The striatum is the most vulnerable region in the brain to mitochondrial energy compromise: a hypothesis to explain its specific vulnerability.

abstract：:Human head trauma is frequently associated with respiratory problems resulting in secondary hypoxic insult. To document the behavioral consequences of secondary hypoxia in an established model of traumatic brain injury (TBI), intubated anesthetized animals were subjected to fluid percussion (FP) injury (1.87-2.17 atm)...

journal_title：Journal of neurotrauma

authors： Bramlett HM,Dietrich WD,Green EJ

更新日期：1999-11-01 00:00:00

abstract：:Visual dysfunction is a common occurrence after traumatic brain injury (TBI). We investigated in this study effects of single or multiple mild TBI on visual function in mice using a closed head injury model that permits unconstrained head movement after impact. Adult mice were briefly anesthetized with isoflurane and ...

journal_title：Journal of neurotrauma

authors： Desai A,Chen H,Kim HY

更新日期：2020-01-15 00:00:00

abstract：:Abstract Traumatic brain injury (TBI) induces microglial activation, which can contribute to secondary tissue loss. Activation of mGluR5 reduces microglial activation and inhibits microglial-mediated neurodegeneration in vitro, and is neuroprotective in experimental models of CNS injury. In vitro studies also suggest ...

journal_title：Journal of neurotrauma

authors： Loane DJ,Stoica BA,Byrnes KR,Jeong W,Faden AI

更新日期：2013-03-01 00:00:00

abstract：:Persistent pain is experienced by more than 50% of persons who sustain a traumatic brain injury (TBI), and more than 30% experience significant pain as early as 6 weeks after injury. Although neuropathic pain is a common consequence after CNS injuries, little attention has been given to neuropathic pain symptoms after...

journal_title：Journal of neurotrauma

authors： Widerström-Noga E,Govind V,Adcock JP,Levin BE,Maudsley AA

更新日期：2016-07-15 00:00:00

abstract：:Traumatic brain damage may cause acute emotional symptoms such as uncontrolled crying, apathy, and sleep problems. Rehabilitation may be less effective in patients afflicted by these symptoms. Citalopram, a selective serotonin reuptake inhibitor (SSRI), has a documented immediate and dramatic effect on pathological cr...

journal_title：Journal of neurotrauma

authors： Andersen G,Stylsvig M,Sunde N

更新日期：1999-04-01 00:00:00

abstract：:There is a need for better tools to objectively, reliably, and precisely assess neurological function after sport-related concussion (SRC). The aim of this study was to use a robotic device (Kinesiological Instrument for Normal and Altered Reaching Movements; KINARM) to quantify neurological impairments in athletes ac...

journal_title：Journal of neurotrauma

authors： Mang CS,Whitten TA,Cosh MS,Scott SH,Wiley JP,Debert CT,Dukelow SP,Benson BW

更新日期：2019-01-15 00:00:00

abstract：:Patients with head injury must overcome central as well as peripheral metabolic insults. In addition to specific tissue damage to the brain, a cellular biochemical cascade occurs that can negatively affect organ function, cause a systemic response to injury, and may cause secondary tissue injury. The metabolites invol...

journal_title：Journal of neurotrauma

authors： Ott L,McClain CJ,Gillespie M,Young B

更新日期：1994-10-01 00:00:00

abstract：:Strategies aimed at improving spinal cord regeneration after trauma are still challenging neurologists and neuroscientists throughout the world. Many cell-based therapies have been tested, with limited success in terms of functional outcome. In this study, we investigated the effects of human dental pulp cells (HDPCs)...

journal_title：Journal of neurotrauma

authors： de Almeida FM,Marques SA,Ramalho Bdos S,Rodrigues RF,Cadilhe DV,Furtado D,Kerkis I,Pereira LV,Rehen SK,Martinez AM

更新日期：2011-09-01 00:00:00

abstract：:The mass media have recently pointed out the likelihood of diagnostic errors in post-coma patients. Late recoveries of consciousness, even after 20 years, might indicate hidden misdiagnoses that are not corrected over a long period of time. The rate of misdiagnoses of patients in a vegetative state is very high when b...

journal_title：Journal of neurotrauma

authors： Pistoia F,Sarà M

更新日期：2012-09-01 00:00:00

abstract：:Non-human primate (NHP) models of spinal cord injury better reflect human injury and provide a better foundation to evaluate potential treatments and functional outcomes. We combined finite element (FE) and surrogate models with impact data derived from in vivo experiments to define the impact mechanics needed to gene...

journal_title：Journal of neurotrauma

authors： Sparrey CJ,Salegio EA,Camisa W,Tam H,Beattie MS,Bresnahan JC

更新日期：2016-06-15 00:00:00

abstract：:This study evaluated the utility of the Balance Error Scoring System (BESS) and the Sensory Organization Test (SOT) as tools for the screening and monitoring of Service members (SMs) with mild traumatic brain injury (mTBI) in a deployed setting during the acute and subacute phases of recovery. Patient records (N = 699...

journal_title：Journal of neurotrauma

authors： Haran FJ,Slaboda JC,King LA,Wright WG,Houlihan D,Norris JN

更新日期：2016-04-01 00:00:00

abstract：:Spinal cord injury (SCI) results in marked atrophy and dysfunction of skeletal muscle. There are currently no effective treatments for SCI-induced muscle atrophy or the dysfunction of the remaining muscle tissue. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-4 (Nox4) produces reactive oxygen species (ROS...

journal_title：Journal of neurotrauma

authors： Liu XH,Harlow L,Graham ZA,Bauman WA,Cardozo C

更新日期：2017-06-15 00:00:00

abstract：:Diagnosis and early prognosis of the vegetative state/unresponsive wakefulness syndrome (VS/UWS) and its differentiation from the minimally-conscious state still rest on the clinical observation of responsiveness. The incidence of established clinical indicators of responsiveness also has proven variable in the single...

journal_title：Journal of neurotrauma

authors： Riganello F,Cortese MD,Dolce G,Lucca LF,Sannita WG

更新日期：2015-07-15 00:00:00

abstract：:Despite limited evidence to support the use of amantadine to enhance cognitive function after traumatic brain injury (TBI), the clinical use for this purpose is highly prevalent and is often based on inferred belief systems. The aim of this study was to assess effect of amantadine on cognition among individuals with a...

journal_title：Journal of neurotrauma

authors： Hammond FM,Sherer M,Malec JF,Zafonte RD,Dikmen S,Bogner J,Bell KR,Barber J,Temkin N

更新日期：2018-10-01 00:00:00

abstract：:Traumatic brain injury (TBI) is an established risk factor for neurodegenerative disorders and dementias. Epigenetic modifications, such as DNA methylation, may alter the expression of genes without altering the DNA sequence in response to environmental factors. We hypothesized that DNA methylation changes may occur i...

journal_title：Journal of neurotrauma

authors： Abu Hamdeh S,Ciuculete DM,Sarkisyan D,Bakalkin G,Ingelsson M,Schiöth HB,Marklund N

更新日期：2021-01-08 00:00:00

abstract：:Athletes in contact sports sustain repetitive subconcussive head impacts in a brief window, yet neurophysiological sequelae from repetitive subconcussion remain unclear. This prospective longitudinal study examined a relationship between changes in plasma Tau protein levels and subconcussive impact kinematic data in 2...

journal_title：Journal of neurotrauma

authors： Kawata K,Rubin LH,Wesley L,Lee JH,Sim T,Takahagi M,Bellamy A,Tierney R,Langford D

更新日期：2018-01-15 00:00:00

abstract：:Traumatic brain injury (TBI) induces transient or persistent dysfunction of gait and balance. Enhancement of cholinergic transmission has been reported to accelerate recovery of cognitive function after TBI, but the effects of this intervention on locomotor activity remain largely unexplored. The hypothesis that enhan...

journal_title：Journal of neurotrauma

authors： Holschneider DP,Guo Y,Roch M,Norman KM,Scremin OU

更新日期：2011-09-01 00:00:00

abstract：:High-mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that is passively released from damaged and necrotic cells, and actively released from immune cells. In contrast, cytochrome c is released from mitochondria in apoptotic cells, and is considered a reliable biomarker of apoptosis. Thus, HMGB1 and cytochr...

journal_title：Journal of neurotrauma

authors： Au AK,Aneja RK,Bell MJ,Bayir H,Feldman K,Adelson PD,Fink EL,Kochanek PM,Clark RS

更新日期：2012-07-20 00:00:00

abstract：:Although sleep-wake disturbances are prevalent and well described after traumatic brain injury, their pathophysiology remains unclear, most likely because human traumatic brain injury is a highly heterogeneous entity that makes the systematic study of sleep-wake disturbances in relation to trauma-induced histological ...

journal_title：Journal of neurotrauma

authors： Noain D,Büchele F,Schreglmann SR,Valko PO,Gavrilov YV,Morawska MM,Imbach LL,Baumann CR

更新日期：2018-01-01 00:00:00

abstract：:In the present study, long-term and short-term rat preparations were used to develop a model for investigating external anal sphincter (EAS) reflexes in intact and spinal cord-injured (SCI) rats. In this model, EAS distension with an external probe elicits reflex contractions of the EAS in intact, unanesthetized anima...

journal_title：Journal of neurotrauma

authors： Holmes GM,Rogers RC,Bresnahan JC,Beattie MS

更新日期：1998-06-01 00:00:00

abstract：:The expression of the heat shock proteins hsp27 and hsp70 was examined in the spinal cord and sciatic nerves of developing rats. Using immunohistochemistry, we found that hsp27 is present in many motoneurones at birth. With development, the intensity of staining increases, reaching adult levels by 21 days, when all sc...

journal_title：Journal of neurotrauma

authors： Kalmár B,Burnstock G,Vrbová G,Greensmith L

更新日期：2002-05-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading cause of death and disability. Yet, despite immense research efforts, treatment options remain elusive. Translational failures in TBI are often attributed to the heterogeneity of the TBI population and limited methods to capture these individual variabilities. Advances in mach...

journal_title：Journal of neurotrauma

authors： Radabaugh H,Bonnell J,Schwartz O,Sarkar D,Dietrich WD,Bramlett HM

更新日期：2021-01-13 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) has been shown to protect cranial and spinal motoneurons, which suggests potential uses of GDNF in the treatment of spinal cord injury (SCI) and motor neuron disease. We examined neuroprotective effect of cationic liposome-mediated GDNF gene transfer in vivo on axonal...

journal_title：Journal of neurotrauma

authors： Lu KW,Chen ZY,Jin DD,Hou TS,Cao L,Fu Q

更新日期：2002-09-01 00:00:00

abstract：:The majority of studies do not support the use of the prophylactic anticonvulsants studied thus far for the prevention of late PTS. Routine seizure prophylaxis later than 1 week following head injury is, therefore, not recommended. If late PTS occur, patients should be managed in accordance with standard approaches to...

journal_title：Journal of neurotrauma

authors：

更新日期：2000-06-01 00:00:00

abstract：:Autonomic dysreflexia (AD) is a potentially life-threatening syndrome in individuals with spinal cord injury (SCI) above the T6 spinal level that is characterized by episodic hypertension in response to noxious stimuli below the lesion. Maladaptive intraspinal plasticity is thought to contribute to the temporal develo...

journal_title：Journal of neurotrauma

authors： Eldahan KC,Cox DH,Gollihue JL,Patel SP,Rabchevsky AG

更新日期：2018-03-15 00:00:00

abstract：:Diagnosis and treatment of stroke and traumatic brain injury remain significant health care challenges to society. Patient care stands to benefit from an improved understanding of the interactive biochemistry underlying neurotrauma pathobiology. In this study, we assessed the power of neuroproteomics to contrast bioch...

journal_title：Journal of neurotrauma

authors： Ottens AK,Bustamante L,Golden EC,Yao C,Hayes RL,Wang KK,Tortella FC,Dave JR

更新日期：2010-10-01 00:00:00

abstract：:Whiplash injury, commonly encountered in road traffic accidents, is a major cause of morbidity. Its pathophysiology is not well understood, and diagnosis remains clinical. Imaging and electrophysiological methods have not provided objective diagnostic evidence. Availability of a sensitive and specific diagnostic metho...

journal_title：Journal of neurotrauma

authors： Lo YL,Tan YE,Fook-Chong S,Boolsambatra P,Yue WM,Chan LL,Tan SB

更新日期：2007-06-01 00:00:00

abstract：:The presence of pelvic visceral inputs to neurons in the rostral medulla that are responsive to electrical stimulation of the abdominal branches of the vagus nerve (VAG-abd) was investigated in a complete chronic T8 spinal transection rat model. Using extracellular electrophysiological recordings from single medullary...

journal_title：Journal of neurotrauma

authors： Kaddumi EG,Hubscher CH

更新日期：2007-07-01 00:00:00

abstract：:Microdialysis sampling was used to characterize the release of norepinephrine and serotonin upon impact injury to the rat spinal cord. Increases in extracellular norepinephrine concentrations in response to injury were small and of short duration. In contrast, serotonin concentrations quickly rose 35-90 times followin...

journal_title：Journal of neurotrauma

authors： Liu DX,Valadez V,Sorkin LS,McAdoo DJ

更新日期：1990-01-01 00:00:00

abstract：:Inducible nitric oxide synthase (iNOS) has been suggested to play a complex role in the response to central nervous system insults such as traumatic brain injury (TBI) and cerebral ischemia. In the current study, we quantified maps of regional cerebral blood flow (CBF) using an arterial spin-labeling magnetic resonanc...

journal_title：Journal of neurotrauma

authors： Foley LM,Hitchens TK,Melick JA,Bayir H,Ho C,Kochanek PM

更新日期：2008-04-01 00:00:00