Silver nanoparticles regulate autophagy through lysosome injury and cell hypoxia in prostate cancer cells.

abstract：:Retinoic acid (RA) alters the developmental fate of the axial skeletal anlagen. "Anteriorizations" or "posteriorizations," the assumption of characteristics of embryonic areas normally anterior or posterior to the affected tissues, are correlated with altered embryonal expression domains of Hox genes after in utero RA...

journal_title：Journal of biochemical and molecular toxicology

authors： Kawanishi CY,Hartig P,Bobseine KL,Schmid J,Cardon M,Massenburg G,Chernoff N

更新日期：2003-01-01 00:00:00

abstract：:Proximal tubule protein take-up is interceded by 2 receptors, megalin and cubilin. These receptors rescue an assortment of filtered ligands including fundamental vitamins and hormones. The objective of this study was to investigate the potential relation of megalin receptor injury with nuclear factor-kappa B (NF-κB) u...

journal_title：Journal of biochemical and molecular toxicology

authors： Elshaer SS,Anwar HM

更新日期：2018-01-01 00:00:00

abstract：:Copper toxicity is associated with formation of reactive oxygen species, which are capable to oxidize proteins. The selective removal of the latter by the 20S proteasome is considered an essential part of the cell antioxidant defense system. The aim of the present study was to investigate whether peptidase activities ...

journal_title：Journal of biochemical and molecular toxicology

authors： Alexandrova A,Petrov L,Georgieva A,Kessiova M,Tzvetanova E,Kirkova M,Kukan M

更新日期：2008-09-01 00:00:00

abstract：:Manganese is an essential trace element found in many enzymes. As it is the case of many essential trace elements, excessive level of manganese is toxic. It has been proven that excessive manganese could cause heart problems. In order to understand the mechanism of manganese toxicity in the heart, the effects of manga...

journal_title：Journal of biochemical and molecular toxicology

authors： Yang H,Wang T,Li J,Gu L,Zheng X

更新日期：2006-01-01 00:00:00

abstract：:Contrary to the fact that doxorubicin is a powerful chemotherapeutic agent for the treatment of neoplastic diseases, cardiotoxicity is too important to be ignored. Thymoquinone serves as a powerful free radical scavenger. In the study, the effects of thymoquinone against doxorubicin-cardiotoxicity will be evaluated. F...

journal_title：Journal of biochemical and molecular toxicology

authors： Karabulut D,Ozturk E,Kaymak E,Akin AT,Yakan B

更新日期：2021-01-01 00:00:00

abstract：:A cDNA clone coding for a mu-class glutathione S-transferase (GST) was isolated from a hepatopancreas cDNA library from the shrimp Litopenaeus vannamei. The deduced amino acid sequence (215 amino acids) has >50% identity to rodents and other mammals mu-class GSTs. Using RT-PCR, the shrimp GST transcript was detected i...

journal_title：Journal of biochemical and molecular toxicology

authors： Contreras-Vergara CA,Harris-Valle C,Sotelo-Mundo RR,Yepiz-Plascencia G

更新日期：2004-01-01 00:00:00

abstract：:Three new phytoecdysteroids have been isolated from the seeds of Chenopodium quinoa and structurally identified as 20,26-dihydroxy, 28-methyl ecdysone, 20,26-dihydroxy, 24(28)-dehydro ecdysone, and 20-hydroxyecdysone 22-glycolate using serial chromatographic and spectroscopic methods. Both previously reported compound...

journal_title：Journal of biochemical and molecular toxicology

authors： Nsimba RY,Kikuzaki H,Konishi Y

更新日期：2008-07-01 00:00:00

abstract：:The cytochrome P450 (CYP) isoform CYP2C11 is specifically expressed in the liver of adult male rats, and 5alpha-reductase is specifically expressed in the liver of the adult female rats. The sexually dimorphic expressions of these hepatic enzymes are regulated by the sex-dependent profiles of the circulating growth ho...

journal_title：Journal of biochemical and molecular toxicology

authors： Ishizuka M,Yonemoto J,Zaha H,Tohyama C,Sone H

更新日期：2003-01-01 00:00:00

abstract：:The objective of the present study was to assess superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), paraoxonase (PON1), glutathione reductase (GR), and catalase (CAT) activities ratio and their relationship with DNA oxidative damage in rats treated with cisplatin (3 mg/kg bwt/day) in the presence and ...

journal_title：Journal of biochemical and molecular toxicology

authors： Harisa GI

更新日期：2013-08-01 00:00:00

abstract：:Sodium dichromate [Cr(VI)] and cadmium chloride [Cd(II)] are both cytotoxic and mutagenic. This study examined the toxic and apoptotic potentials of these two cations on three cell types in vitro, namely, human chronic myelogenous leukemic (CML) K562 cells, promyelocytic leukemic HL-60 cells, and normal human peripher...

journal_title：Journal of biochemical and molecular toxicology

authors： Bagchi D,Joshi SS,Bagchi M,Balmoori J,Benner EJ,Kuszynski CA,Stohs SJ

更新日期：2000-01-01 00:00:00

abstract：:The effects of ellagic acid (EA) and vitamin E succinate (VES) on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative stress in different brain regions of rats have been studied after subchronic exposure to the compounds. TCDD was administered to groups of rats at a dose of 46 ng/kg/day for 90 days. EA and VE...

journal_title：Journal of biochemical and molecular toxicology

authors： Hassoun EA,Vodhanel J,Abushaban A

更新日期：2004-01-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that binds and mediates responses to many halogenated aromatic compounds (HACs). Exposure to mixtures of HACs frequently results in nonadditive behavior in both in vivo and in vitro assays. One cause is antagonism, which results when two or...

journal_title：Journal of biochemical and molecular toxicology

authors： Petrulis JR,Bunce NJ

更新日期：2000-01-01 00:00:00

abstract：:Disruption of the balance oxidants, antioxidants cause various pathophysiological conditions such as lipid peroxidation, protein degradation, or DNA damage. We have examined possible effects of kisspeptin-10 on the structural damage produced by methionine-induced lipid peroxidation in testicle tissue of young rats. Ki...

journal_title：Journal of biochemical and molecular toxicology

authors： Akkaya H,Eyuboglu S,Erkanlı Senturk G,Yilmaz B

更新日期：2017-05-01 00:00:00

abstract：:The widespread opinion that N(2)O(3) as a product of NO oxidation is the only nitros(yl)ating agent under aerobic conditions is based on experiments in homogeneous buffered water solutions. In vivo NO is oxidized in heterogeneous media and this opinion is not correct. The equilibrium in the system being dependent on t...

journal_title：Journal of biochemical and molecular toxicology

authors： Nedospasov AA

更新日期：2002-01-01 00:00:00

abstract：:The aim of this study was to determine the antigenotoxic potential of two newly synthesized β-aminoketones against N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and 9-aminoacridine (9-AA)-induced mutagenesis. The mutant bacterial tester strains were MNNG-sensitive Escherichia coli WP2 uvrA and 9-AA-sensitive Salmonella ...

journal_title：Journal of biochemical and molecular toxicology

authors： Ozturkcan SA,Turhan K,Turgut Z,Karadayi M,Gulluce M

更新日期：2012-07-01 00:00:00

abstract：:Netrin-1 has been found to protect kidneys from ischemia/reperfusion injury. In this study, we aimed to address whether the protective effects were mediated through suppression of oxidative stress and neuropeptide Y. Compared to sham-operated animals, animals after ischemia/reperfusion showed marked kidney damage and ...

journal_title：Journal of biochemical and molecular toxicology

authors： Liu L,Xie S,Liao X,Zhang L,Zhong L

更新日期：2013-04-01 00:00:00

abstract：:Excessive exposure to Copper (Cu) may result in Cu toxicity and adversely affect health outcomes. We investigated the protective role of rutin on Cu-induced brain damage. Experimental rats were treated as follows: group I: control; group II: Cu-sulfate: 200 mg/kg; group III: Cu-sulfate, and rutin 100 mg/kg; and group ...

journal_title：Journal of biochemical and molecular toxicology

authors： Arowoogun J,Akanni OO,Adefisan AO,Owumi SE,Tijani AS,Adaramoye OA

更新日期：2021-01-01 00:00:00

abstract：:Limited research has been performed on S-adenosylhomocysteine (SAH) or homocysteine (Hcy)-evoked cell damage in hepatic and neuronal cells. In this study, we assessed effects of SAH or Hcy on cell cytotoxicity and DNA damage in hepatic and neuronal cells and attempted to find the underlying mechanism. Cell cytotoxicit...

journal_title：Journal of biochemical and molecular toxicology

authors： Liu CC,Ho WY,Leu KL,Tsai HM,Yang TH

更新日期：2009-09-01 00:00:00

abstract：:The effects of Echis pyramidum venom (EPV) (0.25, 0.50, and 1.00 mg/kg) on activities of superoxide dismutase (SOD) and catalase (CAT) and levels of thiobarbituric acid reactive substances (TBARS) and total thiols (T-SH) in liver and kidneys of rats were investigated. EPV significantly and dose dependently decreased t...

journal_title：Journal of biochemical and molecular toxicology

authors： Al Asmari AK,Khan HA,Manthiri RA,Al Yahya KM,Al Otaibi KE

更新日期：2014-09-01 00:00:00

abstract：:Triclocarban (TCC), which is used as an antimicrobial agent in personal care products, has been widely detected in aquatic ecosystems. However, the consequence of TCC exposure on embryo development is still elusive. Here, by using zebrafish embryos, we aimed to understand the developmental defects caused by TCC exposu...

journal_title：Journal of biochemical and molecular toxicology

authors： Shi Q,Zhuang Y,Hu T,Lu C,Wang X,Huang H,Du G

更新日期：2019-05-01 00:00:00

abstract：:There is evidence that glutathione conjugates are the major metabolites formed following systemic uptake of carcinogenic contaminants from the intestine. The effect of commercial diet versus a semi-purified diet on the distribution of glutathione S-transferase (GST) activity was examined in proximal, medial, and dista...

journal_title：Journal of biochemical and molecular toxicology

authors： Gadagbui BK,James MO

更新日期：2000-01-01 00:00:00

abstract：:Pneumonia is a chronic disorder of the respiratory system associated with worsening quality of life and a significant economic burden. Pinitol, a plant cyclic polyol, has been documented for immune-inflammatory potential. The aim of present investigation was to evaluate the potential and possible mechanism of action o...

journal_title：Journal of biochemical and molecular toxicology

authors： Fan Y,Wang J,Feng Z,Cao K,Xu H,Liu J

更新日期：2021-01-01 00:00:00

abstract：:This study examined the possible protective effects of thymoquinone (TQ), the main constituent of the volatile oil of black seed (Nigella sativa), against cyclophosphamide (CP)-induced cardiotoxicity. Adult male Wistar albino rats were divided into four treatment groups. Rats in the first group were served as control....

journal_title：Journal of biochemical and molecular toxicology

authors： Nagi MN,Al-Shabanah OA,Hafez MM,Sayed-Ahmed MM

更新日期：2011-05-01 00:00:00

abstract：:Hepatotoxicants can elicit liver damage by various mechanisms that can result in cell necrosis and death. The changes induced by these compounds can vary from gross alterations in DNA repair mechanisms, protein synthesis, and apoptosis, to more discrete changes in oxidative damage and lipid peroxidation. However, litt...

journal_title：Journal of biochemical and molecular toxicology

authors： Holden PR,James NH,Brooks AN,Roberts RA,Kimber I,Pennie WD

更新日期：2000-01-01 00:00:00

abstract：:A series of novel indenopyrazole derivatives 2a-j and 3a-j were synthesized from the reaction of 1-(4-(hydroxy(1-oxo-1,3-dihydro-2 H-inden-2-ylidene)methyl)phenyl)-3-phenylurea derivatives 1a-j with hydrazine and phenylhydrazine, respectively. The obtained novel indenopyrazoles ( 2a-j and 3a-j) were evaluated for anti...

journal_title：Journal of biochemical and molecular toxicology

authors： Gezegen H,Tutar U,Hepokur C,Ceylan M

更新日期：2019-05-01 00:00:00

abstract：:The current work planned to assess the protecting properties of nimbolide against doxorubicin (DOX)-treated myocardial damage. Myocardial damage was produced with 2.5 mg/kg of DOX given on alternative days (14 days). Thiobarbituric acid reactive substances (TBARS) levels of a lipid peroxidative marker were elevated, w...

journal_title：Journal of biochemical and molecular toxicology

authors： Li H,Xia B,Chen W,Zhang Y,Gao X,Chinnathambi A,Alharbi SA,Zhao Y

更新日期：2020-07-06 00:00:00

abstract：:Colorectal cancer (CRC) is the leading type of diagnosed cancer; globally, it resides in the fourth-leading origin of cancer-interrelated mortality in the globe. The treatment strategies were chemotherapy and potent radiotherapy. Although chemotherapy treatment can eliminate tumor cells, it remains with unnecessary to...

journal_title：Journal of biochemical and molecular toxicology

authors： Li Z,Zhou X,Zhu H,Song X,Gao H,Niu Z,Lu J

更新日期：2020-12-28 00:00:00

abstract：:Cerium oxide nanoparticles (CeO2 NPs) are among the important nanoparticles that are extensively utilized in cosmetics, automotive industries, ultraviolet (UV) filtration, gas sensors, and pharmaceutical products. In this study, CeO2 NPs were synthesized using an aqueous extract of Ziziphus jujube fruit. The synthesiz...

journal_title：Journal of biochemical and molecular toxicology

authors： Miri A,Akbarpour Birjandi S,Sarani M

更新日期：2020-06-01 00:00:00

abstract：:Significant changes in drug-metabolizing enzyme (DME) expression occur during ontogeny. Such changes can have a profound effect on therapeutic efficacy in the fetus and child, as well as the risk for adverse drug reactions. To gain a better understanding of DME ontogeny, enzyme contents for six key cytochromes P450 we...

journal_title：Journal of biochemical and molecular toxicology

authors： Hines RN

更新日期：2007-01-01 00:00:00

abstract：:The antioxidant-activated transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) regulates the induction of cytoprotective genes against chemical toxicity and oxidative injuries. The role of phosphorylation in Nrf2 activation has been suggested but remains elusive. We report that phenolic antioxidant/...

journal_title：Journal of biochemical and molecular toxicology

authors： Apopa PL,He X,Ma Q

更新日期：2008-02-01 00:00:00