Chronic Cadmium Exposure Lead to Inhibition of Serum and Hepatic Alkaline Phosphatase Activity in Wistar Rats.

abstract：:Diepoxybutane (DEB) is the most potent active metabolite of the environmental chemical 1,3-butadiene (BD). BD is a known mutagen and human carcinogen and possesses multisystems organ toxicity. We previously reported the elevation of p53 in human TK6 lymphoblasts undergoing DEB-induced apoptosis. In this study, we have...

journal_title：Journal of biochemical and molecular toxicology

authors： Yadavilli S,Chen Z,Albrecht T,Muganda PM

更新日期：2009-11-01 00:00:00

abstract：:Proximal tubule protein take-up is interceded by 2 receptors, megalin and cubilin. These receptors rescue an assortment of filtered ligands including fundamental vitamins and hormones. The objective of this study was to investigate the potential relation of megalin receptor injury with nuclear factor-kappa B (NF-κB) u...

journal_title：Journal of biochemical and molecular toxicology

authors： Elshaer SS,Anwar HM

更新日期：2018-01-01 00:00:00

abstract：:Zingerone (ZO), an active phenolic agent derived from Zingiber officinale (Ginger), has many pharmacological properties such as antioxidant, antiangiogenic, and antitumor. However, its potential value in cancer and the mechanism by which ZO wields its therapeutic effects remain obscure. Therefore, in this current stud...

journal_title：Journal of biochemical and molecular toxicology

authors： Su P,Veeraraghavan VP,Krishna Mohan S,Lu W

更新日期：2019-12-01 00:00:00

abstract：UNLABELLED:Cellular induction of reductase enzymes can alter the susceptibility of cells toward drugs and chemicals. In this study, we compared the capacity of a single dose of sodium selenite and 3H-1,2-dithiole-3-thione (D3T) to influence the drug-relevant reducing capacity of HT29 cells over time, and defined the pr...

journal_title：Journal of biochemical and molecular toxicology

authors： Erzinger MM,Bovet C,Uzozie A,Sturla SJ

更新日期：2015-01-01 00:00:00

abstract：:A full-length cDNA clone encoding a novel form of the cytochrome P450 3A subfamily (Cyp3a-25) has been isolated from a mouse liver cDNA library. The sequence contained 2010 base pairs and encoded a protein with 503 amino acids. The amino acid sequence shared greater identities with rat CYP3A18 (90%) and golden hamster...

journal_title：Journal of biochemical and molecular toxicology

authors： Dai D,Bai R,Hodgson E,Rose RL

更新日期：2001-01-01 00:00:00

abstract：:CYP1A1 and CYP1A2 enzymes metabolize polycyclic aromatic hydrocarbons (PAHs) to the reactive oxyderivatives. PAHs can induce the activity of both enzymes, which increases its conversion and enhances risk of carcinogenesis. Thus, the inhibition of CYP enzymes is recognized as a cancer chemoprevention strategy. A well-k...

journal_title：Journal of biochemical and molecular toxicology

authors： Skupinska K,Misiewicz-Krzeminska I,Stypulkowski R,Lubelska K,Kasprzycka-Guttman T

更新日期：2009-01-01 00:00:00

abstract：:Triclocarban (TCC), which is used as an antimicrobial agent in personal care products, has been widely detected in aquatic ecosystems. However, the consequence of TCC exposure on embryo development is still elusive. Here, by using zebrafish embryos, we aimed to understand the developmental defects caused by TCC exposu...

journal_title：Journal of biochemical and molecular toxicology

authors： Shi Q,Zhuang Y,Hu T,Lu C,Wang X,Huang H,Du G

更新日期：2019-05-01 00:00:00

abstract：:The genotoxic and cytotoxic potential of lambda-cyhalothrin (LCT), a synthetic pyrethroid insecticide, was investigated on human lymphocytes cultured in vitro. Utilizing the trypan blue dye exclusion technique assay, the LC50 of LCT was found to be 28 microM. Based on the LC50 value, it is seen that LCT was highly tox...

journal_title：Journal of biochemical and molecular toxicology

authors： Naravaneni R,Jamil K

更新日期：2005-01-01 00:00:00

abstract：:Ebselen (EB, compound 1) is an investigational organoselenium compound that reduces fungal growth, in part, through inhibition of the fungal plasma membrane H+ -ATPase (Pma1p). In the present study, the growth inhibitory activity of EB and of five structural analogs was assessed in a fluconazole (FLU)-resistant strain...

journal_title：Journal of biochemical and molecular toxicology

authors： Orie NN,Warren AR,Basaric J,Lau-Cam C,Piętka-Ottlik M,Młochowski J,Billack B

更新日期：2017-06-01 00:00:00

abstract：:In this study, we aimed to determine the inhibition effects of novel synthesized sulfamates (2a-g), sulfonamides (3b-f), carbonyl sulfonamides (3h and i), and carbonyl sulfamates (4h and 4i), which were tested against two human cytosolic carbonic anhydrase I and II isozymes (hCA I and II) and acetylcholinesterase (ACh...

journal_title：Journal of biochemical and molecular toxicology

authors： Atmaca U,Yıldırım A,Taslimi P,Çelik ST,Gülçin İ,Supuran CT,Çelik M

更新日期：2018-08-01 00:00:00

abstract：:With the rapid development of nanotechnology, nanomaterials are now being used for cancer treatment. Although studies on the application of silver nanoparticles in cancer treatment are burgeoning, few studies have investigated the toxicology mechanisms of autophagy in cancer cells under exposure to sublethal silver na...

journal_title：Journal of biochemical and molecular toxicology

authors： Chen Y,Yang T,Chen S,Qi S,Zhang Z,Xu Y

更新日期：2020-05-01 00:00:00

abstract：:There is evidence that glutathione conjugates are the major metabolites formed following systemic uptake of carcinogenic contaminants from the intestine. The effect of commercial diet versus a semi-purified diet on the distribution of glutathione S-transferase (GST) activity was examined in proximal, medial, and dista...

journal_title：Journal of biochemical and molecular toxicology

authors： Gadagbui BK,James MO

更新日期：2000-01-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by a constant high pulmonary artery pressure and the remodeling of the vessel. Chloroquine (CLQ) has been observed to inhibit calcium influx. The aim of this study is to investigate the effect of CLQ on transient receptor cationic protei...

journal_title：Journal of biochemical and molecular toxicology

authors： Kaymak E,Akin AT,Tufan E,Başaran KE,Taheri S,Özdamar S,Yakan B

更新日期：2020-09-21 00:00:00

abstract：:Hepatotoxicants can elicit liver damage by various mechanisms that can result in cell necrosis and death. The changes induced by these compounds can vary from gross alterations in DNA repair mechanisms, protein synthesis, and apoptosis, to more discrete changes in oxidative damage and lipid peroxidation. However, litt...

journal_title：Journal of biochemical and molecular toxicology

authors： Holden PR,James NH,Brooks AN,Roberts RA,Kimber I,Pennie WD

更新日期：2000-01-01 00:00:00

abstract：:The objective of this work is to study the protective effects of Quercetin against sodium nitrite-induced hypoxia on liver, lung, kidney and cardiac tissues, also to explore novel mechanism of this compound. Male albino rats were injected with sodium nitrite (75 mg/kg). Quercetin (200 mg kg-1 ,- i.p.) was administrate...

journal_title：Journal of biochemical and molecular toxicology

authors： Al-Rasheed NM,Fadda LM,Attia HA,Ali HM,Al-Rasheed NM

更新日期：2017-05-01 00:00:00

abstract：:Cerium oxide nanoparticles (CeO2 NPs) are among the important nanoparticles that are extensively utilized in cosmetics, automotive industries, ultraviolet (UV) filtration, gas sensors, and pharmaceutical products. In this study, CeO2 NPs were synthesized using an aqueous extract of Ziziphus jujube fruit. The synthesiz...

journal_title：Journal of biochemical and molecular toxicology

authors： Miri A,Akbarpour Birjandi S,Sarani M

更新日期：2020-06-01 00:00:00

abstract：:The health impacts of airborne particulate matter (PM) are of global concern, and the direct implications to the development/exacerbation of lung disease are immediately obvious. Most studies to date have sought to understand mechanisms associated with PM exposure in adults/adult animal models; however, infants are al...

journal_title：Journal of biochemical and molecular toxicology

authors： Saravia J,Lee GI,Lomnicki S,Dellinger B,Cormier SA

更新日期：2013-01-01 00:00:00

abstract：:It has been reported that the bioactive intermediate metabolites of trazodone might cause hepatotoxicity. This study was designed to investigate the exact mechanism of hepatocellular injury induced by trazodone as well as the protective effects of taurine and/or melatonin against this toxicity. Freshly isolated rat he...

journal_title：Journal of biochemical and molecular toxicology

authors： Taziki S,Sattari MR,Eghbal MA

更新日期：2013-10-01 00:00:00

abstract：:Retinoic acid (RA) alters the developmental fate of the axial skeletal anlagen. "Anteriorizations" or "posteriorizations," the assumption of characteristics of embryonic areas normally anterior or posterior to the affected tissues, are correlated with altered embryonal expression domains of Hox genes after in utero RA...

journal_title：Journal of biochemical and molecular toxicology

authors： Kawanishi CY,Hartig P,Bobseine KL,Schmid J,Cardon M,Massenburg G,Chernoff N

更新日期：2003-01-01 00:00:00

abstract：:Aminoglycoside antibiotics are widely used against Gram-negative infections. On the other hand, nephrotoxicity is a deleterious side effect associated with aminoglycoside therapy. Gentamicin is the most nephrotoxic aminoglycoside. Because of serious health complications ensue the nephrotoxicity induced by aminoglycosi...

journal_title：Journal of biochemical and molecular toxicology

authors： Jamshidzadeh A,Heidari R,Mohammadi-Samani S,Azarpira N,Najbi A,Jahani P,Abdoli N

更新日期：2015-02-01 00:00:00

abstract：:The antioxidant properties of 1,2,3,4-tetra-hydrocarbazole, 6-methoxy-1,2,3,4-tetrahydrocar-bazole (MTC), 2,3-dimethylindole, 5-methoxy-2,3-dimethylindole, and indole were investigated in the case of hemolysis of human erythrocytes and oxidative damage of DNA induced by 2,2'-azobis(2-amidinopropane hydrochloride) (AAP...

journal_title：Journal of biochemical and molecular toxicology

authors： Zhao F,Liu ZQ

更新日期：2009-07-01 00:00:00

abstract：:The modulatory effect of taurine on 7,12-dimethylbenz(a)anthracene (DMBA)-induced breast cancer in rats was studied. DMBA (25 mg/kg body weight) was administered to induce breast cancer in rats. Protein carbonyl levels, activities of membrane bound enzymes (Na(+) /K(+) ATPase, Ca(2+) ATPase, and Mg(2+) ATPase), phase ...

journal_title：Journal of biochemical and molecular toxicology

authors： Vanitha MK,Baskaran K,Periyasamy K,Selvaraj S,Ilakkia A,Saravanan D,Venkateswari R,Revathi Mani B,Anandakumar P,Sakthisekaran D

更新日期：2016-08-01 00:00:00

abstract：:Habitual consumption of some Melanesian medicinal and food plants may influence atherosclerosis development via their antioxidant capacity at the endothelial level. Areca nut (AN; Areca catechu), piper inflorescence (PBI; Piper betle), betel quid (BQ), guava buds (GB; Psidium guajava), the leaves (NL), juice (NJ), fru...

journal_title：Journal of biochemical and molecular toxicology

authors： Owen PL,Matainaho T,Sirois M,Johns T

更新日期：2007-01-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that binds and mediates responses to many halogenated aromatic compounds (HACs). Exposure to mixtures of HACs frequently results in nonadditive behavior in both in vivo and in vitro assays. One cause is antagonism, which results when two or...

journal_title：Journal of biochemical and molecular toxicology

authors： Petrulis JR,Bunce NJ

更新日期：2000-01-01 00:00:00

abstract：:T-2 toxin and Ochratoxin A (OTA) are toxic secondary metabolites produced by various fungi, and together they contaminate feedstuffs worldwide. T-2 toxin and OTA may exert carcinogenic action in rodent. Despite the various in vivo experiments, carcinogenicity of these two mycotoxins has not yet been proven for human. ...

journal_title：Journal of biochemical and molecular toxicology

authors： Abassi H,Ayed-Boussema I,Shirley S,Abid S,Bacha H

更新日期：2016-03-01 00:00:00

abstract：:Some novel derivatives of thiosemicarbazide and 1,2,4-triazole-3-thiol were synthesized and evaluated for their biological activities. The title compounds were prepared starting from readily available pyridine-2,5-dicarboxylic acid. The reaction carboxylic acid with absolute ethanol afforded the corresponding dimethyl...

journal_title：Journal of biochemical and molecular toxicology

authors： Bulut N,Kocyigit UM,Gecibesler IH,Dastan T,Karci H,Taslimi P,Durna Dastan S,Gulcin I,Cetin A

更新日期：2018-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is a well-known neurodegenerative disorder, causing toxicity in different organs, such as spinal cord tissue. The goal of this study was to investigate the protective effect of ellagic acid (EA) against spinal cord and sciatica function in cuprizone (Cup)-induced demyelination model. Animals we...

journal_title：Journal of biochemical and molecular toxicology

authors： Khodaei F,Khoshnoud MJ,Heidaryfar S,Heidari R,Karimpour Baseri MH,Azarpira N,Rashedinia M

更新日期：2020-11-01 00:00:00

abstract：:c-Myc and vascular endothelial growth factor (VEGF) genes are frequently deregulated and overexpressed in this malignancy, and strategies designed to inhibit c-Myc and VEGF expression in cancer cells may have considerable therapeutic value. In the present study, we design and use short interfering RNA (siRNA) to inhib...

journal_title：Journal of biochemical and molecular toxicology

authors： Tai J,Wang G,Liu T,Wang L,Lin C,Li F

更新日期：2012-12-01 00:00:00

abstract：:In the epidermis, keratinocytes are involved in physical and first-line immune protection of the host. In this study, we analyzed the molecular responses to certain contact sensitizers (2,4-dinitrochlorobenzene and NiSO(4)) and irritants (sodium dodecyl sulfate and benzalkonium chloride) in cultured human keratinocyte...

journal_title：Journal of biochemical and molecular toxicology

authors： Yoshikawa Y,Sasahara Y,Kitano Y,Kanazawa N,Shima H,Hashimoto-Tamaoki T

更新日期：2010-01-01 00:00:00

abstract：:The present study examines the chemopreventive role of [6]-gingerol, an active component of ginger, on 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis models. The HBP has been developed with an addition of 0.5% of DMBA to the HBP area three times per week, up to the end of the 1...

journal_title：Journal of biochemical and molecular toxicology

authors： Sun Y,Ren J,Wang F

更新日期：2020-12-21 00:00:00