Abstract：
:Here we investigate the effect of hypothermia on the expression of apoptosis-regulating protein TIMP-3 after fluid percussion traumatic brain injury (TBI) in rats. We began with 210 adult male Sprague-Dawley rats and randomly assigned them to three groups: TBI with hypothermia treatment (32°C), TBI with normothermia (37°C), and sham-injured controls. TBI was induced by a fluid percussion TBI device. Mild hypothermia (32°C) was achieved by partial immersion in a water bath (0°C) under general anesthesia for 4 h. The rats were killed at 4, 6, 12, 24, 48, and 72 h and 1 week after TBI. The mRNA and protein level of TIMP-3 in both the injured and uninjured hemispheres of the brains from each group were measured using RT-PCR and Western blotting. In the normothermic group, TIMP-3 levels in both the injured and uninjured hemispheres were significantly increased after TBI compared with those of sham-injured animals (p < 0.01). In contrast, post-traumatic hypothermia significantly attenuated this increase. According to the RT-PCR and Western blot analyses, the maximum mRNA levels of TIMP-3 were reduced to 60.60 ± 2.30%, 55.83 ± 1.80%, 66.03 ± 2.10%, and 64.51 ± 1.50%, respectively, of the corresponding values in the normothermic group in the injured and uninjured hemispheres (cortex and hippocampus) of the hypothermia group (p < 0.01), while the respective maximum protein levels of TIMP-3 were reduced to 57.50 ± 1.50, 52.67 ± 2.20, 60.31 ± 2.50 and 54.76 ± 1.40 (p < 0.01). Our data suggest that moderate fluid percussion brain injury significantly upregulates TIMP-3 expression, and that this increase may be suppressed by hypothermia treatment.
journal_name
J Neurotraumajournal_title
Journal of neurotraumaauthors
Jia F,Mao Q,Liang YM,Jiang JYdoi
10.1089/neu.2008.0814subject
Has Abstractpub_date
2014-02-15 00:00:00pages
387-94issue
4eissn
0897-7151issn
1557-9042journal_volume
31pub_type
杂志文章abstract：:There is a need for better tools to objectively, reliably, and precisely assess neurological function after sport-related concussion (SRC). The aim of this study was to use a robotic device (Kinesiological Instrument for Normal and Altered Reaching Movements; KINARM) to quantify neurological impairments in athletes ac...
journal_title：Journal of neurotrauma
pub_type： 临床试验,杂志文章
doi：10.1089/neu.2017.5587
更新日期：2019-01-15 00:00:00
abstract：:Sports-related concussion is a major public health problem in the United States and yet its biomechanical mechanisms remain unclear. In vitro studies demonstrate axonal elongation as a potential injury mechanism; however, current response-based injury predictors (e.g., maximum principal strain, ε(ep)) typically do not...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2013.3268
更新日期：2015-04-01 00:00:00
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journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/089771503765355559
更新日期：2003-05-01 00:00:00
abstract：:Traumatic spinal cord injury (SCI) can cause permanent disabilities that seriously reduce quality of life. We evaluated the effects of chronic hyperglycemia before SCI on inflammatory markers and functional recovery after SCI in human patients and a rat model. In the human study, multivariate logistical regression ana...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2019.6724
更新日期：2020-05-01 00:00:00
abstract：:The mechanism by which mechanical impact to brain tissue is transduced to neuronal impairment remains poorly understood. Using an in vitro model of neuronal stretch, we found that mechanical stretch of neurons resulted in a transient plasma membrane permeability increase. Primary cortical neurons, seeded on silicone s...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/089771503770195885
更新日期：2003-10-01 00:00:00
abstract：:The majority of clinical spinal cord injuries (SCIs) are contusive and occur at the cervical level of the spinal cord. Most scientists and clinicians agree that the preclinical evaluation of novel candidate treatments should include testing in a cervical SCI contusion model. Because mice are increasingly used because ...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2012.2405
更新日期：2013-05-15 00:00:00
abstract：:The translation of therapeutic interventions to humans with spinal cord injury with the goal of promoting growth and repair in the central nervous system could, inadvertently, drive mechanisms associated with the development of neuropathic pain. A framework is needed to evaluate the probability that a therapeutic inte...
journal_title：Journal of neurotrauma
pub_type： 杂志文章,meta分析
doi：10.1089/neu.2018.5960
更新日期：2019-05-01 00:00:00
abstract：:The relationship between psychotropic medication use and traumatic brain injury (TBI) is not well understood. The objective of this study was to describe patterns of psychotropic medication use during the months before and after TBI and compare with a non-TBI cohort. We conducted a retrospective cohort study using adm...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2019.6580
更新日期：2020-04-15 00:00:00
abstract：:Traumatic brain damage may cause acute emotional symptoms such as uncontrolled crying, apathy, and sleep problems. Rehabilitation may be less effective in patients afflicted by these symptoms. Citalopram, a selective serotonin reuptake inhibitor (SSRI), has a documented immediate and dramatic effect on pathological cr...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.1999.16.341
更新日期：1999-04-01 00:00:00
abstract：:Spinal cord injury (SCI) is a devastating condition that affects patients on both a personal and societal level. The objective of the study is to improve the prediction of long-term functional outcome following SCI based on the acute clinical findings. A total of 76 patients with acute traumatic SCI were prospectively...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
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更新日期：2017-06-15 00:00:00
abstract：:Pairing vagus nerve stimulation (VNS) with rehabilitation has emerged as a potential strategy to enhance plasticity and improve recovery in a range of neurological disorders. A recent study highlights the therapeutic promise of VNS in promoting motor recovery after spinal cord injury (SCI). We investigated the safety ...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2019.6828
更新日期：2020-05-01 00:00:00
abstract：:The detection of neuron-specific proteins in blood might allow quantification of the degree of neuropathology in experimental and clinical contexts. We have been studying a novel blood biomarker of axonal injury, the heavily phosphorylated axonal form of the high molecular weight neurofilament subunit NF-H (pNF-H). We...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2007.0488
更新日期：2008-09-01 00:00:00
abstract：:Studies measuring the volume of infarcted tissue and survival after pharmacologic intervention in stroke are complicated by the potential effect of survival time on infarct volume. In this study, the volume of infarcted tissue as defined by 2,3,5-triphenyltetrazolium chloride staining was determined in rabbits at 28 h...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.1996.13.583
更新日期：1996-10-01 00:00:00
abstract：:Traumatic brain injuries (TBI) sustained in combat frequently co-occur with significant bodily injuries. Intuitively, more extensive bodily injuries might be associated with increased symptom reporting. In 2012, however, French et al. demonstrated an inverse relation between bodily injury severity and symptom reportin...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2014.3401
更新日期：2014-10-01 00:00:00
abstract：:Injury to the meninges is not uncommon after traumatic brain injury (TBI), yet minimal research has been directed toward understanding the relevant biology. After a concussive event, the meninges are observed to abnormally enhance on post-contrast magnetic resonance imaging (MRI) in some patients, but not all. The aim...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2016.4479
更新日期：2017-02-15 00:00:00
abstract：:Abstract Traumatic brain injury (TBI) induces microglial activation, which can contribute to secondary tissue loss. Activation of mGluR5 reduces microglial activation and inhibits microglial-mediated neurodegeneration in vitro, and is neuroprotective in experimental models of CNS injury. In vitro studies also suggest ...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2012.2589
更新日期：2013-03-01 00:00:00
abstract：:Laser Doppler flowmetry (LDF) was used to study acute ipsilateral and contralateral disturbances of regional cerebral blood flow (rCBF) in a rat model of cerebral cortical contusion trauma. Twelve rats were intubated and artificially ventilated during and after trauma. Injury was produced with a weight drop technique ...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.1996.13.201
更新日期：1996-04-01 00:00:00
abstract：:Mild traumatic brain injury (mTBI) accounts for the vast majority of all pediatric TBI. An important minority of children who have suffered an mTBI have enduring cognitive and emotional symptoms. However, the mechanisms of chronic symptoms in children with pediatric mTBI are not fully understood. This is in part due t...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2019.6417
更新日期：2020-04-01 00:00:00
abstract：:Accumulating evidence suggests that the extent of brain injury and the clinical outcome after traumatic brain injury (TBI) are modulated, to some degree, by genetic variants. Aquaporin-4 (AQP4) is the predominant water channel in the central nervous system and plays a critical role in controlling the water content of ...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2014.3347
更新日期：2014-12-01 00:00:00
abstract：:To compare the effect of levodopa-carbidopa on the visual outcome of patients with indirect traumatic optic neuropathy (ITON), this randomized, double-blind, placebo-controlled study was conducted on 32 patients with ITON within 6 days after trauma. Patients underwent a complete ocular examination, pattern visual evok...
journal_title：Journal of neurotrauma
pub_type： 杂志文章,随机对照试验
doi：10.1089/neu.2010.1362
更新日期：2010-10-01 00:00:00
abstract：:Progesterone is an anti-inflammatory and promyelinating agent after spinal cord injury, but its effectiveness on functional recovery is still controversial. In the current study, we tested the effects of chronic progesterone administration on tissue preservation and functional recovery in a clinically relevant model o...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2013.3162
更新日期：2014-05-01 00:00:00
abstract：:The Glasgow Coma Scale (GCS) was introduced 40 years ago and has received world-wide acceptance. The GCS rates eye, motor, and verbal responses to assess the level of consciousness. Concerns have been expressed with regard to reliability and consistency of assessments. We considered that lack of standardization in app...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2014.3843
更新日期：2016-01-01 00:00:00
abstract：:Spinal cord injury (SCI) is less common in children than in adults, but in children it is generally more severe. Spinal loading conditions (speed and displacement) are also thought to affect SCI severity, but the relationship between these parameters is not well understood. This study aimed to investigate the effects ...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2012.2725
更新日期：2013-08-01 00:00:00
abstract：:Anatomical studies of spinal cord injury (SCI) using magnetic resonance imaging (MRI) report diverging observations, from "no changes" to "tissue atrophy in motor and non-motor regions." These discrepancies among studies can be attributed to heterogeneity in extent, level, and post-injury duration observed within the ...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2018.6040
更新日期：2019-06-15 00:00:00
abstract：:Persistent pain is experienced by more than 50% of persons who sustain a traumatic brain injury (TBI), and more than 30% experience significant pain as early as 6 weeks after injury. Although neuropathic pain is a common consequence after CNS injuries, little attention has been given to neuropathic pain symptoms after...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2015.4098
更新日期：2016-07-15 00:00:00
abstract：:We have shown previously that fresh frozen plasma (FFP) and lyophilized plasma (LP) decrease brain lesion size and improve neurological recovery in a swine model of traumatic brain injury (TBI) and hemorrhagic shock (HS). In this study, we examine whether these findings can be validated in a clinically relevant model ...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2016.4859
更新日期：2017-07-01 00:00:00
abstract：:Head contact-induced loads can result in skull fractures and/or brain injuries. While skull fractures have been produced from post-mortem human cadaver surrogates (PMHS), injury probability curves describing their structural responses have not been developed. The objectives of this study were to develop skull fracture...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2017.5356
更新日期：2018-06-01 00:00:00
abstract：:The role of endothelin (ET) in the pathophysiology of secondary neural damage after experimental spinal cord injury (SCI) was examined in a rat model of weight-drop contusion injury. Initial studies demonstrated a significant increase in spinal ET concentrations in a 7.5-mm segment of tissue (centered at the impact si...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.1996.13.93
更新日期：1996-02-01 00:00:00
abstract：:Repair of the spinal cord and improvement of mobility after injury has been a matter of basic and clinical research for several decades. A number of repair approaches were performed in animals, mainly rodent models of spinal cord injury (SCI). Some of these experimental therapies resulted in significant regeneration o...
journal_title：Journal of neurotrauma
pub_type： 杂志文章,评审
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更新日期：2017-05-01 00:00:00
abstract：:The purpose of this study was to define the relationships among clinical characteristics of chronic pain, injury characteristics, affective factors and autonomic dysreflexia (AD) in people with chronic cervical spinal cord injury (SCI). A survey containing questions concerning the presence of AD, demographic factors, ...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/089771504322778659
更新日期：2004-02-01 00:00:00
