Intrathecal gadolinium-enhanced magnetic resonance cisternography in cerebrospinal fluid rhinorrhea: road ahead?

abstract：:We have investigated time course and characteristics of retinal ganglion cell (RGC) death after partial optic nerve injury. In situ end labeling of DNA fragments with the terminal deoxynucleotidyl transferase (TdT)-mediated deoxyuridine (dUTP)-biotin nick end labeling (TUNEL) method revealed the presence of apoptotic ...

journal_title：Journal of neurotrauma

authors： Bien A,Seidenbecher CI,Böckers TM,Sabel BA,Kreutz MR

更新日期：1999-02-01 00:00:00

abstract：:Coagulopathy is a common phenomenon in traumatic brain injury (TBI) and a major contributor to a poor outcome. Thrombocytopenia is a strong negative prognostic factor in TBI, but bleeding tendency can be present even with a normal platelet count. We investigated platelet function in patients with TBI by means of modif...

journal_title：Journal of neurotrauma

authors： Nekludov M,Bellander BM,Blombäck M,Wallen HN

更新日期：2007-11-01 00:00:00

abstract：:Acute subdural hematoma (ASDH) is associated with high morbidity and mortality. Whether the volume effect of the hematoma and increase of intracranial pressure (ICP) or the local effect of blood are responsible for this severe pathophysiology is unclear. Therefore, we compared subdural infusion of autologous blood and...

journal_title：Journal of neurotrauma

authors： Jussen D,Krenzlin H,Papaioannou C,Ens S,Kempski O,Alessandri B

更新日期：2017-02-15 00:00:00

abstract：:The optimum spinal cord perfusion pressure (SCPP) after traumatic spinal cord injury (TSCI) is unknown. Here, we describe techniques to compute and display the optimum SCPP in real time. We recruited adults within 72 h of severe TSCI (American Spinal Injuries Association [ASIA] grades A-C). A pressure probe and a micr...

journal_title：Journal of neurotrauma

authors： Chen S,Smielewski P,Czosnyka M,Papadopoulos MC,Saadoun S

更新日期：2017-11-01 00:00:00

abstract：:Carbon dioxide is perhaps the most potent available modulator of cerebrovascular tone and thus cerebral blood flow (CBF). These experiments evaluate the impact of induced hypercarbia on the matching of blood flow and metabolism in the injured brain. We explore the hypothesis that hypercarbia will restore the relations...

journal_title：Journal of neurotrauma

authors： Glass TF,Fabian MJ,Schweitzer JB,Weinberg JA,Proctor KG

更新日期：2001-01-01 00:00:00

abstract：:Return to living at home is an important patient-reported outcome following traumatic spinal cord injury (tSCI). Specialized inpatient rehabilitation assists such patients in maximizing function and independence. Our project aim was to describe those patients receiving specialized rehabilitation after tSCI in Canada, ...

journal_title：Journal of neurotrauma

authors： Cheng CL,Plashkes T,Shen T,Fallah N,Humphreys S,O'Connell C,Linassi AG,Ho C,Short C,Ethans K,Charbonneau R,Paquet J,Noonan VK

更新日期：2017-10-15 00:00:00

abstract：:Posttraumatic ischemia appears to be largely responsible for the extension of lesions in acute injury of the spinal cord. In the present study, we have evaluated the putative improvement of axonal function by the calcium channel blocker nimodipine after acute trauma of the spinal cord. Three techniques were used: (1) ...

journal_title：Journal of neurotrauma

authors： Pointillart V,Gense D,Gross C,Bidabé AM,Gin AM,Rivel J,Caillé JM,Sénégas J

更新日期：1993-07-01 00:00:00

abstract：:Anesthetics can either promote or inhibit the development of neurogenic pulmonary edema (NPE) after central nervous system (CNS) injury. The influence of isoflurane was examined in male Wistar rats using 1.5%, 2%, 2.5%, 3%, 4%, or 5% isoflurane in air. Epidural balloon compression of the thoracic spinal cord was perfo...

journal_title：Journal of neurotrauma

authors： Sedý J,Urdzíková L,Likavcanová K,Hejcl A,Burian M,Jendelová P,Zicha J,Kunes J,Syková E

更新日期：2007-09-01 00:00:00

abstract：:Hippocampal-dependent deficits in learning and memory formation are a prominent feature of traumatic brain injury (TBI); however, the role of the hippocampus in cognitive dysfunction after concussion (mild TBI) is unknown. We therefore investigated functional and structural changes in the swine hippocampus following T...

journal_title：Journal of neurotrauma

authors： Wolf JA,Johnson BN,Johnson VE,Putt ME,Browne KD,Mietus CJ,Brown DP,Wofford KL,Smith DH,Grady MS,Cohen AS,Cullen DK

更新日期：2017-07-15 00:00:00

abstract：:A new experimental model was developed to induce diffuse brain injury (DBI) in rats through pure coronal plane angular acceleration. An impactor was propelled down a guide tube toward the lateral extension of the helmet fixture. Upon impactor-helmet contact, helmet and head were constrained to rotate in the coronal pl...

journal_title：Journal of neurotrauma

authors： Fijalkowski RJ,Stemper BD,Pintar FA,Yoganandan N,Crowe MJ,Gennarelli TA

更新日期：2007-08-01 00:00:00

abstract：:Prognostic biomarkers for post-injury outcome are necessary for the development of neuroprotective and antiepileptogenic treatments for traumatic brain injury (TBI). We hypothesized that T2 relaxation magnetic resonance imaging (MRI) predicts the progression of perilesional cortical pathology and epileptogenesis. The ...

journal_title：Journal of neurotrauma

authors： Manninen E,Chary K,Lapinlampi N,Andrade P,Paananen T,Sierra A,Tohka J,Gröhn O,Pitkänen A

更新日期：2020-12-01 00:00:00

abstract：:Studies have shown reduced life expectancy following moderate-severe traumatic brain injury (TBI) with death from unintentional poisoning (UP) being 11 times higher following TBI than in the general population. The characteristics of those who die of unintentional poisoning are compared with the characteristics of tho...

journal_title：Journal of neurotrauma

authors： Hammond FM,Ketchum J,Dams-O'Connor K,Corrigan JD,Miller C,Haarbauer-Krupa J,Faul M,Trexler LE,Harrison-Felix C

更新日期：2020-12-01 00:00:00

abstract：:Previous meta-analyses of methylprednisolone (MPS) for patients with acute traumatic spinal cord injuries (TSCIs) have not addressed confidence in the quality of evidence used for pooled effect estimates, and new primary studies have been recently published. We aimed to determine whether MPS improves motor recovery an...

journal_title：Journal of neurotrauma

authors： Evaniew N,Belley-Côté EP,Fallah N,Noonan VK,Rivers CS,Dvorak MF

更新日期：2016-03-01 00:00:00

abstract：:Diagnosis and treatment of stroke and traumatic brain injury remain significant health care challenges to society. Patient care stands to benefit from an improved understanding of the interactive biochemistry underlying neurotrauma pathobiology. In this study, we assessed the power of neuroproteomics to contrast bioch...

journal_title：Journal of neurotrauma

authors： Ottens AK,Bustamante L,Golden EC,Yao C,Hayes RL,Wang KK,Tortella FC,Dave JR

更新日期：2010-10-01 00:00:00

abstract：:The purpose of this paper is to present results from methodologies used in our laboratory that are targeted toward identifying specific brain injury thresholds. Results from studying one form of brain injury, diffuse axonal injury, are presented in this report. Physical models, or surrogates, of the skull-brain comple...

journal_title：Journal of neurotrauma

authors： Meaney DF,Smith DH,Shreiber DI,Bain AC,Miller RT,Ross DT,Gennarelli TA

更新日期：1995-08-01 00:00:00

abstract：:We have shown previously that fresh frozen plasma (FFP) and lyophilized plasma (LP) decrease brain lesion size and improve neurological recovery in a swine model of traumatic brain injury (TBI) and hemorrhagic shock (HS). In this study, we examine whether these findings can be validated in a clinically relevant model ...

journal_title：Journal of neurotrauma

authors： Georgoff PE,Nikolian VC,Halaweish I,Chtraklin K,Bruhn PJ,Eidy H,Rasmussen M,Li Y,Srinivasan A,Alam HB

更新日期：2017-07-01 00:00:00

abstract：:An increasing number of therapies for spinal cord injury (SCI) are emerging from the laboratory and seeking translation into human clinical trials. Many of these are administered as soon as possible after injury with the hope of attenuating secondary damage and maximizing the extent of spared neurologic tissue. In thi...

journal_title：Journal of neurotrauma

authors： Kwon BK,Okon EB,Plunet W,Baptiste D,Fouad K,Hillyer J,Weaver LC,Fehlings MG,Tetzlaff W

更新日期：2011-08-01 00:00:00

abstract：:Traumatic brain injury (TBI) results in an accumulation of edema and loss of brain tissue. Progesterone (PROG) has been reported to reduce edema and cortical tissue loss in a bilateral prefrontal cortex injury. This study tests the hypothesis that PROG is neuroprotective following a unilateral parietal cortical contus...

journal_title：Journal of neurotrauma

authors： Gilmer LK,Roberts KN,Scheff SW

更新日期：2008-06-01 00:00:00

abstract：:Neuropathic pain develops in 40-70% of spinal cord injury (SCI) patients and markedly compromises quality of life. We examined plasma from SCI patients for autoantibodies to glial fibrillary acidic protein (GFAP) and collapsin response mediator protein-2 (CRMP2) and evaluated their relationship to the development of n...

journal_title：Journal of neurotrauma

authors： Hergenroeder GW,Redell JB,Choi HA,Schmitt L,Donovan W,Francisco GE,Schmitt K,Moore AN,Dash PK

更新日期：2018-11-01 00:00:00

abstract：:Over the last decade, biomarker research has identified potential biomarkers for the diagnosis, prognosis, and management of traumatic brain injury (TBI). Several cerebrospinal fluid (CSF) and serum biomarkers have shown promise in predicting long-term outcome after severe TBI. Despite this increased focus on identify...

journal_title：Journal of neurotrauma

authors： Niyonkuru C,Wagner AK,Ozawa H,Amin K,Goyal A,Fabio A

更新日期：2013-06-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) play a key role in tissue repair and regeneration. Previous studies have shown a positive correlation between the number of circulating EPCs and clinical outcomes of patients with traumatic brain injury (TBI). A recent study has further shown that intravenous infusion of human umbil...

journal_title：Journal of neurotrauma

authors： Huang XT,Zhang YQ,Li SJ,Li SH,Tang Q,Wang ZT,Dong JF,Zhang JN

更新日期：2013-12-15 00:00:00

abstract：:The detection of reactive oxygen species (ROS) after traumatic brain injury (TBI) is based on indirect methods due to the high reactivity and short half-life of ROS in biological tissue. The commonly used salicylate trapping method has several disadvantages making it unsuitable for human use. We have evaluated 4-hydro...

journal_title：Journal of neurotrauma

authors： Marklund N,Clausen F,Lewander T,Hillered L

更新日期：2001-11-01 00:00:00

abstract：:The International Mission on Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) and Corticoid Randomisation After Significant Head injury (CRASH) prognostic models predict functional outcome after moderate and severe traumatic brain injury (TBI). We aimed to assess their performance in a cont...

journal_title：Journal of neurotrauma

authors： Dijkland SA,Helmrich IRAR,Nieboer D,van der Jagt M,Dippel DWJ,Menon DK,Stocchetti N,Maas AIR,Lingsma HF,Steyerberg EW,CENTER-TBI Participants and Investigators.

更新日期：2020-12-14 00:00:00

abstract：:Diffuse axonal injury is recognized as a progressive and long-term consequence of traumatic brain injury. Axonal injury can have sustained negative consequences on neuronal functions such as anterograde and retrograde transport and cellular processes such as autophagy that depend on cytoarchitecture and axon integrity...

journal_title：Journal of neurotrauma

authors： Hensley K,Poteshkina A,Johnson MF,Eslami P,Gabbita SP,Hristov AM,Venkova-Hristova KM,Harris-White ME

更新日期：2016-08-15 00:00:00

abstract：:Here we investigate the effect of hypothermia on the expression of apoptosis-regulating protein TIMP-3 after fluid percussion traumatic brain injury (TBI) in rats. We began with 210 adult male Sprague-Dawley rats and randomly assigned them to three groups: TBI with hypothermia treatment (32°C), TBI with normothermia (...

journal_title：Journal of neurotrauma

authors： Jia F,Mao Q,Liang YM,Jiang JY

更新日期：2014-02-15 00:00:00

abstract：:Although chronic sleepiness is common after head trauma, the cause remains unclear. Transcranial magnetic stimulation (TMS) represents a useful complementary approach in the study of sleep pathophysiology. We aimed to determine in this study whether post-traumatic sleep-wake disturbances (SWD) are associated with chan...

journal_title：Journal of neurotrauma

authors： Nardone R,Bergmann J,Kunz A,Caleri F,Seidl M,Tezzon F,Gerstenbrand F,Trinka E,Golaszewski S

更新日期：2011-07-01 00:00:00

abstract：:Cytokine measurement directly from the brain parenchyma by means of microdialysis has documented the activation of certain procedures in vivo, after brain trauma in humans. However, the intercalation of the micro-catheter insertion with the phenomena triggered by the head trauma renders the assessment of the findings ...

journal_title：Journal of neurotrauma

authors： Bouras TI,Gatzonis SS,Georgakoulias N,Karatza M,Sianouni A,Stranjalis G,Boviatsis E,Vasileiou S,Sakas DE

更新日期：2011-11-18 00:00:00

abstract：:We conducted a study to evaluate the degree of corticospinal tract (CST) dysfunction associated with diffuse axonal injury (DAI) through analyses of both diffusion-tensor magnetic resonance imaging (DTMRI) and motor-evoked potential (MEP). Using DTMRI and MEP with transcranial magnetic stimulation, we evaluated 138 in...

journal_title：Journal of neurotrauma

authors： Yasokawa YT,Shinoda J,Okumura A,Nakayama N,Miwa K,Iwama T

更新日期：2007-01-01 00:00:00

abstract：:Remarkable advances have been made in pharmacologic treatments of acute and chronic spinal cord injury. The recent National Acute Spinal Cord Injury Study (NASCIS) showed that very high dose methylprednisolone given within 8 hr after injury improves neurologic recovery. The mechanism is believed to be inhibition of li...

journal_title：Journal of neurotrauma

authors： Nockels R,Young W

更新日期：1992-03-01 00:00:00

abstract：:Severe traumatic brain injury (TBI) results in significant functional disturbances in the hippocampus. Studies support that sodium cromoglycate (CG) induces neuroprotective effects. This study focused on investigating the effects of post-TBI subchronic administration of CG on hippocampal hyperexcitability and damage a...

journal_title：Journal of neurotrauma

authors： Segovia-Oropeza M,Santiago-Castañeda C,Orozco-Suárez SA,Concha L,Rocha L

更新日期：2020-12-01 00:00:00