Abstract:
:The purpose of this study was to determine the relationship between endothelin-1 (ET-1), a prominent vasoactive agent, and the breakdown of the blood-spinal cord barrier along the axis of the cord after a moderate spinal cord injury. In the first study rats (n = 10) were euthanized 24 h after spinal cord injury and compared to sham (n = 5) and unoperated (n = 10) controls. Endothelin and immunoglobulins (IgG) were immunolocalized in adjacent sections of spinal cord using semiquantitative immunocytochemical techniques. In the second study animals were pretreated with the endothelin antagonist Bosentan (n = 6) or vehicle (n = 6) prior to spinal cord injury. Animals were euthanized at 24 h postinjury. Ten minutes prior to euthanasia animals were given horseradish peroxidase (HRP) intravenously. After perfusion fixation sections of cord were prepared for quantitative HRP histochemistry. After spinal cord injury there was enhanced staining for endothelin along the axis of the cord that correlated with the anatomical pattern of barrier breakdown to IgG. In those animals that were pretreated with Bosentan, there was a significant reduction in barrier breakdown along the axis of the injured cord as compared to those animals that received vehicle only. Taken together, this data implicate involvement of endothelin in the axial pattern of barrier breakdown after spinal cord injury.
journal_name
J Neurotraumajournal_title
Journal of neurotraumaauthors
McKenzie AL,Hall JJ,Aihara N,Fukuda K,Noble LJdoi
10.1089/neu.1995.12.257subject
Has Abstractpub_date
1995-06-01 00:00:00pages
257-68issue
3eissn
0897-7151issn
1557-9042journal_volume
12pub_type
杂志文章abstract::The clinical manifestations that occur after traumatic brain injury (TBI) include a wide range of cognitive, emotional, and behavioral deficits. The loss of excitatory synapses could potentially explain why such diverse symptoms occur after TBI, and a recent preclinical study has demonstrated a loss of dendritic spine...
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abstract::Studies measuring the volume of infarcted tissue and survival after pharmacologic intervention in stroke are complicated by the potential effect of survival time on infarct volume. In this study, the volume of infarcted tissue as defined by 2,3,5-triphenyltetrazolium chloride staining was determined in rabbits at 28 h...
journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.1996.13.583
更新日期:1996-10-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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doi:10.1089/neu.2012.2725
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journal_title:Journal of neurotrauma
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pub_type: 杂志文章
doi:10.1089/neu.2014.3401
更新日期:2014-10-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:
更新日期:1991-07-01 00:00:00
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更新日期:2008-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1089/neu.2006.0079
更新日期:2007-01-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.1993.10.201
更新日期:1993-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1089/neu.2011.1789
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journal_title:Journal of neurotrauma
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Journal of neurotrauma
pub_type: 杂志文章,评审
doi:
更新日期:1992-03-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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更新日期:2002-05-01 00:00:00