Abstract：
:Proximal tubule protein take-up is interceded by 2 receptors, megalin and cubilin. These receptors rescue an assortment of filtered ligands including fundamental vitamins and hormones. The objective of this study was to investigate the potential relation of megalin receptor injury with nuclear factor-kappa B (NF-κB) upregulation in acute kidney injury rat model. Twenty four rats were allocated into two groups: control group received saline, while the second group was intoxicated with cadmium chloride (2.4 mg Cd/kg/day i.p) for 30 days. Blood urea nitrogen, serum creatinine, tissue oxidant-antioxidant parameters (malondialdehyde [MDA] and reduced glutathione [GSH]) and expression levels for NF-κB, toll like receptor-2 (TLR2), toll like receptor-4 (TLR4), and megalin receptor were estimated. Noticeable downregulation of megalin receptor versus upregulation of NF-κB, TLR2, and TLR4 were observed in AKI rat model together with significant elevation in MDA as well as significant reduction in GSH. The study concluded that the oxidative stress in kidney tissue leads to megalin receptor damage, which indeed motivates upregulation of NF-κB through TLRs 2 and 4 pathways.
journal_name
J Biochem Mol Toxicoljournal_title
Journal of biochemical and molecular toxicologyauthors
Elshaer SS,Anwar HMdoi
10.1002/jbt.22014subject
Has Abstractpub_date
2018-01-01 00:00:00issue
1eissn
1095-6670issn
1099-0461journal_volume
32pub_type
杂志文章abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that binds and mediates responses to many halogenated aromatic compounds (HACs). Exposure to mixtures of HACs frequently results in nonadditive behavior in both in vivo and in vitro assays. One cause is antagonism, which results when two or...
journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/(sici)1099-0461(2000)14:2<73::aid-jbt2>3.0
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abstract：:We investigated the effects of chrysin (CHR) on nonalcoholic fatty liver disease (NAFLD) in mice. The NAFLD mouse model was established using a diet deficient in methionine and choline (MCD). CHR was shown to attenuate MCD-induced hepatic fat accumulation, increase very low-density lipoprotein (VLDL) secretion, and de...
journal_title：Journal of biochemical and molecular toxicology
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journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.20255
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journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.22542
更新日期：2020-06-24 00:00:00
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journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/(sici)1099-0461(1998)12:6<315::aid-jbt1>3.
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abstract：:The full-length sequence of the protein phosphatase 2A subunit A (PP2A-A) cDNA from silver carp was cloned and sequenced. Additionally, the transcription of PP2A-A in the liver, kidney, and spleen of fish after microcystin (MC)-exposure were also determined in this study. The results reveal that PP2A-A cDNA is 2833 ba...
journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.21706
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journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.20369
更新日期：2011-05-01 00:00:00
abstract：:Schisandrin A (SchA) has been reported as a multidrug resistance-reversing agent; however, its antitumor effects have been rarely reported. Consequently, we attempted to explore whether SchA per se possesses an antitumor property in choriocarcinoma JEG-3 and BeWo cells and its potential mechanisms. JEG-3, BeWo, and HT...
journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.22455
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journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.22026
更新日期：2018-02-01 00:00:00
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journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/1099-0461(2000)14:5<283::AID-JBT7>3.0.CO;2
更新日期：2000-01-01 00:00:00
abstract：:The widespread opinion that N(2)O(3) as a product of NO oxidation is the only nitros(yl)ating agent under aerobic conditions is based on experiments in homogeneous buffered water solutions. In vivo NO is oxidized in heterogeneous media and this opinion is not correct. The equilibrium in the system being dependent on t...
journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章,评审
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更新日期：2002-01-01 00:00:00
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journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.22665
更新日期：2020-12-28 00:00:00
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journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.20156
更新日期：2007-01-01 00:00:00
abstract：:Hemolysis is the red blood cell abnormality most often associated with adverse effect of drug therapy. Drug-induced or drug-associated hyperglycemia could decrease the activity of hexokinase. The aim of this study was to investigate the inhibitory effects of some commonly used drugs that have hyperglycemic side effect...
journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.21910
更新日期：2017-08-01 00:00:00
abstract：:A number of reduced amino Schiff base ligands and corresponding ruthenium(III) complexes were designed and prepared based on the fact that amino acids not only possess multiple coordinate atoms but also improve the solubility of drugs in the body. The interaction of the complexes with calf thymus DNA was analyzed with...
journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.22510
更新日期：2020-08-01 00:00:00
abstract：:To date, microRNA-4709 (miR-4709) has not been studied in colon adenocarcinoma (COAD) on the basis of experiments. In our study, we aimed to investigate the biological roles and clinical significance of miR-4709 in COAD. The expression difference between miR-4709 and NR3C2 was measured based on The Cancer Genome Atlas...
journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.22411
更新日期：2019-12-01 00:00:00
abstract：:Excessive exposure to Copper (Cu) may result in Cu toxicity and adversely affect health outcomes. We investigated the protective role of rutin on Cu-induced brain damage. Experimental rats were treated as follows: group I: control; group II: Cu-sulfate: 200 mg/kg; group III: Cu-sulfate, and rutin 100 mg/kg; and group ...
journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.22623
更新日期：2021-01-01 00:00:00
abstract：:Oxidative shock and production of reactive oxygen species are known to play a major role in situations leading to neuron degeneration, but the precise mechanisms responsible for cell degeneration remain uncertain. In the present article, we have studied in PC 12 cells the effect of cumene hydroxyperoxide on both cell ...
journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.20377
更新日期：2011-07-01 00:00:00
abstract：:The effects of in vivo administration of the cyclodiene tumor promoter heptachlor epoxide on mouse liver protein kinase C were studied in male B6C3F1 mice by protein kinase C activity assays and Western blotting under conditions known to increase the incidence of hepatocellular carcinoma because protein kinase C is th...
journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/1099-0461(2001)15:1<1::aid-jbt1>3.0.co;2-0
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abstract：:The effects of Echis pyramidum venom (EPV) (0.25, 0.50, and 1.00 mg/kg) on activities of superoxide dismutase (SOD) and catalase (CAT) and levels of thiobarbituric acid reactive substances (TBARS) and total thiols (T-SH) in liver and kidneys of rats were investigated. EPV significantly and dose dependently decreased t...
journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.21578
更新日期：2014-09-01 00:00:00
abstract：:Renal xenobiotic transporters are important determinants of urinary secretion and reabsorption of chemicals. In addition to glomerular filtration, these processes are key to the overall renal clearance of a diverse array of drugs and toxins. Alterations in kidney transporter levels and function can influence the effic...
journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章,评审
doi：10.1002/jbt.21435
更新日期：2012-10-01 00:00:00
abstract：:Aluminum and thallium may reach life-threatening levels in aquatic systems in the near future because of their extensive use in various industrial fields. It is therefore important to study the mechanism of toxicity of aluminum and thallium on fish enzymes. To this aim, the effects of aluminum and thallium on the acti...
journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.20200
更新日期：2007-01-01 00:00:00
abstract：:Habitual consumption of some Melanesian medicinal and food plants may influence atherosclerosis development via their antioxidant capacity at the endothelial level. Areca nut (AN; Areca catechu), piper inflorescence (PBI; Piper betle), betel quid (BQ), guava buds (GB; Psidium guajava), the leaves (NL), juice (NJ), fru...
journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.20186
更新日期：2007-01-01 00:00:00
abstract：:Diepoxybutane (DEB) is the most potent active metabolite of the environmental chemical 1,3-butadiene (BD). BD is a known mutagen and human carcinogen and possesses multisystems organ toxicity. We previously reported the elevation of p53 in human TK6 lymphoblasts undergoing DEB-induced apoptosis. In this study, we have...
journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.20300
更新日期：2009-11-01 00:00:00
abstract：:Ochratoxin A (OTA) is nephrotoxic, immunosuppressive, and teratogenic in many species and is a possible human carcinogen. In this study, we investigated the OTA pollution situations of grains in northern China and the signaling pathway that mediated OTA-induced apoptosis in human tubular kidney cells (HKCs). Samples o...
journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.20420
更新日期：2012-03-01 00:00:00
abstract：:The antioxidant-activated transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) regulates the induction of cytoprotective genes against chemical toxicity and oxidative injuries. The role of phosphorylation in Nrf2 activation has been suggested but remains elusive. We report that phenolic antioxidant/...
journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.20212
更新日期：2008-02-01 00:00:00
abstract：:In this study, groups of B6C3F1 male mice were treated with dichloroacetate (DCA), trichloroacetate (TCA), and mixtures of the compounds (Mix I, II, and III) daily by gavage, for 13 weeks. The tested doses were 7.5, 15, and 30 mg DCA/kg/day and 12.5, 25, and 50 mg TCA/kg/day. The DCA: TCA ratios in Mix I, II, and III ...
journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.21476
更新日期：2013-04-01 00:00:00
abstract：:Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by a constant high pulmonary artery pressure and the remodeling of the vessel. Chloroquine (CLQ) has been observed to inhibit calcium influx. The aim of this study is to investigate the effect of CLQ on transient receptor cationic protei...
journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.22636
更新日期：2020-09-21 00:00:00
abstract：:We reported earlier in a guinea pig model that exposure of 2-chloroethyl ethyl sulfide (CEES), a mustard gas analog, causes lung injury associated with the activation of tumor necrosis factor alpha (TNF-alpha), mitogen activated protein kinases (MAPK) signaling, and activator protein-1 (AP-1) transcription factor. Our...
journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.20329
更新日期：2010-05-01 00:00:00
abstract：:Aminoglycoside antibiotics are widely used against Gram-negative infections. On the other hand, nephrotoxicity is a deleterious side effect associated with aminoglycoside therapy. Gentamicin is the most nephrotoxic aminoglycoside. Because of serious health complications ensue the nephrotoxicity induced by aminoglycosi...
journal_title：Journal of biochemical and molecular toxicology
pub_type： 杂志文章
doi：10.1002/jbt.21667
更新日期：2015-02-01 00:00:00
