当前位置： SCI文献检索 > JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY期刊下所有文献 > Morin Hydrate Mitigates Cisplatin-Induced Renal and Hepatic Injury by Impeding Oxidative/Nitrosative Stress and Inflammation in Mice.

Morin Hydrate Mitigates Cisplatin-Induced Renal and Hepatic Injury by Impeding Oxidative/Nitrosative Stress and Inflammation in Mice.

Abstract：

:Cisplatin is a widely used chemotherapeutic drug; however, it induces damage on kidney and liver at clinically effective higher doses. Morin hydrate possesses antioxidant, anti-inflammatory, and anticancer properties. Therefore, we aimed to investigate the effects of morin hydrate (50 and 100 mg/kg, orally) against the renohepatic toxicity induced by a high dose of cisplatin (20 mg/kg, intraperitoneally). Renal and hepatic function, oxidative/nitrosative stress, and inflammatory markers along with histopathology were evaluated. Morin hydrate ameliorated cisplatin-induced renohepatic toxicity significantly at 100 mg/kg as evidenced from the significant reversal of cisplatin-induced body weight loss, mortality, functional and structural alterations of kidney, and liver. The protective role offered by morin hydrate against cisplatin-induced renohepatic toxicity is by virtue of its free radical scavenging property, thereby abating the depletion of cellular antioxidant defense components and through modulation of inflammatory cytokines. We speculate morin hydrate as a protective candidate against renohepatic toxicity of cisplatin.

journal_name

J Biochem Mol Toxicol

journal_title

Journal of biochemical and molecular toxicology

authors

K V A,Madhana RM,Kasala ER,Samudrala PK,Lahkar M,Gogoi R

doi

10.1002/jbt.21817

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

571-579

issue

12

eissn

1095-6670

issn

1099-0461

journal_volume

30

pub_type

杂志文章

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