Developmental toxicity of triclocarban in zebrafish (Danio rerio) embryos.

abstract：:The current work planned to assess the protecting properties of nimbolide against doxorubicin (DOX)-treated myocardial damage. Myocardial damage was produced with 2.5 mg/kg of DOX given on alternative days (14 days). Thiobarbituric acid reactive substances (TBARS) levels of a lipid peroxidative marker were elevated, w...

journal_title：Journal of biochemical and molecular toxicology

authors： Li H,Xia B,Chen W,Zhang Y,Gao X,Chinnathambi A,Alharbi SA,Zhao Y

更新日期：2020-07-06 00:00:00

abstract：:Paroxetine, a representative of serotonin reuptake inhibitors, has recently gained attention due to its anti-inflammatory properties. However, underlying mechanisms responsible for its immunosuppressive effects remain to be unveiled. To understand the responsible signaling mechanisms, we examined paroxetine's effect o...

journal_title：Journal of biochemical and molecular toxicology

authors： Kabiri M,Hemmatpour A,Zare F,Hadinedoushan H,Karimollah A

更新日期：2020-05-01 00:00:00

abstract：:The effects of ellagic acid (EA) and vitamin E succinate (VES) on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative stress in different brain regions of rats have been studied after subchronic exposure to the compounds. TCDD was administered to groups of rats at a dose of 46 ng/kg/day for 90 days. EA and VE...

journal_title：Journal of biochemical and molecular toxicology

authors： Hassoun EA,Vodhanel J,Abushaban A

更新日期：2004-01-01 00:00:00

abstract：:Retinoic acid (RA) alters the developmental fate of the axial skeletal anlagen. "Anteriorizations" or "posteriorizations," the assumption of characteristics of embryonic areas normally anterior or posterior to the affected tissues, are correlated with altered embryonal expression domains of Hox genes after in utero RA...

journal_title：Journal of biochemical and molecular toxicology

authors： Kawanishi CY,Hartig P,Bobseine KL,Schmid J,Cardon M,Massenburg G,Chernoff N

更新日期：2003-01-01 00:00:00

abstract：:This study examined the possible protective effects of thymoquinone (TQ), the main constituent of the volatile oil of black seed (Nigella sativa), against cyclophosphamide (CP)-induced cardiotoxicity. Adult male Wistar albino rats were divided into four treatment groups. Rats in the first group were served as control....

journal_title：Journal of biochemical and molecular toxicology

authors： Nagi MN,Al-Shabanah OA,Hafez MM,Sayed-Ahmed MM

更新日期：2011-05-01 00:00:00

abstract：:Hemolysis is the red blood cell abnormality most often associated with adverse effect of drug therapy. Drug-induced or drug-associated hyperglycemia could decrease the activity of hexokinase. The aim of this study was to investigate the inhibitory effects of some commonly used drugs that have hyperglycemic side effect...

journal_title：Journal of biochemical and molecular toxicology

authors： Aljamal JA,Badawneh M

更新日期：2017-08-01 00:00:00

abstract：:Alkaline phosphatase (ALP) activity in the serum and liver from rats administered with cadmium (Cd) in drinking water was studied. After metal administration, Cd showed a time-dependent accumulation in the liver, meanwhile metallothionein had a maximum increase at 1 month, remaining in this level until the end of the ...

journal_title：Journal of biochemical and molecular toxicology

authors： Treviño S,Andrade-García A,Herrera Camacho I,León-Chavez BA,Aguilar-Alonso P,Flores G,Brambila E

更新日期：2015-12-01 00:00:00

abstract：:We investigated the effects of chrysin (CHR) on nonalcoholic fatty liver disease (NAFLD) in mice. The NAFLD mouse model was established using a diet deficient in methionine and choline (MCD). CHR was shown to attenuate MCD-induced hepatic fat accumulation, increase very low-density lipoprotein (VLDL) secretion, and de...

journal_title：Journal of biochemical and molecular toxicology

authors： Song Y,Wu W,Sheng L,Jiang B,Li X,Cai K

更新日期：2020-07-01 00:00:00

abstract：:Ebselen (EB, compound 1) is an investigational organoselenium compound that reduces fungal growth, in part, through inhibition of the fungal plasma membrane H+ -ATPase (Pma1p). In the present study, the growth inhibitory activity of EB and of five structural analogs was assessed in a fluconazole (FLU)-resistant strain...

journal_title：Journal of biochemical and molecular toxicology

authors： Orie NN,Warren AR,Basaric J,Lau-Cam C,Piętka-Ottlik M,Młochowski J,Billack B

更新日期：2017-06-01 00:00:00

abstract：:The present study aims to investigate the protective effect of quercetin against Aroclor-1254-induced hepatotoxicity in rats. Male Wistar rats were grouped into Group I control received vehicle (corn oil; 1 mL/kg bwt); Group II quercetin alone (50 mg/kg bwt/day orally); Group III Aroclor-1254 (2 mg/kg bwt/day intraper...

journal_title：Journal of biochemical and molecular toxicology

authors： Sekaran S,Kandaswamy S,Gunasekaran K,Perumal E,Afsar Basha FY,Madhan Mohan BJ,Jagadeesan A

更新日期：2012-12-01 00:00:00

abstract：:In the presence of trifluoroacetic acid, on the basis of three-component condensation of phenylthiourea with its salicylaldehyde and methyl-3-oxobutanoate, an efficient method for the synthesis of 1-(4-(2-hydroxyphenyl)-6-methyl-1-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)ethanone (I) has been worked out. These...

journal_title：Journal of biochemical and molecular toxicology

authors： Maharramova G,Taslimi P,Sujayev A,Farzaliyev V,Durmaz L,Gulçin İ

更新日期：2018-12-01 00:00:00

abstract：:Diabetic neuropathic pain is characterized by spontaneous pain with hyperalgesia and allodynia. We investigated whether (-)-epigallocatechin-3-O-gallate could improve diabetic neuropathic pain development through hypoglycemic, hypolipidemic, antioxidant, and anti-inflammatory effects. Diabetes was induced in rats by s...

journal_title：Journal of biochemical and molecular toxicology

authors： Abo-Salem OM,Ali TM,Harisa GI,Mehanna OM,Younos IH,Almalki WH

更新日期：2020-08-01 00:00:00

abstract：:Paraoxon, the active metabolite of parathion, can be detoxified through a noncatalytic pathway by carboxylesterases and a catalytic pathway by calcium-dependent A-esterases, producing p-nitrophenol as a common metabolite. The detoxication patterns of carboxylesterases and A-esterases were investigated in vitro in the ...

journal_title：Journal of biochemical and molecular toxicology

authors： Tang J,Chambers JE

更新日期：1999-01-01 00:00:00

abstract：:A countermeasure that protects the brain from organophosphate toxicity is an unmet need. Few small molecule reactivators that can cross the blood brain barrier and reactivate brain acetyl cholinesterases have been reported. Herein, we describe preclinical investigations of a new class of amidine-oxime reactivator of c...

journal_title：Journal of biochemical and molecular toxicology

authors： Okolotowicz KJ,Dwyer M,Smith E,Cashman JR

更新日期：2014-01-01 00:00:00

abstract：:The transient receptor potential (TRP) channels are thermo-sensors, and transient receptor potential vanilloid (TRPV)1 and V4 are widely expressed in primary afferent neurons and nonneuronal cells. Although heat acclimation is considered as changes of thermoregulatory responses by thermo-effectors to heat, functional ...

journal_title：Journal of biochemical and molecular toxicology

authors： Sugimoto N,Matsuzaki K,Katakura M,Nakamura H,Ueda Y,Yachie A,Shido O

更新日期：2019-05-01 00:00:00

abstract：:Three new phytoecdysteroids have been isolated from the seeds of Chenopodium quinoa and structurally identified as 20,26-dihydroxy, 28-methyl ecdysone, 20,26-dihydroxy, 24(28)-dehydro ecdysone, and 20-hydroxyecdysone 22-glycolate using serial chromatographic and spectroscopic methods. Both previously reported compound...

journal_title：Journal of biochemical and molecular toxicology

authors： Nsimba RY,Kikuzaki H,Konishi Y

更新日期：2008-07-01 00:00:00

abstract：:Renal xenobiotic transporters are important determinants of urinary secretion and reabsorption of chemicals. In addition to glomerular filtration, these processes are key to the overall renal clearance of a diverse array of drugs and toxins. Alterations in kidney transporter levels and function can influence the effic...

journal_title：Journal of biochemical and molecular toxicology

authors： Yacovino LL,Aleksunes LM

更新日期：2012-10-01 00:00:00

abstract：:The aim of this study was to determine the antigenotoxic potential of two newly synthesized β-aminoketones against N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and 9-aminoacridine (9-AA)-induced mutagenesis. The mutant bacterial tester strains were MNNG-sensitive Escherichia coli WP2 uvrA and 9-AA-sensitive Salmonella ...

journal_title：Journal of biochemical and molecular toxicology

authors： Ozturkcan SA,Turhan K,Turgut Z,Karadayi M,Gulluce M

更新日期：2012-07-01 00:00:00

abstract：:The cytochrome P450 (CYP) isoform CYP2C11 is specifically expressed in the liver of adult male rats, and 5alpha-reductase is specifically expressed in the liver of the adult female rats. The sexually dimorphic expressions of these hepatic enzymes are regulated by the sex-dependent profiles of the circulating growth ho...

journal_title：Journal of biochemical and molecular toxicology

authors： Ishizuka M,Yonemoto J,Zaha H,Tohyama C,Sone H

更新日期：2003-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) are generated as by-product of cellular respiration and also due to the exposure of various xenobiotics, whereas mitochondrial electron transport chain is considered as the main source of ROS generation. The sequential addition to molecular oxygen gives rise to various forms of ROS like s...

journal_title：Journal of biochemical and molecular toxicology

authors： Majumder D,Nath P,Debnath R,Maiti D

更新日期：2020-09-29 00:00:00

abstract：:Aluminum and thallium may reach life-threatening levels in aquatic systems in the near future because of their extensive use in various industrial fields. It is therefore important to study the mechanism of toxicity of aluminum and thallium on fish enzymes. To this aim, the effects of aluminum and thallium on the acti...

journal_title：Journal of biochemical and molecular toxicology

authors： Bozcaarmutlu A

更新日期：2007-01-01 00:00:00

abstract：:Sodium dichromate [Cr(VI)] and cadmium chloride [Cd(II)] are both cytotoxic and mutagenic. This study examined the toxic and apoptotic potentials of these two cations on three cell types in vitro, namely, human chronic myelogenous leukemic (CML) K562 cells, promyelocytic leukemic HL-60 cells, and normal human peripher...

journal_title：Journal of biochemical and molecular toxicology

authors： Bagchi D,Joshi SS,Bagchi M,Balmoori J,Benner EJ,Kuszynski CA,Stohs SJ

更新日期：2000-01-01 00:00:00

abstract：:The use of the cytotoxic antibiotic doxorubicin (DOXR) is limited by its dose-dependent cardiotoxicity. The aim of this study was to evaluate the cardioprotective effect of the combination of carvedilol (CARD) and liposomal resveratrol (LIPO RESV) against DOXR-induced cardiomyopathy in rats. The results of the present...

journal_title：Journal of biochemical and molecular toxicology

authors： Alanazi A,Fadda L,Alhusaini A,Ahmad R

更新日期：2020-07-01 00:00:00

abstract：:Uroporphyrinogen decarboxylase is an essential enzyme in all organisms and functions in the heme biosynthetic pathway, catalyzing the decarboxylation of the four acetate groups of uroporphyrinogen to form coproporphyrinogen. This work examines whether the four sequential decarboxylations occur at the same active site,...

journal_title：Journal of biochemical and molecular toxicology

authors： Chaufan G,Corvi MM,San Martín de Viale LC,Cárdenas ML,Ríos de Molina Mdel C

更新日期：2005-01-01 00:00:00

abstract：:We investigated the effects of acute diazepam (DZP) administration on thiobarbituric acid-reactive substance (TBARS) levels, protein carbonyl content, and on the activities of the antioxidant enzymes catalase, glutathione peroxidase, and superoxide dismutase in the brain of rats. Additionally, we investigated the anti...

journal_title：Journal of biochemical and molecular toxicology

authors： Eger GA,Ferreira VV,Batista CR,Bonde HL,de Lima DD,Rodrigues AF,da Cruz JG,Magro DD

更新日期：2016-10-01 00:00:00

abstract：:The antioxidant-activated transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) regulates the induction of cytoprotective genes against chemical toxicity and oxidative injuries. The role of phosphorylation in Nrf2 activation has been suggested but remains elusive. We report that phenolic antioxidant/...

journal_title：Journal of biochemical and molecular toxicology

authors： Apopa PL,He X,Ma Q

更新日期：2008-02-01 00:00:00

abstract：:Cisplatin is a widely used chemotherapeutic drug; however, it induces damage on kidney and liver at clinically effective higher doses. Morin hydrate possesses antioxidant, anti-inflammatory, and anticancer properties. Therefore, we aimed to investigate the effects of morin hydrate (50 and 100 mg/kg, orally) against th...

journal_title：Journal of biochemical and molecular toxicology

authors： K V A,Madhana RM,Kasala ER,Samudrala PK,Lahkar M,Gogoi R

更新日期：2016-12-01 00:00:00

abstract：:This experiment was performed to evaluate the possible embryotoxic and teratogenic effects of doxycycline during rat development. Twenty-one female rats were used and distributed into three groups equally (seven animals/group). The low dose group received doxycycline at a dose of 5 mg/kg bw/day orally from the 6th to ...

journal_title：Journal of biochemical and molecular toxicology

authors： Abd-Allah ER,Abd El-Rahman HA

更新日期：2021-01-01 00:00:00

abstract：:Minimizing the adverse effects of chemotherapeutic agents remains a therapeutic challenge. Cisplatin (CP) induces hepatotoxicity through activation of oxidative stress, inflammation, and apoptosis cascades which is considered a significant drawback. Thus, this study aimed to highlight the possible hepatoprotective rol...

journal_title：Journal of biochemical and molecular toxicology

authors： Sherif IO

更新日期：2021-01-25 00:00:00

abstract：:β-Hydroxybutyrate (BHB), one of ketone body, has been traditionally regarded as an alternative carrier of energy, but recent studies found that BHB plays versatile roles in inflammation. It has been previously reported that the level BHB declined in mice with lipopolysaccharide (LPS)/d-galactosamine (d-Gal)-induced li...

journal_title：Journal of biochemical and molecular toxicology

authors： Yang Y,Shao R,Jiang R,Zhu M,Tang L,Li L,Zhang L

更新日期：2019-09-01 00:00:00