In vitro inhibition of human erythrocyte hexokinase by various hyperglycemic drugs.

abstract：:This study examined the possible protective effects of thymoquinone (TQ), the main constituent of the volatile oil of black seed (Nigella sativa), against cyclophosphamide (CP)-induced cardiotoxicity. Adult male Wistar albino rats were divided into four treatment groups. Rats in the first group were served as control....

journal_title：Journal of biochemical and molecular toxicology

authors： Nagi MN,Al-Shabanah OA,Hafez MM,Sayed-Ahmed MM

更新日期：2011-05-01 00:00:00

abstract：:Zingerone (ZO), an active phenolic agent derived from Zingiber officinale (Ginger), has many pharmacological properties such as antioxidant, antiangiogenic, and antitumor. However, its potential value in cancer and the mechanism by which ZO wields its therapeutic effects remain obscure. Therefore, in this current stud...

journal_title：Journal of biochemical and molecular toxicology

authors： Su P,Veeraraghavan VP,Krishna Mohan S,Lu W

更新日期：2019-12-01 00:00:00

abstract：:Contrary to the fact that doxorubicin is a powerful chemotherapeutic agent for the treatment of neoplastic diseases, cardiotoxicity is too important to be ignored. Thymoquinone serves as a powerful free radical scavenger. In the study, the effects of thymoquinone against doxorubicin-cardiotoxicity will be evaluated. F...

journal_title：Journal of biochemical and molecular toxicology

authors： Karabulut D,Ozturk E,Kaymak E,Akin AT,Yakan B

更新日期：2021-01-01 00:00:00

abstract：:The interaction between acotiamide hydrochloride and pepsin was systematically characterized by fluorescence and electrochemical approaches. Fluorescence lifetime measurements showed that acotiamide hydrochloride quenched the intrinsic fluorescence of pepsin with a new complex formation via static mode, which was reco...

journal_title：Journal of biochemical and molecular toxicology

authors： He J,Ma X,Wang Q,Huang Y,Li H

更新日期：2016-07-01 00:00:00

abstract：:The dithiocarbamate fungicides maneb and mancozeb induce a short-term stress response in a transgenic Caenorhabditis elegans strain (PC72) carrying a reporter lacZ gene under the control of a homologous heat shock (hsp16) promoter. This response can be readily monitored as induced beta-galactosidase activity, either b...

journal_title：Journal of biochemical and molecular toxicology

authors： Guven K,Power RS,Avramides S,Allender R,de Pomerai DI

更新日期：1999-01-01 00:00:00

abstract：:This experiment was performed to evaluate the possible embryotoxic and teratogenic effects of doxycycline during rat development. Twenty-one female rats were used and distributed into three groups equally (seven animals/group). The low dose group received doxycycline at a dose of 5 mg/kg bw/day orally from the 6th to ...

journal_title：Journal of biochemical and molecular toxicology

authors： Abd-Allah ER,Abd El-Rahman HA

更新日期：2021-01-01 00:00:00

abstract：:The interaction of ceftriaxone sodium (CS), a cephalosporin antibiotic, with the major transport protein, bovine serum albumin (BSA), was investigated using different spectroscopic techniques such as fluorescence, circular dichroism (CD), and UV-vis spectroscopy. Values of binding parameters for BSA-CS interaction in ...

journal_title：Journal of biochemical and molecular toxicology

authors： Pan J,Ye Z,Cai X,Wang L,Cao Z

更新日期：2012-12-01 00:00:00

abstract：:Excessive exposure to Copper (Cu) may result in Cu toxicity and adversely affect health outcomes. We investigated the protective role of rutin on Cu-induced brain damage. Experimental rats were treated as follows: group I: control; group II: Cu-sulfate: 200 mg/kg; group III: Cu-sulfate, and rutin 100 mg/kg; and group ...

journal_title：Journal of biochemical and molecular toxicology

authors： Arowoogun J,Akanni OO,Adefisan AO,Owumi SE,Tijani AS,Adaramoye OA

更新日期：2021-01-01 00:00:00

abstract：:A new μ-oxamido-bridged dicopper(II) complex, [Cu2 (papo)(H2 O)- (phen)]Cl·CH3 OH·H2 O, where H3 papo and phen represent N-(2-hydroxyphenyl)-N'-(3-aminopropyl)oxamide and 1,10-phenanthroline, respectively, has been synthesized and characterized by elemental analysis, molar conductivity measurement, infrared and electr...

journal_title：Journal of biochemical and molecular toxicology

authors： Wang LD,Tao L,Li YT,Wu ZY,Yan CW

更新日期：2015-02-01 00:00:00

abstract：:The action of carbenoxolone on hepatic energy metabolism was investigated in the perfused rat liver and isolated mitochondria. In perfused livers, carbenoxolone (200-300 microM) increased oxygen consumption, glucose production and glycolysis from endogenous glycogen. Gluconeogenesis from lactate or fructose, an energy...

journal_title：Journal of biochemical and molecular toxicology

authors： Pivato LS,Constantin RP,Ishii-Iwamoto EL,Kelmer-Bracht AM,Yamamoto NS,Constantin J,Bracht A

更新日期：2006-01-01 00:00:00

abstract：:The aim of this study was to determine the antigenotoxic potential of two newly synthesized β-aminoketones against N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and 9-aminoacridine (9-AA)-induced mutagenesis. The mutant bacterial tester strains were MNNG-sensitive Escherichia coli WP2 uvrA and 9-AA-sensitive Salmonella ...

journal_title：Journal of biochemical and molecular toxicology

authors： Ozturkcan SA,Turhan K,Turgut Z,Karadayi M,Gulluce M

更新日期：2012-07-01 00:00:00

abstract：:The early research found that the spiderlings of black widow spider (Latrodectus tredecimguttatus) exhibited obvious toxicity to animals. The present work performed a systematical analysis of the aqueous extract of newborn black widow spiderlings. The extract was shown to contain 69.42% of proteins varying in molecula...

journal_title：Journal of biochemical and molecular toxicology

authors： Peng X,Zhang Y,Liu J,Yu H,Chen J,Lei Q,Wang X,Liang S

更新日期：2014-05-01 00:00:00

abstract：:It has been reported that the bioactive intermediate metabolites of trazodone might cause hepatotoxicity. This study was designed to investigate the exact mechanism of hepatocellular injury induced by trazodone as well as the protective effects of taurine and/or melatonin against this toxicity. Freshly isolated rat he...

journal_title：Journal of biochemical and molecular toxicology

authors： Taziki S,Sattari MR,Eghbal MA

更新日期：2013-10-01 00:00:00

abstract：:Cisplatin is a highly cytotoxic anticarcinogenic drug used to treat several kinds of solid tumors such as liver tumors. With the increase in the incidences associated with hepatic tumors and a lack of selectivity of cisplatin to cancer cells, it is important to explore new therapeutic strategies against them. The pres...

journal_title：Journal of biochemical and molecular toxicology

authors： Hassanen EI,Korany RMS,Bakeer AM

更新日期：2021-01-23 00:00:00

abstract：:We investigated the effects of chrysin (CHR) on nonalcoholic fatty liver disease (NAFLD) in mice. The NAFLD mouse model was established using a diet deficient in methionine and choline (MCD). CHR was shown to attenuate MCD-induced hepatic fat accumulation, increase very low-density lipoprotein (VLDL) secretion, and de...

journal_title：Journal of biochemical and molecular toxicology

authors： Song Y,Wu W,Sheng L,Jiang B,Li X,Cai K

更新日期：2020-07-01 00:00:00

abstract：:CYP1A1 and CYP1A2 enzymes metabolize polycyclic aromatic hydrocarbons (PAHs) to the reactive oxyderivatives. PAHs can induce the activity of both enzymes, which increases its conversion and enhances risk of carcinogenesis. Thus, the inhibition of CYP enzymes is recognized as a cancer chemoprevention strategy. A well-k...

journal_title：Journal of biochemical and molecular toxicology

authors： Skupinska K,Misiewicz-Krzeminska I,Stypulkowski R,Lubelska K,Kasprzycka-Guttman T

更新日期：2009-01-01 00:00:00

abstract：:The health impacts of airborne particulate matter (PM) are of global concern, and the direct implications to the development/exacerbation of lung disease are immediately obvious. Most studies to date have sought to understand mechanisms associated with PM exposure in adults/adult animal models; however, infants are al...

journal_title：Journal of biochemical and molecular toxicology

authors： Saravia J,Lee GI,Lomnicki S,Dellinger B,Cormier SA

更新日期：2013-01-01 00:00:00

abstract：:It has been recently postulated from our laboratory that Arabic gum (AG) offers a protective effect in the kidney of rats against nephrotoxicity induced by gentamicin via inhibiting lipid peroxidation. It has also recently shown a powerful antioxidant effect through scavenging superoxide anions. In this study we utili...

journal_title：Journal of biochemical and molecular toxicology

authors： Al-Majed AA,Abd-Allah AR,Al-Rikabi AC,Al-Shabanah OA,Mostafa AM

更新日期：2003-01-01 00:00:00

abstract：:In the presence of trifluoroacetic acid, on the basis of three-component condensation of phenylthiourea with its salicylaldehyde and methyl-3-oxobutanoate, an efficient method for the synthesis of 1-(4-(2-hydroxyphenyl)-6-methyl-1-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)ethanone (I) has been worked out. These...

journal_title：Journal of biochemical and molecular toxicology

authors： Maharramova G,Taslimi P,Sujayev A,Farzaliyev V,Durmaz L,Gulçin İ

更新日期：2018-12-01 00:00:00

abstract：:Multiple sclerosis (MS) is a well-known neurodegenerative disorder, causing toxicity in different organs, such as spinal cord tissue. The goal of this study was to investigate the protective effect of ellagic acid (EA) against spinal cord and sciatica function in cuprizone (Cup)-induced demyelination model. Animals we...

journal_title：Journal of biochemical and molecular toxicology

authors： Khodaei F,Khoshnoud MJ,Heidaryfar S,Heidari R,Karimpour Baseri MH,Azarpira N,Rashedinia M

更新日期：2020-11-01 00:00:00

abstract：:Habitual consumption of some Melanesian medicinal and food plants may influence atherosclerosis development via their antioxidant capacity at the endothelial level. Areca nut (AN; Areca catechu), piper inflorescence (PBI; Piper betle), betel quid (BQ), guava buds (GB; Psidium guajava), the leaves (NL), juice (NJ), fru...

journal_title：Journal of biochemical and molecular toxicology

authors： Owen PL,Matainaho T,Sirois M,Johns T

更新日期：2007-01-01 00:00:00

abstract：:Diabetic neuropathic pain is characterized by spontaneous pain with hyperalgesia and allodynia. We investigated whether (-)-epigallocatechin-3-O-gallate could improve diabetic neuropathic pain development through hypoglycemic, hypolipidemic, antioxidant, and anti-inflammatory effects. Diabetes was induced in rats by s...

journal_title：Journal of biochemical and molecular toxicology

authors： Abo-Salem OM,Ali TM,Harisa GI,Mehanna OM,Younos IH,Almalki WH

更新日期：2020-08-01 00:00:00

abstract：:Sodium dichromate [Cr(VI)] and cadmium chloride [Cd(II)] are both cytotoxic and mutagenic. This study examined the toxic and apoptotic potentials of these two cations on three cell types in vitro, namely, human chronic myelogenous leukemic (CML) K562 cells, promyelocytic leukemic HL-60 cells, and normal human peripher...

journal_title：Journal of biochemical and molecular toxicology

authors： Bagchi D,Joshi SS,Bagchi M,Balmoori J,Benner EJ,Kuszynski CA,Stohs SJ

更新日期：2000-01-01 00:00:00

abstract：:Retinoic acid (RA) alters the developmental fate of the axial skeletal anlagen. "Anteriorizations" or "posteriorizations," the assumption of characteristics of embryonic areas normally anterior or posterior to the affected tissues, are correlated with altered embryonal expression domains of Hox genes after in utero RA...

journal_title：Journal of biochemical and molecular toxicology

authors： Kawanishi CY,Hartig P,Bobseine KL,Schmid J,Cardon M,Massenburg G,Chernoff N

更新日期：2003-01-01 00:00:00

abstract：:In this study, a series of novel bis-sulfone compounds (2a-2j) were synthesized by oxidation of the bis-sulfides under mild reaction conditions. The bis-sulfone derivatives were characterized by 1 H-NMR, 13 C-NMR, Fourier-transform infrared spectroscopy, and elemental analysis techniques. Nuclear Overhauser effect exp...

journal_title：Journal of biochemical and molecular toxicology

authors： Biçer A,Kaya R,Anıl B,Turgut Cin G,Gülcin İ,Gültekin MS

更新日期：2019-11-01 00:00:00

abstract：:Atrazin is currently the most widely used herbicide in agriculture with lots of adverse effects on human health. Curcumin is a polyphenol known for its antioxidant, anti-inflammatory, and anticancer properties. In the present study, the protective effect of curcumin on atrazin-intoxicated rats is evaluated. Toxicity w...

journal_title：Journal of biochemical and molecular toxicology

authors： Keshk WA,Soliman NA,Abo El-Noor MM,Wahdan AA,Shareef MM

更新日期：2014-08-01 00:00:00

abstract：:Three new phytoecdysteroids have been isolated from the seeds of Chenopodium quinoa and structurally identified as 20,26-dihydroxy, 28-methyl ecdysone, 20,26-dihydroxy, 24(28)-dehydro ecdysone, and 20-hydroxyecdysone 22-glycolate using serial chromatographic and spectroscopic methods. Both previously reported compound...

journal_title：Journal of biochemical and molecular toxicology

authors： Nsimba RY,Kikuzaki H,Konishi Y

更新日期：2008-07-01 00:00:00

abstract：:Taxane-based chemotherapy drugs (cabazitaxel, docetaxel, and paclitaxel) are microtubule inhibitors, which are effectively and frequently used to treat metastatic prostate cancer (PCa). Among these, cabazitaxel is offered as a new therapeutic option for patients with metastatic castration-resistant PC as that are resi...

journal_title：Journal of biochemical and molecular toxicology

authors： Cevik O,Acidereli H,Turut FA,Yildirim S,Acilan C

更新日期：2020-06-24 00:00:00

abstract：:We determined the number and the dissociation rate constants of different complexes formed from arsenite and two peptides containing either one (RVCAVGNDYASGYHYGV for peptide 20) or three cysteines (LECAWQGK CVEGTEHLYSMKCK for peptide 10) via radioactive 73As-labeled arsenite and vacuum filtration methodology. Nonline...

journal_title：Journal of biochemical and molecular toxicology

authors： Kitchin KT,Wallace K

更新日期：2006-01-01 00:00:00

abstract：:The metabolic implications of tamoxifen (TAM) used as preventive therapy of young premenopausal women with high risk of breast cancer is unknown. To unravel this problem, an animal model of long-term TAM administration to cycling young adult female rats was used to evaluate its effects in the liver. Body weight and fo...

journal_title：Journal of biochemical and molecular toxicology

authors： Resende AD,Leal S,Batista-Pinto C,Garcez F,Sá SI

更新日期：2019-05-01 00:00:00