Chrysin ameliorates hepatic steatosis induced by a diet deficient in methionine and choline by inducing the secretion of hepatocyte nuclear factor 4α-dependent very low-density lipoprotein.

abstract：:The interaction of ceftriaxone sodium (CS), a cephalosporin antibiotic, with the major transport protein, bovine serum albumin (BSA), was investigated using different spectroscopic techniques such as fluorescence, circular dichroism (CD), and UV-vis spectroscopy. Values of binding parameters for BSA-CS interaction in ...

journal_title：Journal of biochemical and molecular toxicology

authors： Pan J,Ye Z,Cai X,Wang L,Cao Z

更新日期：2012-12-01 00:00:00

abstract：:Nitrofurantoin (N-(5-nitro-2-furfurylidine) 1-amino-hydantoine; NIT) is mainly used for the treatment of acute urinary tract infections. However, its administration can be associated with liver failure or cirrhosis. The aim of this study was to determine whether NIT is a mitochondrial toxicant, if so, what mechanism(s...

journal_title：Journal of biochemical and molecular toxicology

authors： Omidi M,Niknahad H,Mohammadi-Bardbori A

更新日期：2016-12-01 00:00:00

abstract：:Multiple sclerosis (MS) is a well-known neurodegenerative disorder, causing toxicity in different organs, such as spinal cord tissue. The goal of this study was to investigate the protective effect of ellagic acid (EA) against spinal cord and sciatica function in cuprizone (Cup)-induced demyelination model. Animals we...

journal_title：Journal of biochemical and molecular toxicology

authors： Khodaei F,Khoshnoud MJ,Heidaryfar S,Heidari R,Karimpour Baseri MH,Azarpira N,Rashedinia M

更新日期：2020-11-01 00:00:00

abstract：:This study was aimed to predict bisphenol-A (BPA)-responsive miRNA's using an in silico approach and to study their expression in granulosa cells of animals exposed prenatally to BPA. Pregnant Wistar rats were exposed to BPA through water (25 μg/L, 250 μg/L, and 2.5 mg/L) during gestation. The expression of miRNA-133b...

journal_title：Journal of biochemical and molecular toxicology

authors： Lite C,Ahmed SSSJ,Santosh W,Seetharaman B

更新日期：2019-06-01 00:00:00

abstract：:The interaction between acotiamide hydrochloride and pepsin was systematically characterized by fluorescence and electrochemical approaches. Fluorescence lifetime measurements showed that acotiamide hydrochloride quenched the intrinsic fluorescence of pepsin with a new complex formation via static mode, which was reco...

journal_title：Journal of biochemical and molecular toxicology

authors： He J,Ma X,Wang Q,Huang Y,Li H

更新日期：2016-07-01 00:00:00

abstract：:The modulatory effect of taurine on 7,12-dimethylbenz(a)anthracene (DMBA)-induced breast cancer in rats was studied. DMBA (25 mg/kg body weight) was administered to induce breast cancer in rats. Protein carbonyl levels, activities of membrane bound enzymes (Na(+) /K(+) ATPase, Ca(2+) ATPase, and Mg(2+) ATPase), phase ...

journal_title：Journal of biochemical and molecular toxicology

authors： Vanitha MK,Baskaran K,Periyasamy K,Selvaraj S,Ilakkia A,Saravanan D,Venkateswari R,Revathi Mani B,Anandakumar P,Sakthisekaran D

更新日期：2016-08-01 00:00:00

abstract：:Hemolysis is the red blood cell abnormality most often associated with adverse effect of drug therapy. Drug-induced or drug-associated hyperglycemia could decrease the activity of hexokinase. The aim of this study was to investigate the inhibitory effects of some commonly used drugs that have hyperglycemic side effect...

journal_title：Journal of biochemical and molecular toxicology

authors： Aljamal JA,Badawneh M

更新日期：2017-08-01 00:00:00

abstract：:Manganese is an essential trace element found in many enzymes. As it is the case of many essential trace elements, excessive level of manganese is toxic. It has been proven that excessive manganese could cause heart problems. In order to understand the mechanism of manganese toxicity in the heart, the effects of manga...

journal_title：Journal of biochemical and molecular toxicology

authors： Yang H,Wang T,Li J,Gu L,Zheng X

更新日期：2006-01-01 00:00:00

abstract：:Allyl alcohol hepatotoxicity is mediated by an alcohol dehydrogenase-derived biotranformation product, acrolein. This highly reactive alpha,beta-unsaturated aldehyde readily alkylates model proteins in vitro, forming, among other products, Michael addition adducts that possess a free carbonyl group. Whether such damag...

journal_title：Journal of biochemical and molecular toxicology

authors： Burcham PC,Fontaine F

更新日期：2001-01-01 00:00:00

abstract：:The action of carbenoxolone on hepatic energy metabolism was investigated in the perfused rat liver and isolated mitochondria. In perfused livers, carbenoxolone (200-300 microM) increased oxygen consumption, glucose production and glycolysis from endogenous glycogen. Gluconeogenesis from lactate or fructose, an energy...

journal_title：Journal of biochemical and molecular toxicology

authors： Pivato LS,Constantin RP,Ishii-Iwamoto EL,Kelmer-Bracht AM,Yamamoto NS,Constantin J,Bracht A

更新日期：2006-01-01 00:00:00

abstract：:Certain ginsenosides, also known as triterpene glycosides, have been recently reported to have a characteristic effect on cultured intestinal and leukemia cell growth. Ginsenoside aglycones 20(S)-protopanaxadiol (PD), 20(S)-protopanaxatriol (PT), and ginsenoside Rh2 have been identified as having a strong effect on re...

journal_title：Journal of biochemical and molecular toxicology

authors： Popovich DG,Kitts DD

更新日期：2004-01-01 00:00:00

abstract：:A new trinickel(II) complex bridged by N-[3-(dimethylamino)propyl]- N'-(2-hydroxylphenyl)oxamido (H3 pdmapo), namely [Ni3 (pdmapo)2 (H2 O)2 ]⋅4CH3 OH, was synthesized and characterized by X-ray single-crystal diffraction and other methods. In the molecule, two symmetric cis-pdmapo3- mononickel(II) complexes as a "comp...

journal_title：Journal of biochemical and molecular toxicology

authors： Wang JJ,Wang LY,Zheng K,Li YT,Yan CW,Wu ZY

更新日期：2017-01-01 00:00:00

abstract：:A nonhemorrhagic proteinase B-20 from the venom of Bitis arietans has been purified to apparent electrophoretic homogeneity by chromatography on Sephadex G-100, Q-Sepharose, and CM-cellulose. It has a molecular weight of 20 k Da as determined by size exclusion chromatography on Sephadex G-100 and migrated as a single ...

journal_title：Journal of biochemical and molecular toxicology

authors： Nok AJ

更新日期：2001-01-01 00:00:00

abstract：:The aim of this study was to determine the antigenotoxic potential of two newly synthesized β-aminoketones against N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and 9-aminoacridine (9-AA)-induced mutagenesis. The mutant bacterial tester strains were MNNG-sensitive Escherichia coli WP2 uvrA and 9-AA-sensitive Salmonella ...

journal_title：Journal of biochemical and molecular toxicology

authors： Ozturkcan SA,Turhan K,Turgut Z,Karadayi M,Gulluce M

更新日期：2012-07-01 00:00:00

abstract：:Sodium dichromate [Cr(VI)] and cadmium chloride [Cd(II)] are both cytotoxic and mutagenic. This study examined the toxic and apoptotic potentials of these two cations on three cell types in vitro, namely, human chronic myelogenous leukemic (CML) K562 cells, promyelocytic leukemic HL-60 cells, and normal human peripher...

journal_title：Journal of biochemical and molecular toxicology

authors： Bagchi D,Joshi SS,Bagchi M,Balmoori J,Benner EJ,Kuszynski CA,Stohs SJ

更新日期：2000-01-01 00:00:00

abstract：:The present study examines the chemopreventive role of [6]-gingerol, an active component of ginger, on 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis models. The HBP has been developed with an addition of 0.5% of DMBA to the HBP area three times per week, up to the end of the 1...

journal_title：Journal of biochemical and molecular toxicology

authors： Sun Y,Ren J,Wang F

更新日期：2020-12-21 00:00:00

abstract：:Three new phytoecdysteroids have been isolated from the seeds of Chenopodium quinoa and structurally identified as 20,26-dihydroxy, 28-methyl ecdysone, 20,26-dihydroxy, 24(28)-dehydro ecdysone, and 20-hydroxyecdysone 22-glycolate using serial chromatographic and spectroscopic methods. Both previously reported compound...

journal_title：Journal of biochemical and molecular toxicology

authors： Nsimba RY,Kikuzaki H,Konishi Y

更新日期：2008-07-01 00:00:00

abstract：:Here, we aimed to investigate the carcinogenic effects of apolipoprotein C1 (APOC1) in prostate cancer (PCa). APOC1 expression was evaluated in PCa and normal prostate specimens, and lentivirus-mediated RNA interference was used to knockdown APOC1 in DU145 cells. The effects of APOC1 silencing on cell proliferation, c...

journal_title：Journal of biochemical and molecular toxicology

authors： Su WP,Sun LN,Yang SL,Zhao H,Zeng TY,Wu WZ,Wang D

更新日期：2018-05-02 00:00:00

abstract：:In this study, we aimed to determine the inhibition effects of novel synthesized sulfamates (2a-g), sulfonamides (3b-f), carbonyl sulfonamides (3h and i), and carbonyl sulfamates (4h and 4i), which were tested against two human cytosolic carbonic anhydrase I and II isozymes (hCA I and II) and acetylcholinesterase (ACh...

journal_title：Journal of biochemical and molecular toxicology

authors： Atmaca U,Yıldırım A,Taslimi P,Çelik ST,Gülçin İ,Supuran CT,Çelik M

更新日期：2018-08-01 00:00:00

abstract：:Chalcones and chalcone epoxides are important synthetic intermediates in organic and medicinal chemistry. Chalcones possess a broad spectrum of biological activities; however, 1,3-diphenyl-2-propenone or chalcone has not been given the attention it deserve as its substituted derivatives. In this study, the inhibition ...

journal_title：Journal of biochemical and molecular toxicology

authors： Stellenboom N

更新日期：2019-02-01 00:00:00

abstract：:In the presence of trifluoroacetic acid, on the basis of three-component condensation of phenylthiourea with its salicylaldehyde and methyl-3-oxobutanoate, an efficient method for the synthesis of 1-(4-(2-hydroxyphenyl)-6-methyl-1-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)ethanone (I) has been worked out. These...

journal_title：Journal of biochemical and molecular toxicology

authors： Maharramova G,Taslimi P,Sujayev A,Farzaliyev V,Durmaz L,Gulçin İ

更新日期：2018-12-01 00:00:00

abstract：:The expression of glutathione S-transferase (GST) is a crucial factor in determining the sensitivity of cells and organs in response to a variety of toxicants. In this study, we cloned the core nucleotide of alpha, kappa, mu, mGST, pi, rho, and theta-like GST genes from bighead carp (Aristichthys nobilis). Their deriv...

journal_title：Journal of biochemical and molecular toxicology

authors： Li G,Xie P,Li H,Chen J,Hao L,Xiong Q

更新日期：2010-07-01 00:00:00

abstract：:Changes in the chemical or physical conditions of the cell that impose a negative effect on growth demand rapid cellular responses, which are essential for survival. Molecular mechanisms induced upon exposure of cells to such adverse conditions are commonly designated as stress responses. Herein, different methods whi...

journal_title：Journal of biochemical and molecular toxicology

authors： Jamnik P,Raspor P

更新日期：2005-01-01 00:00:00

abstract：:Diepoxybutane (DEB) is the most potent active metabolite of the environmental chemical 1,3-butadiene (BD). BD is a known mutagen and human carcinogen and possesses multisystems organ toxicity. We previously reported the elevation of p53 in human TK6 lymphoblasts undergoing DEB-induced apoptosis. In this study, we have...

journal_title：Journal of biochemical and molecular toxicology

authors： Yadavilli S,Chen Z,Albrecht T,Muganda PM

更新日期：2009-11-01 00:00:00

abstract：:Paroxetine, a representative of serotonin reuptake inhibitors, has recently gained attention due to its anti-inflammatory properties. However, underlying mechanisms responsible for its immunosuppressive effects remain to be unveiled. To understand the responsible signaling mechanisms, we examined paroxetine's effect o...

journal_title：Journal of biochemical and molecular toxicology

authors： Kabiri M,Hemmatpour A,Zare F,Hadinedoushan H,Karimollah A

更新日期：2020-05-01 00:00:00

abstract：:In this work to determine the effects of metals exposure of Oreochromis niloticus on erythrocyte antioxidant systems, fish were exposed to 5.0 mg/L Zn, 1.0 mg/L Cd, and 5.0 mg/L Zn + 1.0 mg/L Cd mixtures for 7 and 14 days and reduced glutathione (GSH) level, catalase (CAT), and glucose-6-phosphate dehydrogenase (G6PD)...

journal_title：Journal of biochemical and molecular toxicology

authors： Firat O,Kargin F

更新日期：2010-07-01 00:00:00

abstract：:The quantitative influence of copper on the interaction between cytochrome c and sulfite, which is a derivate of sulfur dioxide in the human body, has been studied by fluorescence spectrometry and ultraviolet absorption spectrometry in vitro. The results indicate that copper may intensely combine with protein componen...

journal_title：Journal of biochemical and molecular toxicology

authors： Wang J,Guo D,Yuan X

更新日期：2006-01-01 00:00:00

abstract：:Ebselen (EB, compound 1) is an investigational organoselenium compound that reduces fungal growth, in part, through inhibition of the fungal plasma membrane H+ -ATPase (Pma1p). In the present study, the growth inhibitory activity of EB and of five structural analogs was assessed in a fluconazole (FLU)-resistant strain...

journal_title：Journal of biochemical and molecular toxicology

authors： Orie NN,Warren AR,Basaric J,Lau-Cam C,Piętka-Ottlik M,Młochowski J,Billack B

更新日期：2017-06-01 00:00:00

abstract：:The metabolic implications of tamoxifen (TAM) used as preventive therapy of young premenopausal women with high risk of breast cancer is unknown. To unravel this problem, an animal model of long-term TAM administration to cycling young adult female rats was used to evaluate its effects in the liver. Body weight and fo...

journal_title：Journal of biochemical and molecular toxicology

authors： Resende AD,Leal S,Batista-Pinto C,Garcez F,Sá SI

更新日期：2019-05-01 00:00:00

abstract：:We investigated the effects of the herbicide thiobencarb on the growth, photosynthetic activity, and expression profile of photosynthesis-related proteins in the marine diatom Thalassiosira pseudonana. Growth rate was suppressed by 50% at a thiobencarb concentration of 1.26 mg/L. Growth and photosystem II activity (Fv...

journal_title：Journal of biochemical and molecular toxicology

authors： Shimasaki Y,Tsuyama M,Tasmin R,Qiu X,Shimizu M,Sato Y,Yamasaki Y,Kato-Unoki Y,Nukata A,Nakashima T,Ichinose H,Wariishi H,Honjo T,Oshima Y

更新日期：2013-09-01 00:00:00