The acute effects of hemorrhagic shock on cerebral blood flow, brain tissue oxygen tension, and spreading depolarization following penetrating ballistic-like brain injury.

abstract：:The purpose of this study was to determine the relationship between endothelin-1 (ET-1), a prominent vasoactive agent, and the breakdown of the blood-spinal cord barrier along the axis of the cord after a moderate spinal cord injury. In the first study rats (n = 10) were euthanized 24 h after spinal cord injury and co...

journal_title：Journal of neurotrauma

authors： McKenzie AL,Hall JJ,Aihara N,Fukuda K,Noble LJ

更新日期：1995-06-01 00:00:00

abstract：:Many patients with mild traumatic brain injury (MTBI) concurrently sustain extracranial injuries; however, little is known about the impact of these additional injuries on outcome. We assessed the impact of additional injuries on the severity of postconcussional symptoms (PCS) and functional outcome 6 months post-inju...

journal_title：Journal of neurotrauma

authors： Stulemeijer M,van der Werf SP,Jacobs B,Biert J,van Vugt AB,Brauer JM,Vos PE

更新日期：2006-10-01 00:00:00

abstract：:Despite the shift in demographics of spinal cord injury (SCI) due to an aging population, relatively little has been reported regarding the effect of age on outcomes after SCI. This study examines the potential confounding effect of co-morbidities on the age-related differences in the hospital mortality following acut...

journal_title：Journal of neurotrauma

authors： Furlan JC,Kattail D,Fehlings MG

更新日期：2009-08-01 00:00:00

abstract：:Large-scale network analysis characterizes the brain as a complex network of nodes and edges to evaluate functional connectivity patterns. The utility of graph-based techniques has been demonstrated in an increasing number of resting-state functional MRI (rs-fMRI) studies in the normal and diseased brain. However, to ...

journal_title：Journal of neurotrauma

authors： Kaushal M,Oni-Orisan A,Chen G,Li W,Leschke J,Ward BD,Kalinosky B,Budde MD,Schmit BD,Li SJ,Muqeet V,Kurpad SN

更新日期：2017-03-15 00:00:00

abstract：:Here we investigate the effect of hypothermia on the expression of apoptosis-regulating protein TIMP-3 after fluid percussion traumatic brain injury (TBI) in rats. We began with 210 adult male Sprague-Dawley rats and randomly assigned them to three groups: TBI with hypothermia treatment (32°C), TBI with normothermia (...

journal_title：Journal of neurotrauma

authors： Jia F,Mao Q,Liang YM,Jiang JY

更新日期：2014-02-15 00:00:00

abstract：:Risk factors for head injury are also risk factors for becoming homeless but there is little research on this vulnerable group, who can be neglected by health services that specialize in acquired brain injury. This study investigates the prevalence of admissions to hospital with a head injury in the homeless and assoc...

journal_title：Journal of neurotrauma

authors： McMillan TM,Laurie M,Oddy M,Menzies M,Stewart E,Wainman-Lefley J

更新日期：2015-01-15 00:00:00

abstract：:Midcervical contusion injuries disrupt descending ipsilateral excitatory bulbospinal projections to phrenic motoneurons, compromising ventilation. We hypothesized that a unilateral contusion injury at C3 versus C5 would differentially impact phrenic activity reflecting more prominent disruption of ipsilateral descendi...

journal_title：Journal of neurotrauma

authors： Alvarez-Argote S,Gransee HM,Mora JC,Stowe JM,Jorgenson AJ,Sieck GC,Mantilla CB

更新日期：2016-03-01 00:00:00

abstract：:Cultured astrocytes, exposed to glutamate at a dose that is generally neurotoxic in vitro (1 mM), exhibit transient swelling in the absence of cell death. In the present study, we further characterize this response by examining the distribution of intermediate filaments and evaluating cellular ultrastructure in primar...

journal_title：Journal of neurotrauma

authors： Noble LJ,Hall JJ,Chen S,Chan PH

更新日期：1992-10-01 00:00:00

abstract：:Ischemic insults to the brain in stroke or traumatic brain injury produce excessive release of glutamate from depolarized nerve terminals. This excessive glutamate release in turn stimulates massive calcium entry into nerve cells, activating a biochemical cascade that results in cell death. A major pathway of calcium ...

journal_title：Journal of neurotrauma

authors： McBurney RN,Daly D,Fischer JB,Hu LY,Subbarao K,Knapp AG,Kobayashi K,Margolin L,Reddy NL,Goldin SM

更新日期：1992-05-01 00:00:00

abstract：:In terms of human suffering, medical expenses, and lost productivity, head injury is one of the major health care problems in the United States, and inadequate cerebral blood flow is an important contributor to mortality and morbidity after traumatic brain injury. Despite the importance of cerebral vascular dysfunctio...

journal_title：Journal of neurotrauma

authors： DeWitt DS,Prough DS

更新日期：2003-09-01 00:00:00

abstract：:Endocrine dysfunction is common after accidental traumatic brain injury (TBI). Prevalence of endocrine dysfunction after inflicted traumatic brain injury (iTBI) is not known. The aim of this study was to examine endocrinopathy in children after moderate-to-severe iTBI. Children with previous iTBI (n=14) were evaluated...

journal_title：Journal of neurotrauma

authors： Auble BA,Bollepalli S,Makoroff K,Weis T,Khoury J,Colliers T,Rose SR

更新日期：2014-02-15 00:00:00

abstract：:The pattern of injuries in restrained victims of motor vehicle crashes (MVCs) remains an issue of debate. We investigated the association of peripheral nerve injuries with the use of protective devices (seat belt and air bag) during MVCs. We performed a retrospective cohort study of 384,539 adult MVC victims who were ...

journal_title：Journal of neurotrauma

authors： Bekelis K,Missios S,Spinner RJ

更新日期：2014-06-15 00:00:00

abstract：:Cardiometabolic risk factors are sorely underreported after spinal cord injury (SCI), despite the high prevalence of metabolic disorders and cardiovascular mortality in this population. Body-composition analysis and serum-lipid profiling are two assessments that are beginning to be more widely used to document metabol...

journal_title：Journal of neurotrauma

authors： Inskip J,Plunet W,Ramer L,Ramsey JB,Yung A,Kozlowski P,Ramer M,Krassioukov A

更新日期：2010-01-01 00:00:00

abstract：:We explored the effects of recombinant human growth hormone (rhGH) replacement on physical and cognitive functioning in subjects with a moderate-to-severe traumatic brain injury (TBI) with abnormal growth hormone (GH) secretion. Fifteen individuals who sustained a TBI at least 12 months prior to study enrollment were ...

journal_title：Journal of neurotrauma

authors： Mossberg KA,Durham WJ,Zgaljardic DJ,Gilkison CR,Danesi CP,Sheffield-Moore M,Masel BE,Urban RJ

更新日期：2017-02-15 00:00:00

abstract：:Sixty-eight patients were entered into a randomized, prospective, double-blinded controlled trial of supplemental zinc versus standard zinc therapy to study the effects of zinc supplementation on neurologic recovery and nutritional/metabolic status after severe closed head injury. One month after injury, the mortality...

journal_title：Journal of neurotrauma

authors： Young B,Ott L,Kasarskis E,Rapp R,Moles K,Dempsey RJ,Tibbs PA,Kryscio R,McClain C

更新日期：1996-01-01 00:00:00

abstract：:Although sleep-wake disturbances are prevalent and well described after traumatic brain injury, their pathophysiology remains unclear, most likely because human traumatic brain injury is a highly heterogeneous entity that makes the systematic study of sleep-wake disturbances in relation to trauma-induced histological ...

journal_title：Journal of neurotrauma

authors： Noain D,Büchele F,Schreglmann SR,Valko PO,Gavrilov YV,Morawska MM,Imbach LL,Baumann CR

更新日期：2018-01-01 00:00:00

abstract：:Improving survival and brain function after initial resuscitation from cardiac arrest remains a critical challenge with few therapeutic options. The publication of several randomized controlled trials supporting the use of therapeutic hypothermia in cardiac arrest survivors has provided a remarkable opportunity to red...

journal_title：Journal of neurotrauma

authors： Sugerman NT,Abella BS

更新日期：2009-03-01 00:00:00

abstract：:Central nervous system (CNS) axons recover poorly following injury because of the expression of myelin-derived inhibitors of axonal outgrowth such as Nogo, myelin-associated glycoprotein (MAG), and oligodendrocyte-myelin glycoprotein (OMgp), all of which bind to the Nogo-66 receptor 1 (NgR1). Herein we examine the rol...

journal_title：Journal of neurotrauma

authors： Tong J,Liu W,Wang X,Han X,Hyrien O,Samadani U,Smith DH,Huang JH

更新日期：2013-02-15 00:00:00

abstract：:Chronic verbal retrieval deficits have been noted in traumatic brain injury (TBI), but no U.S. Food and Drug Administration-approved interventions are available. The present study investigated whether 10 sessions of 20 min of 1 mA anodal high-definition transcranial direct current stimulation (HD-tDCS) targeting pre-s...

journal_title：Journal of neurotrauma

authors： Motes MA,Spence JS,Yeatman K,Jones PM,Lutrell M,O'Hair R,Shakal S,DeLaRosa BL,To W,Vanneste S,Kraut MA,Hart J , Jr

更新日期：2020-01-01 00:00:00

abstract：:It has been demonstrated that ethanol exerts dose-dependent effects, both beneficial and detrimental, on the outcome of traumatic brain injury (TBI). Recently, it has been reported that co-administration of caffeine (10 mg/kg) and a low amount of alcohol (0.65 g/kg; caffeinol) reduces cortical infarct volume up to 80%...

journal_title：Journal of neurotrauma

authors： Dash PK,Moore AN,Moody MR,Treadwell R,Felix JL,Clifton GL

更新日期：2004-11-01 00:00:00

abstract：:Although mild therapeutic hypothermia is an effective neuroprotective strategy for cardiac arrest/resuscitated patients, and asphyxic newborns, recent randomized controlled trials (RCTs) have equally shown good neurological outcome between targeted temperature management at 33 °C versus 36 °C, and have not shown consi...

journal_title：Journal of neurotrauma

authors： Maekawa T,Yamashita S,Nagao S,Hayashi N,Ohashi Y,Brain-Hypothermia Study Group.

更新日期：2015-04-01 00:00:00

abstract：:ICP monitoring per se has never been subjected to a prospective randomized clinical trial (PRCT) to establish its efficacy (or lack thereof) in improving outcome from severe head injury. Hence, there are insufficient data to support its use as a standard. However, there is a large body of published clinical experience...

journal_title：Journal of neurotrauma

authors：

更新日期：2000-06-01 00:00:00

abstract：:The detection of reactive oxygen species (ROS) after traumatic brain injury (TBI) is based on indirect methods due to the high reactivity and short half-life of ROS in biological tissue. The commonly used salicylate trapping method has several disadvantages making it unsuitable for human use. We have evaluated 4-hydro...

journal_title：Journal of neurotrauma

authors： Marklund N,Clausen F,Lewander T,Hillered L

更新日期：2001-11-01 00:00:00

abstract：:Progesterone is an anti-inflammatory and promyelinating agent after spinal cord injury, but its effectiveness on functional recovery is still controversial. In the current study, we tested the effects of chronic progesterone administration on tissue preservation and functional recovery in a clinically relevant model o...

journal_title：Journal of neurotrauma

authors： Garcia-Ovejero D,González S,Paniagua-Torija B,Lima A,Molina-Holgado E,De Nicola AF,Labombarda F

更新日期：2014-05-01 00:00:00

abstract：:In a new, reproducible model of rodent focal cortical injury, we have shown that in the absence of early traumatic disruption of the microvasculature and subsequent hemorrhage, delayed perivascular protein leakage and polymorphonuclear leukocyte infiltration of the injured cortex occur. In this study we employed a sen...

journal_title：Journal of neurotrauma

authors： Mathew P,Bullock R,Teasdale G,McCulloch J

更新日期：1996-08-01 00:00:00

abstract：:Mild traumatic brain injury (mTBI) is typically followed by various postconcussive symptoms (PCS), including headache, depression, and cognitive deficits. In 15-25% of cases, PCS persists beyond the usual 3-month recovery period, interfering with activities of daily living and responding poorly to pharmacotherapy. We ...

journal_title：Journal of neurotrauma

authors： Koski L,Kolivakis T,Yu C,Chen JK,Delaney S,Ptito A

更新日期：2015-01-01 00:00:00

abstract：:Acute subdural hematomas (ASDHs) are highly morbid and increasingly common. Hematoma expansion is a potentially fatal complication, and few studies have examined whether factors associated with hematoma expansion vary over time. To answer this, we performed a case-control study in a cohort of initially conservatively ...

journal_title：Journal of neurotrauma

authors： Robinson D,Pyle L,Foreman B,Ngwenya LB,Adeoye O,Woo D,Kreitzer N

更新日期：2020-12-14 00:00:00

abstract：:The canine double hemorrhage model is an established model to study cerebral vasospasm, the late sequelae of subarachnoid hemorrhage (SAH). The present study uses magnetic resonance imaging (MRI) to examine the recently reported early brain injury after SAH. Double hemorrhage SAH modeling was obtained by injecting 0.5...

journal_title：Journal of neurotrauma

authors： Jadhav V,Sugawara T,Zhang J,Jacobson P,Obenaus A

更新日期：2008-09-01 00:00:00

abstract：:Despite an improved understanding of traumatic head and neck injury mechanisms, the impact tests required by major motorcycle helmet standards have remained unchanged for decades. Development of new test methods must reflect the specific impact loads causing injury in real crashes as well as test criteria appropriate ...

journal_title：Journal of neurotrauma

authors： Whyte T,Gibson T,Anderson R,Eager D,Milthorpe B

更新日期：2016-10-01 00:00:00

abstract：:Stretching of cultured neurons has been used to model diffuse axonal injury associated with brain trauma. N-Methyl-D-aspartate receptor (NMDAR) activation and group I metabotropic glutamate receptors (mGluRs) are implicated in the pathophysiology of such injury. Here we detail the effects of culture condition and mGlu...

journal_title：Journal of neurotrauma

authors： Lea PM 4th,Custer SJ,Stoica BA,Faden AI

更新日期：2003-11-01 00:00:00