Effects of Echis pyramidum snake venom on hepatic and renal antioxidant enzymes and lipid peroxidation in rats.

abstract：:Multiple sclerosis (MS) is a well-known neurodegenerative disorder, causing toxicity in different organs, such as spinal cord tissue. The goal of this study was to investigate the protective effect of ellagic acid (EA) against spinal cord and sciatica function in cuprizone (Cup)-induced demyelination model. Animals we...

journal_title：Journal of biochemical and molecular toxicology

authors： Khodaei F,Khoshnoud MJ,Heidaryfar S,Heidari R,Karimpour Baseri MH,Azarpira N,Rashedinia M

更新日期：2020-11-01 00:00:00

abstract：:Certain ginsenosides, also known as triterpene glycosides, have been recently reported to have a characteristic effect on cultured intestinal and leukemia cell growth. Ginsenoside aglycones 20(S)-protopanaxadiol (PD), 20(S)-protopanaxatriol (PT), and ginsenoside Rh2 have been identified as having a strong effect on re...

journal_title：Journal of biochemical and molecular toxicology

authors： Popovich DG,Kitts DD

更新日期：2004-01-01 00:00:00

abstract：:In the epidermis, keratinocytes are involved in physical and first-line immune protection of the host. In this study, we analyzed the molecular responses to certain contact sensitizers (2,4-dinitrochlorobenzene and NiSO(4)) and irritants (sodium dodecyl sulfate and benzalkonium chloride) in cultured human keratinocyte...

journal_title：Journal of biochemical and molecular toxicology

authors： Yoshikawa Y,Sasahara Y,Kitano Y,Kanazawa N,Shima H,Hashimoto-Tamaoki T

更新日期：2010-01-01 00:00:00

abstract：:The etiologic link between pesticide toxicity and aplastic anemia in agricultural and agro-industrial setting has been frequently reported in epidemiological studies conducted worldwide. Chronic pesticide toxicity causes long-term bone marrow injury and perturbs the normal hematopoietic physiology, including survival ...

journal_title：Journal of biochemical and molecular toxicology

authors： Chattopadhyay S,Law S

更新日期：2020-05-14 00:00:00

abstract：:Oxidative shock and production of reactive oxygen species are known to play a major role in situations leading to neuron degeneration, but the precise mechanisms responsible for cell degeneration remain uncertain. In the present article, we have studied in PC 12 cells the effect of cumene hydroxyperoxide on both cell ...

journal_title：Journal of biochemical and molecular toxicology

authors： Vimard F,Saucet M,Nicole O,Feuilloley M,Duval D

更新日期：2011-07-01 00:00:00

abstract：:The effect of 2-(2-nitrovinyl)furan on the redox status of male rat liver and kidney was evaluated. Twenty male rats were randomized into four groups; group A received olive oil and groups B, C, and D rats received 12.5, 25, and 50 mg/kg bodyweight of 2-(2-nitrovinyl)furan intraperitoneally, daily at 24 h interval, re...

journal_title：Journal of biochemical and molecular toxicology

authors： Ajiboye TO,Alabi KA,Ariyo FA,Adeleye AO,Ojewuyi OB,Balogun A,Sunmonu TO

更新日期：2015-03-01 00:00:00

abstract：:Colchicine (COL) shows strong anticancer activity but due to its toxicity towards normal cells its wider application is limited. To address this issue, a library of 17 novel COL derivatives, namely N-carbamates of N-deacetyl-4-(bromo/chloro/iodo)thiocolchicine, has been tested against two types of primary cancer cells...

journal_title：Journal of biochemical and molecular toxicology

authors： Urbaniak A,Jousheghany F,Piña-Oviedo S,Yuan Y,Majcher-Uchańska U,Klejborowska G,Moorjani A,Monzavi-Karbassi B,Huczyński A,Chambers TC

更新日期：2020-06-01 00:00:00

abstract：:Pneumonia is a chronic disorder of the respiratory system associated with worsening quality of life and a significant economic burden. Pinitol, a plant cyclic polyol, has been documented for immune-inflammatory potential. The aim of present investigation was to evaluate the potential and possible mechanism of action o...

journal_title：Journal of biochemical and molecular toxicology

authors： Fan Y,Wang J,Feng Z,Cao K,Xu H,Liu J

更新日期：2021-01-01 00:00:00

abstract：:We have analyzed gene expression and histopathology of rat liver treated with a histamine-3 receptor inverse agonist under development for the treatment of obesity 24 h after a single acute administration. While histopathology did not identify a clear liver toxicity, analysis of gene changes strongly suggested the dev...

journal_title：Journal of biochemical and molecular toxicology

authors： Roth A,Boess F,Landes C,Steiner G,Freichel C,Plancher JM,Raab S,de Vera Mudry C,Weiser T,Suter L

更新日期：2011-05-01 00:00:00

abstract：:Ochratoxin A (OTA) is nephrotoxic, immunosuppressive, and teratogenic in many species and is a possible human carcinogen. In this study, we investigated the OTA pollution situations of grains in northern China and the signaling pathway that mediated OTA-induced apoptosis in human tubular kidney cells (HKCs). Samples o...

journal_title：Journal of biochemical and molecular toxicology

authors： Li Z,Zhang X,Cui J,Kang W

更新日期：2012-03-01 00:00:00

abstract：:Increasing interest in the role of oxidative stress and beta-carotene in disease and prevention led us to examine the results of beta-carotene's administration in diabetic rats, a model for high-oxidative stress. In this experiment, amounts of lipid peroxidation, glutathione, and glutathione disulfide, and activity le...

journal_title：Journal of biochemical and molecular toxicology

authors： Maritim A,Dene BA,Sanders RA,Watkins JB 3rd

更新日期：2002-01-01 00:00:00

abstract：:Disruption of the balance oxidants, antioxidants cause various pathophysiological conditions such as lipid peroxidation, protein degradation, or DNA damage. We have examined possible effects of kisspeptin-10 on the structural damage produced by methionine-induced lipid peroxidation in testicle tissue of young rats. Ki...

journal_title：Journal of biochemical and molecular toxicology

authors： Akkaya H,Eyuboglu S,Erkanlı Senturk G,Yilmaz B

更新日期：2017-05-01 00:00:00

abstract：:The modulatory effect of taurine on 7,12-dimethylbenz(a)anthracene (DMBA)-induced breast cancer in rats was studied. DMBA (25 mg/kg body weight) was administered to induce breast cancer in rats. Protein carbonyl levels, activities of membrane bound enzymes (Na(+) /K(+) ATPase, Ca(2+) ATPase, and Mg(2+) ATPase), phase ...

journal_title：Journal of biochemical and molecular toxicology

authors： Vanitha MK,Baskaran K,Periyasamy K,Selvaraj S,Ilakkia A,Saravanan D,Venkateswari R,Revathi Mani B,Anandakumar P,Sakthisekaran D

更新日期：2016-08-01 00:00:00

abstract：:This study was aimed to predict bisphenol-A (BPA)-responsive miRNA's using an in silico approach and to study their expression in granulosa cells of animals exposed prenatally to BPA. Pregnant Wistar rats were exposed to BPA through water (25 μg/L, 250 μg/L, and 2.5 mg/L) during gestation. The expression of miRNA-133b...

journal_title：Journal of biochemical and molecular toxicology

authors： Lite C,Ahmed SSSJ,Santosh W,Seetharaman B

更新日期：2019-06-01 00:00:00

abstract：:Hemolysis is the red blood cell abnormality most often associated with adverse effect of drug therapy. Drug-induced or drug-associated hyperglycemia could decrease the activity of hexokinase. The aim of this study was to investigate the inhibitory effects of some commonly used drugs that have hyperglycemic side effect...

journal_title：Journal of biochemical and molecular toxicology

authors： Aljamal JA,Badawneh M

更新日期：2017-08-01 00:00:00

abstract：:The interaction between acotiamide hydrochloride and pepsin was systematically characterized by fluorescence and electrochemical approaches. Fluorescence lifetime measurements showed that acotiamide hydrochloride quenched the intrinsic fluorescence of pepsin with a new complex formation via static mode, which was reco...

journal_title：Journal of biochemical and molecular toxicology

authors： He J,Ma X,Wang Q,Huang Y,Li H

更新日期：2016-07-01 00:00:00

abstract：:Taxane-based chemotherapy drugs (cabazitaxel, docetaxel, and paclitaxel) are microtubule inhibitors, which are effectively and frequently used to treat metastatic prostate cancer (PCa). Among these, cabazitaxel is offered as a new therapeutic option for patients with metastatic castration-resistant PC as that are resi...

journal_title：Journal of biochemical and molecular toxicology

authors： Cevik O,Acidereli H,Turut FA,Yildirim S,Acilan C

更新日期：2020-06-24 00:00:00

abstract：:The toxicities of 4 short-chain alcohols--namely methanol, ethanol, iso-propanol and iso-butanol--were compared in the nematode Caenorhabditis elegans using several different ecotoxicological endpoints. Range-finding tests were conducted using transgenic PC161 worms carrying a double reporter construct (GFP plus lacZ)...

journal_title：Journal of biochemical and molecular toxicology

authors： Thompson G,de Pomerai DI

更新日期：2005-01-01 00:00:00

abstract：:Schisandrin A (SchA) has been reported as a multidrug resistance-reversing agent; however, its antitumor effects have been rarely reported. Consequently, we attempted to explore whether SchA per se possesses an antitumor property in choriocarcinoma JEG-3 and BeWo cells and its potential mechanisms. JEG-3, BeWo, and HT...

journal_title：Journal of biochemical and molecular toxicology

authors： Ji L,Ma L

更新日期：2020-04-01 00:00:00

abstract：:The aim of this study was to determine the antigenotoxic potential of two newly synthesized β-aminoketones against N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and 9-aminoacridine (9-AA)-induced mutagenesis. The mutant bacterial tester strains were MNNG-sensitive Escherichia coli WP2 uvrA and 9-AA-sensitive Salmonella ...

journal_title：Journal of biochemical and molecular toxicology

authors： Ozturkcan SA,Turhan K,Turgut Z,Karadayi M,Gulluce M

更新日期：2012-07-01 00:00:00

abstract：:Paraoxon, the active metabolite of parathion, can be detoxified through a noncatalytic pathway by carboxylesterases and a catalytic pathway by calcium-dependent A-esterases, producing p-nitrophenol as a common metabolite. The detoxication patterns of carboxylesterases and A-esterases were investigated in vitro in the ...

journal_title：Journal of biochemical and molecular toxicology

authors： Tang J,Chambers JE

更新日期：1999-01-01 00:00:00

abstract：:In the present study, we have tested the beneficial effects of forskolin in protecting the mancozeb-induced reproductive toxicity in rats. Adult male Wistar rats were exposed to either mancozeb (500 mg/kg body weight/day) or forskolin (5 mg/kg body weight/day) or both for 65 days and analyzed for spermatogenesis and s...

journal_title：Journal of biochemical and molecular toxicology

authors： Girish BP,Reddy PS

更新日期：2018-02-01 00:00:00

abstract：:In this study, we aimed to determine the inhibition effects of novel synthesized sulfamates (2a-g), sulfonamides (3b-f), carbonyl sulfonamides (3h and i), and carbonyl sulfamates (4h and 4i), which were tested against two human cytosolic carbonic anhydrase I and II isozymes (hCA I and II) and acetylcholinesterase (ACh...

journal_title：Journal of biochemical and molecular toxicology

authors： Atmaca U,Yıldırım A,Taslimi P,Çelik ST,Gülçin İ,Supuran CT,Çelik M

更新日期：2018-08-01 00:00:00

abstract：:Triclocarban (TCC), which is used as an antimicrobial agent in personal care products, has been widely detected in aquatic ecosystems. However, the consequence of TCC exposure on embryo development is still elusive. Here, by using zebrafish embryos, we aimed to understand the developmental defects caused by TCC exposu...

journal_title：Journal of biochemical and molecular toxicology

authors： Shi Q,Zhuang Y,Hu T,Lu C,Wang X,Huang H,Du G

更新日期：2019-05-01 00:00:00

abstract：:We reported earlier in a guinea pig model that exposure of 2-chloroethyl ethyl sulfide (CEES), a mustard gas analog, causes lung injury associated with the activation of tumor necrosis factor alpha (TNF-alpha), mitogen activated protein kinases (MAPK) signaling, and activator protein-1 (AP-1) transcription factor. Our...

journal_title：Journal of biochemical and molecular toxicology

authors： Mukhopadhyay S,Mukherjee S,Ray BK,Ray A,Stone WL,Das SK

更新日期：2010-05-01 00:00:00

abstract：:It has been reported that the bioactive intermediate metabolites of trazodone might cause hepatotoxicity. This study was designed to investigate the exact mechanism of hepatocellular injury induced by trazodone as well as the protective effects of taurine and/or melatonin against this toxicity. Freshly isolated rat he...

journal_title：Journal of biochemical and molecular toxicology

authors： Taziki S,Sattari MR,Eghbal MA

更新日期：2013-10-01 00:00:00

abstract：:Contrary to the fact that doxorubicin is a powerful chemotherapeutic agent for the treatment of neoplastic diseases, cardiotoxicity is too important to be ignored. Thymoquinone serves as a powerful free radical scavenger. In the study, the effects of thymoquinone against doxorubicin-cardiotoxicity will be evaluated. F...

journal_title：Journal of biochemical and molecular toxicology

authors： Karabulut D,Ozturk E,Kaymak E,Akin AT,Yakan B

更新日期：2021-01-01 00:00:00

abstract：:Nitrofurantoin (N-(5-nitro-2-furfurylidine) 1-amino-hydantoine; NIT) is mainly used for the treatment of acute urinary tract infections. However, its administration can be associated with liver failure or cirrhosis. The aim of this study was to determine whether NIT is a mitochondrial toxicant, if so, what mechanism(s...

journal_title：Journal of biochemical and molecular toxicology

authors： Omidi M,Niknahad H,Mohammadi-Bardbori A

更新日期：2016-12-01 00:00:00

abstract：:Chrysin (CH) or 5,7-dihydroxyflavone is a flavonoid present in various plants, bee propolis, and honey. Cyclophosphamide (CYP) is a chemotherapeutic drug, which is extensively used in the treatment of multiple human malignancies. In our study, we aimed to investigate the effects of CYP and CH on some metabolic enzymes...

journal_title：Journal of biochemical and molecular toxicology

authors： Taslimi P,Kandemir FM,Demir Y,İleritürk M,Temel Y,Caglayan C,Gulçin İ

更新日期：2019-06-01 00:00:00

abstract：:CYP1A1 and CYP1A2 enzymes metabolize polycyclic aromatic hydrocarbons (PAHs) to the reactive oxyderivatives. PAHs can induce the activity of both enzymes, which increases its conversion and enhances risk of carcinogenesis. Thus, the inhibition of CYP enzymes is recognized as a cancer chemoprevention strategy. A well-k...

journal_title：Journal of biochemical and molecular toxicology

authors： Skupinska K,Misiewicz-Krzeminska I,Stypulkowski R,Lubelska K,Kasprzycka-Guttman T

更新日期：2009-01-01 00:00:00