Effects of benzo[a]pyrene on tissue activities of metabolizing enzymes and antioxidant system in normal and protein-malnourished rats.

abstract：:We determined the number and the dissociation rate constants of different complexes formed from arsenite and two peptides containing either one (RVCAVGNDYASGYHYGV for peptide 20) or three cysteines (LECAWQGK CVEGTEHLYSMKCK for peptide 10) via radioactive 73As-labeled arsenite and vacuum filtration methodology. Nonline...

journal_title：Journal of biochemical and molecular toxicology

authors： Kitchin KT,Wallace K

更新日期：2006-01-01 00:00:00

abstract：:The present study evaluates the protective effect of α-lipoic acid (LA) against arsenic-induced testicular and epididymal oxidative damage in rats. Arsenic caused significant reduction in the reproductive organ weights, serum testosterone levels, testicular daily sperm count, epididymal sperm count, sperm motility, sp...

journal_title：Journal of biochemical and molecular toxicology

authors： Prathima P,Pavani R,Sukeerthi S,Sainath SB

更新日期：2018-02-01 00:00:00

abstract：:Limited research has been performed on S-adenosylhomocysteine (SAH) or homocysteine (Hcy)-evoked cell damage in hepatic and neuronal cells. In this study, we assessed effects of SAH or Hcy on cell cytotoxicity and DNA damage in hepatic and neuronal cells and attempted to find the underlying mechanism. Cell cytotoxicit...

journal_title：Journal of biochemical and molecular toxicology

authors： Liu CC,Ho WY,Leu KL,Tsai HM,Yang TH

更新日期：2009-09-01 00:00:00

abstract：:The effects of in vivo administration of the cyclodiene tumor promoter heptachlor epoxide on mouse liver protein kinase C were studied in male B6C3F1 mice by protein kinase C activity assays and Western blotting under conditions known to increase the incidence of hepatocellular carcinoma because protein kinase C is th...

journal_title：Journal of biochemical and molecular toxicology

authors： Hansen ME,Matsumura F

更新日期：2001-01-01 00:00:00

abstract：:A full-length cDNA clone encoding a novel form of the cytochrome P450 3A subfamily (Cyp3a-25) has been isolated from a mouse liver cDNA library. The sequence contained 2010 base pairs and encoded a protein with 503 amino acids. The amino acid sequence shared greater identities with rat CYP3A18 (90%) and golden hamster...

journal_title：Journal of biochemical and molecular toxicology

authors： Dai D,Bai R,Hodgson E,Rose RL

更新日期：2001-01-01 00:00:00

abstract：:The present study aims to investigate the protective effect of quercetin against Aroclor-1254-induced hepatotoxicity in rats. Male Wistar rats were grouped into Group I control received vehicle (corn oil; 1 mL/kg bwt); Group II quercetin alone (50 mg/kg bwt/day orally); Group III Aroclor-1254 (2 mg/kg bwt/day intraper...

journal_title：Journal of biochemical and molecular toxicology

authors： Sekaran S,Kandaswamy S,Gunasekaran K,Perumal E,Afsar Basha FY,Madhan Mohan BJ,Jagadeesan A

更新日期：2012-12-01 00:00:00

abstract：:A nonhemorrhagic proteinase B-20 from the venom of Bitis arietans has been purified to apparent electrophoretic homogeneity by chromatography on Sephadex G-100, Q-Sepharose, and CM-cellulose. It has a molecular weight of 20 k Da as determined by size exclusion chromatography on Sephadex G-100 and migrated as a single ...

journal_title：Journal of biochemical and molecular toxicology

authors： Nok AJ

更新日期：2001-01-01 00:00:00

abstract：:To date, microRNA-4709 (miR-4709) has not been studied in colon adenocarcinoma (COAD) on the basis of experiments. In our study, we aimed to investigate the biological roles and clinical significance of miR-4709 in COAD. The expression difference between miR-4709 and NR3C2 was measured based on The Cancer Genome Atlas...

journal_title：Journal of biochemical and molecular toxicology

authors： Yu M,Yu HL,Li QH,Zhang L,Chen YX

更新日期：2019-12-01 00:00:00

abstract：:A cDNA clone coding for a mu-class glutathione S-transferase (GST) was isolated from a hepatopancreas cDNA library from the shrimp Litopenaeus vannamei. The deduced amino acid sequence (215 amino acids) has >50% identity to rodents and other mammals mu-class GSTs. Using RT-PCR, the shrimp GST transcript was detected i...

journal_title：Journal of biochemical and molecular toxicology

authors： Contreras-Vergara CA,Harris-Valle C,Sotelo-Mundo RR,Yepiz-Plascencia G

更新日期：2004-01-01 00:00:00

abstract：:Hyperglycemia, a major metabolic disturbance present in diabetes, promotes oxidative stress. Activation of antioxidant defense is an important mechanism to prevent cell damage. Levels of heavy metals and their binding proteins can contribute to oxidative stress. Antiradical capacity and levels of metallothionein (MT),...

journal_title：Journal of biochemical and molecular toxicology

authors： Raudenska M,Dvorakova V,Pacal L,Chalasova K,Kratochvilova M,Gumulec J,Ruttkay-Nedecky B,Zitka O,Kankova K,Adam V,Masarik M

更新日期：2017-06-01 00:00:00

abstract：:Our earlier investigation demonstrated that methoxychlor treatment induced hepatic cytochrome P450 2B1/2B2 and 3A proteins in rats and enhanced their respective enzymatic activities. To determine the mechanism of the methoxychlor-mediated induction and whether methoxychlor acts as a frank inducer and not merely by cau...

journal_title：Journal of biochemical and molecular toxicology

authors： Li HC,Kupfer D

更新日期：1998-01-01 00:00:00

abstract：:Endotoxin exposure elicits various responses in mammals including the acute phase response that has been shown to cause changes in the activity of several forms of cytochrome P450s and other enzymes. Therefore, the hepatic conjugating enzyme, glutathione S-transferase (GST), and UDP-glucuronosyltransferase (UDPGT), th...

journal_title：Journal of biochemical and molecular toxicology

authors： Watson AM,Warren G,Howard G,Shedlofsky SI,Blouin RA

更新日期：1999-01-01 00:00:00

abstract：:Colorectal cancer (CRC) is the leading type of diagnosed cancer; globally, it resides in the fourth-leading origin of cancer-interrelated mortality in the globe. The treatment strategies were chemotherapy and potent radiotherapy. Although chemotherapy treatment can eliminate tumor cells, it remains with unnecessary to...

journal_title：Journal of biochemical and molecular toxicology

authors： Li Z,Zhou X,Zhu H,Song X,Gao H,Niu Z,Lu J

更新日期：2020-12-28 00:00:00

abstract：:CYP1A1 and CYP1A2 enzymes metabolize polycyclic aromatic hydrocarbons (PAHs) to the reactive oxyderivatives. PAHs can induce the activity of both enzymes, which increases its conversion and enhances risk of carcinogenesis. Thus, the inhibition of CYP enzymes is recognized as a cancer chemoprevention strategy. A well-k...

journal_title：Journal of biochemical and molecular toxicology

authors： Skupinska K,Misiewicz-Krzeminska I,Stypulkowski R,Lubelska K,Kasprzycka-Guttman T

更新日期：2009-01-01 00:00:00

abstract：:Minimizing the adverse effects of chemotherapeutic agents remains a therapeutic challenge. Cisplatin (CP) induces hepatotoxicity through activation of oxidative stress, inflammation, and apoptosis cascades which is considered a significant drawback. Thus, this study aimed to highlight the possible hepatoprotective rol...

journal_title：Journal of biochemical and molecular toxicology

authors： Sherif IO

更新日期：2021-01-25 00:00:00

abstract：:The cytochrome P450 (CYP) isoform CYP2C11 is specifically expressed in the liver of adult male rats, and 5alpha-reductase is specifically expressed in the liver of the adult female rats. The sexually dimorphic expressions of these hepatic enzymes are regulated by the sex-dependent profiles of the circulating growth ho...

journal_title：Journal of biochemical and molecular toxicology

authors： Ishizuka M,Yonemoto J,Zaha H,Tohyama C,Sone H

更新日期：2003-01-01 00:00:00

abstract：:In the presence of trifluoroacetic acid, on the basis of three-component condensation of phenylthiourea with its salicylaldehyde and methyl-3-oxobutanoate, an efficient method for the synthesis of 1-(4-(2-hydroxyphenyl)-6-methyl-1-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)ethanone (I) has been worked out. These...

journal_title：Journal of biochemical and molecular toxicology

authors： Maharramova G,Taslimi P,Sujayev A,Farzaliyev V,Durmaz L,Gulçin İ

更新日期：2018-12-01 00:00:00

abstract：:Hemolysis is the red blood cell abnormality most often associated with adverse effect of drug therapy. Drug-induced or drug-associated hyperglycemia could decrease the activity of hexokinase. The aim of this study was to investigate the inhibitory effects of some commonly used drugs that have hyperglycemic side effect...

journal_title：Journal of biochemical and molecular toxicology

authors： Aljamal JA,Badawneh M

更新日期：2017-08-01 00:00:00

abstract：:The early research found that the spiderlings of black widow spider (Latrodectus tredecimguttatus) exhibited obvious toxicity to animals. The present work performed a systematical analysis of the aqueous extract of newborn black widow spiderlings. The extract was shown to contain 69.42% of proteins varying in molecula...

journal_title：Journal of biochemical and molecular toxicology

authors： Peng X,Zhang Y,Liu J,Yu H,Chen J,Lei Q,Wang X,Liang S

更新日期：2014-05-01 00:00:00

abstract：:This experiment was performed to evaluate the possible embryotoxic and teratogenic effects of doxycycline during rat development. Twenty-one female rats were used and distributed into three groups equally (seven animals/group). The low dose group received doxycycline at a dose of 5 mg/kg bw/day orally from the 6th to ...

journal_title：Journal of biochemical and molecular toxicology

authors： Abd-Allah ER,Abd El-Rahman HA

更新日期：2021-01-01 00:00:00

abstract：:Colchicine (COL) shows strong anticancer activity but due to its toxicity towards normal cells its wider application is limited. To address this issue, a library of 17 novel COL derivatives, namely N-carbamates of N-deacetyl-4-(bromo/chloro/iodo)thiocolchicine, has been tested against two types of primary cancer cells...

journal_title：Journal of biochemical and molecular toxicology

authors： Urbaniak A,Jousheghany F,Piña-Oviedo S,Yuan Y,Majcher-Uchańska U,Klejborowska G,Moorjani A,Monzavi-Karbassi B,Huczyński A,Chambers TC

更新日期：2020-06-01 00:00:00

abstract：:The metabolic implications of tamoxifen (TAM) used as preventive therapy of young premenopausal women with high risk of breast cancer is unknown. To unravel this problem, an animal model of long-term TAM administration to cycling young adult female rats was used to evaluate its effects in the liver. Body weight and fo...

journal_title：Journal of biochemical and molecular toxicology

authors： Resende AD,Leal S,Batista-Pinto C,Garcez F,Sá SI

更新日期：2019-05-01 00:00:00

abstract：:Toxicogenomics is a term that represents the merging of toxicology with novel genomics techniques. Data generated in the new-age era of toxicology is relatively complex, requires new bioinformatics tools for adequate interpretation, and allows for the rapid generation of testable hypotheses. Hazard identification and ...

journal_title：Journal of biochemical and molecular toxicology

authors： Hamadeh HK,Bushel P,Paules R,Afshari CA

更新日期：2001-01-01 00:00:00

abstract：:It has been shown that carbon monoxide (CO) in low concentration may be an active biochemical and physiological regulator of cell function. The bases of CO toxicity and cell protection are not clearly understood. To provide insights into these mechanisms, we measured superoxide production by D. desulfuricans B-1388 in...

journal_title：Journal of biochemical and molecular toxicology

authors： Davydova M,Sabirova R,Vylegzhanina N,Tarasova N

更新日期：2004-01-01 00:00:00

abstract：:The objective of the present study was to assess superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), paraoxonase (PON1), glutathione reductase (GR), and catalase (CAT) activities ratio and their relationship with DNA oxidative damage in rats treated with cisplatin (3 mg/kg bwt/day) in the presence and ...

journal_title：Journal of biochemical and molecular toxicology

authors： Harisa GI

更新日期：2013-08-01 00:00:00

abstract：:Contrary to the fact that doxorubicin is a powerful chemotherapeutic agent for the treatment of neoplastic diseases, cardiotoxicity is too important to be ignored. Thymoquinone serves as a powerful free radical scavenger. In the study, the effects of thymoquinone against doxorubicin-cardiotoxicity will be evaluated. F...

journal_title：Journal of biochemical and molecular toxicology

authors： Karabulut D,Ozturk E,Kaymak E,Akin AT,Yakan B

更新日期：2021-01-01 00:00:00

abstract：:Nitrofurantoin (N-(5-nitro-2-furfurylidine) 1-amino-hydantoine; NIT) is mainly used for the treatment of acute urinary tract infections. However, its administration can be associated with liver failure or cirrhosis. The aim of this study was to determine whether NIT is a mitochondrial toxicant, if so, what mechanism(s...

journal_title：Journal of biochemical and molecular toxicology

authors： Omidi M,Niknahad H,Mohammadi-Bardbori A

更新日期：2016-12-01 00:00:00

abstract：:The interaction between acotiamide hydrochloride and pepsin was systematically characterized by fluorescence and electrochemical approaches. Fluorescence lifetime measurements showed that acotiamide hydrochloride quenched the intrinsic fluorescence of pepsin with a new complex formation via static mode, which was reco...

journal_title：Journal of biochemical and molecular toxicology

authors： He J,Ma X,Wang Q,Huang Y,Li H

更新日期：2016-07-01 00:00:00

abstract：:Netrin-1 has been found to protect kidneys from ischemia/reperfusion injury. In this study, we aimed to address whether the protective effects were mediated through suppression of oxidative stress and neuropeptide Y. Compared to sham-operated animals, animals after ischemia/reperfusion showed marked kidney damage and ...

journal_title：Journal of biochemical and molecular toxicology

authors： Liu L,Xie S,Liao X,Zhang L,Zhong L

更新日期：2013-04-01 00:00:00

abstract：:Carbonic anhydrase (CA) was purified from Ağrı Balık Lake trout gill (fCA) by affinity chromatography on a sepharose 4B-tyrosine-sulfanilamide column. The fCA enzyme was purified with about a 303.9 purification factor, a specific activity 4130.4 EU (mg-protein)(-1), and a yield of 79.3 by using sepharose-4B-L tyrosine...

journal_title：Journal of biochemical and molecular toxicology

authors： Demirdag R,Comakli V,Kuzu M,Yerlikaya E,Şentürk M

更新日期：2015-03-01 00:00:00