Autonomic dysreflexia in acute spinal cord injury: an under-recognized clinical entity.

abstract：:Recovery of fine motor skills after traumatic brain injury (TBI) is variable, with some patients showing progressive improvements over time while others show poor recovery. We therefore studied possible cellular mechanisms accompanying the recovery process in a non-human primate model system, in which the lateral fron...

journal_title：Journal of neurotrauma

authors： Nagamoto-Combs K,Morecraft RJ,Darling WG,Combs CK

更新日期：2010-03-01 00:00:00

abstract：:Diagnosis and treatment of stroke and traumatic brain injury remain significant health care challenges to society. Patient care stands to benefit from an improved understanding of the interactive biochemistry underlying neurotrauma pathobiology. In this study, we assessed the power of neuroproteomics to contrast bioch...

journal_title：Journal of neurotrauma

authors： Ottens AK,Bustamante L,Golden EC,Yao C,Hayes RL,Wang KK,Tortella FC,Dave JR

更新日期：2010-10-01 00:00:00

abstract：:Central nervous system (CNS) destruction in spinal cord injury (SCI) is caused by a complex series of cellular and molecular events. Recent studies have concentrated on signaling by receptors in the tumor necrosis factor receptor (TNFR) superfamily that mediate diverse biological outcomes ranging from inflammation to ...

journal_title：Journal of neurotrauma

authors： Keane RW,Davis AR,Dietrich WD

更新日期：2006-03-01 00:00:00

abstract：:Despite clinical symptoms, a large majority of people with mild traumatic brain injury (TBI) have normal computed tomography (CT) and magnetic resonance imaging (MRI) scans. Therefore, present-day neuroimaging tools are insufficient to diagnose or classify low grades of TBI. Advanced neuroimaging techniques, such as d...

journal_title：Journal of neurotrauma

authors： Sinke MRT,Otte WM,Meerwaldt AE,Franx BAA,Ali MHM,Rakib F,van der Toorn A,van Heijningen CL,Smeele C,Ahmed T,Blezer ELA,Dijkhuizen RM

更新日期：2021-01-11 00:00:00

abstract：:Increasing clinical and experimental evidence suggests that traumatic brain injury (TBI) is associated with progressive histopathological damage. The aim of the current study was to characterize the time course of motor function, memory performance, and depression-like behavior up to 1 year after experimental TBI, and...

journal_title：Journal of neurotrauma

authors： Mao X,Terpolilli NA,Wehn A,Cheng S,Hellal F,Liu B,Seker B,Plesnila N

更新日期：2020-06-01 00:00:00

abstract：:The potential pathophysiological role of circulating microparticles (MPs) has been recognized in various conditions, such as cardiovascular and thrombotic diseases. Traumatic brain injury (TBI) has a complex pathophysiology that involves coagulopathy and inflammation. We investigated endothelial-, platelet-, and leuko...

journal_title：Journal of neurotrauma

authors： Nekludov M,Mobarrez F,Gryth D,Bellander BM,Wallen H

更新日期：2014-12-01 00:00:00

abstract：:Mild traumatic brain injury (mTBI) contributes to development of affective disorders, including post-traumatic stress disorder (PTSD). Psychiatric symptoms typically emerge in a tardive fashion post-TBI, with negative effects on recovery. Patients with PTSD, as well as rodent models of PTSD, demonstrate structural and...

journal_title：Journal of neurotrauma

authors： Schneider BL,Ghoddoussi F,Charlton JL,Kohler RJ,Galloway MP,Perrine SA,Conti AC

更新日期：2016-09-01 00:00:00

abstract：:Ocular blast injury is a major medical concern for soldiers and explosion victims due to poor visual outcomes. To define the changes in gene expression following a blast injury to the eye, we examined retinal ribonucleic acid (RNA) expression in 54 mouse strains 5 days after a single 50-psi overpressure air wave blast...

journal_title：Journal of neurotrauma

authors： Struebing FL,King R,Li Y,Chrenek MA,Lyuboslavsky PN,Sidhu CS,Iuvone PM,Geisert EE

更新日期：2018-01-01 00:00:00

abstract：:Previous studies have shown that location and direction of injury may affect outcome in experimental models of traumatic brain injury. Significant variability in outcome data has also been noted in studies using the lateral fluid percussion brain injury model (FPI) in rats. In recent studies from our laboratory, we ob...

journal_title：Journal of neurotrauma

authors： Vink R,Mullins PG,Temple MD,Bao W,Faden AI

更新日期：2001-08-01 00:00:00

abstract：:Anecdotal observations of blast victims indicate that significant neuropathological and neurobehavioral defects may develop at later stages of life. To pre-clinically model this phenomenon, we have examined neurobehavioral changes in rats up to 1 year after exposure to single and tightly coupled repeated blasts using ...

journal_title：Journal of neurotrauma

authors： Arun P,Wilder DM,Eken O,Urioste R,Batuure A,Sajja S,Van Albert S,Wang Y,Gist ID,Long JB

更新日期：2020-02-15 00:00:00

abstract：:Abnormal sympathetic tone after spinal cord injury (SCI) initially results in hypotension and is subsequently associated with autonomic dysreflexia characterized by paroxysmal hypertension and bradycardia in response to noxious or visceral stimuli. To evaluate the effect of a clinically relevant compression model of S...

journal_title：Journal of neurotrauma

authors： Maiorov DN,Fehlings MG,Krassioukov AV

更新日期：1998-05-01 00:00:00

abstract：:Large-scale network analysis characterizes the brain as a complex network of nodes and edges to evaluate functional connectivity patterns. The utility of graph-based techniques has been demonstrated in an increasing number of resting-state functional MRI (rs-fMRI) studies in the normal and diseased brain. However, to ...

journal_title：Journal of neurotrauma

authors： Kaushal M,Oni-Orisan A,Chen G,Li W,Leschke J,Ward BD,Kalinosky B,Budde MD,Schmit BD,Li SJ,Muqeet V,Kurpad SN

更新日期：2017-03-15 00:00:00

abstract：:Previous studies have shown that oxygen radical scavengers prevent the reduced cerebral blood flow that occurs following experimental traumatic brain injury. The exact chemical species responsible for the posttraumatic reduction in flow is unknown. We tested whether isoprostanes, which are formed by non-cyclooxygenase...

journal_title：Journal of neurotrauma

authors： Hoffman SW,Rzigalinski BA,Willoughby KA,Ellis EF

更新日期：2000-05-01 00:00:00

abstract：:Behavioral and morphological changes were examined for up to 9 days after moderate cerebral ischemia caused by slow compression of a specific brain area in the sensorimotor cortex of Sprague-Dawley rats. Functional deficits after the cerebral ischemia were assessed by daily beam-walking tests, whereas morphological ch...

journal_title：Journal of neurotrauma

authors： Kundrotiené J,Wägner A,Liljequist S

更新日期：2002-01-01 00:00:00

abstract：:The aim of this systematic review was to critically evaluate the evidence on interventions for depression following traumatic brain injury (TBI) and provide recommendations for clinical practice and future research. We reviewed pharmacological, other biological, psychotherapeutic, and rehabilitation interventions for ...

journal_title：Journal of neurotrauma

authors： Fann JR,Hart T,Schomer KG

更新日期：2009-12-01 00:00:00

abstract：:Several behavioral factors such as violence, impulsivity, and alcohol-related problems are associated with traumatic spinal cord injury (TSCI). Such factors have been associated with inherently low neuronal serotonergic capacity that in turn is reflected in low activity of monoamine oxidase (MAO) as measured in platel...

journal_title：Journal of neurotrauma

authors： Sabre L,Harro J,Eensoo D,Vaht M,Kabel V,Pakkanen M,Asser T,Kõrv J

更新日期：2016-11-01 00:00:00

abstract：:This study investigated corticomotor excitability and inhibition, cognitive functioning, and fine motor dexterity in retired elite and amateur Australian football (AF) players who had sustained concussions during their playing careers. Forty male AF players who played at the elite level (n=20; mean age 49.7±5.7 years)...

journal_title：Journal of neurotrauma

authors： Pearce AJ,Hoy K,Rogers MA,Corp DT,Maller JJ,Drury HG,Fitzgerald PB

更新日期：2014-07-01 00:00:00

abstract：:Patients with spinal cord injury (SCI) typically experience body weight loss, motor function deficits, and a general decline of physical fitness. Animal models with these characteristics can serve to study the detailed adaptive changes following SCI. In the present study, we report the use of an adult paraplegic mouse...

journal_title：Journal of neurotrauma

authors： Landry E,Frenette J,Guertin PA

更新日期：2004-08-01 00:00:00

abstract：:Bone marrow stromal cells (BMSC) transplanted into the contused spinal cord may support repair by improving tissue sparing. We injected allogeneic BMSC into the moderately contused adult rat thoracic spinal cord at 15 min (acute) and at 3, 7, and 21 days (delayed) post-injury and quantified tissue sparing and BMSC sur...

journal_title：Journal of neurotrauma

authors： Nandoe Tewarie RD,Hurtado A,Ritfeld GJ,Rahiem ST,Wendell DF,Barroso MM,Grotenhuis JA,Oudega M

更新日期：2009-12-01 00:00:00

abstract：:This study was designed to assess the effect of spinal cord injury on neurobehavioral, electrophysiological, structural, and biochemical changes in normal and diabetic rats. Experimental diabetes was induced in Sprague-Dawley male rats (weighing 250-280 g) with streptozotocin (50 mg/kg i.p.). Eight weeks after the tre...

journal_title：Journal of neurotrauma

authors： Tariq M,Morais C,Kishore PN,Biary N,Al Deeb S,Al Moutaery K

更新日期：1998-04-01 00:00:00

abstract：:To assess the safety and accuracy of the Camino intraparenchymal sensor, we prospectively evaluated hemorrhagic complications, zero-drift, infection, and system malfunction in 163 patients monitored after a severe head injury. Mean duration of intracranial pressure (ICP) monitoring was 5 +/- 2.2 days (range: 12 h to 1...

journal_title：Journal of neurotrauma

authors： Poca MA,Sahuquillo J,Arribas M,Báguena M,Amorós S,Rubio E

更新日期：2002-04-01 00:00:00

abstract：:Surviving motoneurons undergo dendritic atrophy after spinal cord injury (SCI), suggesting an important therapeutic target for neuroprotective strategies to improve recovery of function after SCI. Our previous studies showed that phospholipase A2 (PLA2) may play an important role in the pathogenesis of SCI. In the pre...

journal_title：Journal of neurotrauma

authors： Liu NK,Byers JS,Lam T,Lu QB,Sengelaub DR,Xu XM

更新日期：2014-11-11 00:00:00

abstract：:The generation of oxygen radicals and the process of lipid peroxidation have become a focus of attention for investigators in the fields of central nervous system (CNS) injury and stroke (e.g., ischemia). While absolute proof for their involvement in the pathophysiology of traumatic and ischemic damage to the CNS rema...

journal_title：Journal of neurotrauma

authors： Braughler JM,Hall ED

更新日期：1992-03-01 00:00:00

abstract：:The exact mechanism of hypothermic cerebroprotection after traumatic brain injury (TBI) is not fully understood. The present study was conducted to investigate the effects of mild hypothermia on trauma-induced synthesis of nitric oxide (NO), which has been implicated in the pathogenesis of ischemic brain damage associ...

journal_title：Journal of neurotrauma

authors： Sakamoto KI,Fujisawa H,Koizumi H,Tsuchida E,Ito H,Sadamitsu D,Maekawa T

更新日期：1997-05-01 00:00:00

abstract：:Although the citation index of an article is not a direct measure of its quality or importance, it is a measure of recognition that may suggest its impact on the scientific community. This study was undertaken to examine the characteristics of the top 100 most frequently cited articles (so-called "citation classics") ...

journal_title：Journal of neurotrauma

authors： Furlan JC,Fehlings MG

更新日期：2006-02-01 00:00:00

abstract：:Physician prescribed rest after traumatic brain injury (TBI) is both commonplace and an increasingly scrutinized approach to TBI treatment. Although this practice remains a standard of patient care for TBI, research of patient outcomes reveals little to no benefit of prescribed rest after TBI, and in some cases prolon...

journal_title：Journal of neurotrauma

authors： Karelina K,Schneiderman K,Shah S,Fitzgerald J,Velazquez Cruz R,Oliverio R,Whitehead B,Yang J,Weil Z

更新日期：2021-01-20 00:00:00

abstract：:Inflammatory lesions in the brain activate a systemic acute-phase response (APR), which is dependent on the release of extracellular vesicles (EVs) into the circulation. The resulting APR is responsible for regulating leukocyte mobilization and subsequent recruitment to the brain. Factors that either exacerbate or inh...

journal_title：Journal of neurotrauma

authors： Hazelton I,Yates A,Dale A,Roodselaar J,Akbar N,Ruitenberg MJ,Anthony DC,Couch Y

更新日期：2018-02-15 00:00:00

abstract：:We explored the effects of recombinant human growth hormone (rhGH) replacement on physical and cognitive functioning in subjects with a moderate-to-severe traumatic brain injury (TBI) with abnormal growth hormone (GH) secretion. Fifteen individuals who sustained a TBI at least 12 months prior to study enrollment were ...

journal_title：Journal of neurotrauma

authors： Mossberg KA,Durham WJ,Zgaljardic DJ,Gilkison CR,Danesi CP,Sheffield-Moore M,Masel BE,Urban RJ

更新日期：2017-02-15 00:00:00

abstract：:Intraspinal injections of lysolecithin were used to produce unilateral demyelination in the dorsal columns of the rat spinal cord. The purpose of this study was to evaluate the effects of demyelination on the conductive properties of axons belonging to a spinal pathway of known origin and site of termination. At 5 and...

journal_title：Journal of neurotrauma

authors： Yezierski RP,Devon RM,Vicedomini JP,Broton JG

更新日期：1992-10-01 00:00:00

abstract：:This paper encompasses the prediction of early and late recovery from traumatic brain injury (TBI). Predictors of the duration of coma and the utilization of posttraumatic amnesia duration to predict residual memory function are discussed. The issues surrounding prediction of long-term neurobehavioral recovery from TB...

journal_title：Journal of neurotrauma

authors： Levin HS

更新日期：1995-10-01 00:00:00