Abstract:
:Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm with high rate of lymph node metastasis and recurrence. The aim of this study is to evaluate the expression profile of T Lymphoma Invasion and Metastasis 1 (TIAM1) in OSCC and its correlation with clinical outcomes including lymph node metastasis and recurrence. Detection of TIAM1 expression in tumor samples from 56 OSCC patients and oral mucosa samples from 20 healthy people was performed by immunohistochemistry. Then immunostaining score of each patient was calculated. The results revealed that TIAM1 was aberrantly expressed in the OSCC group compared with the normal group. Furthermore, high expression of TIAM1 was significantly correlated with lymph node metastasis and the timing of recurrence. Assessment of TIAM1 expression might represent a valid tool in clinical practice for prediction of metastasis, recurrence, and prognosis of OSCC.
journal_name
J Biochem Mol Toxicoljournal_title
Journal of biochemical and molecular toxicologyauthors
Lin L,You J,Qian Y,Han Y,Xiong H,Zhu T,Xia K,Su Tdoi
10.1002/jbt.21875subject
Has Abstractpub_date
2017-04-01 00:00:00issue
4eissn
1095-6670issn
1099-0461journal_volume
31pub_type
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journal_title:Journal of biochemical and molecular toxicology
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journal_title:Journal of biochemical and molecular toxicology
pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00
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abstract::Cisplatin is a widely used chemotherapeutic drug; however, it induces damage on kidney and liver at clinically effective higher doses. Morin hydrate possesses antioxidant, anti-inflammatory, and anticancer properties. Therefore, we aimed to investigate the effects of morin hydrate (50 and 100 mg/kg, orally) against th...
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