Abstract:
:The effect of 2-(2-nitrovinyl)furan on the redox status of male rat liver and kidney was evaluated. Twenty male rats were randomized into four groups; group A received olive oil and groups B, C, and D rats received 12.5, 25, and 50 mg/kg bodyweight of 2-(2-nitrovinyl)furan intraperitoneally, daily at 24 h interval, respectively, for 14 days. 2-(2-Nitrovinyl)furan significantly reduced (P < 0.05) alkaline phosphatase, alanine, and aspartate aminotransferase activities in male rat liver and kidney with a corresponding increase in serum. The activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and levels of reduced glutathione/glutathione disulfide (GSSG) ratio in the liver and kidney of 2-(2-nitrovinyl)furan-treated rats decreased significantly (P < 0.05). In contrast, GSSG, protein carbonyl, conjugated dienes, lipid hydroperoxides, malondialdehyde, and fragmented DNA (%) in 2-(2-nitrovinyl)furan-treated rats increased significantly (P < 0.05). Overall, data from this study revealed that 2-(2-nitrovinyl)furan exhibited its toxic effect by suppressing or depleting the antioxidant systems.
journal_name
J Biochem Mol Toxicoljournal_title
Journal of biochemical and molecular toxicologyauthors
Ajiboye TO,Alabi KA,Ariyo FA,Adeleye AO,Ojewuyi OB,Balogun A,Sunmonu TOdoi
10.1002/jbt.21674subject
Has Abstractpub_date
2015-03-01 00:00:00pages
114-22issue
3eissn
1095-6670issn
1099-0461journal_volume
29pub_type
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