Synthesis of novel bis-sulfone derivatives and their inhibition properties on some metabolic enzymes including carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase.

abstract：:Ochratoxin A (OTA) is nephrotoxic, immunosuppressive, and teratogenic in many species and is a possible human carcinogen. In this study, we investigated the OTA pollution situations of grains in northern China and the signaling pathway that mediated OTA-induced apoptosis in human tubular kidney cells (HKCs). Samples o...

journal_title：Journal of biochemical and molecular toxicology

authors： Li Z,Zhang X,Cui J,Kang W

更新日期：2012-03-01 00:00:00

abstract：:Casearia esculenta root (Roxb.) is widely used in traditional system of medicine to treat diabetes in India. An active compound, 3-hydroxymethyl xylitol (3-HMX), has been isolated, and its optimum dose has been determined in a short duration study and patented. In addition, the long-term effect of 3-HMX in type 2 diab...

journal_title：Journal of biochemical and molecular toxicology

authors： Chandramohan G,Al-Numair KS,Sridevi M,Pugalendi KV

更新日期：2010-03-01 00:00:00

abstract：:Chalcones and chalcone epoxides are important synthetic intermediates in organic and medicinal chemistry. Chalcones possess a broad spectrum of biological activities; however, 1,3-diphenyl-2-propenone or chalcone has not been given the attention it deserve as its substituted derivatives. In this study, the inhibition ...

journal_title：Journal of biochemical and molecular toxicology

authors： Stellenboom N

更新日期：2019-02-01 00:00:00

abstract：:The transient receptor potential (TRP) channels are thermo-sensors, and transient receptor potential vanilloid (TRPV)1 and V4 are widely expressed in primary afferent neurons and nonneuronal cells. Although heat acclimation is considered as changes of thermoregulatory responses by thermo-effectors to heat, functional ...

journal_title：Journal of biochemical and molecular toxicology

authors： Sugimoto N,Matsuzaki K,Katakura M,Nakamura H,Ueda Y,Yachie A,Shido O

更新日期：2019-05-01 00:00:00

abstract：:Aldose reductase (AR) is the key enzyme for the polyol pathway and responsible for sorbitol accumulation during the hyperglycemia. The present article focuses on the role of phenol, pyrogallol, hydroquinone, resorcinol, catechol, and phloroglucinol in in vitro inhibition of AR. For this purpose, AR was purified from t...

journal_title：Journal of biochemical and molecular toxicology

authors： Demir Y,Işık M,Gülçin İ,Beydemir Ş

更新日期：2017-09-01 00:00:00

abstract：:Some novel derivatives of thiosemicarbazide and 1,2,4-triazole-3-thiol were synthesized and evaluated for their biological activities. The title compounds were prepared starting from readily available pyridine-2,5-dicarboxylic acid. The reaction carboxylic acid with absolute ethanol afforded the corresponding dimethyl...

journal_title：Journal of biochemical and molecular toxicology

authors： Bulut N,Kocyigit UM,Gecibesler IH,Dastan T,Karci H,Taslimi P,Durna Dastan S,Gulcin I,Cetin A

更新日期：2018-01-01 00:00:00

abstract：:Triclocarban (TCC), which is used as an antimicrobial agent in personal care products, has been widely detected in aquatic ecosystems. However, the consequence of TCC exposure on embryo development is still elusive. Here, by using zebrafish embryos, we aimed to understand the developmental defects caused by TCC exposu...

journal_title：Journal of biochemical and molecular toxicology

authors： Shi Q,Zhuang Y,Hu T,Lu C,Wang X,Huang H,Du G

更新日期：2019-05-01 00:00:00

abstract：:Diabetes mellitus is a serious worldwide metabolic disease, which is accompanied by hyperglycaemia and affects all organs and body system. Zinc (Zn) is a basic cofactor for many enzymes, which also plays an important role in stabilising the structure of insulin. Liver is the most important target organ after pancreas ...

journal_title：Journal of biochemical and molecular toxicology

authors： Sacan O,Turkyilmaz IB,Bayrak BB,Mutlu O,Akev N,Yanardag R

更新日期：2021-01-01 00:00:00

abstract：:A series of novel indenopyrazole derivatives 2a-j and 3a-j were synthesized from the reaction of 1-(4-(hydroxy(1-oxo-1,3-dihydro-2 H-inden-2-ylidene)methyl)phenyl)-3-phenylurea derivatives 1a-j with hydrazine and phenylhydrazine, respectively. The obtained novel indenopyrazoles ( 2a-j and 3a-j) were evaluated for anti...

journal_title：Journal of biochemical and molecular toxicology

authors： Gezegen H,Tutar U,Hepokur C,Ceylan M

更新日期：2019-05-01 00:00:00

abstract：:M1 macrophages serve one edge as proinflammatory and M2 macrophages serve the other edge as an anti-inflammatory macrophage. It appears that a related "switch" in macrophage morphology may also happen in the course of atherosclerosis, which has not yet been elucidated. An atherogenic diet (AD) was given to rats, and i...

journal_title：Journal of biochemical and molecular toxicology

authors： Binesh A,Devaraj SN,Devaraj H

更新日期：2020-02-01 00:00:00

abstract：:Excessive exposure to Copper (Cu) may result in Cu toxicity and adversely affect health outcomes. We investigated the protective role of rutin on Cu-induced brain damage. Experimental rats were treated as follows: group I: control; group II: Cu-sulfate: 200 mg/kg; group III: Cu-sulfate, and rutin 100 mg/kg; and group ...

journal_title：Journal of biochemical and molecular toxicology

authors： Arowoogun J,Akanni OO,Adefisan AO,Owumi SE,Tijani AS,Adaramoye OA

更新日期：2021-01-01 00:00:00

abstract：:The present study evaluates the protective effect of α-lipoic acid (LA) against arsenic-induced testicular and epididymal oxidative damage in rats. Arsenic caused significant reduction in the reproductive organ weights, serum testosterone levels, testicular daily sperm count, epididymal sperm count, sperm motility, sp...

journal_title：Journal of biochemical and molecular toxicology

authors： Prathima P,Pavani R,Sukeerthi S,Sainath SB

更新日期：2018-02-01 00:00:00

abstract：:The dithiocarbamate fungicides maneb and mancozeb induce a short-term stress response in a transgenic Caenorhabditis elegans strain (PC72) carrying a reporter lacZ gene under the control of a homologous heat shock (hsp16) promoter. This response can be readily monitored as induced beta-galactosidase activity, either b...

journal_title：Journal of biochemical and molecular toxicology

authors： Guven K,Power RS,Avramides S,Allender R,de Pomerai DI

更新日期：1999-01-01 00:00:00

abstract：:Paraoxon, the active metabolite of parathion, can be detoxified through a noncatalytic pathway by carboxylesterases and a catalytic pathway by calcium-dependent A-esterases, producing p-nitrophenol as a common metabolite. The detoxication patterns of carboxylesterases and A-esterases were investigated in vitro in the ...

journal_title：Journal of biochemical and molecular toxicology

authors： Tang J,Chambers JE

更新日期：1999-01-01 00:00:00

abstract：:The genotoxic and cytotoxic potential of lambda-cyhalothrin (LCT), a synthetic pyrethroid insecticide, was investigated on human lymphocytes cultured in vitro. Utilizing the trypan blue dye exclusion technique assay, the LC50 of LCT was found to be 28 microM. Based on the LC50 value, it is seen that LCT was highly tox...

journal_title：Journal of biochemical and molecular toxicology

authors： Naravaneni R,Jamil K

更新日期：2005-01-01 00:00:00

abstract：:The current work planned to assess the protecting properties of nimbolide against doxorubicin (DOX)-treated myocardial damage. Myocardial damage was produced with 2.5 mg/kg of DOX given on alternative days (14 days). Thiobarbituric acid reactive substances (TBARS) levels of a lipid peroxidative marker were elevated, w...

journal_title：Journal of biochemical and molecular toxicology

authors： Li H,Xia B,Chen W,Zhang Y,Gao X,Chinnathambi A,Alharbi SA,Zhao Y

更新日期：2020-07-06 00:00:00

abstract：:We investigated the effects of acute diazepam (DZP) administration on thiobarbituric acid-reactive substance (TBARS) levels, protein carbonyl content, and on the activities of the antioxidant enzymes catalase, glutathione peroxidase, and superoxide dismutase in the brain of rats. Additionally, we investigated the anti...

journal_title：Journal of biochemical and molecular toxicology

authors： Eger GA,Ferreira VV,Batista CR,Bonde HL,de Lima DD,Rodrigues AF,da Cruz JG,Magro DD

更新日期：2016-10-01 00:00:00

abstract：:This study examined the possible protective effects of thymoquinone (TQ), the main constituent of the volatile oil of black seed (Nigella sativa), against cyclophosphamide (CP)-induced cardiotoxicity. Adult male Wistar albino rats were divided into four treatment groups. Rats in the first group were served as control....

journal_title：Journal of biochemical and molecular toxicology

authors： Nagi MN,Al-Shabanah OA,Hafez MM,Sayed-Ahmed MM

更新日期：2011-05-01 00:00:00

abstract：:The effects of benzo[a]pyrene (B[a]P) on some drug-metabolizing and antioxidant systems in liver, lung, and stomach were investigated in normal and protein malnutrition (PM) rats. PM significantly inhibited tissue glutathione (GSH) content and increased hepatic lipid peroxidation. Cytochrome P450 isoform CYP1A1 was si...

journal_title：Journal of biochemical and molecular toxicology

authors： Badary OA,AbdEl-Gawad HM,Taha RA,Ali AA,Hamada FM

更新日期：2003-01-01 00:00:00

abstract：:Colorectal cancer (CRC) is the leading type of diagnosed cancer; globally, it resides in the fourth-leading origin of cancer-interrelated mortality in the globe. The treatment strategies were chemotherapy and potent radiotherapy. Although chemotherapy treatment can eliminate tumor cells, it remains with unnecessary to...

journal_title：Journal of biochemical and molecular toxicology

authors： Li Z,Zhou X,Zhu H,Song X,Gao H,Niu Z,Lu J

更新日期：2020-12-28 00:00:00

abstract：:c-Myc and vascular endothelial growth factor (VEGF) genes are frequently deregulated and overexpressed in this malignancy, and strategies designed to inhibit c-Myc and VEGF expression in cancer cells may have considerable therapeutic value. In the present study, we design and use short interfering RNA (siRNA) to inhib...

journal_title：Journal of biochemical and molecular toxicology

authors： Tai J,Wang G,Liu T,Wang L,Lin C,Li F

更新日期：2012-12-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by a constant high pulmonary artery pressure and the remodeling of the vessel. Chloroquine (CLQ) has been observed to inhibit calcium influx. The aim of this study is to investigate the effect of CLQ on transient receptor cationic protei...

journal_title：Journal of biochemical and molecular toxicology

authors： Kaymak E,Akin AT,Tufan E,Başaran KE,Taheri S,Özdamar S,Yakan B

更新日期：2020-09-21 00:00:00

abstract：:It has been shown that carbon monoxide (CO) in low concentration may be an active biochemical and physiological regulator of cell function. The bases of CO toxicity and cell protection are not clearly understood. To provide insights into these mechanisms, we measured superoxide production by D. desulfuricans B-1388 in...

journal_title：Journal of biochemical and molecular toxicology

authors： Davydova M,Sabirova R,Vylegzhanina N,Tarasova N

更新日期：2004-01-01 00:00:00

abstract：:Effects of Cd2+ and two complexes of bivalent cadmium with 1,3-bis(4-chlorbenzylidenamino)-guanidine and anabasine on ion permeability of the inner membrane and respiration of isolated rat liver mitochondria were studied. Starting from 5 microM, Cd2+ decreased state 3 and DNP-stimulated respiration of mitochondria and...

journal_title：Journal of biochemical and molecular toxicology

authors： Korotkov SM,Glazunov VV,Rozengart EV,Suvorov AA,Nikitina ER

更新日期：1999-01-01 00:00:00

abstract：:A number of reduced amino Schiff base ligands and corresponding ruthenium(III) complexes were designed and prepared based on the fact that amino acids not only possess multiple coordinate atoms but also improve the solubility of drugs in the body. The interaction of the complexes with calf thymus DNA was analyzed with...

journal_title：Journal of biochemical and molecular toxicology

authors： Zhang Z,Yang Z,Wu Y,Yuan Z,Du J,Li L

更新日期：2020-08-01 00:00:00

abstract：:In this study, the effects of astaxanthin (AST) that belongs to carotenoid family and cadmium (Cd), which is an important heavy metal, on rat erythrocyte G6PD, 6PGD, GR, and TrxR enzyme activities in vivo and on rat erythrocyte 6PGD enzyme activity in vitro were studied. In in vitro studies, 6PGD enzyme was purified f...

journal_title：Journal of biochemical and molecular toxicology

authors： Bayramoğlu Akkoyun M,Bengü AŞ,Temel Y,Akkoyun HT,Ekin S,Ciftci M

更新日期：2018-08-01 00:00:00

abstract：:Breviscapine, a cerebrovascular drugs extracted from the Chinese herb Erigeron breviscapinus, has been frequently used to clinically treat cerebrovascular diseases such as cerebral thrombosis, cerebral infarction, and cerebral circulation insufficiency. In order to understand its pharmacology or toxicity, the binding ...

journal_title：Journal of biochemical and molecular toxicology

authors： Liu W,Chen Y,Chen H,Zhang Y

更新日期：2016-09-01 00:00:00

abstract：:Carbohydrate-derived aldehydes cause irreversible loss of protein function via glycation. We previously observed that glyceraldehyde 3-phosphate (Glyc3P) abolishes the enzyme activity of cardiac aspartate aminotransferase (cAAT). We also examined the protective effects of carnosine against Glyc3P-induced loss of enzym...

journal_title：Journal of biochemical and molecular toxicology

authors： Seidler NW

更新日期：2000-01-01 00:00:00

abstract：:Sodium dichromate [Cr(VI)] and cadmium chloride [Cd(II)] are both cytotoxic and mutagenic. This study examined the toxic and apoptotic potentials of these two cations on three cell types in vitro, namely, human chronic myelogenous leukemic (CML) K562 cells, promyelocytic leukemic HL-60 cells, and normal human peripher...

journal_title：Journal of biochemical and molecular toxicology

authors： Bagchi D,Joshi SS,Bagchi M,Balmoori J,Benner EJ,Kuszynski CA,Stohs SJ

更新日期：2000-01-01 00:00:00

abstract：:The fluoroquinolones absorb light in the 320 to 330  nm ultraviolet A (UV-A) wavelength and produce reactive oxygen species (ROS) such as superoxide anion, hydroxyl radical, and hydrogen peroxide; thus, the photodynamic generation of ROS may be the basis of phototoxicity of quinolones in human beings and animals. This...

journal_title：Journal of biochemical and molecular toxicology

authors： Yahia R,Masoud MA,Sheded MS,Mansour HA

更新日期：2020-07-01 00:00:00