Effect of oral administration of Arabic gum on cisplatin-induced nephrotoxicity in rats.

abstract：:Endotoxin exposure elicits various responses in mammals including the acute phase response that has been shown to cause changes in the activity of several forms of cytochrome P450s and other enzymes. Therefore, the hepatic conjugating enzyme, glutathione S-transferase (GST), and UDP-glucuronosyltransferase (UDPGT), th...

journal_title：Journal of biochemical and molecular toxicology

authors： Watson AM,Warren G,Howard G,Shedlofsky SI,Blouin RA

更新日期：1999-01-01 00:00:00

abstract：:We have analyzed gene expression and histopathology of rat liver treated with a histamine-3 receptor inverse agonist under development for the treatment of obesity 24 h after a single acute administration. While histopathology did not identify a clear liver toxicity, analysis of gene changes strongly suggested the dev...

journal_title：Journal of biochemical and molecular toxicology

authors： Roth A,Boess F,Landes C,Steiner G,Freichel C,Plancher JM,Raab S,de Vera Mudry C,Weiser T,Suter L

更新日期：2011-05-01 00:00:00

abstract：:The present study examines the chemopreventive role of [6]-gingerol, an active component of ginger, on 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis models. The HBP has been developed with an addition of 0.5% of DMBA to the HBP area three times per week, up to the end of the 1...

journal_title：Journal of biochemical and molecular toxicology

authors： Sun Y,Ren J,Wang F

更新日期：2020-12-21 00:00:00

abstract：:The early research found that the spiderlings of black widow spider (Latrodectus tredecimguttatus) exhibited obvious toxicity to animals. The present work performed a systematical analysis of the aqueous extract of newborn black widow spiderlings. The extract was shown to contain 69.42% of proteins varying in molecula...

journal_title：Journal of biochemical and molecular toxicology

authors： Peng X,Zhang Y,Liu J,Yu H,Chen J,Lei Q,Wang X,Liang S

更新日期：2014-05-01 00:00:00

abstract：:Effects of Cd2+ and two complexes of bivalent cadmium with 1,3-bis(4-chlorbenzylidenamino)-guanidine and anabasine on ion permeability of the inner membrane and respiration of isolated rat liver mitochondria were studied. Starting from 5 microM, Cd2+ decreased state 3 and DNP-stimulated respiration of mitochondria and...

journal_title：Journal of biochemical and molecular toxicology

authors： Korotkov SM,Glazunov VV,Rozengart EV,Suvorov AA,Nikitina ER

更新日期：1999-01-01 00:00:00

abstract：:The effects of benzo[a]pyrene (B[a]P) on some drug-metabolizing and antioxidant systems in liver, lung, and stomach were investigated in normal and protein malnutrition (PM) rats. PM significantly inhibited tissue glutathione (GSH) content and increased hepatic lipid peroxidation. Cytochrome P450 isoform CYP1A1 was si...

journal_title：Journal of biochemical and molecular toxicology

authors： Badary OA,AbdEl-Gawad HM,Taha RA,Ali AA,Hamada FM

更新日期：2003-01-01 00:00:00

abstract：:The transient receptor potential (TRP) channels are thermo-sensors, and transient receptor potential vanilloid (TRPV)1 and V4 are widely expressed in primary afferent neurons and nonneuronal cells. Although heat acclimation is considered as changes of thermoregulatory responses by thermo-effectors to heat, functional ...

journal_title：Journal of biochemical and molecular toxicology

authors： Sugimoto N,Matsuzaki K,Katakura M,Nakamura H,Ueda Y,Yachie A,Shido O

更新日期：2019-05-01 00:00:00

abstract：:Copper toxicity is associated with formation of reactive oxygen species, which are capable to oxidize proteins. The selective removal of the latter by the 20S proteasome is considered an essential part of the cell antioxidant defense system. The aim of the present study was to investigate whether peptidase activities ...

journal_title：Journal of biochemical and molecular toxicology

authors： Alexandrova A,Petrov L,Georgieva A,Kessiova M,Tzvetanova E,Kirkova M,Kukan M

更新日期：2008-09-01 00:00:00

abstract：:Colchicine (COL) shows strong anticancer activity but due to its toxicity towards normal cells its wider application is limited. To address this issue, a library of 17 novel COL derivatives, namely N-carbamates of N-deacetyl-4-(bromo/chloro/iodo)thiocolchicine, has been tested against two types of primary cancer cells...

journal_title：Journal of biochemical and molecular toxicology

authors： Urbaniak A,Jousheghany F,Piña-Oviedo S,Yuan Y,Majcher-Uchańska U,Klejborowska G,Moorjani A,Monzavi-Karbassi B,Huczyński A,Chambers TC

更新日期：2020-06-01 00:00:00

abstract：:Casearia esculenta root (Roxb.) is widely used in traditional system of medicine to treat diabetes in India. An active compound, 3-hydroxymethyl xylitol (3-HMX), has been isolated, and its optimum dose has been determined in a short duration study and patented. In addition, the long-term effect of 3-HMX in type 2 diab...

journal_title：Journal of biochemical and molecular toxicology

authors： Chandramohan G,Al-Numair KS,Sridevi M,Pugalendi KV

更新日期：2010-03-01 00:00:00

abstract：:The fluoroquinolones absorb light in the 320 to 330  nm ultraviolet A (UV-A) wavelength and produce reactive oxygen species (ROS) such as superoxide anion, hydroxyl radical, and hydrogen peroxide; thus, the photodynamic generation of ROS may be the basis of phototoxicity of quinolones in human beings and animals. This...

journal_title：Journal of biochemical and molecular toxicology

authors： Yahia R,Masoud MA,Sheded MS,Mansour HA

更新日期：2020-07-01 00:00:00

abstract：:Renal xenobiotic transporters are important determinants of urinary secretion and reabsorption of chemicals. In addition to glomerular filtration, these processes are key to the overall renal clearance of a diverse array of drugs and toxins. Alterations in kidney transporter levels and function can influence the effic...

journal_title：Journal of biochemical and molecular toxicology

authors： Yacovino LL,Aleksunes LM

更新日期：2012-10-01 00:00:00

abstract：:In this work to determine the effects of metals exposure of Oreochromis niloticus on erythrocyte antioxidant systems, fish were exposed to 5.0 mg/L Zn, 1.0 mg/L Cd, and 5.0 mg/L Zn + 1.0 mg/L Cd mixtures for 7 and 14 days and reduced glutathione (GSH) level, catalase (CAT), and glucose-6-phosphate dehydrogenase (G6PD)...

journal_title：Journal of biochemical and molecular toxicology

authors： Firat O,Kargin F

更新日期：2010-07-01 00:00:00

abstract：:There is evidence that glutathione conjugates are the major metabolites formed following systemic uptake of carcinogenic contaminants from the intestine. The effect of commercial diet versus a semi-purified diet on the distribution of glutathione S-transferase (GST) activity was examined in proximal, medial, and dista...

journal_title：Journal of biochemical and molecular toxicology

authors： Gadagbui BK,James MO

更新日期：2000-01-01 00:00:00

abstract：:Cisplatin is a widely used chemotherapeutic drug; however, it induces damage on kidney and liver at clinically effective higher doses. Morin hydrate possesses antioxidant, anti-inflammatory, and anticancer properties. Therefore, we aimed to investigate the effects of morin hydrate (50 and 100 mg/kg, orally) against th...

journal_title：Journal of biochemical and molecular toxicology

authors： K V A,Madhana RM,Kasala ER,Samudrala PK,Lahkar M,Gogoi R

更新日期：2016-12-01 00:00:00

abstract：:With the rapid development of nanotechnology, nanomaterials are now being used for cancer treatment. Although studies on the application of silver nanoparticles in cancer treatment are burgeoning, few studies have investigated the toxicology mechanisms of autophagy in cancer cells under exposure to sublethal silver na...

journal_title：Journal of biochemical and molecular toxicology

authors： Chen Y,Yang T,Chen S,Qi S,Zhang Z,Xu Y

更新日期：2020-05-01 00:00:00

abstract：:This study was aimed to predict bisphenol-A (BPA)-responsive miRNA's using an in silico approach and to study their expression in granulosa cells of animals exposed prenatally to BPA. Pregnant Wistar rats were exposed to BPA through water (25 μg/L, 250 μg/L, and 2.5 mg/L) during gestation. The expression of miRNA-133b...

journal_title：Journal of biochemical and molecular toxicology

authors： Lite C,Ahmed SSSJ,Santosh W,Seetharaman B

更新日期：2019-06-01 00:00:00

abstract：:Ebselen (EB, compound 1) is an investigational organoselenium compound that reduces fungal growth, in part, through inhibition of the fungal plasma membrane H+ -ATPase (Pma1p). In the present study, the growth inhibitory activity of EB and of five structural analogs was assessed in a fluconazole (FLU)-resistant strain...

journal_title：Journal of biochemical and molecular toxicology

authors： Orie NN,Warren AR,Basaric J,Lau-Cam C,Piętka-Ottlik M,Młochowski J,Billack B

更新日期：2017-06-01 00:00:00

abstract：:Hemolysis is the red blood cell abnormality most often associated with adverse effect of drug therapy. Drug-induced or drug-associated hyperglycemia could decrease the activity of hexokinase. The aim of this study was to investigate the inhibitory effects of some commonly used drugs that have hyperglycemic side effect...

journal_title：Journal of biochemical and molecular toxicology

authors： Aljamal JA,Badawneh M

更新日期：2017-08-01 00:00:00

abstract：:A new trinickel(II) complex bridged by N-[3-(dimethylamino)propyl]- N'-(2-hydroxylphenyl)oxamido (H3 pdmapo), namely [Ni3 (pdmapo)2 (H2 O)2 ]⋅4CH3 OH, was synthesized and characterized by X-ray single-crystal diffraction and other methods. In the molecule, two symmetric cis-pdmapo3- mononickel(II) complexes as a "comp...

journal_title：Journal of biochemical and molecular toxicology

authors： Wang JJ,Wang LY,Zheng K,Li YT,Yan CW,Wu ZY

更新日期：2017-01-01 00:00:00

abstract：:In the epidermis, keratinocytes are involved in physical and first-line immune protection of the host. In this study, we analyzed the molecular responses to certain contact sensitizers (2,4-dinitrochlorobenzene and NiSO(4)) and irritants (sodium dodecyl sulfate and benzalkonium chloride) in cultured human keratinocyte...

journal_title：Journal of biochemical and molecular toxicology

authors： Yoshikawa Y,Sasahara Y,Kitano Y,Kanazawa N,Shima H,Hashimoto-Tamaoki T

更新日期：2010-01-01 00:00:00

abstract：:The expression of glutathione S-transferase (GST) is a crucial factor in determining the sensitivity of cells and organs in response to a variety of toxicants. In this study, we cloned the core nucleotide of alpha, kappa, mu, mGST, pi, rho, and theta-like GST genes from bighead carp (Aristichthys nobilis). Their deriv...

journal_title：Journal of biochemical and molecular toxicology

authors： Li G,Xie P,Li H,Chen J,Hao L,Xiong Q

更新日期：2010-07-01 00:00:00

abstract：:Paraoxon, the active metabolite of parathion, can be detoxified through a noncatalytic pathway by carboxylesterases and a catalytic pathway by calcium-dependent A-esterases, producing p-nitrophenol as a common metabolite. The detoxication patterns of carboxylesterases and A-esterases were investigated in vitro in the ...

journal_title：Journal of biochemical and molecular toxicology

authors： Tang J,Chambers JE

更新日期：1999-01-01 00:00:00

abstract：:Hyperglycemia, a major metabolic disturbance present in diabetes, promotes oxidative stress. Activation of antioxidant defense is an important mechanism to prevent cell damage. Levels of heavy metals and their binding proteins can contribute to oxidative stress. Antiradical capacity and levels of metallothionein (MT),...

journal_title：Journal of biochemical and molecular toxicology

authors： Raudenska M,Dvorakova V,Pacal L,Chalasova K,Kratochvilova M,Gumulec J,Ruttkay-Nedecky B,Zitka O,Kankova K,Adam V,Masarik M

更新日期：2017-06-01 00:00:00

abstract：:Minimizing the adverse effects of chemotherapeutic agents remains a therapeutic challenge. Cisplatin (CP) induces hepatotoxicity through activation of oxidative stress, inflammation, and apoptosis cascades which is considered a significant drawback. Thus, this study aimed to highlight the possible hepatoprotective rol...

journal_title：Journal of biochemical and molecular toxicology

authors： Sherif IO

更新日期：2021-01-25 00:00:00

abstract：:The effect of 2-(2-nitrovinyl)furan on the redox status of male rat liver and kidney was evaluated. Twenty male rats were randomized into four groups; group A received olive oil and groups B, C, and D rats received 12.5, 25, and 50 mg/kg bodyweight of 2-(2-nitrovinyl)furan intraperitoneally, daily at 24 h interval, re...

journal_title：Journal of biochemical and molecular toxicology

authors： Ajiboye TO,Alabi KA,Ariyo FA,Adeleye AO,Ojewuyi OB,Balogun A,Sunmonu TO

更新日期：2015-03-01 00:00:00

abstract：:In this study, groups of B6C3F1 male mice were treated with dichloroacetate (DCA), trichloroacetate (TCA), and mixtures of the compounds (Mix I, II, and III) daily by gavage, for 13 weeks. The tested doses were 7.5, 15, and 30 mg DCA/kg/day and 12.5, 25, and 50 mg TCA/kg/day. The DCA: TCA ratios in Mix I, II, and III ...

journal_title：Journal of biochemical and molecular toxicology

authors： Hassoun EA,Cearfoss J,Musser B,Krispinsky S,Al-Hassan N,Liu MC

更新日期：2013-04-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by a constant high pulmonary artery pressure and the remodeling of the vessel. Chloroquine (CLQ) has been observed to inhibit calcium influx. The aim of this study is to investigate the effect of CLQ on transient receptor cationic protei...

journal_title：Journal of biochemical and molecular toxicology

authors： Kaymak E,Akin AT,Tufan E,Başaran KE,Taheri S,Özdamar S,Yakan B

更新日期：2020-09-21 00:00:00

abstract：:The interaction between acotiamide hydrochloride and pepsin was systematically characterized by fluorescence and electrochemical approaches. Fluorescence lifetime measurements showed that acotiamide hydrochloride quenched the intrinsic fluorescence of pepsin with a new complex formation via static mode, which was reco...

journal_title：Journal of biochemical and molecular toxicology

authors： He J,Ma X,Wang Q,Huang Y,Li H

更新日期：2016-07-01 00:00:00

abstract：:Diepoxybutane (DEB) is the most potent active metabolite of the environmental chemical 1,3-butadiene (BD). BD is a known mutagen and human carcinogen and possesses multisystems organ toxicity. We previously reported the elevation of p53 in human TK6 lymphoblasts undergoing DEB-induced apoptosis. In this study, we have...

journal_title：Journal of biochemical and molecular toxicology

authors： Yadavilli S,Chen Z,Albrecht T,Muganda PM

更新日期：2009-11-01 00:00:00