Hepatic effects of long-term tamoxifen administration to cycling female rats.

abstract：:The effects of in vivo administration of the cyclodiene tumor promoter heptachlor epoxide on mouse liver protein kinase C were studied in male B6C3F1 mice by protein kinase C activity assays and Western blotting under conditions known to increase the incidence of hepatocellular carcinoma because protein kinase C is th...

journal_title：Journal of biochemical and molecular toxicology

authors： Hansen ME,Matsumura F

更新日期：2001-01-01 00:00:00

abstract：:CYP1A1 and CYP1A2 enzymes metabolize polycyclic aromatic hydrocarbons (PAHs) to the reactive oxyderivatives. PAHs can induce the activity of both enzymes, which increases its conversion and enhances risk of carcinogenesis. Thus, the inhibition of CYP enzymes is recognized as a cancer chemoprevention strategy. A well-k...

journal_title：Journal of biochemical and molecular toxicology

authors： Skupinska K,Misiewicz-Krzeminska I,Stypulkowski R,Lubelska K,Kasprzycka-Guttman T

更新日期：2009-01-01 00:00:00

abstract：:We studied action of inorganic phosphate (P(i)) on toxic effects of Tl+ in isolated rat liver mitochondria. This is a convenient model to study the toxicity of heavy metals. P(i) markedly retarded contraction of energized mitochondria swollen in the TlNO3 medium and even stronger stimulated swelling and state 4 of suc...

journal_title：Journal of biochemical and molecular toxicology

authors： Korotkov SM,Emel'yanova LV,Yagodina OV

更新日期：2008-05-01 00:00:00

abstract：:Changes in the chemical or physical conditions of the cell that impose a negative effect on growth demand rapid cellular responses, which are essential for survival. Molecular mechanisms induced upon exposure of cells to such adverse conditions are commonly designated as stress responses. Herein, different methods whi...

journal_title：Journal of biochemical and molecular toxicology

authors： Jamnik P,Raspor P

更新日期：2005-01-01 00:00:00

abstract：:There is evidence that glutathione conjugates are the major metabolites formed following systemic uptake of carcinogenic contaminants from the intestine. The effect of commercial diet versus a semi-purified diet on the distribution of glutathione S-transferase (GST) activity was examined in proximal, medial, and dista...

journal_title：Journal of biochemical and molecular toxicology

authors： Gadagbui BK,James MO

更新日期：2000-01-01 00:00:00

abstract：:The objective of the present study was to assess superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), paraoxonase (PON1), glutathione reductase (GR), and catalase (CAT) activities ratio and their relationship with DNA oxidative damage in rats treated with cisplatin (3 mg/kg bwt/day) in the presence and ...

journal_title：Journal of biochemical and molecular toxicology

authors： Harisa GI

更新日期：2013-08-01 00:00:00

abstract：:Colorectal cancer (CRC) is the leading type of diagnosed cancer; globally, it resides in the fourth-leading origin of cancer-interrelated mortality in the globe. The treatment strategies were chemotherapy and potent radiotherapy. Although chemotherapy treatment can eliminate tumor cells, it remains with unnecessary to...

journal_title：Journal of biochemical and molecular toxicology

authors： Li Z,Zhou X,Zhu H,Song X,Gao H,Niu Z,Lu J

更新日期：2020-12-28 00:00:00

abstract：:Taxane-based chemotherapy drugs (cabazitaxel, docetaxel, and paclitaxel) are microtubule inhibitors, which are effectively and frequently used to treat metastatic prostate cancer (PCa). Among these, cabazitaxel is offered as a new therapeutic option for patients with metastatic castration-resistant PC as that are resi...

journal_title：Journal of biochemical and molecular toxicology

authors： Cevik O,Acidereli H,Turut FA,Yildirim S,Acilan C

更新日期：2020-06-24 00:00:00

abstract：:Aldose reductase (AR) is the key enzyme for the polyol pathway and responsible for sorbitol accumulation during the hyperglycemia. The present article focuses on the role of phenol, pyrogallol, hydroquinone, resorcinol, catechol, and phloroglucinol in in vitro inhibition of AR. For this purpose, AR was purified from t...

journal_title：Journal of biochemical and molecular toxicology

authors： Demir Y,Işık M,Gülçin İ,Beydemir Ş

更新日期：2017-09-01 00:00:00

abstract：:T-2 toxin and Ochratoxin A (OTA) are toxic secondary metabolites produced by various fungi, and together they contaminate feedstuffs worldwide. T-2 toxin and OTA may exert carcinogenic action in rodent. Despite the various in vivo experiments, carcinogenicity of these two mycotoxins has not yet been proven for human. ...

journal_title：Journal of biochemical and molecular toxicology

authors： Abassi H,Ayed-Boussema I,Shirley S,Abid S,Bacha H

更新日期：2016-03-01 00:00:00

abstract：:The modulatory effect of taurine on 7,12-dimethylbenz(a)anthracene (DMBA)-induced breast cancer in rats was studied. DMBA (25 mg/kg body weight) was administered to induce breast cancer in rats. Protein carbonyl levels, activities of membrane bound enzymes (Na(+) /K(+) ATPase, Ca(2+) ATPase, and Mg(2+) ATPase), phase ...

journal_title：Journal of biochemical and molecular toxicology

authors： Vanitha MK,Baskaran K,Periyasamy K,Selvaraj S,Ilakkia A,Saravanan D,Venkateswari R,Revathi Mani B,Anandakumar P,Sakthisekaran D

更新日期：2016-08-01 00:00:00

abstract：:Our earlier investigation demonstrated that methoxychlor treatment induced hepatic cytochrome P450 2B1/2B2 and 3A proteins in rats and enhanced their respective enzymatic activities. To determine the mechanism of the methoxychlor-mediated induction and whether methoxychlor acts as a frank inducer and not merely by cau...

journal_title：Journal of biochemical and molecular toxicology

authors： Li HC,Kupfer D

更新日期：1998-01-01 00:00:00

abstract：:A nonhemorrhagic proteinase B-20 from the venom of Bitis arietans has been purified to apparent electrophoretic homogeneity by chromatography on Sephadex G-100, Q-Sepharose, and CM-cellulose. It has a molecular weight of 20 k Da as determined by size exclusion chromatography on Sephadex G-100 and migrated as a single ...

journal_title：Journal of biochemical and molecular toxicology

authors： Nok AJ

更新日期：2001-01-01 00:00:00

abstract：:Recent studies have established the importance of estrogen-related receptor γ (ERRγ) as a required participant for insulin secretion in pancreatic β cells. Key downstream genes of ERRγ remain unclear in the pancreatic β cell. To understand the molecular role of ERRγ and elucidate potential key candidate genes involved...

journal_title：Journal of biochemical and molecular toxicology

authors： Lei Z,JunHui L,PeiFeng L

更新日期：2019-10-01 00:00:00

abstract：:In the current study, neuroprotective significance of ellagic acid (EA, a polyohenol) was explored by primarily studying its antioxidant and antiapoptotic potential against arsenic trioxide (As2 O3 )-induced toxicity in SH-SY5Y human neuroblastoma cell lines. The mitigatory effects of EA with particular reference to c...

journal_title：Journal of biochemical and molecular toxicology

authors： Firdaus F,Zafeer MF,Waseem M,Anis E,Hossain MM,Afzal M

更新日期：2018-02-01 00:00:00

abstract：:This study was aimed to predict bisphenol-A (BPA)-responsive miRNA's using an in silico approach and to study their expression in granulosa cells of animals exposed prenatally to BPA. Pregnant Wistar rats were exposed to BPA through water (25 μg/L, 250 μg/L, and 2.5 mg/L) during gestation. The expression of miRNA-133b...

journal_title：Journal of biochemical and molecular toxicology

authors： Lite C,Ahmed SSSJ,Santosh W,Seetharaman B

更新日期：2019-06-01 00:00:00

abstract：:Exposure to arsenic has been linked to the development of type 2 diabetes though its mechanism of toxicity remains unresolved. In this study berberine (BBR) effects on arsenic-induced sirtuin 3 (Sirt3) modifications in isolated mitochondria from rat pancreas were evaluated and compared with metformin (MET). With arsen...

journal_title：Journal of biochemical and molecular toxicology

authors： Javadipour M,Rezaei M,Keshtzar E,Khodayar MJ

更新日期：2019-09-01 00:00:00

abstract：:Drug resistance is a large challenge for the treatment of non-small-cell lung cancer (NSCLC). Deoxyshikonin is the naphthoquinol compound with anticancer activity. However, the role and mechanism of deoxyshikonin in cisplatin resistance of NSCLC remain poorly understood. Cell viability was assessed using 3-(4,5-dimeth...

journal_title：Journal of biochemical and molecular toxicology

authors： Zhang S,Wang Y

更新日期：2020-10-01 00:00:00

abstract：:The health impacts of airborne particulate matter (PM) are of global concern, and the direct implications to the development/exacerbation of lung disease are immediately obvious. Most studies to date have sought to understand mechanisms associated with PM exposure in adults/adult animal models; however, infants are al...

journal_title：Journal of biochemical and molecular toxicology

authors： Saravia J,Lee GI,Lomnicki S,Dellinger B,Cormier SA

更新日期：2013-01-01 00:00:00

abstract：:We investigated the effects of chrysin (CHR) on nonalcoholic fatty liver disease (NAFLD) in mice. The NAFLD mouse model was established using a diet deficient in methionine and choline (MCD). CHR was shown to attenuate MCD-induced hepatic fat accumulation, increase very low-density lipoprotein (VLDL) secretion, and de...

journal_title：Journal of biochemical and molecular toxicology

authors： Song Y,Wu W,Sheng L,Jiang B,Li X,Cai K

更新日期：2020-07-01 00:00:00

abstract：:The effects of ellagic acid (EA) and vitamin E succinate (VES) on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative stress in different brain regions of rats have been studied after subchronic exposure to the compounds. TCDD was administered to groups of rats at a dose of 46 ng/kg/day for 90 days. EA and VE...

journal_title：Journal of biochemical and molecular toxicology

authors： Hassoun EA,Vodhanel J,Abushaban A

更新日期：2004-01-01 00:00:00

abstract：:This experiment was performed to evaluate the possible embryotoxic and teratogenic effects of doxycycline during rat development. Twenty-one female rats were used and distributed into three groups equally (seven animals/group). The low dose group received doxycycline at a dose of 5 mg/kg bw/day orally from the 6th to ...

journal_title：Journal of biochemical and molecular toxicology

authors： Abd-Allah ER,Abd El-Rahman HA

更新日期：2021-01-01 00:00:00

abstract：:In this study, a series of novel bis-sulfone compounds (2a-2j) were synthesized by oxidation of the bis-sulfides under mild reaction conditions. The bis-sulfone derivatives were characterized by 1 H-NMR, 13 C-NMR, Fourier-transform infrared spectroscopy, and elemental analysis techniques. Nuclear Overhauser effect exp...

journal_title：Journal of biochemical and molecular toxicology

authors： Biçer A,Kaya R,Anıl B,Turgut Cin G,Gülcin İ,Gültekin MS

更新日期：2019-11-01 00:00:00

abstract：:The purpose of our study is to assist in understanding the effects of wireless electromagnetic waves on carbonic anhydrase (CA) and acetylcholinesterase (AChE) enzymes activities in the different tissues of the rats. For this purpose, two different groups each of which contains eight rats (n = 8) were formed as being ...

journal_title：Journal of biochemical and molecular toxicology

authors： Kocyigit UM,Taslimi P,Gurses F,Soylu S,Durna Dastan S,Gulcin İ

更新日期：2018-03-01 00:00:00

abstract：:Diepoxybutane (DEB) is the most potent active metabolite of the environmental chemical 1,3-butadiene (BD). BD is a known mutagen and human carcinogen and possesses multisystems organ toxicity. We previously reported the elevation of p53 in human TK6 lymphoblasts undergoing DEB-induced apoptosis. In this study, we have...

journal_title：Journal of biochemical and molecular toxicology

authors： Yadavilli S,Chen Z,Albrecht T,Muganda PM

更新日期：2009-11-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by a constant high pulmonary artery pressure and the remodeling of the vessel. Chloroquine (CLQ) has been observed to inhibit calcium influx. The aim of this study is to investigate the effect of CLQ on transient receptor cationic protei...

journal_title：Journal of biochemical and molecular toxicology

authors： Kaymak E,Akin AT,Tufan E,Başaran KE,Taheri S,Özdamar S,Yakan B

更新日期：2020-09-21 00:00:00

abstract：:Enantiomers of cis,cis-decahydro-2-naphthyl-N-n-butylcarbamate show stereo-specific inhibition for acetylcholinesterase and butyrylcholinesterase. For both inhibition reaction, (2S,4aR,8aS)-cis,cis-decahydro-2-naphthyl-N-n- butylcarbamate is more potent than (2R,4aS,8aR)-cis,cis-decahydro-2-naphthyl-N-n-butylcarbamate...

journal_title：Journal of biochemical and molecular toxicology

authors： Lin MC,Yeh SJ,Chen IR,Lin G

更新日期：2011-09-01 00:00:00

abstract：:The toxicities of 4 short-chain alcohols--namely methanol, ethanol, iso-propanol and iso-butanol--were compared in the nematode Caenorhabditis elegans using several different ecotoxicological endpoints. Range-finding tests were conducted using transgenic PC161 worms carrying a double reporter construct (GFP plus lacZ)...

journal_title：Journal of biochemical and molecular toxicology

authors： Thompson G,de Pomerai DI

更新日期：2005-01-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm with high rate of lymph node metastasis and recurrence. The aim of this study is to evaluate the expression profile of T Lymphoma Invasion and Metastasis 1 (TIAM1) in OSCC and its correlation with clinical outcomes including lymph node metastasi...

journal_title：Journal of biochemical and molecular toxicology

authors： Lin L,You J,Qian Y,Han Y,Xiong H,Zhu T,Xia K,Su T

更新日期：2017-04-01 00:00:00

abstract：:The effects of benzo[a]pyrene (B[a]P) on some drug-metabolizing and antioxidant systems in liver, lung, and stomach were investigated in normal and protein malnutrition (PM) rats. PM significantly inhibited tissue glutathione (GSH) content and increased hepatic lipid peroxidation. Cytochrome P450 isoform CYP1A1 was si...

journal_title：Journal of biochemical and molecular toxicology

authors： Badary OA,AbdEl-Gawad HM,Taha RA,Ali AA,Hamada FM

更新日期：2003-01-01 00:00:00