Towards a definition of recovery of function.

abstract：:Acute pain is a common symptom experienced after spinal cord injury (SCI). The presence of this pain calls for treatment with analgesics, such as buprenorphine. However, there are concerns that the drug may exert other effects besides alleviation of pain. Among those reported are in vitro changes in gene expression, a...

journal_title：Journal of neurotrauma

authors： Santiago JM,Rosas O,Torrado AI,González MM,Kalyan-Masih PO,Miranda JD

更新日期：2009-10-01 00:00:00

abstract：:Mild traumatic brain injury (mTBI) accounts for the vast majority of all pediatric TBI. An important minority of children who have suffered an mTBI have enduring cognitive and emotional symptoms. However, the mechanisms of chronic symptoms in children with pediatric mTBI are not fully understood. This is in part due t...

journal_title：Journal of neurotrauma

authors： Huang MX,Robb Swan A,Angeles Quinto A,Huang JW,De-la-Garza BG,Huang CW,Hesselink JR,Bigler ED,Wilde EA,Max JE

更新日期：2020-04-01 00:00:00

abstract：:Complications in upper and lower urinary function arise after spinal cord injury (SCI), which creates a significant impact on quality of life for those affected. One upper urinary complication is SCI-induced polyuria, or the overproduction of urine, of which the underlying mechanisms have yet to be elucidated. Activit...

journal_title：Journal of neurotrauma

authors： Gumbel JH,Montgomery LR,Yang CB,Hubscher CH

更新日期：2020-02-01 00:00:00

abstract：:Sensorimotor recovery after spinal cord injury (SCI) is of utmost importance to injured individuals and will rely on improved understanding of SCI pathology and recovery. Novel transgenic mouse lines facilitate discovery, but must be understood to be effective. The purpose of this study was to characterize the sensory...

journal_title：Journal of neurotrauma

authors： Faw TD,Lerch JK,Thaxton TT,Deibert RJ,Fisher LC,Basso DM

更新日期：2018-09-15 00:00:00

abstract：:There is a need for better tools to objectively, reliably, and precisely assess neurological function after sport-related concussion (SRC). The aim of this study was to use a robotic device (Kinesiological Instrument for Normal and Altered Reaching Movements; KINARM) to quantify neurological impairments in athletes ac...

journal_title：Journal of neurotrauma

authors： Mang CS,Whitten TA,Cosh MS,Scott SH,Wiley JP,Debert CT,Dukelow SP,Benson BW

更新日期：2019-01-15 00:00:00

abstract：:Traumatic brain injury (TBI) induces transient or persistent dysfunction of gait and balance. Enhancement of cholinergic transmission has been reported to accelerate recovery of cognitive function after TBI, but the effects of this intervention on locomotor activity remain largely unexplored. The hypothesis that enhan...

journal_title：Journal of neurotrauma

authors： Holschneider DP,Guo Y,Roch M,Norman KM,Scremin OU

更新日期：2011-09-01 00:00:00

abstract：:Neuropathic pain develops in 40-70% of spinal cord injury (SCI) patients and markedly compromises quality of life. We examined plasma from SCI patients for autoantibodies to glial fibrillary acidic protein (GFAP) and collapsin response mediator protein-2 (CRMP2) and evaluated their relationship to the development of n...

journal_title：Journal of neurotrauma

authors： Hergenroeder GW,Redell JB,Choi HA,Schmitt L,Donovan W,Francisco GE,Schmitt K,Moore AN,Dash PK

更新日期：2018-11-01 00:00:00

abstract：:Prior studies have shown that neurons within the spinal cord are sensitive to response-outcome relations, a form of instrumental learning. Spinally transected rats that receive shock to one hind leg learn to maintain the leg in a flexed position that minimizes net shock exposure (controllable shock). Prior exposure to...

journal_title：Journal of neurotrauma

authors： Grau JW,Washburn SN,Hook MA,Ferguson AR,Crown ED,Garcia G,Bolding KA,Miranda RC

更新日期：2004-12-01 00:00:00

abstract：:Physician prescribed rest after traumatic brain injury (TBI) is both commonplace and an increasingly scrutinized approach to TBI treatment. Although this practice remains a standard of patient care for TBI, research of patient outcomes reveals little to no benefit of prescribed rest after TBI, and in some cases prolon...

journal_title：Journal of neurotrauma

authors： Karelina K,Schneiderman K,Shah S,Fitzgerald J,Velazquez Cruz R,Oliverio R,Whitehead B,Yang J,Weil Z

更新日期：2021-01-20 00:00:00

abstract：:Proton magnetic resonance spectroscopy (1H-MRS) offers a unique insight into brain cellular metabolism following traumatic brain injury (TBI). The aim of the present study was to assess change in neurometabolite markers of brain injury during the recovery period following TBI. We studied 19 TBI patients at 1.5, 3, and...

journal_title：Journal of neurotrauma

authors： Brooks WM,Stidley CA,Petropoulos H,Jung RE,Weers DC,Friedman SD,Barlow MA,Sibbitt WL Jr,Yeo RA

更新日期：2000-08-01 00:00:00

abstract：:The purpose of this study was to investigate the potential neuroprotective efficacy of the mitochondrial uncoupler 2,4-dinitrophenol (DNP) in rats following a mild to moderate spinal cord contusion injury. Animals received intraperitoneal injections of vehicle (DMSO) or 5 mg/mL of DNP prior to injury. Twenty-four hour...

journal_title：Journal of neurotrauma

authors： Jin Y,McEwen ML,Nottingham SA,Maragos WF,Dragicevic NB,Sullivan PG,Springer JE

更新日期：2004-10-01 00:00:00

abstract：:We have used an in vitro trauma model to examine the effects of modulation of group III metabotropic glutamate receptors (mGluR) on post-traumatic neuronal cell death. Rat cortical neuronal/glial cultures were subjected to standardized mechanical injury using a punch that delivers 28 parallel cuts to 96-well culture p...

journal_title：Journal of neurotrauma

authors： Faden AI,Ivanova SA,Yakovlev AG,Mukhin AG

更新日期：1997-12-01 00:00:00

abstract：:We have shown previously that fresh frozen plasma (FFP) and lyophilized plasma (LP) decrease brain lesion size and improve neurological recovery in a swine model of traumatic brain injury (TBI) and hemorrhagic shock (HS). In this study, we examine whether these findings can be validated in a clinically relevant model ...

journal_title：Journal of neurotrauma

authors： Georgoff PE,Nikolian VC,Halaweish I,Chtraklin K,Bruhn PJ,Eidy H,Rasmussen M,Li Y,Srinivasan A,Alam HB

更新日期：2017-07-01 00:00:00

abstract：:Traumatic brain injury (TBI) often occurs in conjunction with additional trauma, resulting in secondary complications, such as hypotension as a result of blood loss. This study investigated the combined effects of penetrating ballistic-like brain injury (PBBI) and hemorrhagic shock (HS) on physiological parameters, in...

journal_title：Journal of neurotrauma

authors： Leung LY,Wei G,Shear DA,Tortella FC

更新日期：2013-07-15 00:00:00

abstract：:Although the citation index of an article is not a direct measure of its quality or importance, it is a measure of recognition that may suggest its impact on the scientific community. This study was undertaken to examine the characteristics of the top 100 most frequently cited articles (so-called "citation classics") ...

journal_title：Journal of neurotrauma

authors： Furlan JC,Fehlings MG

更新日期：2006-02-01 00:00:00

abstract：:The inflammatory response to moderate-severe controlled cortical impact (CCI) in adult male mice has been shown to exhibit greater glial activation compared with age-matched female mice. However, the relative contributions of resident microglia and infiltrating peripheral myeloid cells to this sexually dimorphic neuro...

journal_title：Journal of neurotrauma

authors： Doran SJ,Ritzel RM,Glaser EP,Henry RJ,Faden AI,Loane DJ

更新日期：2019-04-01 00:00:00

abstract：:Alterations in glutamatergic transmission are thought to contribute to secondary neuronal damage following traumatic brain injury. Using an in vitro cell injury model, we previously demonstrated an apparent reduction in AMPA receptor desensitization and resultant potentiation of AMPA-evoked currents after stretch inju...

journal_title：Journal of neurotrauma

authors： Goforth PB,Ellis EF,Satin LS

更新日期：2004-06-01 00:00:00

abstract：:Increasing clinical and experimental evidence suggests that traumatic brain injury (TBI) is associated with progressive histopathological damage. The aim of the current study was to characterize the time course of motor function, memory performance, and depression-like behavior up to 1 year after experimental TBI, and...

journal_title：Journal of neurotrauma

authors： Mao X,Terpolilli NA,Wehn A,Cheng S,Hellal F,Liu B,Seker B,Plesnila N

更新日期：2020-06-01 00:00:00

abstract：:Since free radicals play a role in the mechanisms of brain injury after hemorrhagic stroke, the effect of melatonin (a potent antioxidant and free-radical scavenger) on outcomes was investigated after intracerebral hemorrhage (ICH) in rats. ICH was induced by clostridial collagenase infusion into the right caudate put...

journal_title：Journal of neurotrauma

authors： Lekic T,Hartman R,Rojas H,Manaenko A,Chen W,Ayer R,Tang J,Zhang JH

更新日期：2010-03-01 00:00:00

abstract：:To evaluate new pharmacologic agents with potentially beneficial effects on posttraumatic spinal cord function, we used a modified weight drop (WD) technique to induce spinal cord injuries. These contusive spinal cord injuries in the rat closely mimic the human clinicopathologic situation. Especially for drug screenin...

journal_title：Journal of neurotrauma

authors： van de Meent H,Hamers FP,Lankhorst AJ,Buise MP,Joosten EA,Gispen WH

更新日期：1996-12-01 00:00:00

abstract：:Increasing evidence indicates that post-traumatic stress disorder (PTSD) may develop following traumatic brain injury (TBI), despite most patients having no conscious memory of their accident. This prospective study examined the frequency, timing of onset, symptom profile, and trajectory of PTSD and its psychiatric co...

journal_title：Journal of neurotrauma

authors： Alway Y,Gould KR,McKay A,Johnston L,Ponsford J

更新日期：2016-05-01 00:00:00

abstract：:A therapeutic strategy for acute spinal cord injury would be to reduce the progressive degeneration and disconnection of axons from their targets. Here, we describe a model to evaluate degeneration of the ascending sensory projections to the nuclei in the medulla following graded spinal cord contusions in adult female...

journal_title：Journal of neurotrauma

authors： Baker KA,Hagg T

更新日期：2005-04-01 00:00:00

abstract：:Athletes in contact sports sustain repetitive subconcussive head impacts in a brief window, yet neurophysiological sequelae from repetitive subconcussion remain unclear. This prospective longitudinal study examined a relationship between changes in plasma Tau protein levels and subconcussive impact kinematic data in 2...

journal_title：Journal of neurotrauma

authors： Kawata K,Rubin LH,Wesley L,Lee JH,Sim T,Takahagi M,Bellamy A,Tierney R,Langford D

更新日期：2018-01-15 00:00:00

abstract：:Acute changes in cerebral perfusion and metabolism after subarachnoid hemorrhage (SAH) have been shown to contribute significantly to acute brain injury. The purpose of this study was to examine the effects of moderate hypothermia on the acute changes after massive experimental SAH as evaluated by diffusion-weighted i...

journal_title：Journal of neurotrauma

authors： Schubert GA,Poli S,Schilling L,Heiland S,Thomé C

更新日期：2008-07-01 00:00:00

abstract：:The aim of this systematic review was to critically evaluate the evidence on interventions for depression following traumatic brain injury (TBI) and provide recommendations for clinical practice and future research. We reviewed pharmacological, other biological, psychotherapeutic, and rehabilitation interventions for ...

journal_title：Journal of neurotrauma

authors： Fann JR,Hart T,Schomer KG

更新日期：2009-12-01 00:00:00

abstract：:Magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) studies have demonstrated that measures of altered metabolism and axonal injury can be detected following traumatic brain injury. The aim of this study was to characterize and compare the distributions of altered image parameters obtained by thes...

journal_title：Journal of neurotrauma

authors： Maudsley AA,Govind V,Levin B,Saigal G,Harris L,Sheriff S

更新日期：2015-07-15 00:00:00

abstract：:Levetiracetam (LEV) is an antiepileptic agent targeting novel pathways. Coupled with a favorable safety profile and increasing empirical clinical use, it was the fifth drug tested by Operation Brain Trauma Therapy (OBTT). We assessed the efficacy of a single 15 min post-injury intravenous (IV) dose (54 or 170 mg/kg) o...

journal_title：Journal of neurotrauma

authors： Browning M,Shear DA,Bramlett HM,Dixon CE,Mondello S,Schmid KE,Poloyac SM,Dietrich WD,Hayes RL,Wang KK,Povlishock JT,Tortella FC,Kochanek PM

更新日期：2016-03-15 00:00:00

abstract：:Cardiometabolic risk factors are sorely underreported after spinal cord injury (SCI), despite the high prevalence of metabolic disorders and cardiovascular mortality in this population. Body-composition analysis and serum-lipid profiling are two assessments that are beginning to be more widely used to document metabol...

journal_title：Journal of neurotrauma

authors： Inskip J,Plunet W,Ramer L,Ramsey JB,Yung A,Kozlowski P,Ramer M,Krassioukov A

更新日期：2010-01-01 00:00:00

abstract：:The neuroprotective effects of 17 beta -estradiol have been shown in models of central nervous system injury, including ischemia, brain injury, and more recently, spinal cord injury (SCI). Recent epidemiological trends suggest that SCIs in elderly women are increasing; however, the effects of menopause on estrogen-med...

journal_title：Journal of neurotrauma

authors： Chaovipoch P,Jelks KA,Gerhold LM,West EJ,Chongthammakun S,Floyd CL

更新日期：2006-06-01 00:00:00

abstract：:The effect of flunarizine and methylprednisolone on the recovery of somatosensory evoked potentials (SEPs) was evaluated in an experimental model of spinal cord impact injury in anesthetized cats. In addition, the effect of flunarizine on posttraumatic spinal cord blood flow (SCBF) (using the hydrogen clearance techni...

journal_title：Journal of neurotrauma

authors： De Ley G,Leybaert L

更新日期：1993-04-01 00:00:00