Effect of benzo[a]pyrene on the expression of miR-126, miR-190a and their target genes EGFL7, TP53INP1 and PHLPP1 in primary endometrial cells.

abstract：:The modulatory effect of taurine on 7,12-dimethylbenz(a)anthracene (DMBA)-induced breast cancer in rats was studied. DMBA (25 mg/kg body weight) was administered to induce breast cancer in rats. Protein carbonyl levels, activities of membrane bound enzymes (Na(+) /K(+) ATPase, Ca(2+) ATPase, and Mg(2+) ATPase), phase ...

journal_title：Journal of biochemical and molecular toxicology

authors： Vanitha MK,Baskaran K,Periyasamy K,Selvaraj S,Ilakkia A,Saravanan D,Venkateswari R,Revathi Mani B,Anandakumar P,Sakthisekaran D

更新日期：2016-08-01 00:00:00

abstract：:β-Lactam antibiotics such as ceftriaxone, are potent stimulators of the expression of l-glutamate transporter GLT-1 and may exert neuroprotective effects when chronically used in rats and mice. In this study, we used two animal models to test the neurological effect of subchronic treatment with ceftriaxone: experiment...

journal_title：Journal of biochemical and molecular toxicology

authors： Fachim HA,Guizzo R,Cunha AOS,Pereira AC,Dos Anjos LC,Mortari MR,Dos Santos WF

更新日期：2020-11-01 00:00:00

abstract：:Aluminum and thallium may reach life-threatening levels in aquatic systems in the near future because of their extensive use in various industrial fields. It is therefore important to study the mechanism of toxicity of aluminum and thallium on fish enzymes. To this aim, the effects of aluminum and thallium on the acti...

journal_title：Journal of biochemical and molecular toxicology

authors： Bozcaarmutlu A

更新日期：2007-01-01 00:00:00

abstract：:Breviscapine, a cerebrovascular drugs extracted from the Chinese herb Erigeron breviscapinus, has been frequently used to clinically treat cerebrovascular diseases such as cerebral thrombosis, cerebral infarction, and cerebral circulation insufficiency. In order to understand its pharmacology or toxicity, the binding ...

journal_title：Journal of biochemical and molecular toxicology

authors： Liu W,Chen Y,Chen H,Zhang Y

更新日期：2016-09-01 00:00:00

abstract：:Ebselen (EB, compound 1) is an investigational organoselenium compound that reduces fungal growth, in part, through inhibition of the fungal plasma membrane H+ -ATPase (Pma1p). In the present study, the growth inhibitory activity of EB and of five structural analogs was assessed in a fluconazole (FLU)-resistant strain...

journal_title：Journal of biochemical and molecular toxicology

authors： Orie NN,Warren AR,Basaric J,Lau-Cam C,Piętka-Ottlik M,Młochowski J,Billack B

更新日期：2017-06-01 00:00:00

abstract：:Three new phytoecdysteroids have been isolated from the seeds of Chenopodium quinoa and structurally identified as 20,26-dihydroxy, 28-methyl ecdysone, 20,26-dihydroxy, 24(28)-dehydro ecdysone, and 20-hydroxyecdysone 22-glycolate using serial chromatographic and spectroscopic methods. Both previously reported compound...

journal_title：Journal of biochemical and molecular toxicology

authors： Nsimba RY,Kikuzaki H,Konishi Y

更新日期：2008-07-01 00:00:00

abstract：:In the present study, we have tested the beneficial effects of forskolin in protecting the mancozeb-induced reproductive toxicity in rats. Adult male Wistar rats were exposed to either mancozeb (500 mg/kg body weight/day) or forskolin (5 mg/kg body weight/day) or both for 65 days and analyzed for spermatogenesis and s...

journal_title：Journal of biochemical and molecular toxicology

authors： Girish BP,Reddy PS

更新日期：2018-02-01 00:00:00

abstract：:Here, we aimed to investigate the carcinogenic effects of apolipoprotein C1 (APOC1) in prostate cancer (PCa). APOC1 expression was evaluated in PCa and normal prostate specimens, and lentivirus-mediated RNA interference was used to knockdown APOC1 in DU145 cells. The effects of APOC1 silencing on cell proliferation, c...

journal_title：Journal of biochemical and molecular toxicology

authors： Su WP,Sun LN,Yang SL,Zhao H,Zeng TY,Wu WZ,Wang D

更新日期：2018-05-02 00:00:00

abstract：:Aminoglycoside antibiotics are widely used against Gram-negative infections. On the other hand, nephrotoxicity is a deleterious side effect associated with aminoglycoside therapy. Gentamicin is the most nephrotoxic aminoglycoside. Because of serious health complications ensue the nephrotoxicity induced by aminoglycosi...

journal_title：Journal of biochemical and molecular toxicology

authors： Jamshidzadeh A,Heidari R,Mohammadi-Samani S,Azarpira N,Najbi A,Jahani P,Abdoli N

更新日期：2015-02-01 00:00:00

abstract：:The present study is the first attempt to report the characterization of a nucleotidase from Cerastes cerastes venom. A 70 kDa 5'-nucleotidase (Cc-5'NTase) was purified to homogeneity. The amino acid sequence of Cc-5'NTase displayed high homology with many nucleotidases. Its activity was optimal at pH 7 with a specifi...

journal_title：Journal of biochemical and molecular toxicology

authors： Saoud S,Chérifi F,Benhassine T,Laraba-Djebari F

更新日期：2017-05-01 00:00:00

abstract：:The aim of this study was to determine the antigenotoxic potential of two newly synthesized β-aminoketones against N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and 9-aminoacridine (9-AA)-induced mutagenesis. The mutant bacterial tester strains were MNNG-sensitive Escherichia coli WP2 uvrA and 9-AA-sensitive Salmonella ...

journal_title：Journal of biochemical and molecular toxicology

authors： Ozturkcan SA,Turhan K,Turgut Z,Karadayi M,Gulluce M

更新日期：2012-07-01 00:00:00

abstract：:We investigated the effects of chrysin (CHR) on nonalcoholic fatty liver disease (NAFLD) in mice. The NAFLD mouse model was established using a diet deficient in methionine and choline (MCD). CHR was shown to attenuate MCD-induced hepatic fat accumulation, increase very low-density lipoprotein (VLDL) secretion, and de...

journal_title：Journal of biochemical and molecular toxicology

authors： Song Y,Wu W,Sheng L,Jiang B,Li X,Cai K

更新日期：2020-07-01 00:00:00

abstract：:Casearia esculenta root (Roxb.) is widely used in traditional system of medicine to treat diabetes in India. An active compound, 3-hydroxymethyl xylitol (3-HMX), has been isolated, and its optimum dose has been determined in a short duration study and patented. In addition, the long-term effect of 3-HMX in type 2 diab...

journal_title：Journal of biochemical and molecular toxicology

authors： Chandramohan G,Al-Numair KS,Sridevi M,Pugalendi KV

更新日期：2010-03-01 00:00:00

abstract：:Multiple sclerosis (MS) is a well-known neurodegenerative disorder, causing toxicity in different organs, such as spinal cord tissue. The goal of this study was to investigate the protective effect of ellagic acid (EA) against spinal cord and sciatica function in cuprizone (Cup)-induced demyelination model. Animals we...

journal_title：Journal of biochemical and molecular toxicology

authors： Khodaei F,Khoshnoud MJ,Heidaryfar S,Heidari R,Karimpour Baseri MH,Azarpira N,Rashedinia M

更新日期：2020-11-01 00:00:00

abstract：:To date, microRNA-4709 (miR-4709) has not been studied in colon adenocarcinoma (COAD) on the basis of experiments. In our study, we aimed to investigate the biological roles and clinical significance of miR-4709 in COAD. The expression difference between miR-4709 and NR3C2 was measured based on The Cancer Genome Atlas...

journal_title：Journal of biochemical and molecular toxicology

authors： Yu M,Yu HL,Li QH,Zhang L,Chen YX

更新日期：2019-12-01 00:00:00

abstract：:There is evidence that glutathione conjugates are the major metabolites formed following systemic uptake of carcinogenic contaminants from the intestine. The effect of commercial diet versus a semi-purified diet on the distribution of glutathione S-transferase (GST) activity was examined in proximal, medial, and dista...

journal_title：Journal of biochemical and molecular toxicology

authors： Gadagbui BK,James MO

更新日期：2000-01-01 00:00:00

abstract：:Minimizing the adverse effects of chemotherapeutic agents remains a therapeutic challenge. Cisplatin (CP) induces hepatotoxicity through activation of oxidative stress, inflammation, and apoptosis cascades which is considered a significant drawback. Thus, this study aimed to highlight the possible hepatoprotective rol...

journal_title：Journal of biochemical and molecular toxicology

authors： Sherif IO

更新日期：2021-01-25 00:00:00

abstract：:The action of carbenoxolone on hepatic energy metabolism was investigated in the perfused rat liver and isolated mitochondria. In perfused livers, carbenoxolone (200-300 microM) increased oxygen consumption, glucose production and glycolysis from endogenous glycogen. Gluconeogenesis from lactate or fructose, an energy...

journal_title：Journal of biochemical and molecular toxicology

authors： Pivato LS,Constantin RP,Ishii-Iwamoto EL,Kelmer-Bracht AM,Yamamoto NS,Constantin J,Bracht A

更新日期：2006-01-01 00:00:00

abstract：:Oxidative shock and production of reactive oxygen species are known to play a major role in situations leading to neuron degeneration, but the precise mechanisms responsible for cell degeneration remain uncertain. In the present article, we have studied in PC 12 cells the effect of cumene hydroxyperoxide on both cell ...

journal_title：Journal of biochemical and molecular toxicology

authors： Vimard F,Saucet M,Nicole O,Feuilloley M,Duval D

更新日期：2011-07-01 00:00:00

abstract：:The health impacts of airborne particulate matter (PM) are of global concern, and the direct implications to the development/exacerbation of lung disease are immediately obvious. Most studies to date have sought to understand mechanisms associated with PM exposure in adults/adult animal models; however, infants are al...

journal_title：Journal of biochemical and molecular toxicology

authors： Saravia J,Lee GI,Lomnicki S,Dellinger B,Cormier SA

更新日期：2013-01-01 00:00:00

abstract：:This study investigated the protective potential of Naringin (NIN) against cadmium chloride (CdCl2 ) mediated hepatotoxicity using human hepatocellular carcinoma (HepG2) cells. An optimal concentration of NIN (5 μM) was potent enough to confer cytoprotection against CdCl2 (50 μM) as was observed by MTT assay. Precondi...

journal_title：Journal of biochemical and molecular toxicology

authors： Rathi VK,Das S,Parampalli Raghavendra A,Rao BSS

更新日期：2017-08-01 00:00:00

abstract：:Hydroxylated polychlorinated biphenyls are the metabolites produced from parent compounds by the drug-metabolizing enzyme cytochrome P450. These compounds are suspected to disrupt postembryonic neural development in the brains of mammals including humans. We studied the effects of these compounds on thyroid hormone fu...

journal_title：Journal of biochemical and molecular toxicology

authors： Ishihara A,Makita Y,Yamauchi K

更新日期：2011-09-01 00:00:00

abstract：:In this study, groups of B6C3F1 male mice were treated with dichloroacetate (DCA), trichloroacetate (TCA), and mixtures of the compounds (Mix I, II, and III) daily by gavage, for 13 weeks. The tested doses were 7.5, 15, and 30 mg DCA/kg/day and 12.5, 25, and 50 mg TCA/kg/day. The DCA: TCA ratios in Mix I, II, and III ...

journal_title：Journal of biochemical and molecular toxicology

authors： Hassoun EA,Cearfoss J,Musser B,Krispinsky S,Al-Hassan N,Liu MC

更新日期：2013-04-01 00:00:00

abstract：:Drug resistance is a large challenge for the treatment of non-small-cell lung cancer (NSCLC). Deoxyshikonin is the naphthoquinol compound with anticancer activity. However, the role and mechanism of deoxyshikonin in cisplatin resistance of NSCLC remain poorly understood. Cell viability was assessed using 3-(4,5-dimeth...

journal_title：Journal of biochemical and molecular toxicology

authors： Zhang S,Wang Y

更新日期：2020-10-01 00:00:00

abstract：:This study was aimed to predict bisphenol-A (BPA)-responsive miRNA's using an in silico approach and to study their expression in granulosa cells of animals exposed prenatally to BPA. Pregnant Wistar rats were exposed to BPA through water (25 μg/L, 250 μg/L, and 2.5 mg/L) during gestation. The expression of miRNA-133b...

journal_title：Journal of biochemical and molecular toxicology

authors： Lite C,Ahmed SSSJ,Santosh W,Seetharaman B

更新日期：2019-06-01 00:00:00

abstract：:Renal xenobiotic transporters are important determinants of urinary secretion and reabsorption of chemicals. In addition to glomerular filtration, these processes are key to the overall renal clearance of a diverse array of drugs and toxins. Alterations in kidney transporter levels and function can influence the effic...

journal_title：Journal of biochemical and molecular toxicology

authors： Yacovino LL,Aleksunes LM

更新日期：2012-10-01 00:00:00

abstract：:β-Hydroxybutyrate (BHB), one of ketone body, has been traditionally regarded as an alternative carrier of energy, but recent studies found that BHB plays versatile roles in inflammation. It has been previously reported that the level BHB declined in mice with lipopolysaccharide (LPS)/d-galactosamine (d-Gal)-induced li...

journal_title：Journal of biochemical and molecular toxicology

authors： Yang Y,Shao R,Jiang R,Zhu M,Tang L,Li L,Zhang L

更新日期：2019-09-01 00:00:00

abstract：:Paraoxon, the active metabolite of parathion, can be detoxified through a noncatalytic pathway by carboxylesterases and a catalytic pathway by calcium-dependent A-esterases, producing p-nitrophenol as a common metabolite. The detoxication patterns of carboxylesterases and A-esterases were investigated in vitro in the ...

journal_title：Journal of biochemical and molecular toxicology

authors： Tang J,Chambers JE

更新日期：1999-01-01 00:00:00

abstract：:In this study, we aimed to determine the inhibition effects of novel synthesized sulfamates (2a-g), sulfonamides (3b-f), carbonyl sulfonamides (3h and i), and carbonyl sulfamates (4h and 4i), which were tested against two human cytosolic carbonic anhydrase I and II isozymes (hCA I and II) and acetylcholinesterase (ACh...

journal_title：Journal of biochemical and molecular toxicology

authors： Atmaca U,Yıldırım A,Taslimi P,Çelik ST,Gülçin İ,Supuran CT,Çelik M

更新日期：2018-08-01 00:00:00

abstract：:The purpose of our study is to assist in understanding the effects of wireless electromagnetic waves on carbonic anhydrase (CA) and acetylcholinesterase (AChE) enzymes activities in the different tissues of the rats. For this purpose, two different groups each of which contains eight rats (n = 8) were formed as being ...

journal_title：Journal of biochemical and molecular toxicology

authors： Kocyigit UM,Taslimi P,Gurses F,Soylu S,Durna Dastan S,Gulcin İ

更新日期：2018-03-01 00:00:00