The possible neurobehavioral protective effects of natural antioxidant against phototoxicity attenuation of antimicrobial quinolone group in rats.

abstract：:Atrazin is currently the most widely used herbicide in agriculture with lots of adverse effects on human health. Curcumin is a polyphenol known for its antioxidant, anti-inflammatory, and anticancer properties. In the present study, the protective effect of curcumin on atrazin-intoxicated rats is evaluated. Toxicity w...

journal_title：Journal of biochemical and molecular toxicology

authors： Keshk WA,Soliman NA,Abo El-Noor MM,Wahdan AA,Shareef MM

更新日期：2014-08-01 00:00:00

abstract：:Oxidative shock and production of reactive oxygen species are known to play a major role in situations leading to neuron degeneration, but the precise mechanisms responsible for cell degeneration remain uncertain. In the present article, we have studied in PC 12 cells the effect of cumene hydroxyperoxide on both cell ...

journal_title：Journal of biochemical and molecular toxicology

authors： Vimard F,Saucet M,Nicole O,Feuilloley M,Duval D

更新日期：2011-07-01 00:00:00

abstract：:The effects of benzo[a]pyrene (B[a]P) on some drug-metabolizing and antioxidant systems in liver, lung, and stomach were investigated in normal and protein malnutrition (PM) rats. PM significantly inhibited tissue glutathione (GSH) content and increased hepatic lipid peroxidation. Cytochrome P450 isoform CYP1A1 was si...

journal_title：Journal of biochemical and molecular toxicology

authors： Badary OA,AbdEl-Gawad HM,Taha RA,Ali AA,Hamada FM

更新日期：2003-01-01 00:00:00

abstract：:Aluminum and thallium may reach life-threatening levels in aquatic systems in the near future because of their extensive use in various industrial fields. It is therefore important to study the mechanism of toxicity of aluminum and thallium on fish enzymes. To this aim, the effects of aluminum and thallium on the acti...

journal_title：Journal of biochemical and molecular toxicology

authors： Bozcaarmutlu A

更新日期：2007-01-01 00:00:00

abstract：:T-2 toxin and Ochratoxin A (OTA) are toxic secondary metabolites produced by various fungi, and together they contaminate feedstuffs worldwide. T-2 toxin and OTA may exert carcinogenic action in rodent. Despite the various in vivo experiments, carcinogenicity of these two mycotoxins has not yet been proven for human. ...

journal_title：Journal of biochemical and molecular toxicology

authors： Abassi H,Ayed-Boussema I,Shirley S,Abid S,Bacha H

更新日期：2016-03-01 00:00:00

abstract：:Increasing interest in the role of oxidative stress and beta-carotene in disease and prevention led us to examine the results of beta-carotene's administration in diabetic rats, a model for high-oxidative stress. In this experiment, amounts of lipid peroxidation, glutathione, and glutathione disulfide, and activity le...

journal_title：Journal of biochemical and molecular toxicology

authors： Maritim A,Dene BA,Sanders RA,Watkins JB 3rd

更新日期：2002-01-01 00:00:00

abstract：:A cDNA clone coding for a mu-class glutathione S-transferase (GST) was isolated from a hepatopancreas cDNA library from the shrimp Litopenaeus vannamei. The deduced amino acid sequence (215 amino acids) has >50% identity to rodents and other mammals mu-class GSTs. Using RT-PCR, the shrimp GST transcript was detected i...

journal_title：Journal of biochemical and molecular toxicology

authors： Contreras-Vergara CA,Harris-Valle C,Sotelo-Mundo RR,Yepiz-Plascencia G

更新日期：2004-01-01 00:00:00

abstract：:Troxerutin, a natural flavonoid guards against oxidative stress and apoptosis with a high capability of passing through the blood-brain barrier. Our aim was to investigate the role of troxerutin in experimentally induced retinal neurodegeneration by modulating the interferon-gamma (IFNγ)-extracellular signal-regulated...

journal_title：Journal of biochemical and molecular toxicology

authors： Ibrahim RR,El-Esawy RO,El-Sakaa MH

更新日期：2020-06-01 00:00:00

abstract：:In this study, the effects of astaxanthin (AST) that belongs to carotenoid family and cadmium (Cd), which is an important heavy metal, on rat erythrocyte G6PD, 6PGD, GR, and TrxR enzyme activities in vivo and on rat erythrocyte 6PGD enzyme activity in vitro were studied. In in vitro studies, 6PGD enzyme was purified f...

journal_title：Journal of biochemical and molecular toxicology

authors： Bayramoğlu Akkoyun M,Bengü AŞ,Temel Y,Akkoyun HT,Ekin S,Ciftci M

更新日期：2018-08-01 00:00:00

abstract：:The widespread opinion that N(2)O(3) as a product of NO oxidation is the only nitros(yl)ating agent under aerobic conditions is based on experiments in homogeneous buffered water solutions. In vivo NO is oxidized in heterogeneous media and this opinion is not correct. The equilibrium in the system being dependent on t...

journal_title：Journal of biochemical and molecular toxicology

authors： Nedospasov AA

更新日期：2002-01-01 00:00:00

abstract：:Contrary to the fact that doxorubicin is a powerful chemotherapeutic agent for the treatment of neoplastic diseases, cardiotoxicity is too important to be ignored. Thymoquinone serves as a powerful free radical scavenger. In the study, the effects of thymoquinone against doxorubicin-cardiotoxicity will be evaluated. F...

journal_title：Journal of biochemical and molecular toxicology

authors： Karabulut D,Ozturk E,Kaymak E,Akin AT,Yakan B

更新日期：2021-01-01 00:00:00

abstract：:The antioxidant properties of 1,2,3,4-tetra-hydrocarbazole, 6-methoxy-1,2,3,4-tetrahydrocar-bazole (MTC), 2,3-dimethylindole, 5-methoxy-2,3-dimethylindole, and indole were investigated in the case of hemolysis of human erythrocytes and oxidative damage of DNA induced by 2,2'-azobis(2-amidinopropane hydrochloride) (AAP...

journal_title：Journal of biochemical and molecular toxicology

authors： Zhao F,Liu ZQ

更新日期：2009-07-01 00:00:00

abstract：:We have analyzed gene expression and histopathology of rat liver treated with a histamine-3 receptor inverse agonist under development for the treatment of obesity 24 h after a single acute administration. While histopathology did not identify a clear liver toxicity, analysis of gene changes strongly suggested the dev...

journal_title：Journal of biochemical and molecular toxicology

authors： Roth A,Boess F,Landes C,Steiner G,Freichel C,Plancher JM,Raab S,de Vera Mudry C,Weiser T,Suter L

更新日期：2011-05-01 00:00:00

abstract：:Breviscapine, a cerebrovascular drugs extracted from the Chinese herb Erigeron breviscapinus, has been frequently used to clinically treat cerebrovascular diseases such as cerebral thrombosis, cerebral infarction, and cerebral circulation insufficiency. In order to understand its pharmacology or toxicity, the binding ...

journal_title：Journal of biochemical and molecular toxicology

authors： Liu W,Chen Y,Chen H,Zhang Y

更新日期：2016-09-01 00:00:00

abstract：:β-Hydroxybutyrate (BHB), one of ketone body, has been traditionally regarded as an alternative carrier of energy, but recent studies found that BHB plays versatile roles in inflammation. It has been previously reported that the level BHB declined in mice with lipopolysaccharide (LPS)/d-galactosamine (d-Gal)-induced li...

journal_title：Journal of biochemical and molecular toxicology

authors： Yang Y,Shao R,Jiang R,Zhu M,Tang L,Li L,Zhang L

更新日期：2019-09-01 00:00:00

abstract：:The interaction of ceftriaxone sodium (CS), a cephalosporin antibiotic, with the major transport protein, bovine serum albumin (BSA), was investigated using different spectroscopic techniques such as fluorescence, circular dichroism (CD), and UV-vis spectroscopy. Values of binding parameters for BSA-CS interaction in ...

journal_title：Journal of biochemical and molecular toxicology

authors： Pan J,Ye Z,Cai X,Wang L,Cao Z

更新日期：2012-12-01 00:00:00

abstract：:A new μ-oxamido-bridged dicopper(II) complex, [Cu2 (papo)(H2 O)- (phen)]Cl·CH3 OH·H2 O, where H3 papo and phen represent N-(2-hydroxyphenyl)-N'-(3-aminopropyl)oxamide and 1,10-phenanthroline, respectively, has been synthesized and characterized by elemental analysis, molar conductivity measurement, infrared and electr...

journal_title：Journal of biochemical and molecular toxicology

authors： Wang LD,Tao L,Li YT,Wu ZY,Yan CW

更新日期：2015-02-01 00:00:00

abstract：:Habitual consumption of some Melanesian medicinal and food plants may influence atherosclerosis development via their antioxidant capacity at the endothelial level. Areca nut (AN; Areca catechu), piper inflorescence (PBI; Piper betle), betel quid (BQ), guava buds (GB; Psidium guajava), the leaves (NL), juice (NJ), fru...

journal_title：Journal of biochemical and molecular toxicology

authors： Owen PL,Matainaho T,Sirois M,Johns T

更新日期：2007-01-01 00:00:00

abstract：:Effects of Cd2+ and two complexes of bivalent cadmium with 1,3-bis(4-chlorbenzylidenamino)-guanidine and anabasine on ion permeability of the inner membrane and respiration of isolated rat liver mitochondria were studied. Starting from 5 microM, Cd2+ decreased state 3 and DNP-stimulated respiration of mitochondria and...

journal_title：Journal of biochemical and molecular toxicology

authors： Korotkov SM,Glazunov VV,Rozengart EV,Suvorov AA,Nikitina ER

更新日期：1999-01-01 00:00:00

abstract：:Enantiomers of cis,cis-decahydro-2-naphthyl-N-n-butylcarbamate show stereo-specific inhibition for acetylcholinesterase and butyrylcholinesterase. For both inhibition reaction, (2S,4aR,8aS)-cis,cis-decahydro-2-naphthyl-N-n- butylcarbamate is more potent than (2R,4aS,8aR)-cis,cis-decahydro-2-naphthyl-N-n-butylcarbamate...

journal_title：Journal of biochemical and molecular toxicology

authors： Lin MC,Yeh SJ,Chen IR,Lin G

更新日期：2011-09-01 00:00:00

abstract：:M1 macrophages serve one edge as proinflammatory and M2 macrophages serve the other edge as an anti-inflammatory macrophage. It appears that a related "switch" in macrophage morphology may also happen in the course of atherosclerosis, which has not yet been elucidated. An atherogenic diet (AD) was given to rats, and i...

journal_title：Journal of biochemical and molecular toxicology

authors： Binesh A,Devaraj SN,Devaraj H

更新日期：2020-02-01 00:00:00

abstract：:Cerium oxide nanoparticles (CeO2 NPs) are among the important nanoparticles that are extensively utilized in cosmetics, automotive industries, ultraviolet (UV) filtration, gas sensors, and pharmaceutical products. In this study, CeO2 NPs were synthesized using an aqueous extract of Ziziphus jujube fruit. The synthesiz...

journal_title：Journal of biochemical and molecular toxicology

authors： Miri A,Akbarpour Birjandi S,Sarani M

更新日期：2020-06-01 00:00:00

abstract：:Multiple sclerosis (MS) is a well-known neurodegenerative disorder, causing toxicity in different organs, such as spinal cord tissue. The goal of this study was to investigate the protective effect of ellagic acid (EA) against spinal cord and sciatica function in cuprizone (Cup)-induced demyelination model. Animals we...

journal_title：Journal of biochemical and molecular toxicology

authors： Khodaei F,Khoshnoud MJ,Heidaryfar S,Heidari R,Karimpour Baseri MH,Azarpira N,Rashedinia M

更新日期：2020-11-01 00:00:00

abstract：:Excessive exposure to Copper (Cu) may result in Cu toxicity and adversely affect health outcomes. We investigated the protective role of rutin on Cu-induced brain damage. Experimental rats were treated as follows: group I: control; group II: Cu-sulfate: 200 mg/kg; group III: Cu-sulfate, and rutin 100 mg/kg; and group ...

journal_title：Journal of biochemical and molecular toxicology

authors： Arowoogun J,Akanni OO,Adefisan AO,Owumi SE,Tijani AS,Adaramoye OA

更新日期：2021-01-01 00:00:00

abstract：:Cisplatin is a highly cytotoxic anticarcinogenic drug used to treat several kinds of solid tumors such as liver tumors. With the increase in the incidences associated with hepatic tumors and a lack of selectivity of cisplatin to cancer cells, it is important to explore new therapeutic strategies against them. The pres...

journal_title：Journal of biochemical and molecular toxicology

authors： Hassanen EI,Korany RMS,Bakeer AM

更新日期：2021-01-23 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by a constant high pulmonary artery pressure and the remodeling of the vessel. Chloroquine (CLQ) has been observed to inhibit calcium influx. The aim of this study is to investigate the effect of CLQ on transient receptor cationic protei...

journal_title：Journal of biochemical and molecular toxicology

authors： Kaymak E,Akin AT,Tufan E,Başaran KE,Taheri S,Özdamar S,Yakan B

更新日期：2020-09-21 00:00:00

abstract：:In the epidermis, keratinocytes are involved in physical and first-line immune protection of the host. In this study, we analyzed the molecular responses to certain contact sensitizers (2,4-dinitrochlorobenzene and NiSO(4)) and irritants (sodium dodecyl sulfate and benzalkonium chloride) in cultured human keratinocyte...

journal_title：Journal of biochemical and molecular toxicology

authors： Yoshikawa Y,Sasahara Y,Kitano Y,Kanazawa N,Shima H,Hashimoto-Tamaoki T

更新日期：2010-01-01 00:00:00

abstract：:A nonhemorrhagic proteinase B-20 from the venom of Bitis arietans has been purified to apparent electrophoretic homogeneity by chromatography on Sephadex G-100, Q-Sepharose, and CM-cellulose. It has a molecular weight of 20 k Da as determined by size exclusion chromatography on Sephadex G-100 and migrated as a single ...

journal_title：Journal of biochemical and molecular toxicology

authors： Nok AJ

更新日期：2001-01-01 00:00:00

abstract：:This study was aimed to predict bisphenol-A (BPA)-responsive miRNA's using an in silico approach and to study their expression in granulosa cells of animals exposed prenatally to BPA. Pregnant Wistar rats were exposed to BPA through water (25 μg/L, 250 μg/L, and 2.5 mg/L) during gestation. The expression of miRNA-133b...

journal_title：Journal of biochemical and molecular toxicology

authors： Lite C,Ahmed SSSJ,Santosh W,Seetharaman B

更新日期：2019-06-01 00:00:00

abstract：:Hydroxylated polychlorinated biphenyls are the metabolites produced from parent compounds by the drug-metabolizing enzyme cytochrome P450. These compounds are suspected to disrupt postembryonic neural development in the brains of mammals including humans. We studied the effects of these compounds on thyroid hormone fu...

journal_title：Journal of biochemical and molecular toxicology

authors： Ishihara A,Makita Y,Yamauchi K

更新日期：2011-09-01 00:00:00