Abstract：
:Return to living at home is an important patient-reported outcome following traumatic spinal cord injury (tSCI). Specialized inpatient rehabilitation assists such patients in maximizing function and independence. Our project aim was to describe those patients receiving specialized rehabilitation after tSCI in Canada, and to determine if such rehabilitation improved the likelihood of returning home. This cohort study utilized data from the Rick Hansen Spinal Cord Injury Registry (RHSCIR) to identify patients with tSCI discharged from 1 of 18 participating acute specialized spine facilities between 2011 and 2015 to either 1 of 13 participating specialized rehabilitation facilities, or to another discharge destination. To determine if specialized rehabilitation affected likelihood of returning home, multiple logistic regressions and propensity score matchings were performed to account for age at injury, gender, neurological severity and level, acute length of stay (LOS), and region of residence. The χ2 test was used to compare rate of return home between matched groups. Of the 1599 patients included, 71% received specialized rehabilitation. Receiving specialized rehabilitation was a significant and strong predictor of return to home after controlling for covariates (adjusted odds ratio = 3.1; 95% confidence interval [CI], 1.6-5.9). The rate of return to home was significantly higher in the matched rehabilitation group than the no rehabilitation group (98% vs. 87%, p = 0.0004). For the matched patients, an extra 11 patients returned home for every 100 patients receiving specialized rehabilitation. However, effect of age on returning home requires further investigation. Improving access to specialized rehabilitation could potentially reduce discharges to nursing homes or other non-home destinations.
journal_name
J Neurotraumajournal_title
Journal of neurotraumaauthors
Cheng CL,Plashkes T,Shen T,Fallah N,Humphreys S,O'Connell C,Linassi AG,Ho C,Short C,Ethans K,Charbonneau R,Paquet J,Noonan VKdoi
10.1089/neu.2016.4930subject
Has Abstractpub_date
2017-10-15 00:00:00pages
2867-2876issue
20eissn
0897-7151issn
1557-9042journal_volume
34pub_type
杂志文章abstract：:This article addresses the need for age-relevant outcome measures for traumatic brain injury (TBI) research and summarizes the recommendations by the inter-agency Pediatric TBI Outcomes Workgroup. The Pediatric Workgroup's recommendations address primary clinical research objectives including characterizing course of ...
journal_title：Journal of neurotrauma
pub_type： 杂志文章,实务指引
doi：10.1089/neu.2011.1838
更新日期：2012-03-01 00:00:00
abstract：:Sixty-eight patients were entered into a randomized, prospective, double-blinded controlled trial of supplemental zinc versus standard zinc therapy to study the effects of zinc supplementation on neurologic recovery and nutritional/metabolic status after severe closed head injury. One month after injury, the mortality...
journal_title：Journal of neurotrauma
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1089/neu.1996.13.25
更新日期：1996-01-01 00:00:00
abstract：:Remarkable advances have been made in pharmacologic treatments of acute and chronic spinal cord injury. The recent National Acute Spinal Cord Injury Study (NASCIS) showed that very high dose methylprednisolone given within 8 hr after injury improves neurologic recovery. The mechanism is believed to be inhibition of li...
journal_title：Journal of neurotrauma
pub_type： 杂志文章,评审
doi：
更新日期：1992-03-01 00:00:00
abstract：:Inflammatory cellular responses to brain injury are promoted by proinflammatory messengers. Cyclooxygenases (prostaglandin endoperoxide H synthases [PGH]) are key enzymes in the conversion of arachidonic acid into prostanoids, which mediate immunomodulation, mitogenesis, apoptosis, blood flow, secondary injury (lipid ...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/089771501750451802
更新日期：2001-09-01 00:00:00
abstract：:Recovery of fine motor skills after traumatic brain injury (TBI) is variable, with some patients showing progressive improvements over time while others show poor recovery. We therefore studied possible cellular mechanisms accompanying the recovery process in a non-human primate model system, in which the lateral fron...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2009.0966
更新日期：2010-03-01 00:00:00
abstract：:Pediatric traumatic brain injury (TBI) research depends on comparisons of profiles and outcomes between brain-injured individuals and groups consisting either of injured controls (e.g., orthopedic injuries, OI) or uninjured, typically developing children recruited from the community (community controls, CC). Children ...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2016.4868
更新日期：2017-09-01 00:00:00
abstract：:Chronic pain and dysesthesias are debilitating conditions that can arise following spinal cord injury (SCI). Research studies frequently employ rodent models of SCI to better understand the underlying mechanisms and develop better treatments for these phenomena. While evoked withdrawal tests can assess hypersensitivit...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2009.1182
更新日期：2010-05-01 00:00:00
abstract：:Clinical studies have documented the importance of secondary brain insults in determining neurologic outcome after head injury. Delayed intracranial hematomas are one of the most easily remediable causes of secondary injury if identified early, but can cause significant disability or death if not promptly recognized a...
journal_title：Journal of neurotrauma
pub_type： 杂志文章,评审
doi：10.1089/neu.1995.12.591
更新日期：1995-08-01 00:00:00
abstract：:Visual dysfunction is a common occurrence after traumatic brain injury (TBI). We investigated in this study effects of single or multiple mild TBI on visual function in mice using a closed head injury model that permits unconstrained head movement after impact. Adult mice were briefly anesthetized with isoflurane and ...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2019.6602
更新日期：2020-01-15 00:00:00
abstract：:Neuroprotection, recovery of function, and gene expression were evaluated in an animal model of traumatic brain injury (TBI) after a combination treatment of nicotinamide (NAM) and progesterone (Prog). Animals received a cortical contusion injury over the sensorimotor cortex, and were treated with either Vehicle, NAM,...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2014.3530
更新日期：2015-06-01 00:00:00
abstract：:Posttraumatic ischemia appears to be largely responsible for the extension of lesions in acute injury of the spinal cord. In the present study, we have evaluated the putative improvement of axonal function by the calcium channel blocker nimodipine after acute trauma of the spinal cord. Three techniques were used: (1) ...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.1993.10.201
更新日期：1993-07-01 00:00:00
abstract：:The degree of post-traumatic brain edema and dysfunction of the blood-brain barrier (BBB) influences the neurofunctional outcome after a traumatic brain injury (TBI). Previous studies have demonstrated that the administration of apolipoprotein E-mimetic peptide COG1410 reduces the brain water content after subarachnoi...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2015.3887
更新日期：2016-01-15 00:00:00
abstract：:The Glasgow Coma Scale (GCS) was introduced 40 years ago and has received world-wide acceptance. The GCS rates eye, motor, and verbal responses to assess the level of consciousness. Concerns have been expressed with regard to reliability and consistency of assessments. We considered that lack of standardization in app...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2014.3843
更新日期：2016-01-01 00:00:00
abstract：:Patients with spinal cord injury (SCI) typically experience body weight loss, motor function deficits, and a general decline of physical fitness. Animal models with these characteristics can serve to study the detailed adaptive changes following SCI. In the present study, we report the use of an adult paraplegic mouse...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/0897715041651060
更新日期：2004-08-01 00:00:00
abstract：:We have used an in vitro trauma model to examine the effects of modulation of group III metabotropic glutamate receptors (mGluR) on post-traumatic neuronal cell death. Rat cortical neuronal/glial cultures were subjected to standardized mechanical injury using a punch that delivers 28 parallel cuts to 96-well culture p...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.1997.14.885
更新日期：1997-12-01 00:00:00
abstract：:The effectiveness of cerebrospinal fluid (CSF) drainage in lowering high intracranial pressure (ICP) is well established in severe traumatic brain injury (TBI). Recently, however, the use of external ventricular drains (EVDs) and ICP monitors in TBI has come under question. The aim of this retrospective study was to i...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2016.4912
更新日期：2017-11-15 00:00:00
abstract：:Spinal cord injury can have a range of debilitating effects, permanently impacting a patient's quality of life. Initially thought to be an immune privileged site, the spinal cord is able to mount a timely and well organized inflammatory response to injury. Intricate immune cell interactions are triggered, typically co...
journal_title：Journal of neurotrauma
pub_type： 杂志文章,评审
doi：10.1089/neu.2014.3429
更新日期：2014-11-01 00:00:00
abstract：:An increasing number of therapies for spinal cord injury (SCI) are emerging from the laboratory and seeking translation into human clinical trials. Many of these are administered as soon as possible after injury with the hope of attenuating secondary damage and maximizing the extent of spared neurologic tissue. In thi...
journal_title：Journal of neurotrauma
pub_type： 杂志文章,评审
doi：10.1089/neu.2009.1150
更新日期：2011-08-01 00:00:00
abstract：:Protection against the progression of secondary injury appears to be an effective therapeutic strategy in spinal cord injury (SCI). Evidence indicates that nicotine can induce potent neuroprotective effects against injury to spinal cord neurons. Therefore, the present study was focused on the effects of nicotine on th...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2005.22.240
更新日期：2005-02-01 00:00:00
abstract：:Recent calls have been made for the inclusion of health-related quality of life (HRQoL) in traumatic brain injury studies. This study reports the impact of TBI on traditional measures (general health, depression, social isolation, labor force participation), self-assessed health function status using the SF-36 version...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2008.0735
更新日期：2009-10-01 00:00:00
abstract：:Sensorimotor recovery after spinal cord injury (SCI) is of utmost importance to injured individuals and will rely on improved understanding of SCI pathology and recovery. Novel transgenic mouse lines facilitate discovery, but must be understood to be effective. The purpose of this study was to characterize the sensory...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2017.5395
更新日期：2018-09-15 00:00:00
abstract：:The current lack of diagnostic and prognostic biomarkers for traumatic brain injury (TBI) confounds treatment and management of patients and is of increasing concern as the TBI population grows. We have generated plasma proteomic profiles from mice receiving TBI by controlled cortical impact at either 1.3 mm or 1.8 mm...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2011.1789
更新日期：2012-01-20 00:00:00
abstract：:Here we investigate the effect of hypothermia on the expression of apoptosis-regulating protein TIMP-3 after fluid percussion traumatic brain injury (TBI) in rats. We began with 210 adult male Sprague-Dawley rats and randomly assigned them to three groups: TBI with hypothermia treatment (32°C), TBI with normothermia (...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2008.0814
更新日期：2014-02-15 00:00:00
abstract：:Traumatic brain injury (TBI) is a major health problem causing disability and death worldwide. There is no effective treatment, due in part to the complexity of the injury pathology and factors affecting its outcome. The extent of brain injury depends on the type of insult, age, sex, lifestyle, genetic risk factors, s...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2019.6955
更新日期：2020-03-01 00:00:00
abstract：:Previous studies have shown that location and direction of injury may affect outcome in experimental models of traumatic brain injury. Significant variability in outcome data has also been noted in studies using the lateral fluid percussion brain injury model (FPI) in rats. In recent studies from our laboratory, we ob...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/089771501316919201
更新日期：2001-08-01 00:00:00
abstract：:Magnetic resonance imaging data were acquired at ∼24 h and ∼3 months post-injury on mild traumatic brain injury (mTBI; n = 75) and orthopedic injury (n = 60) cohorts. The mTBI subjects were randomly assigned to a treatment group with atorvastatin or a non-treatment mTBI group. The treatment group was further divided i...
journal_title：Journal of neurotrauma
pub_type： 杂志文章,随机对照试验
doi：10.1089/neu.2015.4253
更新日期：2016-10-15 00:00:00
abstract：:The detection of reactive oxygen species (ROS) after traumatic brain injury (TBI) is based on indirect methods due to the high reactivity and short half-life of ROS in biological tissue. The commonly used salicylate trapping method has several disadvantages making it unsuitable for human use. We have evaluated 4-hydro...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/089771501317095250
更新日期：2001-11-01 00:00:00
abstract：:This study aimed to investigate the cortical motor excitability characteristics in diffuse axonal injury (DAI) due to severe traumatic brain injury (TBI). A variety of excitatory and inhibitory transcranial magnetic stimulation (TMS) paradigms were applied to primary motor cortices of 17 patients and 11 healthy contro...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2008.0859
更新日期：2009-12-01 00:00:00
abstract：:Traumatic brain injury (TBI) causes damage to the hypothalamo-hypophyseal axis, leading to endocrine dysregulation in up to 40% of TBI patients. Hence, there is an urgent need to identify non-invasive biomarkers for TBI-associated hypothalamo-hypophyseal pathology. Sushi repeat-containing protein X-linked 2 (SRPX2) is...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.2019.6739
更新日期：2020-04-01 00:00:00
abstract：:In human diffuse axonal injury (DAI), axons are exposed to transient tensile strain. Over the ensuing several hours, injured axons enter a "pathological cascade" of events that lead to secondary axotomy. Use of animal models of traumatic axonal injury (TAI) has allowed description of a number of pathological changes b...
journal_title：Journal of neurotrauma
pub_type： 杂志文章
doi：10.1089/neu.1999.16.1225
更新日期：1999-12-01 00:00:00
