The effect of chloroquine on the TRPC1, TRPC6, and CaSR in the pulmonary artery smooth muscle cells in hypoxia-induced experimental pulmonary artery hypertension.

abstract：:Oxidative shock and production of reactive oxygen species are known to play a major role in situations leading to neuron degeneration, but the precise mechanisms responsible for cell degeneration remain uncertain. In the present article, we have studied in PC 12 cells the effect of cumene hydroxyperoxide on both cell ...

journal_title：Journal of biochemical and molecular toxicology

authors： Vimard F,Saucet M,Nicole O,Feuilloley M,Duval D

更新日期：2011-07-01 00:00:00

abstract：:Reactive oxygen species (ROS) are generated as by-product of cellular respiration and also due to the exposure of various xenobiotics, whereas mitochondrial electron transport chain is considered as the main source of ROS generation. The sequential addition to molecular oxygen gives rise to various forms of ROS like s...

journal_title：Journal of biochemical and molecular toxicology

authors： Majumder D,Nath P,Debnath R,Maiti D

更新日期：2020-09-29 00:00:00

abstract：:The current work planned to assess the protecting properties of nimbolide against doxorubicin (DOX)-treated myocardial damage. Myocardial damage was produced with 2.5 mg/kg of DOX given on alternative days (14 days). Thiobarbituric acid reactive substances (TBARS) levels of a lipid peroxidative marker were elevated, w...

journal_title：Journal of biochemical and molecular toxicology

authors： Li H,Xia B,Chen W,Zhang Y,Gao X,Chinnathambi A,Alharbi SA,Zhao Y

更新日期：2020-07-06 00:00:00

abstract：:Alkaline phosphatase (ALP) activity in the serum and liver from rats administered with cadmium (Cd) in drinking water was studied. After metal administration, Cd showed a time-dependent accumulation in the liver, meanwhile metallothionein had a maximum increase at 1 month, remaining in this level until the end of the ...

journal_title：Journal of biochemical and molecular toxicology

authors： Treviño S,Andrade-García A,Herrera Camacho I,León-Chavez BA,Aguilar-Alonso P,Flores G,Brambila E

更新日期：2015-12-01 00:00:00

abstract：:Recent studies have established the importance of estrogen-related receptor γ (ERRγ) as a required participant for insulin secretion in pancreatic β cells. Key downstream genes of ERRγ remain unclear in the pancreatic β cell. To understand the molecular role of ERRγ and elucidate potential key candidate genes involved...

journal_title：Journal of biochemical and molecular toxicology

authors： Lei Z,JunHui L,PeiFeng L

更新日期：2019-10-01 00:00:00

abstract：:We reported earlier in a guinea pig model that exposure of 2-chloroethyl ethyl sulfide (CEES), a mustard gas analog, causes lung injury associated with the activation of tumor necrosis factor alpha (TNF-alpha), mitogen activated protein kinases (MAPK) signaling, and activator protein-1 (AP-1) transcription factor. Our...

journal_title：Journal of biochemical and molecular toxicology

authors： Mukhopadhyay S,Mukherjee S,Ray BK,Ray A,Stone WL,Das SK

更新日期：2010-05-01 00:00:00

abstract：:In this work to determine the effects of metals exposure of Oreochromis niloticus on erythrocyte antioxidant systems, fish were exposed to 5.0 mg/L Zn, 1.0 mg/L Cd, and 5.0 mg/L Zn + 1.0 mg/L Cd mixtures for 7 and 14 days and reduced glutathione (GSH) level, catalase (CAT), and glucose-6-phosphate dehydrogenase (G6PD)...

journal_title：Journal of biochemical and molecular toxicology

authors： Firat O,Kargin F

更新日期：2010-07-01 00:00:00

abstract：:The early research found that the spiderlings of black widow spider (Latrodectus tredecimguttatus) exhibited obvious toxicity to animals. The present work performed a systematical analysis of the aqueous extract of newborn black widow spiderlings. The extract was shown to contain 69.42% of proteins varying in molecula...

journal_title：Journal of biochemical and molecular toxicology

authors： Peng X,Zhang Y,Liu J,Yu H,Chen J,Lei Q,Wang X,Liang S

更新日期：2014-05-01 00:00:00

abstract：:Nitrofurantoin (N-(5-nitro-2-furfurylidine) 1-amino-hydantoine; NIT) is mainly used for the treatment of acute urinary tract infections. However, its administration can be associated with liver failure or cirrhosis. The aim of this study was to determine whether NIT is a mitochondrial toxicant, if so, what mechanism(s...

journal_title：Journal of biochemical and molecular toxicology

authors： Omidi M,Niknahad H,Mohammadi-Bardbori A

更新日期：2016-12-01 00:00:00

abstract：:The action of carbenoxolone on hepatic energy metabolism was investigated in the perfused rat liver and isolated mitochondria. In perfused livers, carbenoxolone (200-300 microM) increased oxygen consumption, glucose production and glycolysis from endogenous glycogen. Gluconeogenesis from lactate or fructose, an energy...

journal_title：Journal of biochemical and molecular toxicology

authors： Pivato LS,Constantin RP,Ishii-Iwamoto EL,Kelmer-Bracht AM,Yamamoto NS,Constantin J,Bracht A

更新日期：2006-01-01 00:00:00

abstract：:Carbonic anhydrase (CA) was purified from Ağrı Balık Lake trout gill (fCA) by affinity chromatography on a sepharose 4B-tyrosine-sulfanilamide column. The fCA enzyme was purified with about a 303.9 purification factor, a specific activity 4130.4 EU (mg-protein)(-1), and a yield of 79.3 by using sepharose-4B-L tyrosine...

journal_title：Journal of biochemical and molecular toxicology

authors： Demirdag R,Comakli V,Kuzu M,Yerlikaya E,Şentürk M

更新日期：2015-03-01 00:00:00

abstract：:The present study was designed to elucidate the involvement of acid phosphatase (ACP) in metastasis and lactate dehydrogenase (LDH) as an immediate compensatory alleviation mechanism for energy stress in liver lesions induced by hexachlorocyclohexane in Swiss mice. Animals were continuously exposed to hexachlorocycloh...

journal_title：Journal of biochemical and molecular toxicology

authors： Bhatt DK,Nagda G

更新日期：2012-11-01 00:00:00

abstract：:c-Myc and vascular endothelial growth factor (VEGF) genes are frequently deregulated and overexpressed in this malignancy, and strategies designed to inhibit c-Myc and VEGF expression in cancer cells may have considerable therapeutic value. In the present study, we design and use short interfering RNA (siRNA) to inhib...

journal_title：Journal of biochemical and molecular toxicology

authors： Tai J,Wang G,Liu T,Wang L,Lin C,Li F

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Cadmium is a nonessential toxic heavy metal, which enters the body easily and damages the cellular system. The sonic hedgehog (Shh) signaling pathway is one of the key regulatory pathways, which define neural growth and development. OBJECTIVES:This study aimed to explore how cadmium exposure affects neural ...

journal_title：Journal of biochemical and molecular toxicology

authors： P M MM,Shahi MH,Tayyab M,Farheen S,Khanam N,Tabassum S,Ali A

更新日期：2019-04-01 00:00:00

abstract：:Ochratoxin A (OTA) is nephrotoxic, immunosuppressive, and teratogenic in many species and is a possible human carcinogen. In this study, we investigated the OTA pollution situations of grains in northern China and the signaling pathway that mediated OTA-induced apoptosis in human tubular kidney cells (HKCs). Samples o...

journal_title：Journal of biochemical and molecular toxicology

authors： Li Z,Zhang X,Cui J,Kang W

更新日期：2012-03-01 00:00:00

abstract：:Disruption of the balance oxidants, antioxidants cause various pathophysiological conditions such as lipid peroxidation, protein degradation, or DNA damage. We have examined possible effects of kisspeptin-10 on the structural damage produced by methionine-induced lipid peroxidation in testicle tissue of young rats. Ki...

journal_title：Journal of biochemical and molecular toxicology

authors： Akkaya H,Eyuboglu S,Erkanlı Senturk G,Yilmaz B

更新日期：2017-05-01 00:00:00

abstract：:The interaction between acotiamide hydrochloride and pepsin was systematically characterized by fluorescence and electrochemical approaches. Fluorescence lifetime measurements showed that acotiamide hydrochloride quenched the intrinsic fluorescence of pepsin with a new complex formation via static mode, which was reco...

journal_title：Journal of biochemical and molecular toxicology

authors： He J,Ma X,Wang Q,Huang Y,Li H

更新日期：2016-07-01 00:00:00

abstract：:The objective of the present study was to assess superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), paraoxonase (PON1), glutathione reductase (GR), and catalase (CAT) activities ratio and their relationship with DNA oxidative damage in rats treated with cisplatin (3 mg/kg bwt/day) in the presence and ...

journal_title：Journal of biochemical and molecular toxicology

authors： Harisa GI

更新日期：2013-08-01 00:00:00

abstract：:The present study evaluates the protective effect of α-lipoic acid (LA) against arsenic-induced testicular and epididymal oxidative damage in rats. Arsenic caused significant reduction in the reproductive organ weights, serum testosterone levels, testicular daily sperm count, epididymal sperm count, sperm motility, sp...

journal_title：Journal of biochemical and molecular toxicology

authors： Prathima P,Pavani R,Sukeerthi S,Sainath SB

更新日期：2018-02-01 00:00:00

abstract：:Changes in the chemical or physical conditions of the cell that impose a negative effect on growth demand rapid cellular responses, which are essential for survival. Molecular mechanisms induced upon exposure of cells to such adverse conditions are commonly designated as stress responses. Herein, different methods whi...

journal_title：Journal of biochemical and molecular toxicology

authors： Jamnik P,Raspor P

更新日期：2005-01-01 00:00:00

abstract：:The full-length sequence of the protein phosphatase 2A subunit A (PP2A-A) cDNA from silver carp was cloned and sequenced. Additionally, the transcription of PP2A-A in the liver, kidney, and spleen of fish after microcystin (MC)-exposure were also determined in this study. The results reveal that PP2A-A cDNA is 2833 ba...

journal_title：Journal of biochemical and molecular toxicology

authors： Ma J,Feng Y,Xie W,Li X

更新日期：2015-09-01 00:00:00

abstract：:The present study investigated the protective effect of gossypol, selenium, zinc, or glutathione (GSH) against dimethylnitrosamine (DMN)-induced hepatotoxicity in the livers of male mice. The expression and the activity of glutathione S-transferase (GST), levels of GSH, and free radicals (malondialdehyde (MDA)), as we...

journal_title：Journal of biochemical and molecular toxicology

authors： Sheweita SA,Mousa N,Al-Masry HM

更新日期：2008-11-01 00:00:00

abstract：:Atrazin is currently the most widely used herbicide in agriculture with lots of adverse effects on human health. Curcumin is a polyphenol known for its antioxidant, anti-inflammatory, and anticancer properties. In the present study, the protective effect of curcumin on atrazin-intoxicated rats is evaluated. Toxicity w...

journal_title：Journal of biochemical and molecular toxicology

authors： Keshk WA,Soliman NA,Abo El-Noor MM,Wahdan AA,Shareef MM

更新日期：2014-08-01 00:00:00

abstract：:The purpose of our study is to assist in understanding the effects of wireless electromagnetic waves on carbonic anhydrase (CA) and acetylcholinesterase (AChE) enzymes activities in the different tissues of the rats. For this purpose, two different groups each of which contains eight rats (n = 8) were formed as being ...

journal_title：Journal of biochemical and molecular toxicology

authors： Kocyigit UM,Taslimi P,Gurses F,Soylu S,Durna Dastan S,Gulcin İ

更新日期：2018-03-01 00:00:00

abstract：:A countermeasure that protects the brain from organophosphate toxicity is an unmet need. Few small molecule reactivators that can cross the blood brain barrier and reactivate brain acetyl cholinesterases have been reported. Herein, we describe preclinical investigations of a new class of amidine-oxime reactivator of c...

journal_title：Journal of biochemical and molecular toxicology

authors： Okolotowicz KJ,Dwyer M,Smith E,Cashman JR

更新日期：2014-01-01 00:00:00

abstract：:The use of the cytotoxic antibiotic doxorubicin (DOXR) is limited by its dose-dependent cardiotoxicity. The aim of this study was to evaluate the cardioprotective effect of the combination of carvedilol (CARD) and liposomal resveratrol (LIPO RESV) against DOXR-induced cardiomyopathy in rats. The results of the present...

journal_title：Journal of biochemical and molecular toxicology

authors： Alanazi A,Fadda L,Alhusaini A,Ahmad R

更新日期：2020-07-01 00:00:00

abstract：:Limited research has been performed on S-adenosylhomocysteine (SAH) or homocysteine (Hcy)-evoked cell damage in hepatic and neuronal cells. In this study, we assessed effects of SAH or Hcy on cell cytotoxicity and DNA damage in hepatic and neuronal cells and attempted to find the underlying mechanism. Cell cytotoxicit...

journal_title：Journal of biochemical and molecular toxicology

authors： Liu CC,Ho WY,Leu KL,Tsai HM,Yang TH

更新日期：2009-09-01 00:00:00

abstract：:Manganese is an essential trace element found in many enzymes. As it is the case of many essential trace elements, excessive level of manganese is toxic. It has been proven that excessive manganese could cause heart problems. In order to understand the mechanism of manganese toxicity in the heart, the effects of manga...

journal_title：Journal of biochemical and molecular toxicology

authors： Yang H,Wang T,Li J,Gu L,Zheng X

更新日期：2006-01-01 00:00:00

abstract：:To date, microRNA-4709 (miR-4709) has not been studied in colon adenocarcinoma (COAD) on the basis of experiments. In our study, we aimed to investigate the biological roles and clinical significance of miR-4709 in COAD. The expression difference between miR-4709 and NR3C2 was measured based on The Cancer Genome Atlas...

journal_title：Journal of biochemical and molecular toxicology

authors： Yu M,Yu HL,Li QH,Zhang L,Chen YX

更新日期：2019-12-01 00:00:00

abstract：:A new μ-oxamido-bridged dicopper(II) complex, [Cu2 (papo)(H2 O)- (phen)]Cl·CH3 OH·H2 O, where H3 papo and phen represent N-(2-hydroxyphenyl)-N'-(3-aminopropyl)oxamide and 1,10-phenanthroline, respectively, has been synthesized and characterized by elemental analysis, molar conductivity measurement, infrared and electr...

journal_title：Journal of biochemical and molecular toxicology

authors： Wang LD,Tao L,Li YT,Wu ZY,Yan CW

更新日期：2015-02-01 00:00:00