in significant and often chronic respiratory dysfunction. Using a pr...

journal_title：Journal of neurotrauma

authors： Nicaise C,Frank DM,Hala TJ,Authelet M,Pochet R,Adriaens D,Brion JP,Wright MC,Lepore AC

更新日期：2013-06-15 00:00:00

abstract：:Rotational acceleration of the head, as occurs in falls, car crashes, and sport injuries, may result in diffuse brain damage, with acute and chronic neurological and psychiatric symptoms. The present study addresses the effects of rotational trauma on the neuronal cytoskeleton, which stabilizes perikaryal, dendritic a...

journal_title：Journal of neurotrauma

authors： Hamberger A,Huang YL,Zhu H,Bao F,Ding M,Blennow K,Olsson A,Hansson HA,Viano D,Haglid KG

更新日期：2003-02-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a silent epidemic affecting approximately 1.4 million Americans annually, at an estimated annual cost of $60 billion in the United States alone. Despite an increased understanding of the pathophysiology of closed head injury, there remains no pharmacological intervention proven to impro...

journal_title：Journal of neurotrauma

authors： Laskowitz DT,McKenna SE,Song P,Wang H,Durham L,Yeung N,Christensen D,Vitek MP

更新日期：2007-07-01 00:00:00

abstract：:Persistent post-traumatic headache (PPTH) is often the most common injury after mild traumatic brain injury (mTBI), reported by 47-95% of patients. Progressive muscle relaxation (PMR) has level A evidence in preventing migraine and tension headaches. However, research on this behavioral therapy for PPTH, let alone sma...

journal_title：Journal of neurotrauma

authors： Usmani S,Balcer L,Galetta S,Minen M

更新日期：2021-01-01 00:00:00

abstract：:To compare the effect of levodopa-carbidopa on the visual outcome of patients with indirect traumatic optic neuropathy (ITON), this randomized, double-blind, placebo-controlled study was conducted on 32 patients with ITON within 6 days after trauma. Patients underwent a complete ocular examination, pattern visual evok...

journal_title：Journal of neurotrauma

authors： Razeghinejad MR,Rahat F,Bagheri M

更新日期：2010-10-01 00:00:00

abstract：:Here we investigate the effect of hypothermia on the expression of apoptosis-regulating protein TIMP-3 after fluid percussion traumatic brain injury (TBI) in rats. We began with 210 adult male Sprague-Dawley rats and randomly assigned them to three groups: TBI with hypothermia treatment (32°C), TBI with normothermia (...

journal_title：Journal of neurotrauma

authors： Jia F,Mao Q,Liang YM,Jiang JY

更新日期：2014-02-15 00:00:00

abstract：:Traumatic brain injury (TBI) induces transient or persistent dysfunction of gait and balance. Enhancement of cholinergic transmission has been reported to accelerate recovery of cognitive function after TBI, but the effects of this intervention on locomotor activity remain largely unexplored. The hypothesis that enhan...

journal_title：Journal of neurotrauma

authors： Holschneider DP,Guo Y,Roch M,Norman KM,Scremin OU

更新日期：2011-09-01 00:00:00