Multiple Mild Traumatic Brain Injuries Lead to Visual Dysfunction in a Mouse Model.

Abstract:

:Visual dysfunction is a common occurrence after traumatic brain injury (TBI). We investigated in this study effects of single or multiple mild TBI on visual function in mice using a closed head injury model that permits unconstrained head movement after impact. Adult mice were briefly anesthetized with isoflurane and given one or three mild TBI with the closed head injury by mechanically engineered rotational acceleration (CHIMERA) device with an interinjury interval of 24 h. Mice were then tested in the Morris water maze, visual cliff, and open field tests from day 19 to day 32 and for visual evoked potential at 5 weeks after the last injury and euthanized. Mice with multiple TBI showed impaired performance in the visible platform water maze test and had increased errors in the visual cliff test. Further, there was a graded difference in visual evoked potential, with the single injury mice showing modest reduction in N1 amplitude whereas the multiple injuries produced significant reduction compared to sham and single injury groups. The optic tract of the injured mice showed increases in glial cell immunostaining. The increase in glial fibrillary acid protein immunostaining reached statistical significance for both injured groups whereas the ionized calcium binding adaptor molecule 1 immunostaining was only significantly increased in the optic tract of repeatedly injured mice. These results indicate that multiple injuries using CHIMERA may result in visual deficits, which can affect certain behavioral performances. The change in vision may be a useful marker when monitoring repeated TBI outcome and screening for protective agents from TBI.

journal_name

J Neurotrauma

journal_title

Journal of neurotrauma

authors

Desai A,Chen H,Kim HY

doi

10.1089/neu.2019.6602

subject

Has Abstract

pub_date

2020-01-15 00:00:00

pages

286-294

issue

2

eissn

0897-7151

issn

1557-9042

journal_volume

37

pub_type

杂志文章
  • Transcriptional Changes in the Mouse Retina after Ocular Blast Injury: A Role for the Immune System.

    abstract::Ocular blast injury is a major medical concern for soldiers and explosion victims due to poor visual outcomes. To define the changes in gene expression following a blast injury to the eye, we examined retinal ribonucleic acid (RNA) expression in 54 mouse strains 5 days after a single 50-psi overpressure air wave blast...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2017.5104

    authors: Struebing FL,King R,Li Y,Chrenek MA,Lyuboslavsky PN,Sidhu CS,Iuvone PM,Geisert EE

    更新日期:2018-01-01 00:00:00

  • Diffusion tensor imaging findings in semi-acute mild traumatic brain injury.

    abstract::The past 10 years have seen a rapid increase in the use of diffusion tensor imaging to identify biomarkers of traumatic brain injury (TBI). Although the literature generally indicates decreased anisotropic diffusion at more chronic injury periods and in more severe injuries, considerable debate remains regarding the d...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章,评审

    doi:10.1089/neu.2014.3337

    authors: Dodd AB,Epstein K,Ling JM,Mayer AR

    更新日期:2014-07-15 00:00:00

  • Activation of JNK in the inner ear following impulse noise exposure.

    abstract::Noise exposure is known to induce cell death signaling in the cochlea. Since c-Jun N-terminal kinase (JNK) signaling is known to induce both cell survival and apoptosis, the present study focused on early changes (within 24 h) after impulse noise exposure, inquiring whether cell death is always related to phosphorylat...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2007.0346

    authors: Murai N,Kirkegaard M,Järlebark L,Risling M,Suneson A,Ulfendahl M

    更新日期:2008-01-01 00:00:00

  • The long-term effects of sports concussion on retired Australian football players: a study using transcranial magnetic stimulation.

    abstract::This study investigated corticomotor excitability and inhibition, cognitive functioning, and fine motor dexterity in retired elite and amateur Australian football (AF) players who had sustained concussions during their playing careers. Forty male AF players who played at the elite level (n=20; mean age 49.7±5.7 years)...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2013.3219

    authors: Pearce AJ,Hoy K,Rogers MA,Corp DT,Maller JJ,Drury HG,Fitzgerald PB

    更新日期:2014-07-01 00:00:00

  • Androgen regulates neuritin mRNA levels in an in vivo model of steroid-enhanced peripheral nerve regeneration.

    abstract::Following crush injury to the facial nerve in Syrian hamsters, treatment with androgens enhances axonal regeneration rates and decreases time to recovery. It has been demonstrated in vitro that the ability of androgen to enhance neurite outgrowth in motoneurons is dependent on neuritin-a protein that is involved in th...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2007.0466

    authors: Fargo KN,Alexander TD,Tanzer L,Poletti A,Jones KJ

    更新日期:2008-05-01 00:00:00

  • The mitochondrial uncoupling agent 2,4-dinitrophenol improves mitochondrial function, attenuates oxidative damage, and increases white matter sparing in the contused spinal cord.

    abstract::The purpose of this study was to investigate the potential neuroprotective efficacy of the mitochondrial uncoupler 2,4-dinitrophenol (DNP) in rats following a mild to moderate spinal cord contusion injury. Animals received intraperitoneal injections of vehicle (DMSO) or 5 mg/mL of DNP prior to injury. Twenty-four hour...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2004.21.1396

    authors: Jin Y,McEwen ML,Nottingham SA,Maragos WF,Dragicevic NB,Sullivan PG,Springer JE

    更新日期:2004-10-01 00:00:00

  • A New Risk Factor for Traumatic Spinal Cord Injury.

    abstract::Several behavioral factors such as violence, impulsivity, and alcohol-related problems are associated with traumatic spinal cord injury (TSCI). Such factors have been associated with inherently low neuronal serotonergic capacity that in turn is reflected in low activity of monoamine oxidase (MAO) as measured in platel...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2016.4462

    authors: Sabre L,Harro J,Eensoo D,Vaht M,Kabel V,Pakkanen M,Asser T,Kõrv J

    更新日期:2016-11-01 00:00:00

  • Alteration in functional brain systems after electrical injury.

    abstract::Neuropsychological studies in electrical injury patients have reported deficits in attention, learning, and working memory, but the neural substrates of these deficits remain poorly characterized. In this study we sought to examine whether electrical injury subjects demonstrate abnormal patterns of brain activation du...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2008.0867

    authors: Ramati A,Pliskin NH,Keedy S,Erwin RJ,Fink JW,Bodnar EN,Lee RC,Cooper MA,Kelley K,Sweeney JA

    更新日期:2009-10-01 00:00:00

  • Caspase pathways, neuronal apoptosis, and CNS injury.

    abstract::Caspases are a family of mammalian proteases related to the ced-3 gene of Caenorhabditis elegans. They mediate many of the morphological and biochemical features of apoptosis, including structural dismantling of cell bodies and nuclei, fragmentation of genomic DNA, destruction of regulatory proteins, and propagation o...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章,评审

    doi:10.1089/neu.2000.17.811

    authors: Eldadah BA,Faden AI

    更新日期:2000-10-01 00:00:00

  • Diminished Dentate Gyrus Filtering of Cortical Input Leads to Enhanced Area Ca3 Excitability after Mild Traumatic Brain Injury.

    abstract::Mild traumatic brain injury (mTBI) disrupts hippocampal function and can lead to long-lasting episodic memory impairments. The encoding of episodic memories relies on spatial information processing within the hippocampus. As the primary entry point for spatial information into the hippocampus, the dentate gyrus is tho...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2017.5350

    authors: Folweiler KA,Samuel S,Metheny HE,Cohen AS

    更新日期:2018-06-01 00:00:00

  • Robotic Rehabilitator of the Rodent Upper Extremity: A System and Method for Assessing and Training Forelimb Force Production after Neurological Injury.

    abstract::Rodent models of spinal cord injury are critical for the development of treatments for upper limb motor impairment in humans, but there are few methods for measuring forelimb strength of rodents, an important outcome measure. We developed a novel robotic device--the Robotic Rehabilitator of the Rodent Upper Extremity ...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2015.3987

    authors: Sharp KG,Duarte JE,Gebrekristos B,Perez S,Steward O,Reinkensmeyer DJ

    更新日期:2016-03-01 00:00:00

  • Morphological characterization of photochemical graded spinal cord injury in the rat.

    abstract::This study characterizes the histological and immunohistochemical changes in the adult rat spinal cord following photochemically induced spinal cord lesions. The spinal cord was exposed by laminectomy (T12-L1 vertebrae) and bathed with 1.5% rose bengal solution for 10 min. The excess dye was removed by saline rinse an...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/089771503765355559

    authors: Verdú E,García-Alías G,Forés J,Vela JM,Cuadras J,López-Vales R,Navarro X

    更新日期:2003-05-01 00:00:00

  • Robotic Assessment of Motor, Sensory, and Cognitive Function in Acute Sport-Related Concussion and Recovery.

    abstract::There is a need for better tools to objectively, reliably, and precisely assess neurological function after sport-related concussion (SRC). The aim of this study was to use a robotic device (Kinesiological Instrument for Normal and Altered Reaching Movements; KINARM) to quantify neurological impairments in athletes ac...

    journal_title:Journal of neurotrauma

    pub_type: 临床试验,杂志文章

    doi:10.1089/neu.2017.5587

    authors: Mang CS,Whitten TA,Cosh MS,Scott SH,Wiley JP,Debert CT,Dukelow SP,Benson BW

    更新日期:2019-01-15 00:00:00

  • Progressive atrophy and neuron death for one year following brain trauma in the rat.

    abstract::Although atrophic changes have been well described following traumatic brain injury (TBI) in humans, little is known concerning the mechanisms or progression of brain tissue loss. In the present study, we evaluated the temporal profile of histopathological changes following parasagittal fluid-percussion (FP) brain inj...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.1997.14.715

    authors: Smith DH,Chen XH,Pierce JE,Wolf JA,Trojanowski JQ,Graham DI,McIntosh TK

    更新日期:1997-10-01 00:00:00

  • Relative risk of mortality after traumatic brain injury: a population-based study of the role of age and injury severity.

    abstract::To test if observed vs. expected mortality differs by age among traumatic brain injury (TBI) cases, a population-based, historical cohort study was conducted in Olmsted County, Minnesota. From all residents with any diagnosis suggestive of TBI 1985-1999, we randomly sampled 7,800 and reviewed their medical records to ...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2006.0119

    authors: Flaada JT,Leibson CL,Mandrekar JN,Diehl N,Perkins PK,Brown AW,Malec JF

    更新日期:2007-03-01 00:00:00

  • Activity-Based Training Reverses Spinal Cord Injury-Induced Changes in Kidney Receptor Densities and Membrane Proteins.

    abstract::Complications in upper and lower urinary function arise after spinal cord injury (SCI), which creates a significant impact on quality of life for those affected. One upper urinary complication is SCI-induced polyuria, or the overproduction of urine, of which the underlying mechanisms have yet to be elucidated. Activit...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2019.6670

    authors: Gumbel JH,Montgomery LR,Yang CB,Hubscher CH

    更新日期:2020-02-01 00:00:00

  • Alterations in Hippocampal Network Activity after In Vitro Traumatic Brain Injury.

    abstract::Traumatic brain injury (TBI) alters function and behavior, which can be characterized by changes in electrophysiological function in vitro. A common cognitive deficit after mild-to-moderate TBI is disruption of persistent working memory, of which the in vitro correlate is long-lasting, neuronal network synchronization...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2014.3667

    authors: Kang WH,Cao W,Graudejus O,Patel TP,Wagner S,Meaney DF,Morrison B 3rd

    更新日期:2015-07-01 00:00:00

  • Temporal effect of severe controlled cortical impact injury in the rat on the myogenic response of the middle cerebral artery.

    abstract::The present study examined the effect of severe traumatic brain injury (TBI) on the myogenic response in the rat middle cerebral artery (MCA). Rats were subjected to severe controlled cortical impact (CCI; 5 m/sec, 130-msec duration, 3-mm deformation) injury over the right parietal cortex. At 2, 24, and 120 h postinju...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.1998.15.973

    authors: Golding EM,Contant CF Jr,Robertson CS,Bryan RM Jr

    更新日期:1998-11-01 00:00:00

  • N-acetylcysteine improves hemodynamics and reduces oxidative stress in the brains of newborn piglets with hypoxia-reoxygenation injury.

    abstract::Reactive oxygen species have been implicated in the pathogenesis of hypoxic-ischemic injury. It has been shown previously that treating an animal with N-acetyl-L-cysteine (NAC), a scavenger of free radicals, significantly minimizes hypoxic-ischemic-induced brain injury in various acute models. Using a subacute swine m...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2010.1325

    authors: Liu JQ,Lee TF,Chen C,Bagim DL,Cheung PY

    更新日期:2010-10-01 00:00:00

  • Concussive brain trauma in the mouse results in acute cognitive deficits and sustained impairment of axonal function.

    abstract::Concussive brain injury (CBI) accounts for approximately 75% of all brain-injured people in the United States each year and is particularly prevalent in contact sports. Concussion is the mildest form of diffuse traumatic brain injury (TBI) and results in transient cognitive dysfunction, the neuropathologic basis for w...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2010.1729

    authors: Creed JA,DiLeonardi AM,Fox DP,Tessler AR,Raghupathi R

    更新日期:2011-04-01 00:00:00

  • Mechanical stretch to neurons results in a strain rate and magnitude-dependent increase in plasma membrane permeability.

    abstract::The mechanism by which mechanical impact to brain tissue is transduced to neuronal impairment remains poorly understood. Using an in vitro model of neuronal stretch, we found that mechanical stretch of neurons resulted in a transient plasma membrane permeability increase. Primary cortical neurons, seeded on silicone s...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/089771503770195885

    authors: Geddes DM,Cargill RS 2nd,LaPlaca MC

    更新日期:2003-10-01 00:00:00

  • Traumatic Intracerebral Hemorrhage: Risk Factors Associated with Progression.

    abstract::The increase in the volume of a traumatic intracerebral hemorrhage (TICH) is a widely studied phenomenon that has a direct impact on the prognosis of patients. The objective of this study was to identify the risk factors associated with the progression of TICH. We retrospectively analyzed the records of 1970 adult pat...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2014.3808

    authors: Cepeda S,Gómez PA,Castaño-Leon AM,Martínez-Pérez R,Munarriz PM,Lagares A

    更新日期:2015-08-15 00:00:00

  • Mild traumatic brain injury does not modify the cerebral blood flow profile of secondary forebrain ischemia in Wistar rats.

    abstract::The rat hippocampus is hypersensitive to secondary cerebral ischemia after mild traumatic brain injury (TBI). An unconfirmed assumption in previous studies of mild TBI followed by forebrain ischemia has been that antecedent TBI did not alter cerebral blood flow (CBF) dynamics in response to secondary ischemia. Using l...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.1998.15.615

    authors: Davis KL,Jenkins LW,DeWitt DS,Prough DS

    更新日期:1998-08-01 00:00:00

  • Redistribution of neurofilaments and accumulation of beta-amyloid protein after brain injury by rotational acceleration of the head.

    abstract::Rotational acceleration of the head, as occurs in falls, car crashes, and sport injuries, may result in diffuse brain damage, with acute and chronic neurological and psychiatric symptoms. The present study addresses the effects of rotational trauma on the neuronal cytoskeleton, which stabilizes perikaryal, dendritic a...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/08977150360547080

    authors: Hamberger A,Huang YL,Zhu H,Bao F,Ding M,Blennow K,Olsson A,Hansson HA,Viano D,Haglid KG

    更新日期:2003-02-01 00:00:00

  • Dynamics of extracellular calcium activity following contusion of the rat spinal cord.

    abstract::The role of Ca2+ in cellular injury has received particular attention in studies of acute spinal cord trauma. In this context, the spatial and temporal distribution of extracellular Ca2+ ([Ca2+]e) may have an important bearing on the development of secondary tissue injury. We therefore studied the spatial-temporal dis...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.1994.11.255

    authors: Moriya T,Hassan AZ,Young W,Chesler M

    更新日期:1994-06-01 00:00:00

  • Clinical performance of NICE recommendations versus NCWFNS proposal in patients with mild head injury.

    abstract::Recommendations on treatment of patients with head injury were recently proposed by the National Institute for Clinical Excellence (NICE). We tested the clinical performance of NICE variables versus the proposal of the Neurotraumatology Committee of the World Federation of Neurosurgical Societies (NCWFNS). Over a 5-ye...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2005.22.1419

    authors: Fabbri A,Servadei F,Marchesini G,Dente M,Iervese T,Spada M,Vandelli A

    更新日期:2005-12-01 00:00:00

  • Transplantation of neural progenitor and stem cells: developmental insights may suggest new therapies for spinal cord and other CNS dysfunction.

    abstract::Multipotent neural progenitors and stem cells may integrate appropriately into the developing and degenerating central nervous system. They may also be effective in the replacement of genes, cells, and nondiffusible factors in either a widespread or a more circumscribed manner, depending on the therapeutic demands of ...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章,评审

    doi:10.1089/neu.1999.16.675

    authors: Park KI,Liu S,Flax JD,Nissim S,Stieg PE,Snyder EY

    更新日期:1999-08-01 00:00:00

  • Neuro-inflammatory sequelae of minimal trauma in the non-traumatized human brain. A microdialysis study.

    abstract::Cytokine measurement directly from the brain parenchyma by means of microdialysis has documented the activation of certain procedures in vivo, after brain trauma in humans. However, the intercalation of the micro-catheter insertion with the phenomena triggered by the head trauma renders the assessment of the findings ...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2011.1790

    authors: Bouras TI,Gatzonis SS,Georgakoulias N,Karatza M,Sianouni A,Stranjalis G,Boviatsis E,Vasileiou S,Sakas DE

    更新日期:2011-11-18 00:00:00

  • The effects of age and ketogenic diet on local cerebral metabolic rates of glucose after controlled cortical impact injury in rats.

    abstract::Previous studies from our laboratory have shown the neuroprotective potential of ketones after TBI in the juvenile brain. It is our premise that acutely after TBI, glucose may not be the optimum fuel and decreasing metabolism of glucose in the presence of an alternative substrate will improve cellular metabolism and r...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2008.0769

    authors: Prins ML,Hovda DA

    更新日期:2009-07-01 00:00:00

  • Investigating the properties of the hemodynamic response function after mild traumatic brain injury.

    abstract::Abstract Although several functional magnetic resonance imaging (fMRI) studies have been conducted in human models of mild traumatic brain injury (mTBI), to date no studies have explicitly examined how injury may differentially affect both the positive phase of the hemodynamic response function (HRF) as well as the po...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/neu.2013.3069

    authors: Mayer AR,Toulouse T,Klimaj S,Ling JM,Pena A,Bellgowan PS

    更新日期:2014-01-15 00:00:00