Abstract:
:Changes in the chemical or physical conditions of the cell that impose a negative effect on growth demand rapid cellular responses, which are essential for survival. Molecular mechanisms induced upon exposure of cells to such adverse conditions are commonly designated as stress responses. Herein, different methods which can be used to monitor oxidative stress response in yeasts are presented including monitoring of oxygen partial pressure during yeast cultivation, cell viability determination, measuring activity of enzymatic and level of nonenzymatic primary antioxidant defense systems, and examination of transcriptome and proteome changes. Additionally, some studies are given as examples of particular method's application for studying oxidative stress response in yeasts.
journal_name
J Biochem Mol Toxicoljournal_title
Journal of biochemical and molecular toxicologyauthors
Jamnik P,Raspor Pdoi
10.1002/jbt.20091subject
Has Abstractpub_date
2005-01-01 00:00:00pages
195-203issue
4eissn
1095-6670issn
1099-0461journal_volume
19pub_type
杂志文章,评审abstract::Zingerone (ZO), an active phenolic agent derived from Zingiber officinale (Ginger), has many pharmacological properties such as antioxidant, antiangiogenic, and antitumor. However, its potential value in cancer and the mechanism by which ZO wields its therapeutic effects remain obscure. Therefore, in this current stud...
journal_title:Journal of biochemical and molecular toxicology
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journal_title:Journal of biochemical and molecular toxicology
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abstract::The genotoxic and cytotoxic potential of lambda-cyhalothrin (LCT), a synthetic pyrethroid insecticide, was investigated on human lymphocytes cultured in vitro. Utilizing the trypan blue dye exclusion technique assay, the LC50 of LCT was found to be 28 microM. Based on the LC50 value, it is seen that LCT was highly tox...
journal_title:Journal of biochemical and molecular toxicology
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abstract::In this work to determine the effects of metals exposure of Oreochromis niloticus on erythrocyte antioxidant systems, fish were exposed to 5.0 mg/L Zn, 1.0 mg/L Cd, and 5.0 mg/L Zn + 1.0 mg/L Cd mixtures for 7 and 14 days and reduced glutathione (GSH) level, catalase (CAT), and glucose-6-phosphate dehydrogenase (G6PD)...
journal_title:Journal of biochemical and molecular toxicology
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journal_title:Journal of biochemical and molecular toxicology
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abstract:BACKGROUND:Cadmium is a nonessential toxic heavy metal, which enters the body easily and damages the cellular system. The sonic hedgehog (Shh) signaling pathway is one of the key regulatory pathways, which define neural growth and development. OBJECTIVES:This study aimed to explore how cadmium exposure affects neural ...
journal_title:Journal of biochemical and molecular toxicology
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abstract::Garlic has been used as a traditional medicine to treat various diseases. Garlic reduces the risk of some diseases. This protective effect is due to the organosulfur compounds of garlic. The aim of this study was to investigate the inhibition effects of garlic-derived compounds on human immunodeficiency virus type 1 (...
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pub_type: 杂志文章
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journal_title:Journal of biochemical and molecular toxicology
pub_type: 杂志文章
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更新日期:2008-11-01 00:00:00
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journal_title:Journal of biochemical and molecular toxicology
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journal_title:Journal of biochemical and molecular toxicology
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journal_title:Journal of biochemical and molecular toxicology
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:Journal of biochemical and molecular toxicology
pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
abstract::Previous studies have shown that the antidepressive-like effect of tricyclic antidepressants is blocked by repeated treatments with adrenocorticotropic hormone (ACTH). However, little is known about the neuroanatomy underlying the mechanism of the imipramine treatment-resistant depression model. In the present study, ...
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journal_title:Journal of biochemical and molecular toxicology
pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
abstract::Aluminum and thallium may reach life-threatening levels in aquatic systems in the near future because of their extensive use in various industrial fields. It is therefore important to study the mechanism of toxicity of aluminum and thallium on fish enzymes. To this aim, the effects of aluminum and thallium on the acti...
journal_title:Journal of biochemical and molecular toxicology
pub_type: 杂志文章
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journal_title:Journal of biochemical and molecular toxicology
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abstract::Aminoglycoside antibiotics are widely used against Gram-negative infections. On the other hand, nephrotoxicity is a deleterious side effect associated with aminoglycoside therapy. Gentamicin is the most nephrotoxic aminoglycoside. Because of serious health complications ensue the nephrotoxicity induced by aminoglycosi...
journal_title:Journal of biochemical and molecular toxicology
pub_type: 杂志文章
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更新日期:2015-02-01 00:00:00
abstract::It has been recently postulated from our laboratory that Arabic gum (AG) offers a protective effect in the kidney of rats against nephrotoxicity induced by gentamicin via inhibiting lipid peroxidation. It has also recently shown a powerful antioxidant effect through scavenging superoxide anions. In this study we utili...
journal_title:Journal of biochemical and molecular toxicology
pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
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journal_title:Journal of biochemical and molecular toxicology
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journal_title:Journal of biochemical and molecular toxicology
pub_type: 杂志文章,评审
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更新日期:2012-10-01 00:00:00
abstract::The antioxidant properties of 1,2,3,4-tetra-hydrocarbazole, 6-methoxy-1,2,3,4-tetrahydrocar-bazole (MTC), 2,3-dimethylindole, 5-methoxy-2,3-dimethylindole, and indole were investigated in the case of hemolysis of human erythrocytes and oxidative damage of DNA induced by 2,2'-azobis(2-amidinopropane hydrochloride) (AAP...
journal_title:Journal of biochemical and molecular toxicology
pub_type: 杂志文章
doi:10.1002/jbt.20289
更新日期:2009-07-01 00:00:00
abstract::The etiologic link between pesticide toxicity and aplastic anemia in agricultural and agro-industrial setting has been frequently reported in epidemiological studies conducted worldwide. Chronic pesticide toxicity causes long-term bone marrow injury and perturbs the normal hematopoietic physiology, including survival ...
journal_title:Journal of biochemical and molecular toxicology
pub_type: 杂志文章
doi:10.1002/jbt.22523
更新日期:2020-05-14 00:00:00