β-Hydroxybutyrate exacerbates lipopolysaccharide/ d-galactosamine-induced inflammatory response and hepatocyte apoptosis in mice.

abstract：:Colorectal cancer (CRC) is the leading type of diagnosed cancer; globally, it resides in the fourth-leading origin of cancer-interrelated mortality in the globe. The treatment strategies were chemotherapy and potent radiotherapy. Although chemotherapy treatment can eliminate tumor cells, it remains with unnecessary to...

journal_title：Journal of biochemical and molecular toxicology

authors： Li Z,Zhou X,Zhu H,Song X,Gao H,Niu Z,Lu J

更新日期：2020-12-28 00:00:00

abstract：:Alkaline phosphatase (ALP) activity in the serum and liver from rats administered with cadmium (Cd) in drinking water was studied. After metal administration, Cd showed a time-dependent accumulation in the liver, meanwhile metallothionein had a maximum increase at 1 month, remaining in this level until the end of the ...

journal_title：Journal of biochemical and molecular toxicology

authors： Treviño S,Andrade-García A,Herrera Camacho I,León-Chavez BA,Aguilar-Alonso P,Flores G,Brambila E

更新日期：2015-12-01 00:00:00

abstract：:A new μ-oxamido-bridged dicopper(II) complex, [Cu2 (papo)(H2 O)- (phen)]Cl·CH3 OH·H2 O, where H3 papo and phen represent N-(2-hydroxyphenyl)-N'-(3-aminopropyl)oxamide and 1,10-phenanthroline, respectively, has been synthesized and characterized by elemental analysis, molar conductivity measurement, infrared and electr...

journal_title：Journal of biochemical and molecular toxicology

authors： Wang LD,Tao L,Li YT,Wu ZY,Yan CW

更新日期：2015-02-01 00:00:00

abstract：:Carbonic anhydrase (CA) was purified from Ağrı Balık Lake trout gill (fCA) by affinity chromatography on a sepharose 4B-tyrosine-sulfanilamide column. The fCA enzyme was purified with about a 303.9 purification factor, a specific activity 4130.4 EU (mg-protein)(-1), and a yield of 79.3 by using sepharose-4B-L tyrosine...

journal_title：Journal of biochemical and molecular toxicology

authors： Demirdag R,Comakli V,Kuzu M,Yerlikaya E,Şentürk M

更新日期：2015-03-01 00:00:00

abstract：:Aminoglycoside antibiotics are widely used against Gram-negative infections. On the other hand, nephrotoxicity is a deleterious side effect associated with aminoglycoside therapy. Gentamicin is the most nephrotoxic aminoglycoside. Because of serious health complications ensue the nephrotoxicity induced by aminoglycosi...

journal_title：Journal of biochemical and molecular toxicology

authors： Jamshidzadeh A,Heidari R,Mohammadi-Samani S,Azarpira N,Najbi A,Jahani P,Abdoli N

更新日期：2015-02-01 00:00:00

abstract：:In this work to determine the effects of metals exposure of Oreochromis niloticus on erythrocyte antioxidant systems, fish were exposed to 5.0 mg/L Zn, 1.0 mg/L Cd, and 5.0 mg/L Zn + 1.0 mg/L Cd mixtures for 7 and 14 days and reduced glutathione (GSH) level, catalase (CAT), and glucose-6-phosphate dehydrogenase (G6PD)...

journal_title：Journal of biochemical and molecular toxicology

authors： Firat O,Kargin F

更新日期：2010-07-01 00:00:00

abstract：:The oxysterol 7beta-hydroxycholesterol (7beta-OH) has been shown to induce apoptosis in a number of cell lines. Though not fully elucidated, the mechanism through which this oxysterol induces cell death is thought to involve the generation of an oxidative stress leading to perturbation of the mitochondrion and release...

journal_title：Journal of biochemical and molecular toxicology

authors： Ryan L,O'Callaghan YC,O'Brien NM

更新日期：2004-01-01 00:00:00

abstract：:Previous studies of triclocarban suggest that its biotransformation could yield reactive metabolites that form protein adducts. Since the skin is the major route of triclocarban exposure, present work examined this possibility in cultured human keratinocytes. The results provide evidence for considerable biotransforma...

journal_title：Journal of biochemical and molecular toxicology

authors： Schebb NH,Buchholz BA,Hammock BD,Rice RH

更新日期：2012-06-01 00:00:00

abstract：:In this study, we aimed to determine the inhibition effects of novel synthesized sulfamates (2a-g), sulfonamides (3b-f), carbonyl sulfonamides (3h and i), and carbonyl sulfamates (4h and 4i), which were tested against two human cytosolic carbonic anhydrase I and II isozymes (hCA I and II) and acetylcholinesterase (ACh...

journal_title：Journal of biochemical and molecular toxicology

authors： Atmaca U,Yıldırım A,Taslimi P,Çelik ST,Gülçin İ,Supuran CT,Çelik M

更新日期：2018-08-01 00:00:00

abstract：:Pneumonia is a chronic disorder of the respiratory system associated with worsening quality of life and a significant economic burden. Pinitol, a plant cyclic polyol, has been documented for immune-inflammatory potential. The aim of present investigation was to evaluate the potential and possible mechanism of action o...

journal_title：Journal of biochemical and molecular toxicology

authors： Fan Y,Wang J,Feng Z,Cao K,Xu H,Liu J

更新日期：2021-01-01 00:00:00

abstract：:Breviscapine, a cerebrovascular drugs extracted from the Chinese herb Erigeron breviscapinus, has been frequently used to clinically treat cerebrovascular diseases such as cerebral thrombosis, cerebral infarction, and cerebral circulation insufficiency. In order to understand its pharmacology or toxicity, the binding ...

journal_title：Journal of biochemical and molecular toxicology

authors： Liu W,Chen Y,Chen H,Zhang Y

更新日期：2016-09-01 00:00:00

abstract：:Minimizing the adverse effects of chemotherapeutic agents remains a therapeutic challenge. Cisplatin (CP) induces hepatotoxicity through activation of oxidative stress, inflammation, and apoptosis cascades which is considered a significant drawback. Thus, this study aimed to highlight the possible hepatoprotective rol...

journal_title：Journal of biochemical and molecular toxicology

authors： Sherif IO

更新日期：2021-01-25 00:00:00

abstract：:Uroporphyrinogen decarboxylase is an essential enzyme in all organisms and functions in the heme biosynthetic pathway, catalyzing the decarboxylation of the four acetate groups of uroporphyrinogen to form coproporphyrinogen. This work examines whether the four sequential decarboxylations occur at the same active site,...

journal_title：Journal of biochemical and molecular toxicology

authors： Chaufan G,Corvi MM,San Martín de Viale LC,Cárdenas ML,Ríos de Molina Mdel C

更新日期：2005-01-01 00:00:00

abstract：:Paraoxon, the active metabolite of parathion, can be detoxified through a noncatalytic pathway by carboxylesterases and a catalytic pathway by calcium-dependent A-esterases, producing p-nitrophenol as a common metabolite. The detoxication patterns of carboxylesterases and A-esterases were investigated in vitro in the ...

journal_title：Journal of biochemical and molecular toxicology

authors： Tang J,Chambers JE

更新日期：1999-01-01 00:00:00

abstract：:T-2 toxin and Ochratoxin A (OTA) are toxic secondary metabolites produced by various fungi, and together they contaminate feedstuffs worldwide. T-2 toxin and OTA may exert carcinogenic action in rodent. Despite the various in vivo experiments, carcinogenicity of these two mycotoxins has not yet been proven for human. ...

journal_title：Journal of biochemical and molecular toxicology

authors： Abassi H,Ayed-Boussema I,Shirley S,Abid S,Bacha H

更新日期：2016-03-01 00:00:00

abstract：:The effect of 2-(2-nitrovinyl)furan on the redox status of male rat liver and kidney was evaluated. Twenty male rats were randomized into four groups; group A received olive oil and groups B, C, and D rats received 12.5, 25, and 50 mg/kg bodyweight of 2-(2-nitrovinyl)furan intraperitoneally, daily at 24 h interval, re...

journal_title：Journal of biochemical and molecular toxicology

authors： Ajiboye TO,Alabi KA,Ariyo FA,Adeleye AO,Ojewuyi OB,Balogun A,Sunmonu TO

更新日期：2015-03-01 00:00:00

abstract：:To date, microRNA-4709 (miR-4709) has not been studied in colon adenocarcinoma (COAD) on the basis of experiments. In our study, we aimed to investigate the biological roles and clinical significance of miR-4709 in COAD. The expression difference between miR-4709 and NR3C2 was measured based on The Cancer Genome Atlas...

journal_title：Journal of biochemical and molecular toxicology

authors： Yu M,Yu HL,Li QH,Zhang L,Chen YX

更新日期：2019-12-01 00:00:00

abstract：:The cytochrome P450 (CYP) isoform CYP2C11 is specifically expressed in the liver of adult male rats, and 5alpha-reductase is specifically expressed in the liver of the adult female rats. The sexually dimorphic expressions of these hepatic enzymes are regulated by the sex-dependent profiles of the circulating growth ho...

journal_title：Journal of biochemical and molecular toxicology

authors： Ishizuka M,Yonemoto J,Zaha H,Tohyama C,Sone H

更新日期：2003-01-01 00:00:00

abstract：:The current work planned to assess the protecting properties of nimbolide against doxorubicin (DOX)-treated myocardial damage. Myocardial damage was produced with 2.5 mg/kg of DOX given on alternative days (14 days). Thiobarbituric acid reactive substances (TBARS) levels of a lipid peroxidative marker were elevated, w...

journal_title：Journal of biochemical and molecular toxicology

authors： Li H,Xia B,Chen W,Zhang Y,Gao X,Chinnathambi A,Alharbi SA,Zhao Y

更新日期：2020-07-06 00:00:00

abstract：:Limited research has been performed on S-adenosylhomocysteine (SAH) or homocysteine (Hcy)-evoked cell damage in hepatic and neuronal cells. In this study, we assessed effects of SAH or Hcy on cell cytotoxicity and DNA damage in hepatic and neuronal cells and attempted to find the underlying mechanism. Cell cytotoxicit...

journal_title：Journal of biochemical and molecular toxicology

authors： Liu CC,Ho WY,Leu KL,Tsai HM,Yang TH

更新日期：2009-09-01 00:00:00

abstract：:A nonhemorrhagic proteinase B-20 from the venom of Bitis arietans has been purified to apparent electrophoretic homogeneity by chromatography on Sephadex G-100, Q-Sepharose, and CM-cellulose. It has a molecular weight of 20 k Da as determined by size exclusion chromatography on Sephadex G-100 and migrated as a single ...

journal_title：Journal of biochemical and molecular toxicology

authors： Nok AJ

更新日期：2001-01-01 00:00:00

abstract：:Ebselen (EB, compound 1) is an investigational organoselenium compound that reduces fungal growth, in part, through inhibition of the fungal plasma membrane H+ -ATPase (Pma1p). In the present study, the growth inhibitory activity of EB and of five structural analogs was assessed in a fluconazole (FLU)-resistant strain...

journal_title：Journal of biochemical and molecular toxicology

authors： Orie NN,Warren AR,Basaric J,Lau-Cam C,Piętka-Ottlik M,Młochowski J,Billack B

更新日期：2017-06-01 00:00:00

abstract：:Recent studies have established the importance of estrogen-related receptor γ (ERRγ) as a required participant for insulin secretion in pancreatic β cells. Key downstream genes of ERRγ remain unclear in the pancreatic β cell. To understand the molecular role of ERRγ and elucidate potential key candidate genes involved...

journal_title：Journal of biochemical and molecular toxicology

authors： Lei Z,JunHui L,PeiFeng L

更新日期：2019-10-01 00:00:00

abstract：:β-Lactam antibiotics such as ceftriaxone, are potent stimulators of the expression of l-glutamate transporter GLT-1 and may exert neuroprotective effects when chronically used in rats and mice. In this study, we used two animal models to test the neurological effect of subchronic treatment with ceftriaxone: experiment...

journal_title：Journal of biochemical and molecular toxicology

authors： Fachim HA,Guizzo R,Cunha AOS,Pereira AC,Dos Anjos LC,Mortari MR,Dos Santos WF

更新日期：2020-11-01 00:00:00

abstract：:The use of the cytotoxic antibiotic doxorubicin (DOXR) is limited by its dose-dependent cardiotoxicity. The aim of this study was to evaluate the cardioprotective effect of the combination of carvedilol (CARD) and liposomal resveratrol (LIPO RESV) against DOXR-induced cardiomyopathy in rats. The results of the present...

journal_title：Journal of biochemical and molecular toxicology

authors： Alanazi A,Fadda L,Alhusaini A,Ahmad R

更新日期：2020-07-01 00:00:00

abstract：:Three new phytoecdysteroids have been isolated from the seeds of Chenopodium quinoa and structurally identified as 20,26-dihydroxy, 28-methyl ecdysone, 20,26-dihydroxy, 24(28)-dehydro ecdysone, and 20-hydroxyecdysone 22-glycolate using serial chromatographic and spectroscopic methods. Both previously reported compound...

journal_title：Journal of biochemical and molecular toxicology

authors： Nsimba RY,Kikuzaki H,Konishi Y

更新日期：2008-07-01 00:00:00

abstract：:Here, we aimed to investigate the carcinogenic effects of apolipoprotein C1 (APOC1) in prostate cancer (PCa). APOC1 expression was evaluated in PCa and normal prostate specimens, and lentivirus-mediated RNA interference was used to knockdown APOC1 in DU145 cells. The effects of APOC1 silencing on cell proliferation, c...

journal_title：Journal of biochemical and molecular toxicology

authors： Su WP,Sun LN,Yang SL,Zhao H,Zeng TY,Wu WZ,Wang D

更新日期：2018-05-02 00:00:00

abstract：:Hepatotoxicants can elicit liver damage by various mechanisms that can result in cell necrosis and death. The changes induced by these compounds can vary from gross alterations in DNA repair mechanisms, protein synthesis, and apoptosis, to more discrete changes in oxidative damage and lipid peroxidation. However, litt...

journal_title：Journal of biochemical and molecular toxicology

authors： Holden PR,James NH,Brooks AN,Roberts RA,Kimber I,Pennie WD

更新日期：2000-01-01 00:00:00

abstract：:In the current study, neuroprotective significance of ellagic acid (EA, a polyohenol) was explored by primarily studying its antioxidant and antiapoptotic potential against arsenic trioxide (As2 O3 )-induced toxicity in SH-SY5Y human neuroblastoma cell lines. The mitigatory effects of EA with particular reference to c...

journal_title：Journal of biochemical and molecular toxicology

authors： Firdaus F,Zafeer MF,Waseem M,Anis E,Hossain MM,Afzal M

更新日期：2018-02-01 00:00:00

abstract：:Cisplatin is a highly cytotoxic anticarcinogenic drug used to treat several kinds of solid tumors such as liver tumors. With the increase in the incidences associated with hepatic tumors and a lack of selectivity of cisplatin to cancer cells, it is important to explore new therapeutic strategies against them. The pres...

journal_title：Journal of biochemical and molecular toxicology

authors： Hassanen EI,Korany RMS,Bakeer AM

更新日期：2021-01-23 00:00:00