Moderate intensity treadmill exercise increases survival of newborn hippocampal neurons and improves neurobehavioral outcomes following traumatic brain injury.

abstract：:The purpose of this study was to define the relationships among clinical characteristics of chronic pain, injury characteristics, affective factors and autonomic dysreflexia (AD) in people with chronic cervical spinal cord injury (SCI). A survey containing questions concerning the presence of AD, demographic factors, ...

journal_title：Journal of neurotrauma

authors： Widerström-Noga E,Cruz-Almeida Y,Krassioukov A

更新日期：2004-02-01 00:00:00

abstract：:Recently, locomotor training has been shown to improve overground locomotion in patients with spinal cord injury (SCI). This has triggered renewed interest in the role of exercise in rehabilitation after SCI. However, there are no mouse models for voluntary exercise and recovery of function following SCI. Here, we rep...

journal_title：Journal of neurotrauma

authors： Engesser-Cesar C,Anderson AJ,Basso DM,Edgerton VR,Cotman CW

更新日期：2005-01-01 00:00:00

abstract：:Axon retraction greatly limits functional recovery after spinal cord injury (SCI) and neuron polarization, which affects processes including axon formation and development, is a promising target for promoting axon regeneration. Increasing microtubule stability has been demonstrated to improve intrinsic axon regenerati...

journal_title：Journal of neurotrauma

authors： Wang Q,Cai H,Hu Z,Wu Y,Guo X,Li J,Wang H,Liu Y,Liu Y,Xie L,Xu K,Xu H,He H,Zhang H,Xiao J

更新日期：2019-06-15 00:00:00

abstract：:The imaging and clinical examination (ICE) algorithm used in the Benchmark Evidence from South American Trials: Treatment of Intracranial Pressure (BEST TRIP) randomized controlled trial is the only prospectively investigated clinical protocol for traumatic brain injury management without intracranial pressure (ICP) m...

journal_title：Journal of neurotrauma

authors： Chesnut RM,Temkin N,Dikmen S,Rondina C,Videtta W,Petroni G,Lujan S,Alanis V,Falcao A,de la Fuenta G,Gonzalez L,Jibaja M,Lavarden A,Sandi F,Mérida R,Romero R,Pridgeon J,Barber J,Machamer J,Chaddock K

更新日期：2018-01-01 00:00:00

abstract：:An impaired ability to regulate microglia activation by fractalkine (CX3CL1) leads to microglia chronic sub-activation. How this condition affects outcome after acute brain injury is still debated, with studies showing contrasting results depending on the timing and the brain pathology. Here, we investigated the early...

journal_title：Journal of neurotrauma

authors： Zanier ER,Marchesi F,Ortolano F,Perego C,Arabian M,Zoerle T,Sammali E,Pischiutta F,De Simoni MG

更新日期：2016-06-01 00:00:00

abstract：:Sports-related concussion is a major public health problem in the United States and yet its biomechanical mechanisms remain unclear. In vitro studies demonstrate axonal elongation as a potential injury mechanism; however, current response-based injury predictors (e.g., maximum principal strain, ε(ep)) typically do not...

journal_title：Journal of neurotrauma

authors： Ji S,Zhao W,Ford JC,Beckwith JG,Bolander RP,Greenwald RM,Flashman LA,Paulsen KD,McAllister TW

更新日期：2015-04-01 00:00:00

abstract：:Fatalities or injuries following motorized and non-motorized vehicle accidents (MNMVA) are reported by police or health care systems. However, limited data exist for spinal injuries. Using an epidemiological database of road accidents occurring in a defined geographic area, we measured the incidence of major spinal tr...

journal_title：Journal of neurotrauma

authors： Lieutaud T,Ndiaye A,Frost F,Chiron M,Registry Group.

更新日期：2010-06-01 00:00:00

abstract：:The etiology of multiple sclerosis (MS) is still not well known. Previous data show conflicting results regarding the association between MS and prior brain trauma. This study aims to investigate the risk for MS following a traumatic brain injury (TBI) using a large-scale cohort study design. This study used data from...

journal_title：Journal of neurotrauma

authors： Kang JH,Lin HC

更新日期：2012-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) can trigger disturbances of cerebral pressure autoregulation that can translate into the generation of secondary insults and increased morbidity/mortality. Few therapies have been developed to attenuate the damaging consequences of disturbed autoregulatory control, although some suggest th...

journal_title：Journal of neurotrauma

authors： Fujita M,Wei EP,Povlishock JT

更新日期：2012-05-01 00:00:00

abstract：:Diffuse axonal injury (DAI) secondary to traumatic brain injury (TBI) contributes to long-term functional morbidity. The corpus callosum (CC) is particularly vulnerable to this type of injury. Magnetic resonance spectroscopy (MRS) was used to characterize the metabolic status of two CC regions of interest (ROIs) (ante...

journal_title：Journal of neurotrauma

authors： Babikian T,Marion SD,Copeland S,Alger JR,O'Neill J,Cazalis F,Mink R,Giza CC,Vu JA,Hilleary SM,Kernan CL,Newman N,Asarnow RF

更新日期：2010-03-01 00:00:00

abstract：:Despite limited evidence to support the use of amantadine to enhance cognitive function after traumatic brain injury (TBI), the clinical use for this purpose is highly prevalent and is often based on inferred belief systems. The aim of this study was to assess effect of amantadine on cognition among individuals with a...

journal_title：Journal of neurotrauma

authors： Hammond FM,Sherer M,Malec JF,Zafonte RD,Dikmen S,Bogner J,Bell KR,Barber J,Temkin N

更新日期：2018-10-01 00:00:00

abstract：:The role of Ca2+ in cellular injury has received particular attention in studies of acute spinal cord trauma. In this context, the spatial and temporal distribution of extracellular Ca2+ ([Ca2+]e) may have an important bearing on the development of secondary tissue injury. We therefore studied the spatial-temporal dis...

journal_title：Journal of neurotrauma

authors： Moriya T,Hassan AZ,Young W,Chesler M

更新日期：1994-06-01 00:00:00

abstract：:Sixty-eight patients were entered into a randomized, prospective, double-blinded controlled trial of supplemental zinc versus standard zinc therapy to study the effects of zinc supplementation on neurologic recovery and nutritional/metabolic status after severe closed head injury. One month after injury, the mortality...

journal_title：Journal of neurotrauma

authors： Young B,Ott L,Kasarskis E,Rapp R,Moles K,Dempsey RJ,Tibbs PA,Kryscio R,McClain C

更新日期：1996-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) induces transient or persistent dysfunction of gait and balance. Enhancement of cholinergic transmission has been reported to accelerate recovery of cognitive function after TBI, but the effects of this intervention on locomotor activity remain largely unexplored. The hypothesis that enhan...

journal_title：Journal of neurotrauma

authors： Holschneider DP,Guo Y,Roch M,Norman KM,Scremin OU

更新日期：2011-09-01 00:00:00

abstract：:Controlled cortical impact (CCI) produces blood-brain barrier (BBB) permeability and an acute inflammatory response in injured brain, associated with upregulation of cell adhesion molecules and accumulation of neutrophils. Nevertheless, the role of acute inflammation in the pathogenesis of BBB permeability after traum...

journal_title：Journal of neurotrauma

authors： Whalen MJ,Carlos TM,Kochanek PM,Clark RS,Heineman S,Schiding JK,Franicola D,Memarzadeh F,Lo W,Marion DW,Dekosky ST

更新日期：1999-07-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) is commonly observed in military service members with mild traumatic brain injury (mTBI); however, the relationship between mTBI and PTSD is complex and not well understood. The present study aims to elucidate a link between the degree of alteration in limbic system-related white ...

journal_title：Journal of neurotrauma

authors： Santhanam P,Teslovich T,Wilson SH,Yeh PH,Oakes TR,Weaver LK

更新日期：2019-04-01 00:00:00

abstract：:A critical component for accelerating the clinical uptake of research data in the area of pediatric concussion or mild traumatic brain injury (MTBI) pertains to the establishment and utilization of common databases. The objective of the first phase of our CanPedCDE initiative was to agree upon pediatric common data el...

journal_title：Journal of neurotrauma

authors： Gagnon I,Friedman D,Beauchamp MH,Christie B,DeMatteo C,Macartney G,McFadyen BJ,Sirois K,Taneja C,Zabjek K,Zemek R,Mrazik M

更新日期：2018-08-15 00:00:00

abstract：:Restraint stress (RS) protects auditory function against acoustic trauma by activating glucocorticoid receptors (GR) in the cochlea. In a search for the signaling pathways downstream to GR that may be involved in RS-induced protection we report here (1) a downregulation of phosphorylated extracellular signal-regulated...

journal_title：Journal of neurotrauma

authors： Meltser I,Tahera Y,Canlon B

更新日期：2009-10-01 00:00:00

abstract：:Striking gender differences have been reported in the pathophysiology and outcome of acute neurological injury. Greater neuroprotection in females versus males may be due, in part, to direct and indirect sex hormone-mediated antioxidant mechanisms. Progesterone administration decreases brain levels of F(2)-isoprostane...

journal_title：Journal of neurotrauma

authors： Bayir H,Marion DW,Puccio AM,Wisniewski SR,Janesko KL,Clark RS,Kochanek PM

更新日期：2004-01-01 00:00:00

abstract：:Cognitive deficits are the most enduring and disabling sequelae of human traumatic brain injury (TBI), but quantifying the magnitude, duration, and pattern of cognitive deficits produced by different types of TBI has received little emphasis in preclinical animal models. The objective of the present study was to use a...

journal_title：Journal of neurotrauma

authors： Lindner MD,Plone MA,Cain CK,Frydel B,Francis JM,Emerich DF,Sutton RL

更新日期：1998-03-01 00:00:00

abstract：:Mild traumatic brain injury (mTBI) disrupts hippocampal function and can lead to long-lasting episodic memory impairments. The encoding of episodic memories relies on spatial information processing within the hippocampus. As the primary entry point for spatial information into the hippocampus, the dentate gyrus is tho...

journal_title：Journal of neurotrauma

authors： Folweiler KA,Samuel S,Metheny HE,Cohen AS

更新日期：2018-06-01 00:00:00

abstract：:After experimental traumatic brain injury (TBI), calcineurin is upregulated; blocking calcineurin is associated with improved outcomes. In humans, variation in the calcineurin A-gamma gene (PPP3CC) has been associated with neuropsychiatric disorders, though any role in TBI recovery remains unknown. This study examines...

journal_title：Journal of neurotrauma

authors： Osier ND,Bales JW,Pugh B,Shin S,Wyrobek J,Puccio AM,Okonkwo DO,Ren D,Alexander S,Conley YP,Dixon CE

更新日期：2017-01-01 00:00:00

abstract：:This study examines the effects of combination therapy of collagen scaffolds and human marrow stromal cells (hMSCs) on the expression of tissue plasminogen activator (tPA) after traumatic brain injury (TBI) in rats. Adult male Wistar rats (n=48) were injured with controlled cortical impact and treated either with scaf...

journal_title：Journal of neurotrauma

authors： Mahmood A,Qu C,Ning R,Wu H,Goussev A,Xiong Y,Irtenkauf S,Li Y,Chopp M

更新日期：2011-07-01 00:00:00

abstract：:Posttraumatic ischemia appears to be largely responsible for the extension of lesions in acute injury of the spinal cord. In the present study, we have evaluated the putative improvement of axonal function by the calcium channel blocker nimodipine after acute trauma of the spinal cord. Three techniques were used: (1) ...

journal_title：Journal of neurotrauma

authors： Pointillart V,Gense D,Gross C,Bidabé AM,Gin AM,Rivel J,Caillé JM,Sénégas J

更新日期：1993-07-01 00:00:00

abstract：:The objective of this study was to determine whether clinically significant ocular trauma can be induced by a survivable isolated primary blast using a live animal model. Both eyes of 18 Dutch Belted rabbits were exposed to various survivable low-level blast overpressures in a large-scale shock tube simulating a prima...

journal_title：Journal of neurotrauma

authors： Jones K,Choi JH,Sponsel WE,Gray W,Groth SL,Glickman RD,Lund BJ,Reilly MA

更新日期：2016-07-01 00:00:00

abstract：:While autonomic dysreflexia (AD) is well recognized in the chronic stage of spinal cord injury (SCI) this potentially life-threatening complication has been only rarely documented in the acute phase (1 month) after SCI. Based on our clinical experience we hypothesized that AD is under-recognized in the acute phase of ...

journal_title：Journal of neurotrauma

authors： Krassioukov AV,Furlan JC,Fehlings MG

更新日期：2003-08-01 00:00:00

abstract：:Ischemic insults to the brain in stroke or traumatic brain injury produce excessive release of glutamate from depolarized nerve terminals. This excessive glutamate release in turn stimulates massive calcium entry into nerve cells, activating a biochemical cascade that results in cell death. A major pathway of calcium ...

journal_title：Journal of neurotrauma

authors： McBurney RN,Daly D,Fischer JB,Hu LY,Subbarao K,Knapp AG,Kobayashi K,Margolin L,Reddy NL,Goldin SM

更新日期：1992-05-01 00:00:00

abstract：:Bone marrow stromal cells (BMSC) transplanted into the contused spinal cord may support repair by improving tissue sparing. We injected allogeneic BMSC into the moderately contused adult rat thoracic spinal cord at 15 min (acute) and at 3, 7, and 21 days (delayed) post-injury and quantified tissue sparing and BMSC sur...

journal_title：Journal of neurotrauma

authors： Nandoe Tewarie RD,Hurtado A,Ritfeld GJ,Rahiem ST,Wendell DF,Barroso MM,Grotenhuis JA,Oudega M

更新日期：2009-12-01 00:00:00

abstract：:Secondary insults, such as hemorrhagic shock (HS), worsen outcome from traumatic brain injury (TBI). Both TBI and HS modulate levels of inflammatory mediators. We evaluated the addition of HS on the inflammatory response to TBI. Adult male C57BL6J mice were randomized into five groups (n=4 [naïve] or 8/group): naïve; ...

journal_title：Journal of neurotrauma

authors： Shein SL,Shellington DK,Exo JL,Jackson TC,Wisniewski SR,Jackson EK,Vagni VA,Bayır H,Clark RS,Dixon CE,Janesko-Feldman KL,Kochanek PM

更新日期：2014-08-15 00:00:00

abstract：:Closed head injury often has a devastating outcome, partly because the insult, like other injuries to the central nervous system (CNS), triggers self-destructive processes. During studies of the response to other CNS insults, it was unexpectedly discovered that the immune system, if well controlled, provides protectio...

journal_title：Journal of neurotrauma

authors： Kipnis J,Nevo U,Panikashvili D,Alexandrovich A,Yoles E,Akselrod S,Shohami E,Schwartz M

更新日期：2003-06-01 00:00:00