The inhibition effect of garlic-derived compounds on human immunodeficiency virus type 1 and saquinavir.

abstract：:In this study, a series of novel bis-sulfone compounds (2a-2j) were synthesized by oxidation of the bis-sulfides under mild reaction conditions. The bis-sulfone derivatives were characterized by 1 H-NMR, 13 C-NMR, Fourier-transform infrared spectroscopy, and elemental analysis techniques. Nuclear Overhauser effect exp...

journal_title：Journal of biochemical and molecular toxicology

authors： Biçer A,Kaya R,Anıl B,Turgut Cin G,Gülcin İ,Gültekin MS

更新日期：2019-11-01 00:00:00

abstract：:A cDNA clone coding for a mu-class glutathione S-transferase (GST) was isolated from a hepatopancreas cDNA library from the shrimp Litopenaeus vannamei. The deduced amino acid sequence (215 amino acids) has >50% identity to rodents and other mammals mu-class GSTs. Using RT-PCR, the shrimp GST transcript was detected i...

journal_title：Journal of biochemical and molecular toxicology

authors： Contreras-Vergara CA,Harris-Valle C,Sotelo-Mundo RR,Yepiz-Plascencia G

更新日期：2004-01-01 00:00:00

abstract：:We determined the number and the dissociation rate constants of different complexes formed from arsenite and two peptides containing either one (RVCAVGNDYASGYHYGV for peptide 20) or three cysteines (LECAWQGK CVEGTEHLYSMKCK for peptide 10) via radioactive 73As-labeled arsenite and vacuum filtration methodology. Nonline...

journal_title：Journal of biochemical and molecular toxicology

authors： Kitchin KT,Wallace K

更新日期：2006-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) are generated as by-product of cellular respiration and also due to the exposure of various xenobiotics, whereas mitochondrial electron transport chain is considered as the main source of ROS generation. The sequential addition to molecular oxygen gives rise to various forms of ROS like s...

journal_title：Journal of biochemical and molecular toxicology

authors： Majumder D,Nath P,Debnath R,Maiti D

更新日期：2020-09-29 00:00:00

abstract：:The antioxidant properties of 1,2,3,4-tetra-hydrocarbazole, 6-methoxy-1,2,3,4-tetrahydrocar-bazole (MTC), 2,3-dimethylindole, 5-methoxy-2,3-dimethylindole, and indole were investigated in the case of hemolysis of human erythrocytes and oxidative damage of DNA induced by 2,2'-azobis(2-amidinopropane hydrochloride) (AAP...

journal_title：Journal of biochemical and molecular toxicology

authors： Zhao F,Liu ZQ

更新日期：2009-07-01 00:00:00

abstract：:Breviscapine, a cerebrovascular drugs extracted from the Chinese herb Erigeron breviscapinus, has been frequently used to clinically treat cerebrovascular diseases such as cerebral thrombosis, cerebral infarction, and cerebral circulation insufficiency. In order to understand its pharmacology or toxicity, the binding ...

journal_title：Journal of biochemical and molecular toxicology

authors： Liu W,Chen Y,Chen H,Zhang Y

更新日期：2016-09-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that binds and mediates responses to many halogenated aromatic compounds (HACs). Exposure to mixtures of HACs frequently results in nonadditive behavior in both in vivo and in vitro assays. One cause is antagonism, which results when two or...

journal_title：Journal of biochemical and molecular toxicology

authors： Petrulis JR,Bunce NJ

更新日期：2000-01-01 00:00:00

abstract：:The aim of this study was to determine the antigenotoxic potential of two newly synthesized β-aminoketones against N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and 9-aminoacridine (9-AA)-induced mutagenesis. The mutant bacterial tester strains were MNNG-sensitive Escherichia coli WP2 uvrA and 9-AA-sensitive Salmonella ...

journal_title：Journal of biochemical and molecular toxicology

authors： Ozturkcan SA,Turhan K,Turgut Z,Karadayi M,Gulluce M

更新日期：2012-07-01 00:00:00

abstract：:β-Lactam antibiotics such as ceftriaxone, are potent stimulators of the expression of l-glutamate transporter GLT-1 and may exert neuroprotective effects when chronically used in rats and mice. In this study, we used two animal models to test the neurological effect of subchronic treatment with ceftriaxone: experiment...

journal_title：Journal of biochemical and molecular toxicology

authors： Fachim HA,Guizzo R,Cunha AOS,Pereira AC,Dos Anjos LC,Mortari MR,Dos Santos WF

更新日期：2020-11-01 00:00:00

abstract：:Aminoglycoside antibiotics are widely used against Gram-negative infections. On the other hand, nephrotoxicity is a deleterious side effect associated with aminoglycoside therapy. Gentamicin is the most nephrotoxic aminoglycoside. Because of serious health complications ensue the nephrotoxicity induced by aminoglycosi...

journal_title：Journal of biochemical and molecular toxicology

authors： Jamshidzadeh A,Heidari R,Mohammadi-Samani S,Azarpira N,Najbi A,Jahani P,Abdoli N

更新日期：2015-02-01 00:00:00

abstract：:Schisandrin A (SchA) has been reported as a multidrug resistance-reversing agent; however, its antitumor effects have been rarely reported. Consequently, we attempted to explore whether SchA per se possesses an antitumor property in choriocarcinoma JEG-3 and BeWo cells and its potential mechanisms. JEG-3, BeWo, and HT...

journal_title：Journal of biochemical and molecular toxicology

authors： Ji L,Ma L

更新日期：2020-04-01 00:00:00

abstract：:In the epidermis, keratinocytes are involved in physical and first-line immune protection of the host. In this study, we analyzed the molecular responses to certain contact sensitizers (2,4-dinitrochlorobenzene and NiSO(4)) and irritants (sodium dodecyl sulfate and benzalkonium chloride) in cultured human keratinocyte...

journal_title：Journal of biochemical and molecular toxicology

authors： Yoshikawa Y,Sasahara Y,Kitano Y,Kanazawa N,Shima H,Hashimoto-Tamaoki T

更新日期：2010-01-01 00:00:00

abstract：:The present study was designed to elucidate the involvement of acid phosphatase (ACP) in metastasis and lactate dehydrogenase (LDH) as an immediate compensatory alleviation mechanism for energy stress in liver lesions induced by hexachlorocyclohexane in Swiss mice. Animals were continuously exposed to hexachlorocycloh...

journal_title：Journal of biochemical and molecular toxicology

authors： Bhatt DK,Nagda G

更新日期：2012-11-01 00:00:00

abstract：:Chalcones and chalcone epoxides are important synthetic intermediates in organic and medicinal chemistry. Chalcones possess a broad spectrum of biological activities; however, 1,3-diphenyl-2-propenone or chalcone has not been given the attention it deserve as its substituted derivatives. In this study, the inhibition ...

journal_title：Journal of biochemical and molecular toxicology

authors： Stellenboom N

更新日期：2019-02-01 00:00:00

abstract：:Hyperglycemia, a major metabolic disturbance present in diabetes, promotes oxidative stress. Activation of antioxidant defense is an important mechanism to prevent cell damage. Levels of heavy metals and their binding proteins can contribute to oxidative stress. Antiradical capacity and levels of metallothionein (MT),...

journal_title：Journal of biochemical and molecular toxicology

authors： Raudenska M,Dvorakova V,Pacal L,Chalasova K,Kratochvilova M,Gumulec J,Ruttkay-Nedecky B,Zitka O,Kankova K,Adam V,Masarik M

更新日期：2017-06-01 00:00:00

abstract：:Endotoxin exposure elicits various responses in mammals including the acute phase response that has been shown to cause changes in the activity of several forms of cytochrome P450s and other enzymes. Therefore, the hepatic conjugating enzyme, glutathione S-transferase (GST), and UDP-glucuronosyltransferase (UDPGT), th...

journal_title：Journal of biochemical and molecular toxicology

authors： Watson AM,Warren G,Howard G,Shedlofsky SI,Blouin RA

更新日期：1999-01-01 00:00:00

abstract：:The effects of benzo[a]pyrene (B[a]P) on some drug-metabolizing and antioxidant systems in liver, lung, and stomach were investigated in normal and protein malnutrition (PM) rats. PM significantly inhibited tissue glutathione (GSH) content and increased hepatic lipid peroxidation. Cytochrome P450 isoform CYP1A1 was si...

journal_title：Journal of biochemical and molecular toxicology

authors： Badary OA,AbdEl-Gawad HM,Taha RA,Ali AA,Hamada FM

更新日期：2003-01-01 00:00:00

abstract：:Colchicine (COL) shows strong anticancer activity but due to its toxicity towards normal cells its wider application is limited. To address this issue, a library of 17 novel COL derivatives, namely N-carbamates of N-deacetyl-4-(bromo/chloro/iodo)thiocolchicine, has been tested against two types of primary cancer cells...

journal_title：Journal of biochemical and molecular toxicology

authors： Urbaniak A,Jousheghany F,Piña-Oviedo S,Yuan Y,Majcher-Uchańska U,Klejborowska G,Moorjani A,Monzavi-Karbassi B,Huczyński A,Chambers TC

更新日期：2020-06-01 00:00:00

abstract：:The effects of ellagic acid (EA) and vitamin E succinate (VES) on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative stress in different brain regions of rats have been studied after subchronic exposure to the compounds. TCDD was administered to groups of rats at a dose of 46 ng/kg/day for 90 days. EA and VE...

journal_title：Journal of biochemical and molecular toxicology

authors： Hassoun EA,Vodhanel J,Abushaban A

更新日期：2004-01-01 00:00:00

abstract：:A series of novel indenopyrazole derivatives 2a-j and 3a-j were synthesized from the reaction of 1-(4-(hydroxy(1-oxo-1,3-dihydro-2 H-inden-2-ylidene)methyl)phenyl)-3-phenylurea derivatives 1a-j with hydrazine and phenylhydrazine, respectively. The obtained novel indenopyrazoles ( 2a-j and 3a-j) were evaluated for anti...

journal_title：Journal of biochemical and molecular toxicology

authors： Gezegen H,Tutar U,Hepokur C,Ceylan M

更新日期：2019-05-01 00:00:00

abstract：:Hemolysis is the red blood cell abnormality most often associated with adverse effect of drug therapy. Drug-induced or drug-associated hyperglycemia could decrease the activity of hexokinase. The aim of this study was to investigate the inhibitory effects of some commonly used drugs that have hyperglycemic side effect...

journal_title：Journal of biochemical and molecular toxicology

authors： Aljamal JA,Badawneh M

更新日期：2017-08-01 00:00:00

abstract：:T-2 toxin and Ochratoxin A (OTA) are toxic secondary metabolites produced by various fungi, and together they contaminate feedstuffs worldwide. T-2 toxin and OTA may exert carcinogenic action in rodent. Despite the various in vivo experiments, carcinogenicity of these two mycotoxins has not yet been proven for human. ...

journal_title：Journal of biochemical and molecular toxicology

authors： Abassi H,Ayed-Boussema I,Shirley S,Abid S,Bacha H

更新日期：2016-03-01 00:00:00

abstract：:In the present study, we have tested the beneficial effects of forskolin in protecting the mancozeb-induced reproductive toxicity in rats. Adult male Wistar rats were exposed to either mancozeb (500 mg/kg body weight/day) or forskolin (5 mg/kg body weight/day) or both for 65 days and analyzed for spermatogenesis and s...

journal_title：Journal of biochemical and molecular toxicology

authors： Girish BP,Reddy PS

更新日期：2018-02-01 00:00:00

abstract：:β-Hydroxybutyrate (BHB), one of ketone body, has been traditionally regarded as an alternative carrier of energy, but recent studies found that BHB plays versatile roles in inflammation. It has been previously reported that the level BHB declined in mice with lipopolysaccharide (LPS)/d-galactosamine (d-Gal)-induced li...

journal_title：Journal of biochemical and molecular toxicology

authors： Yang Y,Shao R,Jiang R,Zhu M,Tang L,Li L,Zhang L

更新日期：2019-09-01 00:00:00

abstract：:Casearia esculenta root (Roxb.) is widely used in traditional system of medicine to treat diabetes in India. An active compound, 3-hydroxymethyl xylitol (3-HMX), has been isolated, and its optimum dose has been determined in a short duration study and patented. In addition, the long-term effect of 3-HMX in type 2 diab...

journal_title：Journal of biochemical and molecular toxicology

authors： Chandramohan G,Al-Numair KS,Sridevi M,Pugalendi KV

更新日期：2010-03-01 00:00:00

abstract：:We investigated the effects of chrysin (CHR) on nonalcoholic fatty liver disease (NAFLD) in mice. The NAFLD mouse model was established using a diet deficient in methionine and choline (MCD). CHR was shown to attenuate MCD-induced hepatic fat accumulation, increase very low-density lipoprotein (VLDL) secretion, and de...

journal_title：Journal of biochemical and molecular toxicology

authors： Song Y,Wu W,Sheng L,Jiang B,Li X,Cai K

更新日期：2020-07-01 00:00:00

abstract：:We investigated the effects of acute diazepam (DZP) administration on thiobarbituric acid-reactive substance (TBARS) levels, protein carbonyl content, and on the activities of the antioxidant enzymes catalase, glutathione peroxidase, and superoxide dismutase in the brain of rats. Additionally, we investigated the anti...

journal_title：Journal of biochemical and molecular toxicology

authors： Eger GA,Ferreira VV,Batista CR,Bonde HL,de Lima DD,Rodrigues AF,da Cruz JG,Magro DD

更新日期：2016-10-01 00:00:00

abstract：:Colorectal cancer (CRC) is the leading type of diagnosed cancer; globally, it resides in the fourth-leading origin of cancer-interrelated mortality in the globe. The treatment strategies were chemotherapy and potent radiotherapy. Although chemotherapy treatment can eliminate tumor cells, it remains with unnecessary to...

journal_title：Journal of biochemical and molecular toxicology

authors： Li Z,Zhou X,Zhu H,Song X,Gao H,Niu Z,Lu J

更新日期：2020-12-28 00:00:00

abstract：:CYP1A1 and CYP1A2 enzymes metabolize polycyclic aromatic hydrocarbons (PAHs) to the reactive oxyderivatives. PAHs can induce the activity of both enzymes, which increases its conversion and enhances risk of carcinogenesis. Thus, the inhibition of CYP enzymes is recognized as a cancer chemoprevention strategy. A well-k...

journal_title：Journal of biochemical and molecular toxicology

authors： Skupinska K,Misiewicz-Krzeminska I,Stypulkowski R,Lubelska K,Kasprzycka-Guttman T

更新日期：2009-01-01 00:00:00

abstract：:Toxicogenomics is a term that represents the merging of toxicology with novel genomics techniques. Data generated in the new-age era of toxicology is relatively complex, requires new bioinformatics tools for adequate interpretation, and allows for the rapid generation of testable hypotheses. Hazard identification and ...

journal_title：Journal of biochemical and molecular toxicology

authors： Hamadeh HK,Bushel P,Paules R,Afshari CA

更新日期：2001-01-01 00:00:00