Abstract：
:Significant changes in drug-metabolizing enzyme (DME) expression occur during ontogeny. Such changes can have a profound effect on therapeutic efficacy in the fetus and child, as well as the risk for adverse drug reactions. To gain a better understanding of DME ontogeny, enzyme contents for six key cytochromes P450 were measured in 240 human liver samples representing ages from 8 weeks gestation to 18 years. Where possible, both quantitative western blotting and activity assays with probe substrates were performed. Although oversimplified, the DME can be grouped into one of three categories. As typified by CYP3A7, some enzymes are expressed at their highest level during the first trimester and either remain at high concentrations or decrease during gestation and are silenced or expressed at low levels within 1-2 years after birth. These data cause one to query whether these enzymes have an important endogenous function. Representatives of a second group, CYP3A5 and CYP2C19, are expressed at relatively constant levels throughout gestation. Postnatal increases in CYP2C19 are observed within the first year, but not for CYP3A5. CYP2C9, 2E1, and 3A4 are more typical of a third group of enzymes that are not expressed or are expressed at low levels in the fetus with the onset of expression generally in either the second or third trimester. Substantial increases in expression are observed within the first 1-2 years after birth; however, considerable interindividual variability is observed in the immediate postnatal (1-6 months) onset or increase in expression of these enzymes, often resulting in a window of hypervariability.
journal_name
J Biochem Mol Toxicoljournal_title
Journal of biochemical and molecular toxicologyauthors
Hines RNdoi
10.1002/jbt.20179subject
Has Abstractpub_date
2007-01-01 00:00:00pages
169-75issue
4eissn
1095-6670issn
1099-0461journal_volume
21pub_type
杂志文章,评审abstract：:A new μ-oxamido-bridged dicopper(II) complex, [Cu2 (papo)(H2 O)- (phen)]Cl·CH3 OH·H2 O, where H3 papo and phen represent N-(2-hydroxyphenyl)-N'-(3-aminopropyl)oxamide and 1,10-phenanthroline, respectively, has been synthesized and characterized by elemental analysis, molar conductivity measurement, infrared and electr...
journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
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更新日期：2015-02-01 00:00:00
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journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.21883
更新日期：2017-05-01 00:00:00
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journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.20127
更新日期：2006-01-01 00:00:00
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journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.21667
更新日期：2015-02-01 00:00:00
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journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.20108
更新日期：2006-01-01 00:00:00
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journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.22368
更新日期：2019-09-01 00:00:00
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journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.20333
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journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
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pub_type： 杂志文章
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journal_title：Journal of biochemical and molecular toxicology
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journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
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journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
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更新日期：2014-05-01 00:00:00
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journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
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更新日期：2003-01-01 00:00:00
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journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.22221
更新日期：2018-12-01 00:00:00
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journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
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journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.20019
更新日期：2004-01-01 00:00:00
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journal_title：Journal of biochemical and molecular toxicology
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journal_title：Journal of biochemical and molecular toxicology
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journal_title：Journal of biochemical and molecular toxicology
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pub_type： 杂志文章,多中心研究
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journal_title：Journal of biochemical and molecular toxicology
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journal_title：Journal of biochemical and molecular toxicology
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更新日期：2017-01-01 00:00:00
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journal_title：Journal of biochemical and molecular toxicology
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更新日期：2016-04-01 00:00:00
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journal_title：Journal of biochemical and molecular toxicology
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journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
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journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
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更新日期：2019-06-01 00:00:00
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journal_title：Journal of biochemical and molecular toxicology
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journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
